-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

632.Oral1.6 632. Chronic Myeloid Leukemia: Therapy: Results of Clinical Trials

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Adult, Biological, Diseases, Therapies, CML, Pediatric, Study Population, Clinically relevant, Myeloid Malignancies, TKI
Monday, December 11, 2017: 6:15 PM-7:45 PM
Bldg C, Lvl 2, C202-C204 (Georgia World Congress Center)
Moderators:
Carlo Gambacorti-Passerini, MD, University of Milano Bicocca and Thomas Ernst, MD, Jena University Hospital
Disclosures:
Gambacorti-Passerini: Pfizer: Consultancy, Honoraria, Research Funding; BMS: Consultancy.
6:15 PM

Anna G Turkina, Prof., MD1, Oleg Shukhov, MD, PhD1*, Ekaterina Chelysheva, MD, PhD1*, Irina Nemchenko, MD, PhD1*, Anna Petrova, MD1*, Anastasiya Bykova, MD1*, Andrey Zaritskey2*, Elza Lomaia, MD3*, Vasily Shuvaev, MD 4, Fedor Novikov, PhD5*, Veronika Shulgina, PhD, MD5*, Ghermes Chilov, PhD5* and Jorge E. Cortes, MD6

1National Research Center for Hematology, Moscow, Russian Federation
2Almazov Medical Research Center of the Russian Ministry of Health, St Petersburg, Russian Federation
3Federal Almazov North-West Medical Research Centre, Saint-Petersburg, Russian Federation
4Russian Scientific and Research Institute of Hematology and Transfusiology of Federal Medical Biological Agency, Saint-Petersburg, Russian Federation
5Fusion Pharma LLC, Moscow, Russian Federation
6Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

6:30 PM

Carlo Gambacorti-Passerini, MD1, Michael W. Deininger, MD, PhD2, Michael J. Mauro, MD3, Charles Chuah, MD4, Dong-Wook Kim, MD, PhD5, Iryna Dyagil, MD PhD6*, Natalia Glushko7*, Dragana Milojkovic, MBBS, PhD8*, Philipp D. le Coutre, MD9, Valentín García Gutiérrez, PhD10, Rocco J. Crescenzo, DO, FACOI11*, Eric Leip, PhD12*, Nathalie Bardy-Bouxin, PhD13*, Andreas Hochhaus, MD14, Timothy H. Brümmendorf15 and Jorge E. Cortes, MD16

1University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy
2University of Utah, Salt Lake City, UT
3Myeloproliferative Neoplasms Program, Memorial Sloan Kettering Cancer Center, New York, NY
4Singapore General Hospital, Duke-NUS Medical School, Singapore, Singapore
5Seoul St. Mary’s Hospital, Leukemia Research Institute, The Catholic University of Korea, Seoul, Korea, Republic of (South)
6Hematology, National Research Center For Radiation Medicine, Kiev, UKR
7Ivano-Frankivsk Regional Clinical Hospital, Ivan0-Frankivsk, Ukraine
8Department of Haematology, Hammersmith Hospital, Imperial College, London, United Kingdom
9Charité-Universitätsmedizin Berlin, Berlin, Germany
10Hematology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
11Pfizer, Collegeville, PA
12Pfizer, Cambridge, MA
13Global Research and Development, Pfizer International Operation-Oncology, Paris, France
14Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Germany
15Universitätsklinikum RWTH Aachen, Aachen, Germany
16Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

