Gabriela Pavlasova, MSc^1,2*, Vaclav Seda, MSc^1,2*, Marek Borsky, MSc.^2*, Katerina Cerna, MSc^1,2*, Jitka Osickova, PhD^1,2*, Jiri Mayer², Sarka Pospisilova^1,2*, Matthew S. Davids, MD³, Jennifer R. Brown, MD, PhD⁴ and Marek Mraz, MD, PhD^1,2*

¹Molecular Medicine, CEITEC MU, Brno, Czech Republic
²Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
³Dana-Farber Cancer Institute, Boston, MA
⁴Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA

Uri Rozovski, MD¹, David M. Harris^2*, Ping LI, PhD^2*, Zhiming Liu^2*, Alessandra Ferrajoli, MD³, Jan A Burger, MD, PhD³, Philip Thompson, MBBS^3*, Nitin Jain, MD³, William Wierda, MD, PhD⁴, Michael Keating, MBBS² and Zeev Estrov, MD²

¹Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
²The University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Daniel Noerenberg*^1*, Emma Young*^2*, Viktor Ljungström^2*, Larry Mansouri^3*, Karla Plevova^4*, Panagiotis Baliakas^3*, Stuart Blakemore^5*, Davide Rossi, MD, PhD⁶, Ruth Clifford^7*, Veronika Navrkalova, PhD^4*, Lesley-Ann Sutton^3*, Karin E Smedby, MD, PhD^8*, Gunnar Juliusson⁹, Chrysoula Belessi¹⁰, Panagiotis Panagiotidis^11*, Nicholas Chiorazzi, MD.¹², Frederic Davi^13*, Anton W. Langerak^14*, Anna Schuh, MD, PhD^7*, Gianluca Gaidano, MD, PhD⁶, Jonathan C Strefford, PhD¹⁵, Paolo Ghia¹⁶, Kostas Stamatopoulos¹⁷, Sarka Pospisilova^4*, Thorsten Zenz^18*, Richard Rosenquist**² and Frederik Damm**^1*

¹Department of Hematology, Oncology and Tumor Immunology, Charité, University Hospital, Berlin, Germany
²Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
³Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
⁴Central European Institute of Technology, Masaryk University, Brno, Czech Republic
⁵Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⁶Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
⁷Oxford National Institute for Health Research Biomedical Research Centre/Molecular Diagnostic Centre, University of Oxford, Oxford, United Kingdom
⁸Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
⁹Stem Cell Center, Hematology and Transplantation, Lund University, Lund, Sweden
¹⁰Hematology Department, Nikea General Hospital, Piraeus, Greece
¹¹First Department of Propaedeutic Medicine, School of Medicine, University of Athens, Athens, Greece
¹²The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY
¹³Laboratoire d’Hématologie, Hôpital Pitié-Salpêtrière et Université Pierre et Marie Curie, Paris, France
¹⁴Department of Immunology, Erasmus MC Rotterdam, Rotterdam, Netherlands
¹⁵Cancer Sciences Unit, University of Southampton, Southampton, United Kingdom
¹⁶Division of Molecular Oncology and Department of Oncology, Università Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milano, Italy
¹⁷Institute of Applied Biosciences, CERTH, Thessaloniki, Greece
¹⁸Department of Internal Medicine V, University Hospital Heidelberg and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany

Basile Stamatopoulos, PhD^1,2*, Adele Timbs, Msc^2*, Hélène Dreau, MSc^2*, Ruth Clifford^1,2*, Pauline Robbe, MSc^1,2*, Adam Burns, BSc^1,2*, Joanne Mason, PhD^2* and Anna Schuh, MD, PhD^3,4*

¹Nuffield Department of Laboratory Sciences, University of Oxford, Oxford, United Kingdom
²Molecular Diagnostic Center, John Radcliffe Site, Oxford University Hospitals, Oxford, United Kingdom
³Department of Oncology, University of Oxford, Oxford, United Kingdom
⁴Oxford National Institute for Health Research Biomedical Research Centre/Molecular Diagnostic Centre, University of Oxford, Oxford, United Kingdom

Yueming Chang, MD, PhD¹, Jeffrey S Wasser, MD², Adam Boruchov, MD³, Bruce J Mayer, PhD^4* and Kazuya Machida, MD, PhD^4*

