-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

631.Oral1.6 631. Chronic Myeloid Leukemia: Biology and Pathophysiology, excluding Therapy: Novel Targets and CML Stem Cell Biology Clinically Relevant Abstract

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Adult, Diseases, Non-Biological, Therapies, CML, Mechanisms, Technology and Procedures, Study Population, cytogenetics, Clinically relevant, genomics, Xenograft models, hematopoiesis, Myeloid Malignancies, pharmacology, signal transduction
Saturday, December 9, 2017: 7:30 AM-9:00 AM
Bldg B, Lvl 5, Murphy BR 3-4 (Georgia World Congress Center)
Moderators:
Mhairi Copland, PhD, MBBChir, FRCP, FRCPath, Gartnavel General Hospital and Michael W. Deininger, MD, PhD, Huntsman Cancer Institute, University of Utah
Disclosures:
Copland: Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Conference attendance supported, Speakers Bureau; Incyte: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Celgene: Honoraria, Other: Conference attendance supported, Speakers Bureau; Takeda: Honoraria, Speakers Bureau; Bristol-Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Conference attendance supported, Research Funding, Speakers Bureau. Deininger: Novartis: Consultancy, Research Funding; Incyte: Consultancy; Ariad Pharmaceuticals, Bristol Myers Squibb, CTI BioPharma Corp, Gilead, Incyte, Novartis, Pfizer, Celgene, Blue Print, Galena: Consultancy, Membership on an entity's Board of Directors or advisory committees; Pfizer: Consultancy, Research Funding; Blueprint: Consultancy; Galena Biopharma: Consultancy.
7:30 AM

Hein Than, MD, FRCPath, MRCP1,2, Anthony D. Pomicter, MS1*, Clinton C. Mason, PhD3*, Anna M. Eiring, PhD4, William L. Heaton, MS1*, Dongqing Yan1*, Anna Senina, MS1*, Phillip M. Clair, MS1*, Tessa L. Holyoake, MD, PhD, FRCP, FRCPath5, Thomas O'Hare, PhD1,6 and Michael W. Deininger, MD, PhD1,6

1Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT
2Department of Hematology, Singapore General Hospital, Singapore, Singapore
3Department of Pediatrics, The University of Utah, Salt Lake City, UT
4Huntsman Cancer Institute, University of Utah/Huntsman Cancer Institute, Salt Lake City, UT
5Paul O'Gorman Leukaemia Research Centre, University of Glasgow, Glasgow, United Kingdom
6Division of Hematology and Hematologic Malignancies, The University of Utah, Salt Lake City, UT

7:45 AM

Manuela Mancini, PhD1*, Sara De Santis1*, Cecilia Monaldi1*, Luana Bavaro1*, Margherita Martelli2*, Fausto Castagnetti, MD, PhD3, Gabriele Gugliotta, MD, PhD1, Gianantonio Rosti, MD4*, Alessandra Iurlo, MD, PhD5*, Elisabetta Abruzzese, MD6, Marzia Salvucci, MD7*, Patrizia Pregno, MD8*, Antonella Gozzini, MD9*, Monica Crugnola, MD10*, Francesco Albano, MD11,12*, Massimiliano Bonifacio, MD13*, Elisabetta Calistri, MD14*, Mario Tiribelli, MD15*, Gianni Binotto, MD16*, Annalisa Imovilli, MD17*, Elena Trabacchi, MD18*, Sara Galimberti, PhD, MD19*, Claudia Baratè, MD, PhD20*, Elena Tenti, PhD21*, Michele Baccarani, MD22, Michele Cavo, MD23*, Giovanni Martinelli, MD24 and Simona Soverini, PhD25

