-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

632.Oral2.6 632. Chronic Myeloid Leukemia: Therapy: NGS-based and Mechanistic Studies

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Biological, Diseases, Therapies, CML, Mechanisms, Technology and Procedures, Myeloid Malignancies, TKI, NGS, multi-systemic interactions
Saturday, December 9, 2017: 4:00 PM-5:30 PM
Bldg B, Lvl 2, B206 (Georgia World Congress Center)
Moderators:
Fausto Castagnetti, MD, PhD, Bologna University School of Medicine and Dong-Wook Kim, MD, PhD, Seoul St. Mary's Hospital The Catholic University of Korea
Disclosures:
Castagnetti: Incyte: Consultancy, Honoraria; Bristol Myers Squibb: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria; Novartis: Consultancy, Honoraria. Kim: Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; BMS: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Pfizer: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Il-Yang: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda: Membership on an entity's Board of Directors or advisory committees, Research Funding; SUN Pharma: Consultancy, Research Funding.
4:00 PM

Zimu Gong, MD1, L. Jeffrey Medeiros, MD1, Jorge E. Cortes, MD2, Wei Wang, MD, PhD1*, Hagop M. Kantarjian, MD2 and Shimin Hu, PhD, MD1

1Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
2Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

4:15 PM

Simona Soverini, PhD1, Luana Bavaro2*, Caterina De Benedittis, PhD1*, Margherita Martelli3*, Stefania Stella, PhD4*, Paolo Vigneri, MD, PhD5*, Alessandra Iurlo, MD, PhD6*, Nicola Orofino, MD6*, Simona Sica, MD7,8*, Federica Sorà, MD7*, Sara Galimberti, PhD, MD9*, Claudia Baratè, MD, PhD10*, Francesco Albano, MD11*, Antonella Russo Rossi, MD12*, Fabio Ciceri, MD13*, Francesca Lunghi, MD14*, Fausto Castagnetti, MD15, Gabriele Gugliotta, MD, PhD2, Gianantonio Rosti, MD16*, Elena Tenti, PhD15*, Fabio Stagno, MD, PhD17, Elisabetta Novella, PhD18*, Eros Di Bona, MD18*, Massimiliano Bonifacio, MD19*, Elisabetta Abruzzese, MD, PhD20*, Marzia Salvucci, MD21*, Mariella D'Adda, MD22*, Rosaria Sancetta, MD23*, Elisabetta Calistri, MD24*, Monica Bocchia, MD25*, Isabella Capodanno, MD26*, Giuseppina Spinosa, MD27*, Maria Antonella Laginestra, PhD28*, Santa Errichiello, PhD29*, Anna Serra, Dr30*, Francesca Carnuccio, Dr30*, Sabrina Coluzzi, PhD31*, Mario Annunziata, MD32*, Caterina Musolino, MD33*, Fabrizio Pane, MD34, Giuseppe Saglio, MD, PhD30, Michele Baccarani, MD35*, Michele Cavo, MD36* and Giovanni Martinelli, MD37