¹Department of Medicine, Division of Hematology-Oncology, Carol and Ray Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT
²Department of Medicine, Division of Hematology-Oncology, University of Connecticut School of Medicine, Farmington, CT
³Saint Francis/Mount Sinai Regional Cancer Center, Hartford., St.Francis Hospital and Medical Center, Hartford, CT
⁴Genetics and Genome Sciences, Raymond and Beverly Sackler Laboratory of Genetics and Molecular Medicine, University of Connecticut School of Medicine, Farmington, CT

Maria Gounari, PhD^1*, Claudia Minici, PhD^2*, Marcus Dühren-von Minden^3*, Schneider Dunja^3*, Alkhatib Alabbas^3*, Übelhart Rudolf^4*, Andreas Agathangelidis^1*, Stavroula Ntoufa^5*, Nicholas Chiorazzi, MD.⁶, Hassan Jumaa^4*, Kostas Stamatopoulos^5*, Massimo Degano^2* and Paolo Ghia, MD, PhD^1,7,8*

¹B Cell Neoplasia unit, Division of Experimental Oncology, IRCCS Istituto Scientifico San Raffaele, Milano, Italy
²Biocrystallography Unit, Department of Immunology, Transplantation, and Infectious Diseases,, IRCCS Istituto Scientifico San Raffaele, Milano, Italy
³Centre for Biological Signaling Studies, Faculty of Biology, Albert-Ludwigs University of Freiburg, Freiburg, Germany
⁴Universiteitsklinik Ulm, Ulm, Germany
⁵Institute of Applied Biosciences, CERTH, Thessaloniki, Greece
⁶Experimental Immunology, The Feinstein Institute for Medical Research - NSLIJHS, Manhasset, NY
⁷Università Vita-Salute San Raffaele, Milano, Italy
⁸Department of Onco-Hematology, Ospedale San Raffaele, Milano, Italy

Lindsay Smith, PhD^1*, Elizabeth Hogg, BSc(Hons)^1*, Angus Haynes^1*, Jonathan C Strefford, PhD¹, Francesco Forconi, MD, DM, PhD, FRCPath^2*, Freda K Stevenson, DPhil¹, Graham Packham, PhD^1*, Mark S Cragg, PhD^3*, David Tumbarello^4*, Matthew D Blunt, PhD^1* and Andrew J Steele, PhD¹

¹Cancer Sciences Unit, University of Southampton, Southampton, United Kingdom
²Cancer Sciences Unit, Haematological Oncology Group, University of Southampton, Southampton, United Kingdom
³Cancer Sciences Unit, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, United Kingdom
⁴Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom

Stefania Gobessi, PhD¹, Binu K Sasi, PhD^1*, Luca Laurenti, MD^2* and Dimitar G Efremov, MD, PhD¹

¹Molecular Hematology, ICGEB, Rome, Italy
²Institute of Hematology, Catholic University of the Sacred Heart, Rome, Italy

Marzia Palma, MD PhD^1,2*, Giusy Gentilcore, MSc^2*, Fariba Mozaffari, PhD^2*, Kia Heimersson^2*, Barbro Näsman-Glaser^2*, Lotta Hansson, MD, PhD^1,3*, Anders Österborg, MD PhD^1,2 and Håkan Mellstedt, MD, Ph.D^4*

¹Department of Hematology, Karolinska University Hospital, Stockholm, Sweden
²Department of Oncology & Pathology, Karolinska Institutet, Stockholm, Sweden
³Department of Hematology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
⁴Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institute and Karolinska University Hospital Solna, Stockholm, Sweden

Sarah Brophy^1*, Paul Browne, MD^1,2, Elisabeth A. Vandenberghe, MB, PhD^1,2, David O'Brien, FAMLs^2* and Anthony M. McElligott, PhD^1*

¹The John Durkan Leukaemia Laboratories, Institute of Molecular Medicine, Trinity College, Dublin, Ireland
²Department of Haematology, St James's Hospital, Dublin, Ireland

