-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

604. Molecular Pharmacology and Drug Resistance in Myeloid Diseases: Poster III

Program: Oral and Poster Abstracts
Type: Poster
Monday, December 3, 2018: 6:00 PM-8:00 PM
Hall GH (San Diego Convention Center)

Jiao MA, PhD1*, Bin Liu, MSc2,3*, Dan Yu, BSc4*, Wayne Tam, MD, PhD5, Jianmin Yang, PhD6* and Jinke Cheng, PhD7*

1Department of Biochemistry and Molecular Cell Biology, Shanghai JiaoTong University School of Medicine, Shanghai, China
2Hematology, Changhai Hospital, Navy Medical School, Shanghai, China
3Respiratory Medcine, People's Liberation Army General Hospital, Beijing, China
4Biochemistry and Molecular Cell Biology, Shanghai JiaoTong University Medical School, Shanghai, China
5Department of Pathology and Laboratory Medicine, Well Cornell Medical College, New York, NY
6Changhai Hospital, Navy Medical School, Shanghai, China
7Shanghai JiaoTong University Medical School, Shanghai, China

Warren Fiskus, BSc, PhD1, Christopher Peter Mill, PhD, BA2*, Raffaella Soldi3*, Roulan Han3*, Dyana T. Saenz, PhD2, Agnieszka J Nowak2*, Baohua Sun, MD, PhD4*, David N Saenz2*, Courtney D. DiNardo, MD, MSc5, Gautam Borthakur, MD6, Tapan M. Kadia, MD7, Wendy Jin8*, Thurika Ganesh9*, Vaishnavi Rao8*, Joseph David Khoury, MD10, Sunil Sharma, MD11* and Kapil N. Bhalla, MD6

1The University of Texas MD Anderson Cancer Center, Houston
2MD Anderson Cancer Center, Houston, TX
3Beta Cat Pharma, Houston
4M.D. Anderson Cancer Ctr., Houston, TX
5University of Texas MD Anderson Cancer Center, Houston, TX
6Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
7Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX
8MD Anderson Cancer Center, Houston
9Leukemia, MD Anderson Cancer Center, Houston
10Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
11Huntsman Cancer Institute, Salt Lake City, UT

Shaneice Renee Mitchell, BS1*, Nicole Grieselhuber, MD, PhD1*, Yerdanos Asemelash1*, Matthew Cannon, BA1, Shelley Orwick, BS1*, Pratibha Sharma, PhD2*, Virginia Goettl, DVM, PhD1*, Vinay K Puduvalli, MD, MBBS2*, Deepa Sampath, PhD1, Alice S. Mims, MD3, James S. Blachly, MD1, Amy M. Lehman, PhD4*, Bonnie K. Harrington, DVM1,5, Justin Breitbach5*, Erkan Baloglu6*, William Senapedis, PhD6*, Rosa Lapalombella, PhD1 and John C. Byrd, MD1,7

1Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
2Division of Neuro-oncology, Department of Neurosurgery, The Ohio State University, Columbus, OH
3Comprehensive Cancer Center, The Ohio State University, Columbus, OH
4Center for Biostatistics, The Ohio State University, Columbus, OH
5College of Veterinary Medicine, The Ohio State University, Columbus, OH
6Karyopharm Therapeutics Inc, Newton, MA
7Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH

Amit Subedi, PhD1, Qiang Liu, PhD, BSc2, David Sharon, PhD3, Changjiang Xu4*, Veronique Voisin, PhD5*, Gary D Bader4*, Jean Wang, MD6 and Steven M Chan, MD, PhD7

1Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
2Princess Margaret, University Health Network, Toronto, ON, Canada
3University Health Network, Toronto, ON, Canada
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Terrence Donnelly Centre for Cellular and Biomedical Research, University of Toronto, Toronto, ON, Canada
6Department of Medicine, Ontario Cancer Institute University Health Network, Toronto, ON, Canada
7Princess Margaret Cancer Centre, Division of Medical Oncology and Hematology, University Health Network, University of Toronto, Toronto, ON, Canada