1Hematology/Oncology "L. e A. Seragnoli", University of Bologna, Bologna, ITA
2Department of Experimental Diagnostic and Specialty Medicine - DIMES Institute of Hematology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy
3Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy
4Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
5Dep. Clinical and Experimental Medicine, University of Catania Medical School, Catania, Italy
6Hematology Division, IRCCS Cà Granda - Maggiore Policlinico Hospital Foundation, Milano, Italy
7Institute of Hematology, Catholic University of Rome, Rome, Italy
8Institute of Hematology, Università Cattolica del Sacro Cuore - Policlinico A. Gemelli, Roma, Italy
9Hematology Division, AOUP, Pisa, Italy
10Department of Clinical and Experimental Medicine, Section of hematology, University of Pisa, Pisa, Italy
11University of Bari, Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, Bari, Italy
12Hematology, University of Bari, Bari, ITA
13Hematology and BMT Unit IRCCS San Raffaele Scientific Institute, Milan, Italy
14U.O. Ematologia e Trapianto di Midollo Osseo, Ospedale San Raffaele IRCCS, Milan, Italy
15Hematology/Oncology "Seragnoli", University of Bologna, Bologna, Italy
16Institute of Hematology " L. & A. Seràgnoli",, St. Orsola University Hospital, Bologna, Italy
17Chair and Hematology Section, Ferrarotto Hospital, Catania, Italy
18Ospedale San Bortolo, UO Hematology, Vicenza, Italy
19Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
20Haematology Unit, S. Eugenio Hospital, Rome, Italy
21Hematology Unit, S. Maria delle Croci Hospital, Ravenna, Italy
22Department of Hematology, Spedali Civili, Brescia, Italy
23Hematology Unit, Ospedale dell'Angelo Mestre, Venezia, Italy
24UO Hematology, Ca Foncello Hospital, Treviso, Italy
25Azienda Ospedaliera Universitaria, University of Siena, Siena, Italy
26UO Hematology, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy
27UO Hematology, Foggia, Italy
28Department of Experimental, Diagnostic, and Specialty Medicine, Hematopathology Section, Bologna, Italy
29Department of Clinical Medicine and Surgery- University of Naples “Federico II” - CEINGE-Biotecnologie Avanzate Napoli-Italy, Naples, Italy
30Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy
31UO Hematology, San Carlo Hospital, Potenza, ITA
32Hematology, Ospedale Cardarelli, NAPOLI, Italy
33Section of Hematology, A.O.U. Policlinico, Messina, Italy
34Hematology - Departments of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
35Institute of Hematology " L. & A. Seràgnoli", St. Orsola University Hospital, Bologna, Italy
36Department of Physics and Astronomy, University of Bologna, Bologna, Italy
37Institute of Hematology 'Seragnoli', Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna,, Bologna, Italy

4:30 PM

Monica Bocchia, MD1*, Marzia Defina2*, Santina Sirianni2*, Bruno Martino3*, Elisabetta Abruzzese, MD4, Patrizia Pregno, MD5*, Sara Galimberti, PhD, MD6*, Giulia Alunni7*, Anna Sicuranza2*, Antonella Gozzini, MD8*, Carmen Fava, MD, PhD9*, Luca Puccetti2*, Federica Sorà, MD10*, Claudia Baratè, MD, PhD11*, Fausto Castagnetti, MD, PhD12, Lara Aprile2*, Alessandra Iurlo, MD, PhD13*, Daniele Cattaneo, MD14*, Simona Sica, MD15*, Luigiana Luciano16*, Monica Crugnola, MD17*, Mario Annunziata, MD18*, Giovanni Caocci, MD19*, Olga Mulas19*, Emilio Usala, MD20*, Nicola Sgherza21*, Gianantonio Rosti, MD22* and Donatella Raspadori2*

1Azienda Ospedaliera Universitaria, University of Siena, Siena, Italy
2Hematology, University of Siena, Siena, Italy
3Haematology Dept.- Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy
4Hematology Unit, S.Eugenio Hospital, Tor Vergata University, Rome, ITA
5AZ OSP CITTA' DELLA SALUTE E SCIENZA TORINO, University of Torino, TORINO, Italy
6Hematology Division, AOUP, Pisa, Italy
7Azienda Ospedaliera Terni, Terni, Italy
8SC Terapie Cellulari e Medicina Trasfusionale, AOU Careggi, Florence, Italy
9Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy
10Institute of Hematology, Catholic University of Rome, Rome, Italy
11Department of Clinical and Experimental Medicine, Section of hematology, University of Pisa, Pisa, Italy
12Department of Experimental Diagnostic and Specialty Medicine - DIMES Institute of Hematology "L. e A. Seràgnoli", Bologna University School of Medicine, Bologna, Italy
13Hematology Division, IRCCS Cà Granda - Maggiore Policlinico Hospital Foundation, Milano, Italy
14Hematology Division, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Milan, Italy
15Institute of Hematology, Università Cattolica del Sacro Cuore - Policlinico A. Gemelli, Roma, Italy
16AOU Università degli Studi di Napoli "Federico II", Napoli, Italy
17Division of Hematology, University Hospital of Parma, Parma, Italy
18Hematology, Ospedale Cardarelli, NAPOLI, Italy
19Department of Medical Sciences, University of Cagliari, Cagliari, Italy
20Hematology and Bone Marrow Transplantation Unit, Ospedale Oncologico di Riferimento Regionale "Armando Businco", Cagliari, Italy
21Division of Hematology, IRCCS Ospedale Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy
22Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Institute of Hematology "L. and A. Seràgnoli", S.Orsola-Malpighi University Hospital, Bologna, Italy