1Department of Experimental Diagnostic and Specialty Medicine - DIMES Institute of Hematology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy
2Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy
3Department of Experimental Diagnostic and Specialty Medicine - DIMES Institute of Hematology "L. e A. Seràgnoli", Bologna University School of Medicine, Bologna, Italy
4Bologna University School of Medicine, Bologna, Italy
5Hematology Division, IRCCS Cà Granda - Maggiore Policlinico Hospital Foundation, Milano, Italy
6Hematology Unit, S.Eugenio Hospital, Tor Vergata University, Rome, ITA
7Hematology Unit, S. Maria delle Croci Hospital, Ravenna, Italy
8AZ OSP CITTA' DELLA SALUTE E SCIENZA TORINO, University of Torino, TORINO, Italy
9SC Terapie Cellulari e Medicina Trasfusionale, AOU Careggi, Florence, Italy
10Division of Hematology, University Hospital of Parma, Parma, Italy
11University of Bari, Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, Bari, Italy
12Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, Bari, Italy
13Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
14UO Hematology, Ca Foncello Hospital, Treviso, Italy
15Division of Hematology and BMT, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy
16UO Ematologia e Immunologia Clinica, AOU di Padova, PADOVA, ITA
17UO Hematology, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy
18Hematology Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy
19Hematology Division, AOUP, Pisa, Italy
20Department of Clinical and Experimental Medicine, Section of hematology, University of Pisa, Pisa, Italy
21Hematology/Oncology "Seragnoli", University of Bologna, Bologna, Italy
22Institute of Hematology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy
23Department of Physics and Astronomy, University of Bologna, Bologna, Italy
24Institute of Hematology 'Seragnoli', Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna,, Bologna, Italy
25Institute of Hematology "L. e A. Seràgnoli", University of Bologna, Castel Maggiore, Bologna, Italy

8:00 AM

VERA Magistroni, PhD1*, Rocco Piazza, MD, PhD1*, Mario Mauri, PhD1*, Caterina Mezzatesta, M.Sc.1*, Nitesh Sharma, PhD1*, Wendy Parker, PhD2*, Andreas Schreiber, PhD3*, David T Yeung, PhD, BSc, FRACP, FRCPA, MBBS4, Sara Redaelli, PhD1*, Paul Wang5*, Alessandra Pirola, M.Sc.6*, Luca Massimino, PhD1*, Praveen Khandelwal1*, Stefania Citterio7*, Michela Viltadi8*, Jacqueline Boultwood, PhD9, Alessandro Morotti, MD, PhD10, Giuseppe Saglio, MD, PhD11, Dong-Wook Kim, MD, PhD12, Susan Branford, PhD13 and Carlo Gambacorti-Passerini, MD14

1Dept. of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
2Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, Australia
3ACRF Cancer Genomics Facility, SA Pathology, Adelaide, Australia
4School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia
5Centre for Cancer Biology, SA Pathology, Adelaide, Australia
6GalSeq s.r.l, Bresso (MI), Italy
7University of Milano Bicocca, Milano, Italy
8School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
9Bloodwise Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
10University of Turin, Dept of Clinical and Biological Sciences, Orbassano, Italy
11University of Turin, Orbassano, Torino, Italy
12Seoul St. Mary's Hospital The Catholic University of Korea, Seoul, South Korea
13School of Medicine, Faculty of Health Sciences, SA Pathology, Adelaide, SA, Australia
14Hematology Unit, ASST-Monza, University of Milano Bicocca, Monza, MB, Italy

8:15 AM

Giovannino Silvestri, PhD1, Lorenzo Stramucci, PhD2, Justin Ellis3*, Jason Harb, PhD4*, Paolo Neviani, PhD5*, Bin Zhang, PhD6*, Klara Srutova, PhD7*, Carlo Gambacorti-Passerini, MD8, Gabriel Pineda, PhD9, Catriona Jamieson, MD, PhD10, Bruno Calabretta, MD, PhD11*, Fabio Stagno, MD, PhD12, Paolo Vigneri, MD, PhD13*, G. Nteliopoulos14*, Philippa May15*, Alistair Reid, BSc, PhD16*, Ramiro Garzon, MD17, Denis-Claude Roy, MD18, Martin Guimond, PhD19*, Peter Hokland, MD20, Michael W. Deininger, MD, PhD21, Garrett Fitzgerald, MD22*, Chris Harman, MD23*, Francesco Dazzi, PhD24*, Dragana Milojkovic, MBBS, PhD25*, Jane F. Apperley, FRCP, FRCPath, MD, MBChB26, Guido Marcucci, MD27, Jianfei Qi, Ph.D28*, Kateřina Machová Poláková, PhD29*, Xiaoxuan Fan, PhD28*, Maria R. Baer, MD30, Rossana Trotta, PhD31* and Danilo Perrotti, MD, PhD32