Konstantinos Mintzas, MSc*, Arnold Kloos*, Razif Gabdoulline*, Renate Schottmann*, Simon Danisch, PhD*, Renata Stripecke, Prof., Arnold Ganser, MD, Felicitas Thol, MD and Michael Heuser, MD

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

Seemana Bhattacharya, PhD1*, Sujan Piya, PhD1, Qi Zhang, PhD1*, Natalia Baran, PhD, MD1, Teresa McQueen, MS1*, R. Eric Davis, MD2*, Nicholas Cosford, PhD3*, Marina Y. Konopleva, MD, PhD1, Michael Andreeff, MD, PhD1 and Gautam Borthakur, MD1

1Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
3Sanford-Burnham Medical Research Institute, La Jolla, CA

Sophie M. Stief, M.Sc.1,2,3*, Anna-Li Hanneforth1*, Raphael Mattes1*, Sabrina Weser, M.Sc.1*, Binje Vick, PhD4*, Michael D. Bartoschek, M.Sc.5*, Helena Domínguez Moreno, M.Sc.6*, Wen-Hsin Liu, PhD7*, Bianka Ksienzyk8*, Maja Rothenberg-Thurley, PhD8*, Hilmar Quentmeier, PhD9*, Wolfgang Hiddemann2,8,10, Klaus H. Metzeler, MD1,8, Gunnar Schotta, PhD6*, Sebastian Bultmann, PhD5*, Irmela Jeremias, MD, PhD2,3,11,12, Heinrich Leonhardt, PhD5* and Karsten Spiekermann, MD2,10,13

1Department of Internal Medicine III, Experimental Leukemia and Lymphoma Research (ELLF), University Hospital, LMU Munich, Munich, Germany
2German Cancer Research Center (DKFZ), Heidelberg, Germany
3Partner Site Munich, German Consortium for Translational Cancer Research (DKTK), Munich, Germany
4Department of Apoptosis in Hematopoietic Stem Cells (AHS), Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany
5Department of Biology II and Center for Integrated Protein Science Munich (CIPSM), Human Biology and BioImaging, LMU Munich, Martinsried, Germany
6Biomedical Center and Center for Integrated Protein Science Munich, LMU Munich, Martinsried, Germany
7Department of Apoptosis in Hematopoietic Stem Cells (AHS), Helmholtz Zentrum München, Munich, Bayern, Germany
8Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital, LMU Munich, Munich, Germany
9Department of Human and Animal Cell Lines, Leibniz-Institute DSMZ, Braunschweig, Germany
10German Consortium for Translational Cancer Research (DKTK), Partner Site Munich, Munich, Germany
11Department of Apoptosis in Hematopoietic Stem Cells (AHS), Helmholtz Zentrum, Neuherberg, Bavaria, Germany
12Department of Pediatrics, Dr. von Hauner Children´s Hospital, LMU Munich, Munich, Germany
13Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, University of Munich, Munich, Germany

Yongwei Su1*, Xinyu Li1*, Holly Edwards, BS2*, Lisa Polin, PhD3*, Juiwanna Kushner3*, Sijana H Dzinic, PhD3*, Katie Hege4*, Yu Fukuda5*, John D. Schuetz, PhD6*, Joshua E. Allen, PhD7*, Martin Stogniew7*, Varun Vijay Prabhu, BPharm, MS, PhD7*, Jeffrey W. Taub, MD8, Hai Lin, MD9* and Yubin Ge, PhD3

1Jilin University, Changchun, China
2Department of Oncology, Wayne State University School of Medicine, Detroit, MI
3Oncology, Wayne State University School of Medicine, Detroit, MI
4Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI
5Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
6St. Jude Children's Research Hospital, Memphis, TN
7Oncoceutics, Inc., Philadelphia, PA
8Division of Pediatric Hematology and Oncology, Children's Hospital of Michigan, Detroit, MI
9Department of Hematology and Oncology, The First Hospital of Jilin University, Changchun, China

