-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

632.O3.6 632. Chronic Myeloid Leukemia: Therapy: TFR Failure, Resistance, and New Drug Development

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Diseases, CML, Myeloid Malignancies
Monday, December 3, 2018: 2:45 PM-4:15 PM
Room 6E (San Diego Convention Center)
Moderators:
Neelam Varma, MBBS, MD, PGIMER and David M Ross, Flinders University
Disclosures:
Ross: Celgene: Research Funding; Novartis: Consultancy, Honoraria, Research Funding, Speakers Bureau; BMS: Honoraria.
2:45 PM

Dennis Dong Hwan Kim, MD1, Lambert Busque, MD2, Donna L. Forrest, MD3, Lynn Savoie, MD4*, Isabelle Bence-Bruckler5*, Stephen Couban, MD, BSc6, Robert Delage, MD7, Anargyros Xenocostas, MD8, Elena Liew, MD, BSc, FRCPC9, Pierre Laneuville, MD, FRCPC10, Kristjan Paulson, MD11, Jeffrey H. Lipton, MD, PhD12, Suzanne Kamel-Reid, BA, MA, PhD, FACMG13 and Brian Leber, MD14

1Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
2Department of Laboratory Hematology, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montreal, QC, Canada
3Leukemia/BMT Program of BC, BC Cancer, Vancouver, BC, Canada
4University of Calgary, Calgary, AB, Canada
5The Ottawa Hospital Research Institute, Ottawa, ON, CAN
6Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada
7Hôpital de l'Enfant-Jésus, Division of Hematology and Medical Oncology, CHU de Québec - Université Laval, Québec, QC, Canada
8Department of Medicine, Division of Hematology, London Health Sciences Centre, London, ON, CAN
9University of Alberta Hospital, Edmonton, AB, CAN
10McGill University Health Centre, Montreal, QC, Canada
11Cancercare Manitoba, Winnipeg, MB, Canada
12Blood and Marrow Transplant Program, Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
13Advanced Molecular Diagnostics Laboratory, UHN, Toronto, ON, Canada
14Hamilton Health Sciences Centre, Juravinski Cancer Centre, Hamilton, ON, Canada

3:00 PM

Jorge E. Cortes, MD1, Qian Jiang, MD2, Jianxiang Wang, MD3, Jianyu Weng, MD4, Huanling Zhu, MD5*, Liu Xiaoli, MD6*, Andreas Hochhaus, MD7, Dong-Wook Kim, MD, PhD8, Jerald Radich, MD9*, Michael R. Savona, MD10, Patricia Martin Regueira11*, Oumar Sy, PhD11*, Renuka Gurnani, BA11* and Giuseppe Saglio12

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Peking University People’s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
3Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China
4Guangdong Medical University, Guangdong, China
5West China Hospital of Sichuan University, Chengdu Sichuan, China
6Nanfang Hospital, Southern Medical University, Guangzhou, China
7Universitätsklinikum Jena, Jena, Germany
8The Catholic University of Korea, Seoul, Korea, Republic of (South)
9Fred Hutchinson Cancer Research Center, Seattle, WA
10Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
11Bristol-Myers Squibb, Princeton, NJ
12Hematology Division, Ospedale Mauriziano, University of Turin, Torino, Italy

3:15 PM

Simona Soverini, PhD1, Luana Bavaro1*, Margherita Martelli1*, Caterina De Benedittis, PhD2*, Alessandra Iurlo3*, Nicola Orofino, MD4*, Livio Pagano5*, Marianna Criscuolo6*, Massimiliano Bonifacio7*, Luigi Scaffidi, MD8*, Simona Sica, MD9*, Federica Sorà, MD10*, Elena Maino11*, Michela Rondoni, MD12*, Maria Antonella Laginestra, PhD13*, Francesca Lunghi14*, Anna Ermacora15*, Mariella D'adda, MD16*, Gabriele Gugliotta, MD, PhD17, Fausto Castagnetti18, Gianantonio Rosti17*, Cristina Papayannidis19, Giovanni Marconi19, Antonio Curti1*, Maria Cristina Miggiano20*, Sara Galimberti21*, Antonio Percesepe, MD, PhD22*, Fabio Stagno, MD, PhD23, Rosaria Sancetta, MD24*, Mario Annunziata25*, Franca Falzetti, MD26*, Isabella Capodanno27*, Patrizia Pregno28*, Margherita Maffioli, MD29*, Tamara Intermesoli, MD30*, Eros Di Bona, MD31*, Giovanni Caocci, MD32*, Imma Attolico, MD33*, Gianni Binotto34*, Monica Bocchia, MD, PhD35*, Emanuele Angelucci, MD36, Nicola Sgherza, MD37*, Luigiana Luciano38*, Flavio Mignone39*, Stefano A. Pileri, MD, PhD40, Giovanni Martinelli41 and Michele Cavo, MD1*

