Session: 311. Disorders of Platelet Number or Function: Poster I
Hematology Disease Topics & Pathways:
Adult, Diseases, Bleeding and Clotting, Study Population, TTP
Methods: We performed retrospective study using the National Inpatient Sample database, a part of the Healthcare Cost and Utilization Project (HCUP) of the agency for Healthcare Research and Quality (AHRQ). We extracted the study cohort of adult admissions with TTP from 2007-2017 by using International Classification of Diseases (9th/10th editions) Clinical Modification diagnosis codes. In the final study cohort we only included patients who received plasmapheresis to restrict patient population with active TTP disease. This approach has been validated in prior publications from administrative databases. Other diagnosis of interests and other comorbidities were identified by ICD-9/10-CM codes and Elixhauser comorbidity software. We utilized Cochran Armitage trend test and survey logistic multivariable regression modeling to analyze trends and predictors of outcomes with weighted analysis. Statistical analyses were performed using SAS software, version 9.4.
Results: There were a total 22,054 hospitalizations due to TTP, which increased from 1,620 in 2007 to 1,870 in 2017. The median age was 47-years (IQR:33-60) with 25% hospitalizations among the age group of 18-34 years, 66.1% were females, 46.7% were Caucasians followed by 39.2% African American race. The overall length of stay was 16-days which declined from 17-days in 2007 to 15-days is 2017 (pTrend<0.001). In the study cohort, 14.5% were discharged to a facility, and 9.8% died during the hospitalization. In trend analysis, in-hospital mortality decreased (13.4% in 2007 to 8.02% in 2017; pTrend<0.001) but discharge to facilities increased (8.9% in 2007 to 14.4% in 2017; pTrend<0.001). Furthermore, in multivariable regression analysis, increasing age (OR 1.4; 95%CI 1.3-1.5; p<0.001), Caucasians (OR 1.4; 95%CI 1.2-1.7; p<0.001), pneumonia (OR 1.8; 95%CI 1.4-2.5; p<0.001), septicemia (OR 3.4; 95%CI 2.6-4.5; p<0.001), cardiovascular events (OR 2.2; 95%CI 1.5-3.2; p<0.0001), electrolytes imbalance (OR 1.4; 95%CI 1.1-1.9; p=0.005), and liver disorders (OR 1.7; 95%CI 1.1-2.6; p=0.02) were associated with higher odds of in-hospital mortality.
Conclusion: In this study, we described national trends of hospitalizations and outcomes of TTP. We observed in-hospital mortality has decreased coupled with an increase in discharge to facilities over the past decade. We also identified risk factors for poorer outcomes, including advanced age, caucasian background and associated sepsis, revealing higher odds of in-hospital mortality. Early identifications of these potential risk stratifiers may play a crucial role in initiating early treatment in addition to identifying populations who may benefit from immune-modulatory therapy along with prophylactic plasma exchange.
Disclosures: No relevant conflicts of interest to declare.
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