Mirco di Marco, PhD student^1*, Serena Veschi^2*, Rosa Visone^2*, Giuseppe Leone³, Paola Lanuti^2*, Sara Pagotto, PhD^4*, Felice Pepe^2*, Stefania Pacillo^2*, Claudia Curcio^2*, Marco Marchisio^2*, Sebastiano Miscia^2*, Idanna Innocenti, MD^5*, Francesco Autore^6*, Barbara Vannata^6*, Mario Di Gioacchino^2*, Renato Mariani-Costantini^2*, Luca Laurenti, MD^5* and Angelo Veronese^2*

¹University of Chieti, Cheiti, Italy
²University of Chieti, Chieti, Italy
³Istituto di Ematologia, Catholic University Hospital A. Gemelli, Rome, Italy
⁴Unit of General Pathology, Aging Research Center (Ce.S.I.), G. d'Annunzio University Foundation, Chieti, Italy
⁵Institute of Hematology, Catholic University of the Sacred Heart, Rome, Italy
⁶Catholic University of the Sacred Heart, Rome, Italy, Rome, Italy

Ashima Shukla, BSc¹, Melissa Shadoin^2*, Samuel Pirruccello, M.D.^3* and Shantaram S. Joshi, PhD⁴

¹Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE
²University of Nebraska Medical Center, Omaha, NE
³College of Medicine Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
⁴Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, OMAHA, NE

Koichi Takahashi, MD¹, Candida Vitale, MD^1*, Carlos Bueso-Ramos^2*, Feng Wang, Ph.D.^3*, Ekaterina Kim, MS^1*, Jianhua Zhang^3*, Curtis Gumbs^3*, Mark Routbort, MD, PhD^2*, Zeev Estrov, MD¹, Nitin Jain, MD¹, Guillermo Garcia-Manero, MD¹, Hagop M. Kantarjian, MD¹, Jan A. Burger, MD, PhD¹, Alessandra Ferrajoli, MD¹, Michael Keating, MBBS¹, Andrew Futreal, PhD^3* and William Wierda, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Agnieszka Malecka^1*, Gunhild Trøen, PhD^2*, Anne Tierens, MD, PhD³, Ingunn Østlie^1*, Ulla Randen, MD, PhD^1*, Sigbjorn Berentsen, MD, PhD^4*, Geir Tjønnfjord, MD, PhD^5* and Jan M.A. Delabie, MD, PhD^6*

¹Department of Pathology, Oslo University Hospital, Oslo, Norway
²Pathology, Oslo University Hospital, Oslo, Norway
³Laboratory Medicine Program, University Health Network and University of Toronto, Toronto, ON, Canada
⁴Department of Medicine, Haugesund Hospital, Haugesund, Norway
⁵Department of Haematology, Oslo University Hospital, Oslo, Norway
⁶Department of Pathobiology and Laboratory Medicine, University Health Network, Toronto, ON, Canada

Ferran Nadeu^1*, Julio Delgado^1,2*, Cristina Royo^1*, Tycho Bauman^2*, Tatjana Stankovic³, Magda Pinyol^4*, Pedro Jares^4*, Alba Navarro^1*, David Martín-García^1*, Sílvia Beà^1*, Itziar Salaverria^1*, Ceri Oldreive^3*, Marta Aymerich^1,2*, Helena Suárez-Cisneros^4*, Maria Rozman^1,2*, Neus Villamor^1,2, Dolors Colomer^1,2*, Armando López-Guillermo^1,2, Marcos González, MD, PhD^5*, Miguel Alcoceba^5*, María José Terol^6*, Enrique Colado^7*, Xose S Puente^8*, Carlos López-Otín^8*, Anna Enjuanes^4* and Elías Campo^1,2,9

¹Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
²Hospital Clínic, Barcelona, Spain
³School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom
⁴Genomics Unit, IDIBAPS, Barcelona, Spain
⁵Hospital Clínico Universitario de Salamanca, Salamanca, Spain
⁶Hospital Clínico Universitario, Valencia, Spain
⁷Hospital Universitario Central de Asturias, Oviedo, Spain
⁸Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain
⁹Universitat de Barcelona, Barcelona, Spain