4:45 PM

Shady Adnan Awad, MD1*, Matti Kankainen, PhD2*, Samuli Eldfors2*, Bhagwan Yadav, PhD3*, Soili Kytölä4*, Pekka Ellonen2*, Mahmoud Kamel, MD, PhD5*, Caroline A Heckman, PhD2, Kimmo Porkka, MD, PhD1* and Satu Mustjoki, MD, PhD1

1Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
2Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
3Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Centre, Helsinki, Finland
4Laboratory of Genetics, HUSLAB, Helsinki University Hospital, Helsinki, Finland
5Clinical and Chemical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt

5:00 PM

Susan Branford, PhD1, Paul Wang2*, David Yeung, PhD, BSc, FRACP, FRCPA, MBBS3, Adrian Purins2*, Justine Ellen Marum, PhD, BSc4*, Nathalie Nataren2*, Hezrin Shahrin2*, Daniel Thomson2*, Carol Wadham2*, Christopher N. Hahn, PhD5*, Anna L. Brown, PhD2,6, David M Ross, MBBS, PhD, FRACP, FRCPA7*, Agnes S. M. Yong, MD, PhD8, Naranie Shanmuganathan, MBBS3, Martin Müller, MD9*, Christian Dietz, PhD10*, Dong-Wook Kim, MD, PhD11, Soo-Hyun Kim12*, Soo Young Choi13*, Sahee Park13*, Hamish S. Scott, PhD, FFSc (RCPA), FAHMS14, Andreas Schreiber, PhD15* and Timothy P. Hughes, MD, MBBS, FRACP, FRCPA16

1Genetic and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia
2Centre for Cancer Biology, SA Pathology, Adelaide, Australia
3Department of Haematology, SA Pathology, Adelaide, Australia
4Murdoch Childrens Research Institute, Adelaide, AUS
5Department of Genetics and Molecular Pathology, University of South Australia, Adelaide, Australia
6Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, Australia
7Department of Haematology, Royal Adelaide Hospital and SA Pathology, Adelaide, Australia
8South Australian Health and Medical Research Institute, Adelaide, Australia
9Universitätsmedizin Mannheim, Universität Heidelberg, Mannheim, DEU
10Institute for Hematology and Oncology (IHO GmbH), Mannheim, Germany
11Seoul St. Mary's Hospital The Catholic University of Korea, Seoul, South Korea
12Korea Leukemia Bank, The Catholic University of Korea, Seoul, Korea, Republic of (South)
13Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Korea, Republic of (South)
14Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, Australia
15School of Molecular and Biological Sciences, Univerisity of Adelaide, Adelaide, Australia
16Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, Australia

5:15 PM

Georg-Nikolaus Franke, MD1*, Jacqueline Maier, PhD2*, Kathrin Wildenberger2*, Christine Günther2*, Michael Cross, PhD2*, Thomas Ernst, MD3, Christian Fabisch, PhD3*, Dietger Niederwieser, MD4, Andreas Hochhaus, MD5 and Thoralf Lange, MD6,7*

1Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany
2Department for Hematology and Oncology, University Hospital of Leipzig, Leipzig, Germany
3Internal Medicine II, Jena University Hospital, Jena, Germany
4Department of Hematology, University of Leipzig, Leipzig, Germany
5Jena University Hospital, Jena, Germany
6Department of Hematology and Oncology, University Leipzig, Leipzig, Germany
7Asklepios Klinikum Weissenfels, Weissenfels, Germany

*signifies non-member of ASH