1Hematology/Oncology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy
2Hematology/Oncology "L. e A. Seragnoli", University of Bologna, Bologna, Italy
3Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
4Hematology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico - University of Milan, Milan, Italy
5Institute of Hematology, Fondazione Policlinico A. Gemelli- IRCCS- Università Cattolica S. Cuore, Rome, Italy
6Institute of Hematology, Fondazione Policlinico A. Gemelli- IRCCS- Università Cattolica S. Cuore, Roma, Italy
7Department of Medicine, Section of Haematology, University of Verona, Verona, Italy
8Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
9Hematology Department, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Roma, Italy
10Fondazione Policlinico Universitario A Gemelli IRCSS, Catholic University of Rome, Rome, Italy
11Ospedale dell' Angelo, Hematology, Mestre, Italy
12Azienda Unità Sanitaria Locale della Romagna, Haematology Department, Ravenna, Italy
13Department of Experimental, Diagnostic, and Specialty Medicine, Hematopathology Section, Bologna, Italy
14Haematology and Bone Marrow Transplant Unit, San Raffaele Scientific Institute IRCCS, Milano, Italy
15Azienda Ospedaliera S Maria Angeli, Pordenone, Italy
16Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
17Institute of Hematology "L. and A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine, Bologna, Italy
18Institute of Hematology "L. e A. Seràgnoli", DIMES, University of Bologna, Bologna, Italy
19Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy
20Hematology Unit, Vicenza, Italy
21Section of Hematology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
22Department of Medicine and Surgery, Medical Genetics Unit, University of Parma, Parma, Italy
23Hematology Unit, Hematology Section, Biomedical Sciences, Trecastagni, Catania, Italy
24Hematology Unit, Ospedale dell'Angelo Mestre, Venezia, Italy
25Hematology, Ospedale Cardarelli, Napoli, Italy
26Institute of Hematology, Centro di Ricerche Emato-Oncologiche (CREO), University of Perugia, Perugia, Italy
27Hematology Department, Arcispedale Santa Maria Nuova - IRCCS Reggio, Reggio Emilia, Italy
28Hematology Unit, Az Ospedaliero Universitaria Città' della Salute e della Scienza, Torino, Italy
29Hematology, Department of Medicine and Surgery, Ospedale di Circolo, ASST Sette Laghi, Varese, Italy
30Hematology and Bone Marrow Transplantation Unit, ASST Papa Giovanni XXIII, Bergamo, Italy
31Ospedale San Bortolo, UO Hematology, Vicenza, Italy
32Department of Medical Sciences and Public Health, University of Cagliari, "A.Businco" Hospital, Cagliari, Italy
33Haematology, University of Bari, Potenza, Italy
34Dept. of Medicine, Hematology and Clinical Immunology, Padua School of Medicine, PADOVA, Italy
35Chair of Hematology, University of Siena, Azienda Ospedaliera Universitaria, Siena, Italy
36Hematology and Transplant Centre, Unita Operativa Ematologia Ospedale 'A. Businco', Genova, Italy
37Division of Hematology, IRCCS Ospedale Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy
38AOU Università degli Studi di Napoli "Federico II", Napoli, Italy
39Department of Science and Innovation Technology (DISIT), University of Piemonte Orientale, Alessandria, Italy
40Unit of Hematopathology, European Institute of Oncology, MILANO, Italy
41Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, Meldola, Italy