Noortje Van Gils, MSc1*, Han J.M.P. Verhagen, MSc1*, Arjo Rutten1*, Renee X. Menezes2*, Mei-Ling Tsui1*, Esmee Dekens1*, Fedor Denkers1*, E Vermue1*, Jeroen J. W. M. Janssen, MD, PhD1*, Gert J. Ossenkoppele, MD, PhD1 and Linda Smit, PhD1*

1Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands
2Department of Epidemiology and Biostatistics, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands

Ralf Buettner, PhD1, Le Xuan Truong Nguyen, PhD1*, Bijender Kumar, PhD1*, Corey James Morales, BA, BS1*, Chao Liu, PhD2*, Lisa S Chen, PhD3*, Tea Pemovska, PhD4*, Ryan Thompson, BS5*, Ling Li, PhD1, Dinh Hoa Hoang, BS1*, Bin Zhang, PhD1*, Lucy Ghoda, PhD1*, Claudia Kowolik, PhD6*, Mika Kontro, MD7*, Krister Wennerberg, PhD8*, Calum Leitch, PhD9*, Xiaochun Yu, MD, PhD2*, Ching-Cheng Chen, PhD1, David Horne, PhD6*, Varsha Gandhi, PhD 3, Vinod A. Pullarkat, MD1, Guido Marcucci, MD1 and Steven T Rosen1

1Gehr Family Center for Leukemia Research, City of Hope National Medical Center, Duarte, CA
2Department of Cancer Genetics and Epigenetics, City of Hope National Medical Center, Duarte, CA
3Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
4CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
5Chicago Medical School, Rosalind Franklin University, Chicago, IL
6Department of Molecular Medicine, City of Hope National Medical Center, Duarte, CA
7Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
8Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
9Center for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway

Aniket Bankar, MBBS, MD, DM1*, Thirushi Piyumika Siriwardena1*, Biljana Rizoska, PhD2*, Christina Rydergård, BSc2*, Helen Kylefjord, BSc2*, Vilma Rraklli, PhD2*, Anders Eneroth, PhD2*, Pedro Pinho, PhD2*, Stefan Norin, MD, PhD2*, Johan Bylund, PhD2*, Sara Moses, PhD2*, Richard Bethell, PhD2*, Simon Kavanagh, MBBS(Hons), FRACP, FRCPA1*, Xiaoming Wang1*, Rose Hurren, BSc1*, Mark D. Minden, MD, PhD3, Paul Targett-Adams, PhD, BSc2*, Aaron D Schimmer, MD, PhD4 and Mark Albertella, PhD2*

1Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
2Medivir AB, Huddinge, Sweden
3Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada
4Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada

Anna Skwarska, PhD1,2*, Natalia Baran, PhD, MD2 and Marina Y. Konopleva, MD, PhD2

1Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Faculty of Chemistry, Gdansk, Poland
2Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Xin Xu, PhD1, Wilhelm G Dirks, PhD2*, Hans G. Drexler, MD, PhD3 and Zhenbo Hu, MD, PhD4*

1Laboratory for Stem Cell and Regenerative Medicine, Weifang Medical University, Weifang, China
2Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
3Human and Animal Cell Lines, Leibniz-Institute DSMZ - German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
4Department of Hematology, Affiliated Hospital of Weifang Medical University, Weifang, China

Katherine Tarlock, MD1,2, Zixing Wang3*, Rory Rohm3*, Travis Biechele4*, Rhonda E. Ries, MA5*, Tiffany Hylkema, BS5*, Jatinder K Lamba, PhD6, Gary D Means, PhD4*, Robert Thurman4*, Bill Arthur4* and Soheil Meshinchi, MD, PhD7,8

1Pediatric Hematology/Oncology, Seattle Children's Hospital, Seattle, WA
2Fred Hutchinson Cancer Research Center, Seattle, WA
3Seattle Genetics, Bothell
4Seattle Genetics, Bothell, WA
5Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
6Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, Pharmacotherapy and Translational Re, Gainesville, FL
7Department of Pediatrics, University of Washington, Seattle
8Clinical Research Division, Fred Hutchinson Cancer Rsrch. Ctr., Seattle, WA