6:45 PM

Rüdiger Hehlmann, MD1, Michael Lauseker, PhD2*, Susanne Saussele, MD 3, Markus Pfirrmann4*, Stefan W. Krause, MD5*, Hans-Jochem Kolb, MD6, Andreas Neubauer, MD7, Dieter K. Hossfeld8*, Christoph Nerl, MD9*, Alois Gratwohl, MD10*, Gabriela M. Baerlocher11, Dominik Heim, MD12, Tim Henrik Bruemmendorf13*, Alice Fabarius, PhD1*, Claudia Haferlach, MD14, Brigitte Schlegelberger, MD, PhD15, Martin C. Müller, MD1*, Sabine Jeromin, PhD16*, Ulrike Proetel, PhD17*, Katharina Kohlbrenner, PhD18*, Astghik Voskanyan, PhD19*, Sébastien Rinaldetti1*, Wolfgang Seifarth, PhD20*, Birgit Spiess21*, Leopold Balleisen, MD22, Maria E Goebeler, MD23*, Mathias Hänel, MD24*, Anthony D. Ho, MD25, J Dengler26*, C Falge27*, Lothar Kanz, MD28, Claus-Henning Köhne, M.D., Ph.D.29*, Andreas Burchert, MD30, Michael Kneba, MD, PhD31, Frank Stegelmann, MD32*, C Köhne33*, Hans-Walter Lindemann34*, C Waller35*, Michael Pfreundschuh, MD36,37, Karsten Spiekermann38, Wolfgang E Berdel, MD39, L Müller40*, Matthias Edinger, MD41, Jiri Mayer, MD42, Dietrich W Beelen, MD, PhD43, Martin Bentz, MD44, Hartmut Link, MD, PhD45*, Bernd Hertenstein, MD46*, R Fuchs47*, Martin Wernli, MD48, F Schlegel49*, Rudolph Schlag50*, M de Wit51*, Lorenz Trümper, MD52*, H Hebarth53*, M Hahn54*, Jörg Thomalla, MD55*, Christof Scheid, MD56, Philippe Schafhausen, MD57*, Walter Verbeek, MD58*, Michael J. Eckart, MD59*, Winfried Gassmann, MD, PhD60, Antonio Pezzutto, MD61, Michael Schenk62*, Peter Brossart, MD63, Thomas Geer, MD64, Stephan Bildat65*, E Schäfer66*, Andreas Hochhaus, MD67 and Joerg Hasford4*