Kamila Brazdilova, MSc.^1,2*, Karla Plevova, PhD^1,2*, Hana Skuhrova Francova, MSc^1*, Helena Kockova, MSc^1,2*, Magdalena Chmelikova, MSc^1*, Marek Borsky, MSc.^1*, Katerina Burckova, MSc^1*, Barbara Kantorova, MSc^1,2*, Boris Tichy, PhD^2*, Hana Skabrahova^1*, Yvona Brychtova, Ph.D., MD^1*, Jiri Mayer, Prof, MD, PhD^1*, Michael Doubek, MD, PhD^1,2 and Sarka Pospisilova, Prof.^1,2*

¹Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
²Central European Institute of Technology, Masaryk University, Brno, Czech Republic

Irina Idler, PhD^1,2*, Deyan Yosifov, PhD^1,2*, Nupur Bhattacharya, PhD^3*, Michaela Reichenzeller, PhD^1*, Viola Meyer-Pannwitt^1*, Daria Ezerina^4*, Annika Scheffold, M.Sc.^1*, Sabrina Kugler, PhD^1*, Tobias Dick, PhD^4*, Hartmut Dohner, MD⁵, Stephan Stilgenbauer, MD¹ and Daniel Mertens, PhD^1,2*

¹Department of Internal Medicine III, University of Ulm, Ulm, Germany
²Mechanisms of Leukemogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany
³Department of Pathology, Stanford University, Stanford, CA
⁴Redox Regulation, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁵Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

Savita Bhalla, PhD¹ and Leo I. Gordon, MD²

¹Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Division of Hematology/Oncology, Chicago, IL
²Northwestern University Feinberg School of Medicine, Division of Hematology/Oncology, Chicago, IL

Stavroula Ntoufa^1*, Nikos Papakonstantinou^1*, Despoina Papazoglou^1*, Maria Tsagiopoulou^1*, Sarka Pospisilova^2*, Achilles Anagnostopoulos³, Richard Rosenquist^4,5, Paolo Ghia^6* and Kostas Stamatopoulos^1*

¹Institute of Applied Biosciences, CERTH, Thessaloniki, Greece
²Center of Molecular Biology and Gene Therapy, Department of Internal Medicine–Hematology and Oncology, University Hospital Brno and Medical Faculty of the Masaryk University, Brno, Czech Republic
³Department of Hematology - BMT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
⁴Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
⁵Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
⁶Division of Experimental Oncology and Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute, Milan, Italy

Uri Rozovski, MD¹, David M. Harris^1*, Ping LI, PhD^1*, Zhiming Liu^1*, Alessandra Ferrajoli, MD², Jan A Burger, MD, PhD², Philip Thompson, MBBS^2*, Nitin Jain, MD², William Wierda, MD, PhD^1*, Michael Keating, MBBS¹ and Zeev Estrov, MD³

¹The University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX

Erik Slinger, PhD^*, Felix Wensveen, PhD^*, Arnon P. Kater, MD, PhD and Eric Eldering, PhD^*

Departments of Experimental Immunology and Hematology, Lymphoma and Myeloma Center Amsterdam, Academic Medical Center, Amsterdam, Netherlands

Sara Serra, PhD^1,2*, Davide Brusa, PhD^1,2*, Tiziana Vaisitti, PhD^1,2, Roberta Buonincontri, PhD^1,2*, Valentina Audrito, PhD^1,2*, Marta Coscia, MD, PhD^3*, Davide Rossi, MD, PhD⁴, Erica B. Bhavsar^5*, Richard R. Furman, MD⁵, Gianluca Gaidano, MD, PhD⁴ and Silvia Deaglio, MD, PhD^1,2

¹Department of Medical Sciences, University of Turin, Turin, Italy
²Human Genetics Foundation, Turin, Italy
³Division of Hematology, A.O. Città della Salute e della Scienza di Torino, Turin, Italy
⁴Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
⁵Department of Hematology/Oncology, Weill Cornell Medical College, New York, NY

Andy C Rawstron¹, Karl-Anton Kreuzer^2*, Asha Soosapilla^3*, Martin Spacek^4*, Peter Gambell^5*, Neil McIver-brown^6*, Katherina Psarra^7*, Maria Arroz^8*, Raffaella Milani^9*, Javier de la Serna^10*, M. Teresa Cedena^10*, Ozren Jaksic¹¹, Josep F. Nomdedeu^12*, Carol Moreno^13*, Gian Matteo Rigolin^14*, Antonio Cuneo^14*, Preben Johansen^15*, Hans Erik Johnsen¹⁶, Richard Rosenquist¹⁷, Carsten Utoft Niemann¹⁸, Wolfgang Kern, MD¹⁹, David A Westerman²⁰, Marek Trneny²¹, Stephen P. Mulligan²², Peter Hillmen²³, David G Oscier²⁴, Michael Hallek, MD²⁵, Paolo Ghia, MD, PhD²⁶ and Emili Montserrat²⁷