Constance Baer, PhD1, Stephan Hutter, PhD1*, Alexander Höllein, MD2, Wencke Walter, PhD1*, Manja Meggendorfer, PhD1, Wolfgang Kern, MD1, Claudia Haferlach, MD1 and Torsten Haferlach, MD3

1MLL Munich Leukemia Laboratory, Munich, Germany
2MLL Munich, München, Germany
3MLL Munchner Leukamie Labor Gmbh, Munchen, Germany

Kotoko Yamatani, MD1*, Yoko Tabe, MD, PhD2,3,4, Kaori Saito1*, Haeun Yang1,5*, Yuko Murakami-Tonami, MD, PhD1*, Koya Suzuki, PhD1,6*, Weiguo Zhang, MD, PhD7, Sonoko Kinjo, PhD8*, Kazuho Ikeo, PhD8*, Kaoru Mogushi, PhD9,10*, Masaki Hosoya, PhD10,11*, Shigeo Yamaguchi, MD.PhD11*, Hironori Harada, MD, PhD12, Takashi Miida, MD, PhD1*, Neil P. Shah, MD, PhD13, Marina Y. Konopleva, MD, PhD14, Yoshihide Hayashizaki, MD, PhD15* and Michael Andreeff, MD, PhD4

1Department of Clinical Laboratory Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan
2Department of Clinical Laboratory Medicine, Juntendo Univ. School of Medicine, Tokyo, Japan
3Department of Next Generation Hematology Laboratory Medicine, Graduate School of Medcine, Juntendo University, Tokyo, Japan
4Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
5Leading Center for the Development and Research of Cancer Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan
6Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, Tokyo, Japan
7U.T.M.D. Anderson Cancer Center, Houston, TX
8Centers for Information Biology, National Institute of Genetics, Shizuoka, Japan
9Department of Diagnostics and Therapeutics of Intractable Diseases, Graduate School of Medicine, Juntendo University, Tokyo, Japan
10Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan
11Department of Oncology, Juntendo University School of Medicine, Tokyo, Japan
12Department of Hematology, Graduate School of Medicine, Juntendo University, Tokyo, Japan
13Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
14Section of Leukemia Biology Research, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
15Preventive Medicine & Diagnosis Innovation Program, RIKEN Center for Life Science Technoligies, Kanagawa, Japan

Jacqueline Cloos, PhD1*, Godefridus J Peters, PhD2*, Marjon Al, BSc3*, Yehuda G Assaraf, PhD4*, Lixia Wang, PhD5*, Jack W. Singer, MD6, Jorge E. Cortes, MD7, Gert J. Ossenkoppele, MD, PhD8 and Gerrit Jansen, PhD3*

1Cancer Center Amsterdam, Department of Hematology, VU University Medical Center, Amsterdam, Netherlands
2Cancer Center Amsterdam, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
3Amsterdam Rheumatology and immunology Center, Department of Rheumatology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
4Faculty of Biology, The Fred Wyszkowski Cancer Research, The Technion-Israel Institute of Technology Laboratory, Haifa, Israel
5CTI BioPharma Corp., Seattle, WA
6CTI Biopharma, Seattle, WA
7Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
8Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands

Justin Cidado, PhD1*, Scott Boiko, MS2*, Theresa Proia, PhD1*, Haley Woods, MS2*, Omid Tavana, PhD2*, Maryann San Martin, MS2*, Adriana E. Tron, PhD2*, Wenlin Shao, PhD1* and Lisa Drew, PhD1*

1Oncology IMED Biotech Unit, AstraZeneca, Waltham, MA
2AstraZeneca, Waltham, MA

Quy Le, PhD1*, Brandon Hadland, MD, PhD1, Soheil Meshinchi, MD, PhD2 and Irwin D. Bernstein, MD2

