-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

612.O2.6 612. Acute Lymphoblastic Leukemia: Clinical Studies: Molecular Features, Toxicity of Therapy, and New Approaches to Immunotherapy Clinically Relevant Abstract

Acute Lymphoblastic Leukemia: Clinical Studies Program: Oral and Poster Abstracts
Type: Oral
Monday, December 5, 2016: 7:00 AM-8:30 AM
Marriott Grand 2-4 (Marriott Marquis San Diego Marina)
Moderators:
and Alan S. Wayne, MD, Children's Center for Cancer and Blood Diseases, Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles, USC-Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Disclosures:
No relevant conflicts of interest to declare.
7:00 AM

Elisabeth M.P. Steeghs, MSc1*, Isabel S. Jerchel, MSc1*, Willemieke de Goffau-Nobel, MSc1*, Alex Q. Hoogkamer, BSc1*, Judith M. Boer, PhD1, Aurélie Boeree, BSc1*, Cesca van de Ven, PhD1*, Marco J. Koudijs, PhD2,3*, Nicolle J.M. Besselink, BSc2,3*, Hester A. de Groot-Kruseman, PhD4*, C. Michel Zwaan, MD, PhD1,4, Martin A. Horstmann, MD5*, Rob Pieters, MD, PhD4,6 and Monique L. Den Boer, PhD1,4

1Department of Pediatric Oncology/Hematology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands
2Center for Personalized Cancer Treatment, University Medical Center Utrecht, Utrecht, Netherlands
3Center for Molecular Medicine, Cancer Genomics Netherlands, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
4Dutch Childhood Oncology Group (DCOG), The Hague, Netherlands
5University Medical Center Hamburg Eppendorf, German Cooperative Study Group for Childhood Acute Lymphoblastic Leukemia (COALL), Hamburg, Germany
6Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands

7:15 AM

Ondrej Hrusak, MD, PhD1, Valerie De Haas, MD, PhD2,3, Ales Luks4*, Iveta Janotova4*, Ester Mejstrikova, MD, PhD1*, Kirsten Bleckmann, MD5*, Anja Moricke, MD5*, Julie Irving, PhD6, Benigna Konatkowska7*, Thomas B. Alexander, MD, MPH8, Hiroto Inaba, MD, PhD8, Kjeld Schmiegelow, MD, DMSc9, Simone Stokley, FRCPath,10*, Jorge Gabriel Rossi, PhD11*, Maria Sara Felice, MD, PhD12*, Luciano Dalla-Pozza, MB BS FRACP13, Jessa Morales14*, Michael Dworzak, MD15*, Barbara Buldini, MD16*, Giuseppe Basso16, Myriam Campbell17*, Maria Elena Cabrera18*, Neda Marinov18*, Sarah Elitzur, MD19*, Shai Izraeli, MD20, Drorit Luria, PhD19*, Tamar Feuerstein, PhD19*, Alexandra Kolenova, MD, PhD21, Peter Svec21*, Elena Kreminska22*, Karen R. Rabin, MD23, Sophia Polychronopoulou, MD, PhD24*, Elaine da Costa25*, Hanne Vibeke Marquart, MD, PhD26*, Antonis Kattamis, MD27, Richard Ratei28*, Dirk Reinhardt, MD, Ph.D.29, Anthony V Moorman, PhD6, Martin Schrappe, MD5 and Jan Stary, MD, D.Sc.4

12nd Faculty of Medicine, Dept. Pediatric Hem/Onc, CLIP, Charles University, Univ. Hospital Motol, Prague, Czech Republic
2Dutch Childhood Oncology Group (DCOG), The Hague, Netherlands
3Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
4Dept. Pediatric Hem/Onc, Charles University, Hospital Motol, Prague, Czech Republic
5Department of General Pediatrics, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
6Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
7Department of Pediatric Hematology, Oncology and Transplantology, University of Medical Sciences, Poznan, Poznan, Poland
8Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN
9Department of Pediatrics and Adolescent Medicine,The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital and University of Copenhagen, Copenhagen, Denmark
10Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
11Immunology and Rheumatology, Hospital Nacional de Pediatria Prof. Dr. J. P. Garrahan, Buenos Aires, Argentina
12Hematology and Oncology, Hospital Nacional de Pediatria Prof. Dr. J. P. Garrahan, Buenos Aires, Argentina
13Australian and New Zealand Children's Haematology/Oncology Group, Melbourne, Australia
14Sydney Children’s Hospital Network, NSW, Westmead, Australia
15Department of Pediatrics, Medical University of Vienna, St. Anna Children's Hospital and Children’s Cancer Research Institute, Vienna, Austria
16Department of Woman’s and Child’s Health, University of Padova, Padova, Italy
17Department of Pediatric Hematology Oncology, PINDA, Hosp Roberto del Rio / Universidad de Chile, Santiago, Chile
18Universidad de Chile, Hospital del Salvador, Santiago, Chile
19Pediatric Hematology Oncology, Schneider Children's Medical Center, Petah-Tikva, Israel
20Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel
21Commenius Univ. Children's Hospital, Bratislava, Slovakia
22Regional Oncologic Hospital, Kiev, Ukraine
23Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX
24Department of Pediatric Hematology/Oncology, Athens, Greece
25Bone Marrow Transplantation Center, National Cancer Institute (INCA), Rio de Janeiro, Brazil
26Dept. Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
27First Department of Pediatrics, University of Athens, Athens, Greece
28HELIOS Klinikum Berlin-Buch, Berlin, Germany
29Department of Pediatric Hematology and Oncology, University Children’s Hospital, Essen, Germany