¹Haematological Malignancy Diagnostic Service, St. James's n, Leeds, United Kingdom
²Department I of Internal Medicine, University of Cologne, Cologne, Germany
³Laverty Pathology, Macquarie Park, Australia
⁴University Hospital, Prague, Czech Republic
⁵Peter MacCallum Cancer Centre, Melbourne, Australia
⁶Royal Bournemouth Hospital, Bournemouth, United Kingdom
⁷Evangelismos Hospital, Athens, Greece
⁸Hospital S. Francisco Xavier, Lisbon, Portugal
⁹Immunohematology and Transfusion Medicine Unit, San Raffaele Scientific Institute, Milan, Italy
¹⁰Hospital Universitario 12 de Octubre, madrid, Spain
¹¹Dubrava University Hospital, Zagreb, Croatia
¹²Department of Hematology Lab, On behalf of CETLAM Cooperative Group, Barcelona, Spain
¹³Hematologia, Hospital De La Santa Creu I Sant Pau, Barcelona, Spain
¹⁴Hematology Section, Azienda Ospedaliero-Universitaria S. Anna, University of Ferrara, Ferrara, Italy
¹⁵Aalborg University Hospital, Aalborg, Denmark
¹⁶Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark
¹⁷Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
¹⁸Department of Hematology, Rigshospitalet, Copenhagen, Denmark
¹⁹MLL Munich Leukemia Laboratory, Munich, Germany
²⁰Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Australia
²¹First Dep. of Medicine, Charles University General Hospital, Prague, Czech Republic
²²Department of Haematology, Royal North Shore Hospital, St Leonards, Australia
²³St. James's Institute of Oncology, Leeds, United Kingdom
²⁴Department of Molecular Pathology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
²⁵Department of Internal Medicine, University of Cologne, Cologne, Germany
²⁶Università Vita-Salute San Raffaele and IRCCS Istituto Scientifico San Raffaele, Milano, Italy
²⁷Department of Hematology, Hospital Clinic, Barcelona, Spain

Christine Le Roy, PhD^1*, Dominique Ledoux, PhD^1*, Stephane Saint Georges, PhD^1*, Maud Quettier, PhD^1*, Marouane Boubaya^2*, Stephanie Le Coquil^1*, Vanessa Lauriente^1*, Lionel Guittat, PhD^1*, Vincent Levy, MD, PhD^3*, Florence Cymbalista, MD, PhD^1,4 and Nadine Varin-Blank, PhD^1*

¹INSERM U978, Université Paris 13, Sorbonne Paris Cité, Labex “Inflamex”,, Bobigny, France
²Clinical Research Center, Hopital Avicenne, AP-HP, Bobigny, France
³URC/CRC, Hopital Avicenne, AP-HP, Bobigny, France
⁴Hematology Biology, Hopital Avicenne, AP-HP, Bobigny, France

Lei Fan, MD., PhD.^*, Tingmei Shen^*, Rong Wang^*, Yi Miao^*, Yujie Wu^*, Hui Yang^*, Li Wang^*, Wei Xu^* and Jianyong Li, MD, PhD

Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

Florencia Palacios, PhD^1*, Xiao-Jie Yan, MD, PhD¹, Jaqueline C. Barrientos, MD^1,2, Jonathan E. Kolitz, MD^1,2, Steven L. Allen, MD^1,2, Kanti R. Rai, MD^1,2 and Nicholas Chiorazzi, MD.^1,2

¹The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY
²Department of Medicine, Hofstra North Shore - LIJ School of Medicine, Hempstead, NY

Christina Wu, PhD^*, Fitzgerald S Lao, BS^*, Michael Y. Choi, M.D. and Dennis A. Carson, M.D.

Moores Cancer Center, University of California, San Diego, La Jolla, CA