1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
2Fred Hutchinson Cancer Research Center, Seattle, WA

Matthew Johnson1,2*, Kaitlyn Dykstra, PhD1, Tara Cronin, BA1*, Linda Lutgen-Dunckley1*, Brandon L Martens, BS1*, Monica L. Guzman, PhD3 and Eunice S. Wang, MD4

1Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
2Roanoke College, Salem, VA
3Division of Hematology and Oncology, Weill Cornell Medical College Division of Hematology/Oncology, New York, NY
4Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY

Sravanti Rangaraju, MBBS1, Silvia Marino, PhD2*, Daniela Nicoleta Petrusca, PhD2*, Larry D Cripe, MD3*, Katie J Sargent, RN4*, G. David Roodman, MD, PhD2,5, Hamid Sayar, MD, MSc6, Baskar Ramdas, PhD7*, Lakshmi Reddy Palam, PhD8*, Rajasubramaniam Shanmugam, PhD9*, Adriana Rogozea10*, Heiko Konig, MD, PhD10, Reuben Kapur, PhD11 and H. Scott Boswell, MD12,13

1Indiana University and Melvin and Bren Simon Cancer Center, Indianapolis
2Medicine/Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN
3Indiana University Simon Cancer Center, Indianapolis
4IU Health Partners, Indianapolis
5Richard L. Roudebush VA Medical Center, Indianapolis, IN
6Indiana University Cancer Center, Indianapolis, IN
7Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, INDIANAPOLIS, IN
8Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, INDIANAPOLIS, IN
9ICMR, National Institute for Research in Tribal Health, Jabalpur, India
10Indiana University Simon Cancer Center, Indianapolis, IN
11Indiana Univ. School of Med., Indianapolis, IN
12Veterans Affairs Medical Center, Indianapolis, IN
13Indiana Cancer Research Inst., Indianapolis, IN

Yasuhiro Shingai, MD1*, Takafumi Yokota, MD1, Takayuki Ozawa, MD1*, Tomoaki Ueda1*, Yukiko Doi1*, Tomohiko Ishibashi2*, Akira Tanimura1*, Michiko Ichii, MD, PhD1*, Hirohiko Shibayama, MD, PhD1 and Yuzuru Kanakura, MD, PhD3

1Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan
2Department of Vascular Physiology, Research Institute National Cerebral and Cardiovascular Center, Suita, Japan
3Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Mario Scarpa, PhD1*, Shivani Kapoor, MS1*, Danilo Perrotti, MD, PhD2 and Maria R. Baer, MD1,3

1University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
2Greenebaum Cancer Center, Baltimore, MD
3Veterans Affairs Medical Center, Baltimore, MD

Melanie Maerken, MS, BSc1*, David MacEwan, PhD2*, Nicholas Harper, PhD2*, Joseph R Slupsky, PhD3* and Adam Linley, PhD3*

1Department of Molecular and Clinical Pharmacology, University of Liverpool, Chester, United Kingdom
2Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom
3Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom

Brea Lipe, MD1, Thomas Conley2*, Hani Awad, PhD2*, Jason H. Mendler, MD, PhD3, Jason R Myers, MS4*, John M Ashton, Ph.D4*, Michael W. Becker, MD3 and Omar S. Aljitawi, MD3

1University of Rochester Medical College, Rochester, NY
2University of Rochester Medical Center, Rochester, NY
3Division of Hematology/Oncology, University of Rochester Medical Center, Rochester, NY
4Genomics Resource Center, University of Rochester Medical Center, Rochester, NY

Patrizia Mondello, MD, PhD, MSc1,2, Cristian Di Mirto2*, Carmela Arrigo2*, Vincenzo Pitini, MD2* and Michael Mian, MD3

1Medicine, Lahey Clinic, Burlington, MA
2Medical Oncology, University of Messina, Messina, Italy
3Department of Hematology & CBMT, Ospedale di Bolzano, Bolzano, Italy

*signifies non-member of ASH