-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

661. Malignant Stem and Progenitor Cells: Poster II

Malignant Stem and Progenitor Cells Program: Oral and Poster Abstracts
Type: Poster
Sunday, December 6, 2015: 6:00 PM-8:00 PM
Hall A, Level 2 (Orange County Convention Center)
3060
Single-Cell Analysis Reveals Molecular Mechanisms of NRAS-Mediated Leukemia Stem Cell Self-Renewal in a Murine Model of AML

Rebecca S. Larue, PhD1*, Klara E Noble, B.S.1*, Conner Hansen, B.S.1*, Ngoc Ha, B.S.1*, David A Largaespada, Ph.D.2 and Zohar Sachs, MD, PhD1

1Hematology, Oncology, and Transplantation, Dept of Medicine, University of Minnesota, Minneapolis, MN
2Masonic Cancer Center, University of Minnesota, Minneapolis, MN
3061
Targeting F2r/Beta-Catenin/JNK Signaling for Leukemia Stem Cell Eradication

Jennifer Lynch, PhD1*, Hangyu Yi, BA2*, Brendon Martinez, BA1*, Florida Voli, MSc1* and Jenny Yingzi Wang, PhD1

1University of New South Wales, Children's Cancer Institute, Sydney, Australia
2Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia
3062
Functional Diversity of Single Stem Cell Clones in Patients' Acute Lymphoblastic Leukemia Growing in Mice: An Adverse Subclone with Distinct DNA-Methylation Pattern, Slow Growth In Vivo and Drug Resistance

Cornelia Finkenzeller, M.Sc.1*, Michela Carlet, PhD1*, Sebastian Vosberg, MSc2,3*, Philipp A. Greif, MD2,4 and Irmela Jeremias, MD1,5,6*

1Research Unit Gene Vectors, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany
2Department of Internal Medicine III, Ludwig-Maximilians-University, Munich, Germany
3German Cancer Consortium (DKTK), Heidelberg, Germany
4German Cancer Consortium (DKTK), Munich, Germany
5German Consortium for Translational Cancer Research (DKTK) and German Cancer Research Center (DKFZ), Munich, Germany
6Department of Oncology, Dr. von Haunersches Kinderspital, Ludwig Maximilians University, Munich, Germany
3063
Mir-99 Is a Regulator of Hematopoietic and Leukemic Stem Cell Differentiation

Mona Khalaj, PhD candidate1,2*, Wenhuo Hu, PhD1 and Christopher Y. Park, M.D., Ph.D.3

1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
2Cornell Graduate School of Medical Sciences (Weill), New York, NY
3Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY
3064
Protein Kinase C-ß Dependent IL-8 Release Promotes Acute Myeloid Leukemia Blast Cell Survival in Co-Cultures with Bone Marrow Stromal Cells

Amina M Abdul-Aziz, MSc.1*, Manar S Shafat, MSc1*, Matthew J Lawes, MD2*, Kristian M Bowles, MB BS, PhD1,2 and Stuart A Rushworth, PhD, BSc1*

1Norwich Medical School, University of East Anglia, Norwich, United Kingdom
2Department of Haematology, Norfolk and Norwich University Hospital, Norwich, United Kingdom
3065
FABP4 Regulates Fatty Acid Transfer from Bone Marrow Adipocytes to Acute Myeloid Leukemia Blasts

Manar S Shafat, MSc1*, Matthew E Fenech, MD, PhD2*, Amina M Abdul-Aziz, MSc.1*, Jeremy Turner, MB, DPhil2*, Kristian M Bowles, MB BS, PhD1,3 and Stuart A Rushworth, PhD, BSc1*

1Norwich Medical School, University of East Anglia, Norwich, United Kingdom
2Department of Endocrinology, Norfolk and Norwich University Hospital, Norwich, United Kingdom
3Department of Haematology, Norfolk and Norwich University Hospital, Norwich, United Kingdom
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*signifies non-member of ASH