7:30 AM

Wolthers Benjamin Ole, MD1*, Thomas Leth Frandsen, MD2*, Andre Baruchel, MD3, Andishe Attarbaschi, MD4*, Shlomit Barzilai, MD5*, Antonella Colombini, MD6*, Escherich Gabriele, MD7*, Hiroto Inaba, MD, PhD8, Gábor Kovács, MD9*, Der-Cherng Liang, MD10, Marion Mateos, MBBS (Hons) BSc (Med) FRACP11*, Veerle Mondelaers, MD12*, Anja Moricke, MD13*, Tomasz Ociepa, MD14*, Elizabeth Raetz, MD15, Sujith Samarasinghe, MD, PhD16*, Lewis B. Silverman, MD17, Inge M. van der Sluis, MD, PhD18, Martin Stanulla, MD19*, Lynda M. Vrooman, MD, MSc20, Michihiro Yano, MD21*, Ester Zapotocka, MD22* and Kjeld Schmiegelow, MD, DMSc23

1University Hospital Rigshospitalet, Department of Pediatrics and Adolescent Medicine, Kbh Ø, Denmark
2Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark
3Dept. of Pediatric Hematology, Hopital Saint Louis, Paris, France
4Medical University of Vienna, Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Vienna, Austria
5Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel
6University of Milano-Bicocca, Department of Pediatrics, Ospedale San Gerardo, Monza, Italy
7University Hospital Eppendorf, Clinic for pediatric hematology and oncology, Hamburg, Germany
8Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN
92nd Department of Pediatrics, Semmelweis University, Budapest, HUN
10Division of Pediatric Hematology-Oncology, Mackay Children’s Hospital and Mackay Medical College, Taipei, Taiwan
11Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia
12Ghent University Hospital, Pediatric Hemato-oncology and Stem Cell Transplantation, Gent, Belgium
13Department of General Pediatrics, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
14Pomeranian Medical University, Department of Pediatrics, Hematology and Oncology, Szczecin, Poland
15Department of Pediatrics, Huntsman Cancer Institute and Primary Children's Hospital, University of Utah, Salt Lake City, UT
16Department of Haematology, Great Ormond Street Hospital For Children, London, United Kingdom
17Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA
18Department of Pediatric Oncology/Hematology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands
19Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
20Dana-Farber Cancer Institute, Boston, MA
21Department of Pediatrics, AKITA University Hospital, Akita, Japan
22Department of Pediatric Hematology/Oncology, University Hospital Motol, Prague, Czech Republic
23Department of Pediatrics and Adolescent Medicine,The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital and University of Copenhagen, Copenhagen, Denmark

7:45 AM

Rebecca Gardner, MD1,2*, Kasey J Leger, MD, MSc2, Colleen E. Annesley, MD2, Corinne Summers, MD2,3,4, Julie Rivers, MD2*, Juliane Gust, MD2*, Katherine Tarlock, MD3, Todd M Cooper, DO5, Navin R. Pinto, MD2*, Olivia Finney, PhD2*, Hannah Smithers, MS2*, Assaf Oron, PhD2*, Daniel Li, PhD6*, Julie R Park, MD7,8* and Michael C Jensen, MD8,9*

1Department of Pediatics, University of Washington, Seattle, WA
2Seattle Children's Hospital, Seattle, WA
3Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
4Department of Pediatrics, UW, Seattle, WA
5Department of Pediatrics, Seattle Children's Hospital, Seattle, WA
6Juno Therapeutics, Seattle, WA
7Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, WA
8Department of Pediatrics, University of Washington, Seattle, WA
9Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA

8:00 AM

Lung-Ji Chang, PhD1,2, Lujia Dong, MD2,3, Yu-Chen Liu, MSc2*, Shih-Ting Tsao, MSc2*, Ya-Chen Li, PhD2*, Li Liu, MD4*, Zhiyong Gao, MD3*, Xiyou Tan, MD3*, Dao-Pei Lu, MD3,5, Jian-Ping Zhang5*, Jing-Bo Wang6*, Yu-Ming Ying, MD6*, Le-Ping Zhang, MD7*, Huyong Zheng, MD, PhD8, Kai Wang, MD, PhD8*, Xiao-Li Zheng, MD9*, Heng-Xiang Wang, MD9*, Xun Lai, MD10* and Dong Li, MD11*

1Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL
2Shenzhen Genoimmune Medical Institute (GIMI), Shenzhen, China
3BMT Center, Fu Dan University Shanghai Dao-Pei Hospital, Shanghai, China
4Department of Biomedical Informatics, Biodesign Institute, Arizona State University, Tempe, AZ
5Hebei Yanda Lu Daopei Hospital, Beijing, China
6Department of Hematology, Beijing Aerospace General Hospital, Beijing, China
7Department of Pediatric Hematology, Peking University, People’s Hospital, Beijing, China
8Department of Pediatric Hematology, Beijing Children’s Hospital, Capital Medical University, Beijing, China
9Department of Hematology, Air Force General Hospital, PLA, Beijing, China
10Department of Hematology, First People’s Hospital of Yunnan Province, Kunming, China
11Department of Hematology, Ming-Ji Hospital, Nanjing, China

8:15 AM

Koji Sasaki, MD1, Elias J. Jabbour, MD2, Susan M. O'Brien, MD3, Farhad Ravandi, MD2, Deborah A Thomas, MD2, Guillermo Garcia-Manero, MD2, Naval Daver, MD2, Gautam Borthakur, MD2, Nitin Jain, MD2, Marina Konopleva, MD, PhD2, Nicholas J. Short, MD1, Naveen Pemmaraju, MD2, Yesid Alvarado, MD2, Jovitta Jacob, RN2*, Rebecca Garris, MS2*, Philip A Thompson, MBBS2*, Jorge E. Cortes, MD2 and Hagop M. Kantarjian, MD2

1Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
2Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
3Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA

*signifies non-member of ASH