1University of Maryland School of Medicine, Baltimore, MD
2University of Maryland Baltimore, Baltimore, MD
3the Ohio state University Comprehensive Cancer Center, Columbus, OH
4Blood Research Institute BloodCenter of Wisconsin, Milwaukee, WI
5Norris Comprehensive Cancer center, Children's Hospital Los Angeles, Los Angeles, CA
6Department of Hematologic Malignancies Translational Science, Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, Beckman Research Institute at City of Hope, Duarte, CA
7University of Prague, Prague, CZE
8Clinical Research Unit S. Gerardo Hospital, University of Milano Bicocca, Monza, MB, ITA
9University of California, San Diego, La Jolla, CA
10Moores Cancer Center, University of California, San Diego, La Jolla, CA
11Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
12Chair and Hematology Section, Ferrarotto Hospital, Catania, Italy
13Dep. Clinical and Experimental Medicine, University of Catania Medical School, Catania, Italy
14Imperial College, London, GBR
15Imperial College, London, United Kingdom
16Hammersmith Hospital Du Cane Road, London, GBR
17The Ohio State University, Division of Hematology, Department of Internal Medicine, Columbus, OH
18Division of Hematology and Hematopoietic Stem Cell Transplant Program, Hopital Maisonneuve-Rosemont, Montreal, QC, Canada
19University of Montreal, Maisonneuve-Rosemont Hospital, Montreal, QC, CAN
20Department of Hematology, Aarhus University Hospital, Aarhus C, Denmark
21University of Utah, Salt Lake City, UT
22University of Maryland Medical Center, Baltimore, MD
23University of Maryland Medical center, Baltimore, MD
24Imperial College School of Medicine, London, GBR
25Department of Haematology, Hammersmith Hospital (Imperial College Healthcare NHS Trust), London, United Kingdom
26Centre for Haematology, Hammersmith Hospital, Imperial College London, London, United Kingdom
27Division of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute at City of Hope, Duarte, CA
28University of Maryland, Baltimore, MD
29Institute of Hematology and Blood Transfusion, Prague, Czech Republic
30University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
31Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore, Baltimore, MD
32Greenebaum Cancer Center, Baltimore, MD

8:30 AM

Jeevisha Bajaj, PhD1, Eric L Van Nostrand, PhD2*, Gene W Yeo, PhD2* and Tannishtha Reya, PhD2

1Pharmacology, University of California, San Diego, La Jolla, CA
2University of California, San Diego, La Jolla, CA

8:45 AM

Ghayas C. Issa, MD1*, Hagop M. Kantarjian, MD1, Feng Wang, PhD2*, Graciela Nogueras González3*, Gautam Borthakur, MD1, Guilin Tang, MD4*, Carlos E. Bueso-Ramos, MD, PhD4, Rashmi Kanagal-Shamanna, MD4, Juliana Elisa Hidalgo Lopez, MD4, Chong Zhao4*, Marcus Coyle2*, Koichi Takahashi, MD2, Preetesh Jain, MBBS, MD, DM, PhD5, Farhad Ravandi, MBBS6, Tapan Kadia, MD1, Guillermo Garcia-Manero, MD1, Elias J. Jabbour, MD 7, Andrew Futreal, PhD2* and Jorge E. Cortes, MD1

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
3Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
4Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
5Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
6Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
7Department of Leukemia, University of Texas M.D. Anderson Cancer Ctr., Houston, TX

*signifies non-member of ASH