57th ASH Annual Meeting and Exposition (December 5-8, 2015): 701. Experimental Transplantation: Basic Biology, Engraftment and Disease Activity: Poster III

Experimental Transplantation: Basic Biology, Engraftment and Disease Activity Oral and Poster Abstracts
Poster

Hall A, Level 2 (Orange County Convention Center)

Preclinical Study for the Use of Abatacept to Prevent Rejection of Allogeneic CD34+ Cells in a Xenograft Model

Annie L. Oh, MD¹, Dolores Mahmud, PhD¹^*, Vitalyi Senyuk, PhD¹, Elisa Bonetti, PhD²^*, Nadim Mahmud, MD, PhD¹, Pritesh R. Patel, MB, ChB¹ and Damiano Rondelli, MD³

¹Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
²IRCCS Policlinico San Matteo Foundation, Pavia, Italy
³Section of Hematology/Oncology, Dept. of Medicine, University of Illinois at Chicago, Chicago

4272

Transient Ex Vivo Inhibition of Heme Oxygenase 1 (HO-1) in Hematopoietic Stem/Progenitor Cells (HSPCs) By Small-Molecule Inhibitors Enhances Their Migratory Responsiveness to Bone Marrow (BM)-Secreted Chemoattractants a Novel and Simple Strategy to Improve Homing of HSPCs

Mateusz Adamiak, MS¹^*, Joseph B Moore IV, PhD²^*, John Zhao, BS²^*, Ahmed Abdelbaset-Ismail, PhD¹^*, Marcin Wysoczynski, PhD³^* and Mariusz Z Ratajczak, MD, PhD¹

¹Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY
²Institute of Molecular Cardiology, University of Louisville, Louisville, KY
³Institute of Meolecular Cardiology, University of Louisville, Louisville, KY

4273

A Humanized Zebrafish Transplant Model Expressing CXCL12 Provides an Enhanced In Vivo Therapeutic Screening Platform for T-ALL

Vinothkumar Rajan, B.Tech¹^*, Nicole Melong, M.Sc²^*, Clinton JV Campbell, Ph.D, M.D³^*, Graham Dellaire, PhD⁴^* and Jason N. Berman, MD⁵

¹Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada
²Pediatrics, Dalhousie University, Halifax, NS, Canada
³Pathology, Dalhousie University, Halifax, NS, Canada
⁴Pathology and Biochemistry & Molecular Biology, Dalhousie University, Halifax, NS, Canada
⁵Pediatrics/Microbiology and Immunology, IWK Health Centre/Dalhousie University, Halifax, NS, Canada

4274

Asymmetric Allospecific Signals Shape iNKT Cell Lineage Fate Decisions

Beverly SI Strong, PhD¹, Tess J Newkold¹^*, Amanda E Lee, MD¹^*, Lucas E Turner¹^*, Jonathon W Heusel, MD, PhD²^* and Aimen F Shaaban, MD¹

¹Center for Fetal Cellular and Molecular Therapy, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
²Pathology and Immunology, Washington University, Saint Louis, MO

4275

TGFB1 Functional Polymorphisms in Sibling HSCT. "Tto be or Not Tto be"

Mariano Berro, MD¹^*, Virginia Palau²^*, Maria Marta Rivas, MD¹^*, Maria Cecilia Foncuberta, MD³, Adriana Vitriu, MD³^*, Guillermina Remaggi, MD⁴^*, Gregorio Jaimovich, MD⁵^*, Alejandro Requejo, MD⁵^*, Juliana Martinez Rolon, MD⁶^*, Irene Larripa, PhD⁷^*, Karin Padros⁸^*, Maria Beatriz Rodriguez⁸^*, Carolina Barbara Belli, PhD⁹^*, Gustavo Daniel Kusminsky, MD¹ and Leonardo J Feldman, MD¹⁰

¹Servicio de Hematologia, Hospital Universitario Austral, Pilar, Argentina
²Academia Nacional de Medicina, Buenos Aires, Argentina
³Servicio de Hematología y Trasplante Hematopoyético, Instituto Alexander Fleming, Buenos Aires, Argentina
⁴Fundaleu, Buenos Aires, Argentina
⁵Fundacion Favaloro, CABA, Argentina
⁶Fundaleu, CABA, Argentina
⁷Laboratory of Hematological Genetics, IMEX/Conicet- Academia Nacional de Medicina, CABA, Argentina
⁸PRICAI, CABA, Argentina
⁹Academia Nacional de Medicina/IMEX/Conicet, CABA, Argentina
¹⁰Bone Marrow Transplant Unit, Fundacion Favaloro, Buenos Aires, Argentina

4276

Conditioned Medium Represents a Useful Solution to Increase the Expansion of Multipotent Progenitors with Strong Platelet Engraftment Activity

Ahmad Abu-Khader, PhD¹^*, Gwendoline Bugnot, MSc¹^*, Manal Alsheikh, BSc^1,2^*, Roya Pasha, MSc¹^* and Nicolas Pineault, PhD^1,2

¹Centre for Innovation, Canadian Blood Services, Ottawa, Canada
²Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada

4277

A Novel Quantitative PCR Approach Targeting Insertion/Deletion Polymorphisms (Indel-PCR) for Chimerism Quantification: Finally High Sensitivity and Quantification Capacity Together

Almudena Navarro-Bailón, MD¹^*, Carolina Martinez-Laperche, PhD^1,2^*, Diego Carbonell¹^*, Elena Buces^1,2^*, Milagros González-Rivera²^*, Mariana Bastos^1,2^*, Pascual Balsalobre^1,2^*, Mi Kwon, MD^1,2^*, David Serrano^1,2^*, Javier Anguita, MD, PhD^1,2^*, Jorge Gayoso, MD^1,2^*, Jose Luis Diez-Martin, MD, PhD^1,2 and Ismael Buño, PhD^1,2^*

¹Hematology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
²Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

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^*signifies non-member of ASH