1III. Medizinische Klinik, Medizinische Fakultät Mannheim der Uni Heidelberg, Mannheim, Germany
2Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität München, München, Germany
3III. Medizinische Klinik, Universitätsmedizin Mannheim, Universität Heidelberg, Mannheim, Germany
4Institut für medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität, München, Germany
5Department of Internal Medicine 5, Haematology/Oncology, University of Erlangen, Erlangen, Germany
6Department of Internal Medicine III, University of Munich-Grosshadern, Munich, Germany
7Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg, Germany
8II. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg, Germany
9Klinik für Hämatologie, Onkologie, Immunologie, Palliativmedizin, Infektiologie und Tropenmedizin, Klinikum Schwabing, München, Germany
10Hematology, University Hospital of Basel, Basel, Switzerland
11Universitätsklinik für Hämatologie und hämatologisches Zentrallabor, Inselspital, Bern, Switzerland
12Klinik für Hämatologie, Universitätsspital, Basel, Switzerland
13Direktor der Klinik für Onkologie, Hämatologie und Stammzelltransplantation Euregionales Comprehensive Cancer Center Aachen (ECCA), Aachen, Germany
14MLL Munich Leukemia Laboratory GmbH, Munich, Germany
15Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
16MLL Munich Leukemia Laboratory, Munich, Germany
17III. Medizinische Klinik, Universität Heidelberg, Medizinische Fakultät, Mannheim, Germany
18III. Med. Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany
19Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany
20Department of Hematology and Oncology, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
21University Hospital Mannheim, Heidelberg University, Department of Hematology and Oncology, Mannheim, Germany
22Evangelisches Krankenhaus, Hamm, DEU
23Leitung CCC Trial Office, Würzburg, Germany
24Klinikum Chemnitz, Chemnitz, Germany
25Medizinische Klinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany
26Schwerpunktpraxis Heildbronn, Heilbronn, Germany
27Klinikum Nürnberg Nord, Nürnberg, Germany
28Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany, Tuebingen, Germany
29Klinik für Onkologie und Hämatologie, Klinikum Oldenburg, Oldenburg, Germany
30Hem./Onc./Immunology, University of Marburg, Marburg, Germany
31Department of Internal Medicine II, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany
32Department of Internal Medicine III, University Hospital of Ulm, Germany, Ulm, Germany
33Klinik für Innere Medizin I, Universität des Saarlandes, Homburg, Homburg, Germany
34Klinik für Hämatologie / Onkologie, Kath. Krankenhaus Hagen gem. GmbH - St.-Marien-Hospital, Hagen, Germany
35Universitätsklinikum Freiburg, Freiburg, Germany
36José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Universität des Saarlandes, Homburg, Germany
37Innere Medizin I, Universität des Saarlandes, Homburg, Germany
38Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany
39Department of Medicine A - Hematology and Oncology, University Hospital of Muenster, Muenster, Germany
40MLL München, München, Germany
41Abteilung Hämatologie und Internistische Onkologie, Universitätsklinikum, Regensburg, Germany
42Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic
43Department of Bone Marrow Transplantation, West German Cancer Center, University of Duisburg-Essen, Essen, Germany
44Department of Internal Medicine III, Municipal Hospital of Karlsruhe, Karlsruhe, Germany
45Medizinische Klinik I Westpfalz-Klinikum, Kaiserslautern, Germany
46I. Medizinische Klinik, Klinikum Bremen-Mitte, Bremen, Germany
47Medizinische Klinik IV, Uniklinik RWTH Aachen, Aachen, Germany
48Onkologie/Hämatologie, Kantonsspital, Aarau, Switzerland
49Schwerpunkt Hämatologie / Internistische Onkologie, Stauferklinikum Schwäbisch Gmünd, Mutlangen, Mutlangen, Germany
50Ambulantes Onkologie-Zentrum, Ansbach, Wurzburg, DEU
51Klinik I für Innere Medizin, Universitätsklinikum Köln, Köln, Germany
52Department of Hematology and Oncology, Universitätsmedizin Göttingen, Georg-August-Universität, Göttingen, Germany
53Internistische Schwerpunktpraxis Erlangen, Erlangen, Germany
54Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Campus Benjamin Franklin, Charité, Berlin, Berlin, Germany
55Praxisklinik für Hämatologie und Onkologie, Koblenz, Germany
56University of Cologne, Cologne, Germany
57Department of Hematology and Oncology with Sections BMT and Pneumology, Hubertus Wald Tumorzentrum, University Hospital Hamburg-Eppendorf, Hamburg, Germany
58Center of Outpatient Hematology/Oncology, Bonn, Germany
59Onkologische Schwerpunktpraxis Erlangen, Erlangen, Germany
60St. Marien-Krankenhaus gGmbH, Siegen, Germany
61Charite Research Organization, Berlin, Germany
62Krankenhaus Barmherzige Brüder, Regensburg, Germany
63Department of Internal Medicine III, Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany
64Innere Medizin Hämatologie und Onkologie, Schwabisch Hall, Germany
65Klinikum Herford, Herford, Germany
66Onkologische Schwerpunktpraxis Bielefeld, Bielefeld, Germany
67Jena University Hospital, Jena, Germany

7:00 PM

Meinolf Suttorp, MD, PhD1, Philipp Schulze2*, Ingmar Glauche, PhD2*, Gudrun Göhring, MD3*, Nils Von Neuhoff, PhD4*, Markus Metzler, MD5*, Petr Sedlacek, MD6*, Eveline S. de Bont, MD7, Adriana Balduzzi, MD8, Birgitte Lausen, MD9*, Olga Aleinikova, MD, PhD10*, Sabina Sufliarska, MD11*, Guenter Henze, MD, PhD12*, Gabriele Strauss, MD13*, Angelika Eggert, MD, PhD14*, Bernhard Kremens, MD, PhD15*, Andreas H Groll, MD, PhD16*, Frank Berthold, MD, PhD17*, Christoph Klein, MD, PhD18, Ute Gross-Wieltsch, MD19*, Karl-Walter Sykora, MD20*, Arndt Borkhardt, Prof MD21, Andreas E. Kulozik, MD, PhD22*, Martin Schrappe, MD, PhD23, Christina Nowasz24*, Manuela Krumbholz, PhD25*, Josephine Tabea Tauer, PhD26*, Alexander Claviez, MD27, Jochen Harbott, PhD28*, Hans H Kreipe, MD, PhD29*, Brigitte Schlegelberger, Prof. Dr.3 and Christian Thiede, MD30