3:30 PM

Anna G Turkina, Prof., MD1, Olga Vinogradova, MD, PhD2*, Elza Lomaia, MD3*, Evgeniya Shatokhina, MD, PhD4*, Oleg Shukhov, MD, PhD5*, Ekaterina Chelysheva, MD, PhD6*, Irina Nemchenko, MD, PhD1*, Anna Petrova, MD5*, Anastasiya Bykova, MD1*, Andrey Zaritskey, MD, PhD7*, Nadia Siordia, MD8*, Dzhariyat Shikhbabaeva2*, Vasily Shuvaev, MD 9, Jorge E. Cortes, MD10, Robert Peter Gale11, Michele Baccarani, MD12, Oliver G. Ottmann, MD13, Ilya Mikhailov14*, Fedor Novikov, PhD15*, Veronika Shulgina, PhD, MD15* and Ghermes Chilov, PhD16*

1National Research Center for Hematology, Moscow, Russian Federation
2Hematological Moscow City Center, Botkin City Clinical Hospital, Moscow, Russian Federation
3Federal Almazov North-West Medical Research Centre, Saint-Petersburg, Russian Federation
4Central State Medical Academy, Affairs of the President of Russian Federation, Moscow, Russian Federation
5National Research Center for Hematology, Moscow, Russia
6National Research Center for Hematology, Moscow, AZ
7Federal Almazov North-West Medical Research Centre, St Petersburg, Russian Federation
8Federal Almazov North-West Medical Research Centre, Saint-petersburg, Russian Federation
9Federal State Budget Institution “Russian Scientific-Research Institute of Hematology and Transfusiology of Federal Medical-Biological Agency”, Saint-Petersburg, Russian Federation
10Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
11Haematology Research Center, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom
12Institute of Hematology "L. and A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine, Bologna, Italy
13Department of Haematology, Cardiff University, Cardiff, United Kingdom
14Fusion Pharma, Moscow, Russian Federation
15Fusion Pharma LLC, Moscow, Russian Federation
16Fusion Pharma, LLC, Moscow, Russia

3:45 PM

Qian Jiang, MD1, Xiao Jun Huang1, Zi Chen, MD2*, Lichuang Men2*, Wei Liu2*, Xuemei Sun2*, Jiao JI, PhD, MD3*, Hengbang Wang2*, Yue Hou1*, Po Hu2*, Lei Zou2*, Hua Yan2*, Yingjie Huang2,4*, Dajun Yang, MD, PhD4* and Yifan Zhai, MD, PhD2,4*

1Peking University People’s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
2HealthQuest Pharma Inc., Guangzhou, China
3HealthQuest Pharma Inc., Shanghai, China
4Ascentage Pharma Group Inc., Rockville, MD

4:00 PM

Delphine Rea, MD1, Fabian Lang, MD2*, Dong-Wook Kim, MD, PhD3,4, Jorge E. Cortes, MD5,6, Timothy P. Hughes, MD, MBBS, FRACP, FRCPA7, Hironobu Minami, MD, PhD8, Massimo Breccia, MD9*, Daniel J. Deangelo, MD10*, Andreas Hochhaus, MD11, Moshe Talpaz, MD 12, Yeow Tee Goh, MBBS, MD13, Philipp le Coutre, MD14, Michael W. Deininger, MD, PhD15, Gabriel Etienne, MD, PhD16,17*, Manu Sondhi, MD, PhD18*, Kaushal Mishra, PhD18*, Paola Aimone, MD19*, Janet Ng-Sikorski, PhD19* and Michael J. Mauro, MD20

1Hôpital Saint-Louis, Paris, France
2Department of Hematology/Oncology, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany
3Leukemia Research Institute, The Catholic University of Korea, Seoul, Korea, Republic of (South)
4Seoul St Mary’s Hospital, Leukemia Research Institute, The Catholic University of Korea, Seoul, Korea, Republic of (South)
5Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
6M.D. Anderson Cancer Center, Houston, TX
7Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, Australia
8Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
9Sapienza University, Rome, Italy
10Dana-Farber Cancer Institute, Boston, MA
11Univerisitätsklinikum Jena, Jena, Germany
12University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
13Singapore General Hospital, Singapore, Singapore
14Charité - Universitätsmedizin Berlin, Berlin, Germany
15Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
16Hematology Department, Institut Bergonié, Bordeaux, France
17Groupe Fi-LMC, Institut Bergonié, Bordeaux, France
18Novartis Pharmaceuticals Corporation, East Hanover, NJ
19Novartis Pharma, Basel, Switzerland
20Memorial Sloan-Kettering Cancer Center, New York, NY

*signifies non-member of ASH