-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

604.O1.6 604. Molecular Pharmacology and Drug Resistance in Myeloid Diseases: Targeting RNA Binding Proteins, Metabolism, and Leukemia Stem Cells

Program: Oral and Poster Abstracts
Type: Oral
Sunday, December 2, 2018: 4:30 PM-6:00 PM
Grand Hall C (Manchester Grand Hyatt San Diego)
Moderators:
Bjorn Gjertsen, MD, PhD, Haukeland University Hospital and Gabriel Ghiaur, MD, PhD, Johns Hopkins University School of Medicine
Disclosures:
No relevant conflicts of interest to declare.
4:30 PM

Sydney X. Lu, MD, PhD1, Eric Wang2*, Alessandro Pastore1, Chen Xufeng, PhD2*, Jochen Imig, PhD2*, Stanley C Lee, PhD1, Yohana Ghebrechristos2*, Akihide Yoshimi, MD, PhD1*, Lillian E Bitner, BSc1*, Michelle Ki, BSc1*, Andreas Kloetgen2*, Kuan-Ting Lin, PhD3*, Raoul Tibes, MD, PhD4*, Adrian R. Krainer, PhD3*, Taisuke Uehara5*, Takashi Owa, PhD6*, Iannis Aifantis, PhD7* and Omar I Abdel-Wahab, MD1

1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
2Department of Pathology, NYU, New York, NY
3Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
4Hematology and Medical Oncology, Mayo Clinic Arizona, Scottsdale, AZ
5Tsukuba Research Laboratories, Eisai Co., Ltd, Tsukuba,, Ibaraki,, Japan
6Eisai PCS, Woodcliff Lake, NJ
7NYU School of Medicine, New York, NY

4:45 PM

Gerard Minuesa Dinares, PhD1*, Steven K. Albanese, BS2*, Arthur Chow, BA3*, Alexandra Schurer, BS4*, Sun Mi Park, PhD3, Christina Z. Rotsides, PhD5*, James Taggart, BS1*, Andrea Rizzi, BS6*, Levi N. Naden, PhD7*, Timothy Chou, BS3*, Saroj Gourkanti, BA4*, Daniel Cappel, PhD8*, Maria C. Passarelli, BS9*, Lauren Fairchild, PhD10*, Carolina Adura, PhD11*, Joseph Fraser Glickman, MSPH, PhD12*, Jessica Schulman, BSc13*, Christopher Famulare, MS14*, Minal Patel, BA15*, Joseph K. Eibl, PhD16*, Gregory M. Ross, PhD16*, Derek Tan, PhD17*, Christina Leslie, PhD10*, Thijs Beuming, PhD18*, Yehuda Goldgur, PhD19*, John D. Chodera, PhD7* and Michael G. Kharas, PhD3

1Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York City, NY
2Louis V. Gerstner Jr. Graudate School of Biomedical Sciences, Memorial Sloan-Kettering Cancer Center, New York City, NY
3Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY
4Memorial Sloan Kettering Cancer Center, New York, NY
5Chemical Biology Program and Tri-Institutional Research Program, Memorial Sloan-Kettering Cancer Center, New York City, NY
6Computational and Systems Biology Program and Tri-Institutional Training Program in Computational Biology and Medicine, Memorial Sloan-Kettering Cancer Center, New York City, NY
7Computational and Systems Biology Program, Memorial Sloan-Kettering Cancer Center, New York City, NY
8Schrödinger GmbH, Mannheim, Germany
9Computational and Systems Biology Program and Weill Cornell Medical College, Rockefeller University & Sloan Kettering Institute Tri-Institutional MD-PhD Program, Memorial Sloan Kettering Cancer Center, New York, NY
10Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY
11High-Throughput and Spectroscopy Resource Center, Rockefeller University, New York City, NY
12High-Throughput and Spectroscopy Resource Center, Rockefeller University, New York, NY
13Center for Hematologic malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
14Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
15Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
16Northern Ontario School of Medicine, Sudbury, Canada
17Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY
18Schrödinger, Inc., New York City, NY
19Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY

5:00 PM

Courtney L Jones, PhD1, Brett M Stevens, PhD2, Rachel Culp-Hill, BS1*, Travis Nemkov3*, Angelo D'Alessandro, PhD1*, Shanshan Pei, PhD1*, Daniel A Pollyea, MD4 and Craig T Jordan, PhD2

1University of Colorado, Aurora, CO
2Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO
3Department of Biochemistry and Molecular Genetics,, University of Colorado School of Medicine, Aurora,
4Division of Hematology, University of Colorado Denver, Aurora, CO

5:15 PM

Haeun Yang1*, Yoko Tabe, MD, PhD2, Kaori Saito1*, Rodrigo Jacamo, PhD3*, Helen Ma, MS4*, Vivian Ruvolo, MS3*, Junichi Imoto5*, Kazuho Ikeo, PhD6*, Kaoru Mogushi, PhD7*, Masaki Hosoya, PhD8*, Shigeo Yamaguchi9*, Kotoko Yamatani, MD1*, Yuko Murakami-Tonami, MD10*, Koya Suzuki, PhD1,11*, Takashi Miida, MD, PhD1*, Michael Andreeff, MD, PhD3, Joseph R Marszalek, PhD12* and Marina Y. Konopleva, MD, PhD13

1Department of Clinical Laboratory Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan
2Department of Next Generation Hematology Laboratory Medicine, Graduate School of Medcine, Juntendo University, Tokyo, Japan
3Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
4Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
5National Institute of Genetics, Shizuoka, Japan
6Centers for Information Biology, National Institute of Genetics, Shizuoka, Japan
7Department of Diagnostics and Therapeutics of Intractable Diseases, Graduate School of Medicine, Juntendo University, Tokyo, Japan
8Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan
9Juntendo University of Medicine, Tokyo, Japan
10Juntendo Univ., Tokyo, Japan
11Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, Tokyo, Japan
12Institute for Applied Cancer Science and Center for Co-Clinical Trials, The University of Texas MD Anderson Cancer Center, Houston, TX
13Section of Leukemia Biology Research, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

5:30 PM

Courtney L Jones, PhD1, Brett M Stevens, PhD2, Angelo D'Alessandro3*, Rachel Culp-Hill, BS1*, Julie Reisz, PhD4*, Haobin Ye, PhD5, Nabilah Khan6*, Mohd Minhajuddin, PhD7*, James DeGregori, Ph.D.8*, Daniel A Pollyea, MD9 and Craig T Jordan, PhD2

1University of Colorado, Aurora, CO
2Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO
3University of Colorado Denver - Anschutz Medical Campus, Aurora, CO
4Biochemistry, University of Colorado, Aurora, CO
5University of Colorado School of Medicine, Aurora, CO
6Division of Hematology, Department of Medicine, University of Colorado, Aurora, CO
7Division of Hematology, University of Colorado, Aurora, CO
8University of Colorado Anschutz Medical Campus, Aurora, CO
9Division of Hematology, University of Colorado Denver, Aurora, CO

5:45 PM

Daniel A Pollyea, MD1, Courtney L Jones, PhD2, Brett M Stevens, PhD3, Shanshan Pei, PhD2*, Angelo D'Alessandro, PhD2*, Rachel Culp-Hill, BS2*, Diana Abbott, PhD4*, Andrew Hammes, MS5*, James Dugan, MD6, Jonathan A Gutman, MD1, Enkhtsetseg Purev, MD, PhD1, Clayton Smith, MD7 and Craig T Jordan, PhD3

1University of Colorado, Denver, CO
2University of Colorado, Aurora, CO
3Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO
4Department of Biostatistics and Bioinformatics, University of Colorado Denver, Aurora, CO
5Division of Hematology, University of Colorado, Aurora, CO
6Department of Hematology, University of Colorado, Denver, CO
7Division of Hematology, University of Colorado, Denver, CO

*signifies non-member of ASH