1Univ. Children's Hospital, Dresden, Dresden, Germany
2Institute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
3Institute of Human Genetics, Hannover Medical School, Hannover, Germany
4Pediatric Hematology and Oncology, University Children’s Hospital Essen, Essen, Germany
5Department of Pediatrics, University Hospital Erlangen, Erlangen, Germany
6Department of Pediatric Hematology–Oncology, University Hospital Motol, Charles University, Prague, Czech Republic
7University Medical Center Groningen, University of Groningen, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
8Clinica Pediatrica Università degli Studi di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
9Rigshospitalet, Copenhagen, Denmark., Department of Pediatric and Adolescent Medicine, University Hospital,, Copenhagen, Denmark
10Republican Scientific and Practical Centre of Children Oncology, MINSK, BLR
11Bone Marrow Transplantation Unit, Comenius University Children's Hospital, Bratislava, Slovakia
12Pediatric oncology, Charite Universitaetsmedizin Berlin, Berlin, Germany
13Helios Kliniken Berlin Buch, Pediatric Hematology and Oncology,, Berlin, Germany
14Charité Berlin,, Pediatric Hematology and Oncology, University Children’s Hospital,, Berlin, Germany
15University of Duisburg-Essen,, Department of Pediatrics III, University Hospital, Essen, Germany
16University Children’s Hospital, Muenster, Pediatric Hematology and Oncology, Muenster, Germany
17University Children’s Hospital, Cologne, Pediatric Hematology and Oncology, Cologne, Germany
18University Children's Hospital, Munich, Germany
19Klinikum Stuttgart – Olgahospital, Stuttgart, Pediatric Oncology, Hematology, Immunology, Stuttgart Cancer Center, Stuttgart, Germany
20Pediatric Hematology/Oncology, Medical School Hannover, Hannover, Germany
21Pediatric Oncology, University Hospital Duesseldorf, Duesseldorf, Germany
22UniversitätsKlinikum Heidelberg, Heidelberg, Germany
23Department of Pediatric Hematology and Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
24TU Dresden, Dresden,, Pediatric Hematology and Oncology, Department of Pediatrics, University Hospital “Carl Gustav Carus”,, Dresden, Germany
25Pediatric Hematology & Oncology, Univ. Hospital Erlangen, Erlangen, Germany
26Shriner's Hospital for Children, Montreal, Canada
27Department of Pediatrics, Medical University of Schleswig-Holstein, Kiel, Germany
28University Children’s Hospital, Oncogenetic Laboratory, Pediatric Hematology and Oncology, Giessen, Germany
29Institute of Pathology, Hannover Medical School, Hannover, Germany
30Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden, Germany

7:15 PM

Franck Emmanuel Nicolini, MD, PhD1,2,3, Gabriel Etienne, MD, PhD1,4*, Francoise Huguet, MD1,5*, Agnes Guerci-Bresler1,6*, Aude Charbonnier, MD1,7*, Martine Escoffre-Barbe, MD1,8*, Viviane Dubruille, MD1,9*, Hyacinthe Johnson-Ansah, MD1,10*, Laurence Legros, MD, PhD1,11*, Valerie Coiteux, MD1,12*, Pascale Cony-Makhoul, MD, PhD1,13*, Pascal Lenain, MD1,14*, Lydia Roy, MD1,15*, Philippe Rousselot, MD1,16,17*, Denis Guyotat1,18*, Jean-Christophe Ianotto, MD1,19*, Martine Gardembas, MD1,20*, Fabrice Larosa, MD1,21*, Denis Caillot, MD1,22*, Pascal Turlure, MD1,23*, Stephane Courby, MD1,24*, Philippe Quittet, MD1,25, Eric Hermet, MD1,26*, Shanti Ame, MD27,28*, Simona Lapusan, MD1,29*, Verane Schwiertz, PharmD30*, Stephane Morisset, Stat31*, Madeleine Etienne, CRA1,32*, Delphine Rea, MD, PhD1,33*, Stephanie Dulucq, PhD34,35* and Francois-Xavier Mahon, MD, PhD1,36

