Session: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma—Clinical Studies: Poster III
Hematology Disease Topics & Pathways:
Adult, Therapies, Combinations, Study Population, Clinically relevant
Methods: In this multicenter phase I clinical trial, pts age ≥18 with stage ≥IB CTCL, good organ function, ECOG PS≤2, <G2 neuropathy, who require systemic treatment, are enrolled, irrespective of CD30 expression. A traditional “3+3” design with 4 dose levels (DL -2, -1, 0, and 1) was used to define the maximum tolerated dose (MTD). Prior HDACi or BV use is allowed. Enrollment started at dose level (DL) 0, where R is given at 10mg/m2 on days (D) 1, 8 & 15, with BV at 1.2mg/kg (max. 120mg) on D1 & 15 of a 28 day cycle for up to 16 cycles. Dose level 1 dosing is R 14mg/m2 and BV 1.2mg/kg, both on D1 & 15. Dosing in the de-escalation cohorts -1 and -2 is as follows: R 10mg/m2 and BV 1.2mg/kg D1 & D15 (DL-1) or R 10mg/m2 D1, 8 & 15 with BV 0.9mg/kg D1&15 (DL-2). Once the MTD had been established, 9-12 additional pts are being enrolled in an expansion cohort to better define toxicities and efficacy. Response is measured during treatment using the mSWAT for skin assessment with every cycle, and flow cytometry and CT imaging after every 3rd cycle for extracutaneous sites. The Global Response Score is used for response assessment. There is a “run-in” phase of treatment with R alone given 14 days prior to D1 (D-14). Skin biopsies are taken at baseline and prior to D1 of cycle 1 to assess changes in CD30 expression after a single dose of R. The trial is registered in clinicaltrials.gov as NCT02616965.
Results: At the time of abstract submission, 7 pts have been enrolled (DL0: n=3; DL1: n=3; expansion cohort: n=1). No pt experienced a cycle 1 DLT and DL1 was deemed the MTD. No pts were enrolled in the de-escalation cohorts. Enrollment in the expansion cohort is ongoing. Median age of pts was 64 years (range 51-79); 72% (n=5) were male; median ECOG PS 1 (0-2); median prior lines of systemic therapy were 4 (0-4), including 1 pt with prior HDACi, and 1 pt with prior BV and R exposure. All pts had MF. Stage at enrollment was stage IIB in 5 (72%), IB and IVA2 in 1 each (14% each). No pts have experienced G4 or 5 adverse events (AE). The only G3 AEs observed during treatment were transaminitis and fever (n=1 each), both resolved spontaneously. The most common AEs were nausea (71%), vomiting (43%), gastro-esophageal reflux, constipation, peripheral sensory neuropathy, anorexia, fatigue, and thrombophlebitis (29% each; see Table 1). Response assessment is available for 5 of 7 pts. The overall response rate was 80% (4/5), all of which partial responses, including 1 pt who had received both prior R and BV. The median change in mSWAT was a decrease of 59% from baseline (range -19.5 to -81.8%). After a median follow up of 6.1 months, median estimated progression-free survival was 12 months (PFS probability 0.42; 95%CI 0.1-1.0). Four pts came off treatment: 2 due to progression, 1 due to non-adherence related to COVID-19 concerns, 1 because of recurrent thrombophlebitis; 3 pts remain on treatment.
Conclusion: Preliminary findings from this phase I study exploring the combination of R+BV indicate that R+BV is well tolerated at a dose of R 14mg/m2 and BV 1.2mg/kg given every 2 weeks and appears efficacious in CTCL. Updated results will be presented at the time of the meeting. Enrollment in the expansion cohort and correlative studies, including analysis of changes in CD30 expression after 1 dose of R, and association of response with CD30 expression, are ongoing.
Disclosures: Barta: Pfizer: Honoraria; Janssen: Honoraria; Seattle Genetics: Honoraria, Research Funding; Atara: Honoraria; Monsanto: Consultancy; Acrotech: Honoraria. Feldman: AstraZeneca: Consultancy; Janssen: Speakers Bureau; Portola: Research Funding; Pfizer: Research Funding; Kyowa Kirin: Consultancy, Research Funding; Eisai: Research Funding; Cell Medica: Research Funding; Amgen: Research Funding; Pharmacyclics: Honoraria, Other, Speakers Bureau; Abbvie: Honoraria; Bayer: Consultancy, Honoraria; Trillium: Research Funding; Viracta: Research Funding; Rhizen: Research Funding; Corvus: Research Funding; BMS: Consultancy, Honoraria, Research Funding; Kite: Honoraria, Other: Travel expenses, Speakers Bureau; Celgene: Honoraria, Research Funding; Takeda: Honoraria, Other: Travel expenses; Seattle Genetics, Inc.: Consultancy, Honoraria, Other: Travel expenses, Research Funding, Speakers Bureau. DeSimone: Sanofi/Genzyme: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Soligenix: Other: Investigator; Helsinn: Speakers Bureau. Fung: Genentech: Honoraria, Other: speakers' bureau, travel support; Sanotif: Honoraria, Other: speakers' bureau, travel support; AstraZeneca: Honoraria, Other: speakers' bureau, travel support; Kite, a Gilead Company: Honoraria, Other: speakers' bureau, travel support; Takeda: Honoraria, Other: speakers' bureau, travel support; Janssen Oncology: Honoraria, Other: speakers' bureau, travel support; AbbVie: Honoraria, Other: speakers' bureau, travel support. Khan: Celgene: Research Funding; Seattle Genetics: Research Funding; Janssen: Honoraria; Pharmacyclics: Honoraria; Bristol Myers Squibb: Research Funding.
OffLabel Disclosure: Combination of romidepsin and brentuximab vedotin.
See more of: Oral and Poster Abstracts