-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

602.O3.6 602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Single Cell Profiling/Actionable Leukemia Targets

Program: Oral and Poster Abstracts
Type: Oral
Monday, December 3, 2018: 7:00 AM-8:30 AM
Room 9 (San Diego Convention Center)
Moderators:
Alejandro Gutierrez, MD, Children's Hospital Boston and Lars Bullinger, MD, University of Ulm
Disclosures:
No relevant conflicts of interest to declare.
7:00 AM

Anna S Nam, MD1, Kyu-Tae Kim, PhD2*, Ronan Chaligne, PhD3*, Franco Izzo, PhD4*, Chelston Ang, MS5*, Nathaniel Omans, MS5*, Alessandro Pastore6, Justin Taylor, MD6, Alicia Alonso7*, Wayne Tam, MD, PhD8, Ronald Hoffman, MD9, Joseph Scandura, MD, PhD10, Raul Rabadan, PhD11*, Omar I Abdel-Wahab, MD6, Peter Smibert, PhD12* and Dan A. Landau, MD, PhD4

1Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, NEW YORK, NY
2Weill Cornell Medical College, New York, NY
3Meyer Cancer Center, Weill Cornell Medicine, New York, NY
4Meyer Cancer Center & Institute of Computational Biomedicine, Weill Cornell Medicine, New York, NY
5Weill Cornell Medical College, New York
6Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
7Epigenomic core, Weill Cornell Medical College, New York
8Department of Pathology and Laboratory Medicine, Well Cornell Medical College, New York, NY
9Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
10Department of Hematology and Oncology, Weill Cornell Medicine, New York, NY
11Department of Systems Biology, Columbia University, New York, NY
12New York Genome Center, New York, NY

7:15 AM

Peter Van Galen, PhD1, Volker Hovestadt, PhD1*, Marc Wadsworth II2*, Travis Hughes2*, Gabriel Kenneth Griffin, MD3*, Julia A. Verga1*, Jason Stephansky3*, Timothy J. Pastika3*, Jennifer Lombardi Story4*, Geraldine S. Pinkus, MD3*, Olga Pozdnyakova, MD, PhD3*, Ilene Galinsky5, Richard M. Stone, MD5, Timothy A. Graubert, MD4, Alex K. Shalek, PhD2*, Jon C. Aster, MD, PhD3, Andrew A. Lane, MD, PhD5 and Bradley E. Bernstein, MD, PhD1*

1Massachusetts General Hospital and Broad Institute of MIT and Harvard, Boston, MA
2Massachusetts Institute of Technology, Cambridge, MA
3Brigham and Women's Hospital, Boston, MA
4Massachusetts General Hospital Cancer Center, Boston, MA
5Dana-Farber Cancer Institute, Boston, MA

7:30 AM

Maurice Labuhn, MSc1*, Kelly Perkins, PhD2*, Elli Papaemmanuil, PhD3, Catherine Garnett2*, Soeren Matzk4*, Vyacheslav Amstislavskiy4*, Marlen Metzner2*, Alison Kennedy2*, Carina Scheer5*, Kenichi Yoshida, MD, PhD6*, Adrian Schwarzer, MD, PhD5*, John D. Crispino, PhD, MBA7, Jeffrey W. Taub, MD8,9, Mitchell J. Weiss, MD, PhD10, Etsuro Ito, MD, PhD11, Seishi Ogawa, MD, PhD12,13, Dirk Reinhardt14, Marie-Laure Yaspo, PhD15*, Peter J. Campbell, PhD16*, Dirk Heckl, PhD5*, Jan-Henning Klusmann17 and Paresh Vyas, MRCP FRCP FRCPath2

1Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Nds, Germany
2MRC Molecular Haematology Unit and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
3Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
4Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
5Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
6Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
7Division of Hematology and Oncology, Northwestern University, Chicago, IL
8Division of Pediatric Hematology and Oncology, Children's Hospital of Michigan, Detroit, MI
9Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI
10Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
11Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
12Department of Pathology and Tumor Biology, Kyoto University, Sakyoku, Japan
13Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Huddinge, Sweden
14Pediatric Hematology and Oncology, Essen University Hospital, Essen, Germany
15Max Planck Institute for Molecular Genetics, Berlin, Germany
16The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, United Kingdom
17Pediatric Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

7:45 AM

Bo-Rui Chen, PhD1*, Anagha Deshpande, PhD2*, Maria Kleppe, PhD3, Narayana Yeddula, PhD2*, Sunnie Yoh, PHD2*, Scott A. Armstrong, MD, PhD4, Ross L. Levine, MD3, Sumit Chanda, PhD2* and Aniruddha J. Deshpande, PhD2

1Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, SAN DIEGO, CA
2Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
4Department of Pediatric Oncology, Dana-Farber Cancer Institute - Harvard Medical School, Boston, MA

8:00 AM

Laura Belver, PhD1*, Alexander Y Yang1*, Daniel Herranz, PharmD2, Aidan Quinn3*, Francesco G Brundu, PhD4*, Pablo Perez-Duran, PhD5*, Silvia Alvarez, PhD5*, Devya Gurung5*, Pedro P Rocha, PhD6*, Ramya Raviram, PhD7*, Marissa Rashkovan, PhD5*, Raul Rabadan, PhD4,8* and Adolfo A. Ferrando, MD, PhD9

1Institute for Cancer Genetics, Columbia University, New York, NY
2Cancer Institute of NJ, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
3Columbia University, New York, NY
4Department of Systems Biology, Columbia University, New York, NY
5Institute for Cancer Genetics, Columbia University, New York
6Division of Developmental Biology, National Institutes of Health, Bethesda
7Department of Chemistry and Biochemistry, University of California San Diego, La Jolla
8Department of Biomedical Informatics, Columbia University, New York
9Department of Systems Biology, Columbia University, New York

8:15 AM

Hannah J. Uckelmann, PhD1*, Stephanie M. Kim, BA1*, Noa J. C. Antonissen1*, Andrei V. Krivtsov, PhD1*, Charles Hatton1*, Gerard M. McGeehan, PhD2*, Ross L. Levine, MD3, George S. Vassiliou4* and Scott A. Armstrong, MD, PhD1

1Dana-Farber Cancer Institute, Boston, MA
2Syndax Pharmaceuticals, Inc., Waltham, MA
3Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
4Wellcome Trust Sanger Institute, Cambridge, United Kingdom

*signifies non-member of ASH