1Fi-LMC group, Pessac, France
2Département d'Hématologie, Centre Leon Berard, Lyon, France
3Hematology department 1 G, Centre Hospitalier Lyon Sud, Pierre Benite, France
4Hematology Department, Institut Bergonie, Bordeaux, France
5Hematology Department, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France
6Hematology department, CHU Brabois, Nancy, France
7Hematology department, Institut Paoli Calmettes, Marseille, France
8Hematology department, CHU Rennes, Rennes, France
9Clinical Hematology, Nantes University Hospital, Nantes, France
10Hematology department, CHU Caen, Caen, France
11Hematology department, Hopital Archet, Nice, France
12Hematology department, CHU de Lille, Lille, France
13Centre Hospitalier Annecy-Genevois, Pringy, France
14Hematology department, Centre Henri Becquerel, Rouen, France
15Hematology department, Hopital Henri Mondor, Creteil, France
16Hematology department, CH de Versailles, Le Chesnay, France
17Hôpital de Versailles, Le Chesnay, France
18Hematology department, Institut de Cancerologie Lucien Neuwirth, Saint-Priest-en-Jarez, France
19Centre Hospitalier Universitaire, Brest, France
20Hematology department, University Hospital Angers, Angers, France
21Hematology department, CHU Jean Minjoz, Besancon, France
22Department of Hematology, University Hospital of Dijon, Dijon, France
23Hematology department, Hopital Dupuytren, Limoges, France
24Hematology department, CHU Grenoble, Grenoble, France
25Hematology department, CHU Saint Eloi Montpellier, Montpellier, France
26university hospital of Clermont-Ferrand, Unit of adult cell therapy and clinical hematology, Clermont-Ferrand, France
27Hematology department, Hopital Civil , CHU Strasbourg, Strasbourg, France
28Fi-LMC Group, Pessac, France
29APHP, Hôpital Saint Antoine, Service d'Hématologie Clinique et de Thérapie cellulaire, Paris, France
30Pharmacy, Centre Hospitalier Lyon Sud, Pierre Benite, France
31Hematology department, Centre Leon Berard, Lyon, France
32Hematology department 1G, Centre Hospitalier Lyon Sud, Pierre Benite, France
33Hematology department, Hopital Saint Louis, Paris, France
34Laboratory of Hematology, Hopital Haut Leveque, Pessac, France
35Molecular Biology Laboratory, Hôpital Haut Lévèque, Pessac, France
36Hematology Laboratory, Bordeaux University,Bordeaux Hospital, INSERM 1035, BORDEAUX, France

7:30 PM

Tim H. Brümmendorf, MD1, Carlo Gambacorti-Passerini, MD2, Dong-Wook Kim, MD, PhD3, Yeow Tee Goh, MBBS, MD4, Iryna Dyagil, MD PhD5*, Katia B Pagnano, MD6, Árpád Bátai, MD7*, Anna G Turkina, Prof., MD8, Jean M. Aguiar, RN9*, Eric Leip, PhD10* and Jorge E. Cortes, MD11

1Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Universitätsklinikum RWTH, Aachen, Germany
2Hematology Unit, ASST-Monza, University of Milano Bicocca, Monza, MB, Italy
3Seoul St. Mary’s Hospital, Leukemia Research Institute, The Catholic University of Korea, Seoul, KOR
4Singapore General Hospital, Duke-NUS Graduate Medical School, Singapore, SGP
5Hematology, National Research Center For Radiation Medicine, Kiev, UKR
6Centro de Hematologia e Hemoterapia, Hematology and Hemotherapy Center, Campinas, SP, Brazil
7Department of Hematology and Stem Cell Transplantation, Joint St. Stephen and St. László Hospital, Budapest, Hungary
8National Research Center for Hematology, Moscow, Russian Federation
9Pfizer, New York, NY
10Pfizer, Cambridge, MA
11Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

*signifies non-member of ASH