Type: Oral
Session: 902. Health Services Research—Malignant Conditions (Lymphoid Disease) I
Hematology Disease Topics & Pathways:
Diseases, Combinations, Elderly, Lymphoid Malignancies, Study Population, Clinically relevant, Quality Improvement
Methods: We selected adults with a MM diagnosis between 07/07-12/15 from the SEER-Medicare linked database. We required continuous Medicare Parts A and B enrollment and no HMO/PPO coverage from 12 months prior to diagnosis (1 month prior for Part D) through death or end of study (12/16) and MM therapy initiation w/in 12 months post diagnosis. Outcomes including 1st treatment line PI-IMiD combination, SCT, MT, and 2nd, 3rd, and 4th treatment lines were constructed by applying a complex algorithm to claims-based indicators for oral and IV drugs and receipt dates. Provider setting was assigned as academic and/or NCI designated cancer center (NCI-CC), other hospital (other teaching or non-teaching), or community (non-hospital), based on claims from the most recent hematologist or oncologist evaluation and management visit prior to 1st line initiation. The percentage of each oncologist’s patient panel diagnosed with a hematologic malignancy (HEME%) was calculated for each 3-year period, using a pooled sample of 11 major cancer sites (reported in SEER-Medicare) for the denominator; HEME% was linked back to each patient based on the oncologist of record at the visit prior to 1st line initiation. Bivariate analyses and multivariable regressions tested for associations with treatment (logistic regression) and OS (Cox proportional hazards models). Regressions controlled for demographics, health status, and diagnosis year.
Results: The cohort (n=4932) was 14% Black, and 51% age ≥75 years [Table 1]. Care setting was 14.5% academic/NCI-CC, 22.4% other hospital, and 63.0% community; community setting decreased from 72.4 to 57.8% during the observation period (2007 to 2015). Mean HEME% (31% overall) was higher for academic/NCI-CC (51%), where there was a bimodal distribution with peaks at 25% and 85-90% (Figure 1). Mean HEME% was 27% at both other hospital and community practices, with a peak at 25%. 1st treatment line PI-IMiD combinations, MT after PI-IMiD, and SCT were received by 21%, 53%, and 4%, respectively. 2nd, 3rd, and 4th treatment lines were received by 55%, 31% and 18% respectively. After adjustment, higher HEME% was associated with increased likelihood of receiving a PI-IMiD combination and SCT during 1st line, receiving 3rd line (all at p<.05), with a trend for receiving 4th line, but lower likelihood of MT at PI-ImiD combination. Relative to academic/NCI-CC, other hospital and community settings were associated with lower adjusted odds for 4th line receipt: aOR 0.65 (p=.017) and aOR 0.61 (p=.001), and worse OS (adjusted hazard ratio (aHR) 1.20 (p=.009) and aHR 1.21 (p=.002)), respectively.
Conclusion: Using a novel measure of oncologist sub-specialization in hematologic malignancies, we found strong positive associations with receipt of 1st line PI-IMiD combination therapy and ongoing treatment lines in a Medicare insured population with MM. In contrast to HEME%, care setting was less likely to be associated with treatment in our multivariable models. The bimodal distribution of HEME% within academic centers is consistent with academic acquisition of community oncology practices. Future research should consider the role of oncologist sub-specialization in other cancers and with additional outcomes, including patient care experience and cost of care.
Disclosures: Davidoff: Amgen: Consultancy; AbbVie: Consultancy; Celgene: Research Funding. Neparidze: Janssen: Research Funding; Eidos Therapeutics: Membership on an entity's Board of Directors or advisory committees, Other: Diagnostic committee member ; Sanofi: Membership on an entity's Board of Directors or advisory committees, Other: Advisory board; GlaxoSmithKline: Research Funding. Podoltsev: Jazz Pharmaceuticals: Research Funding; Sunesis Pharmaceuticals: Research Funding; Astex Pharmaceuticals: Research Funding; Samus Therapeutics: Research Funding; AI Therapeutics: Research Funding; Genentech: Research Funding; Arog Pharmaceuticals: Research Funding; Kartos Therapeutics: Research Funding; Incyte: Consultancy, Honoraria; Blueprint Medicines: Consultancy, Honoraria; Agios Pharmaceuticals: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria, Research Funding; Alexion: Consultancy, Honoraria; Daiichi Sankyo: Research Funding; Astellas Pharma: Research Funding; Boehringer Ingelheim: Research Funding; CTI biopharma: Consultancy, Honoraria, Research Funding; Bristol-Myers Squib: Consultancy, Honoraria; Celgene: Consultancy, Honoraria, Research Funding; Novartis: Consultancy, Honoraria. Wang: Celgene/BMS: Research Funding. Gore: Abbvie: Consultancy, Honoraria, Research Funding. Zeidan: Boehringer-Ingelheim: Consultancy, Honoraria, Research Funding; Novartis: Consultancy, Honoraria, Research Funding; Acceleron: Consultancy, Honoraria; Astellas: Consultancy, Honoraria; Daiichi Sankyo: Consultancy, Honoraria; Cardinal Health: Consultancy, Honoraria; Taiho: Consultancy, Honoraria; Seattle Genetics: Consultancy, Honoraria; BeyondSpring: Consultancy, Honoraria; Cardiff Oncology: Consultancy, Honoraria, Other; Takeda: Consultancy, Honoraria, Research Funding; Ionis: Consultancy, Honoraria; Epizyme: Consultancy, Honoraria; Leukemia and Lymphoma Society: Other; CCITLA: Other; Astex: Research Funding; MedImmune/Astrazeneca: Research Funding; Trovagene: Consultancy, Honoraria, Research Funding; Aprea: Research Funding; Agios: Consultancy, Honoraria; ADC Therapeutics: Research Funding; Incyte: Consultancy, Honoraria, Research Funding; Jazz: Consultancy, Honoraria; Celgene / BMS: Consultancy, Honoraria, Research Funding; Pfizer: Consultancy, Honoraria, Research Funding; Otsuka: Consultancy, Honoraria; Abbvie: Consultancy, Honoraria, Research Funding. Huntington: Bayer: Consultancy, Honoraria; Pharmacyclics: Honoraria; Novartis: Consultancy; Genentech: Consultancy; DTRM: Research Funding; AbbVie: Consultancy; Astrazeneca: Honoraria; Celgene: Consultancy, Research Funding; TG Therapeutics: Research Funding; Flatiron Health: Consultancy; BeiGene: Consultancy.
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