Samantha L. Kendrick, PhD¹, David Tannahill, PhD^2*, Shankar Balasubramanian, PhD^3* and Lisa M. Rimsza, MD¹

¹Department of Pathology, University of Arizona, Tucson, AZ
²Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom
³Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

Leo WK Cheung^1*, Karl J. Schweighofer^1*, Shiquan Wu^1*, Hsu-Ping Kuo¹, Karl Eckert^1*, Sriram Balasubramanian, PhD², Deborah Ricci^3*, Yu Liang^1*, Darrin Beaupre^4* and Betty Y. Chang¹

¹Research Department, Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA
²Janssen Research & Development, Springhouse, PA
³Janssen Research and Development, Raritan, NJ
⁴Clinical Science Department, Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA

Keisuke Kataoka, MD, Ph.D.^1*, Yasunobu Nagata, MD, Ph.D.^1*, Akira Kitanaka, MD, PhD², Jun-ichirou Yasunaga, MD, PhD³, Masako Iwanaga, M.D., Ph.D.⁴, Yuichi Shiraishi, MD, Ph.D.^5*, Kenichi Chiba, BA^5*, Aiko Sato-Otsubo, PhD^1*, Masashi Sanada, MD, Ph.D.^6*, Hiroko Tanaka, BA^5*, Hiromichi Suzuki, MD, PhD^1*, Yusuke Sato, MD, PhD^1*, Yusuke Shiozawa, MD^1*, Tetsuichi Yoshizato, MD^1*, Kenichi Yoshida, MD, Ph.D.^1*, Hideki Makishima, MD, Ph.D.¹, Kisato Nosaka, MD. PhD⁷, Masakatsu Hishizawa^8*, Hidehiro Itonaga, MD, PhD^9*, Yoshitaka Imaizumi, MD, PhD^10*, Wataru Munakata, MD^11*, Kotaro Shide, MD, PhD², Yoko Kubuki^2*, Tomonori Hidaka^2*, Takuro Kameda^2*, Tsuyoshi Nakamaki, MD¹², Ken Ishiyama, MD, Ph.D.¹³, Shuichi Miyawaki, MD¹⁴, Kensei Tobinai, MD, PhD¹⁵, Yasushi Miyazaki, MD, Ph.D.¹⁰, Akifumi Takaori-Kondo, MD, PhD⁸, Tatsuhiro Shibata^16*, Satoru Miyano, MD, Ph.D.^5*, Masao Matsuoka, MD, PhD³, Kazuya Shimoda, MD, PhD², Toshiki Watanabe, M.D., Ph.D.^17* and Seishi Ogawa, MD, Ph.D.¹

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
³Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Kyoto, Japan
⁴Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
⁵Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁶Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
⁷Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan
⁸Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁹Department of Hematology, Sasebo City General Hospital, Sasebo, Japan
¹⁰Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
¹¹Department of Hematology, National Cancer Center Hospital, Tokyo, Japan
¹²Division of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
¹³Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
¹⁴Division of Hematology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo, Japan
¹⁵National Cancer Center Hospital, Tokyo, Japan
¹⁶Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan
¹⁷Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan

Bartlomiej Getta, MBBS,^1*, Omar Abdel-Wahab¹, Jae H. Park, MD² and Martin S Tallman, MD³

¹Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
³Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

Daniela Drandi^1*, Elisa Genuardi^1*, Paola Ghione^1*, Daniele Grimaldi^1*, Barbara Mantoan^1*, Marina Ruggeri^1*, Daniela Barbero^1*, Luigia Monitillo^1*, Marika Vasta^1*, Eleonora Marzanati^1*, Giulia Verardo^1*, Paola Omedè^2*, Federica Cavallo^1*, Mario Boccadoro, MD^1,2, Marco Ladetto³ and Simone Ferrero^1*

¹Department of Molecular Biotechnologies and health sciences, Hematology Division, University of Torino, Torino, Italy
²Division of Hematology, ASO S. Giovanni Battista, Torino, Italy
³Division of Hematology, Az Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy

Olga A. Gavrilina, MD^1*, Eugene E. Zvonkov, MD, PhD^2*, Elena N. Parovichnikova, MD, PhD^2* and Valeri G. Savchenko, MD, PhD, Prof.²

¹National Research Center For Hematology, Moscow, Russia
²National Research Center for Hematology, Moscow, Russia

Sandrine Roulland, Pharm.D., Ph.D.¹, Nathalie Jouve^1*, Agnes Bru^1* and Marie-Helene Delfau-Larue, MD, PhD^2,3*

¹Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, INSERM U1104, Marseille, France
²EQ 9, INSERM U955, CRETEIL, France
³Department of Biological Hematology and immunology, APHP, Groupe Hospitalier Mondor, CRETEIL, France

Evgeny Arons, PhD¹, Sarah Davies^2*, Katherine Still^2*, Nathan Chai^2*, Katherine Potocka^2*, Hong Zhou^2* and Robert J. Kreitman, MD¹

¹Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD
²Laboratory of Molecular Biology, National Cancer Institute/National Institute of Health, Bethesda, MD

Vaishali Aggarwal^1*, Radhika Srinivasan, MD, PhD^2*, Amanjit Bal, MD^1*, Pankaj Malhotra, MD, MBBS³, Gaurav Prakash, MD, DM^4*, Subhash Varma, MBBS, MD^5* and Ashim Das, MD^1*

¹Department of Histopathology, PGIMER, Chandigarh, Chandigarh, India
²Department of Cytology and Gynaecological Pathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
³Department of Internal Medicine (Clinical Hematology Division), Postgraduate Institute of Medical Education & Research, Chandigarh, India
⁴PGIMER, Department of Internal Medicine and Hematology, Oncology, and BMT division, Chandigarh, India
⁵Department of Internal Medicine (Clinical Hematology Division), PGIMER, Chandigarh, India

Barbara Botto^1*, Alessia Castellino^1*, Annalisa Chiappella^1*, Mattia Novo^1*, Luigi Zattera^1*, Federica Cavallo^2*, Paola Ghione^2*, Andrea Evangelista^3*, Chiara Ciochetto^1*, Giovannino Ciccone^3*, Maria Stella Scalzo^4*, Roberto Chiarle⁵, Domenico Novero^4* and Umberto Vitolo¹

¹SC Ematologia, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Torino, Italy
²Hematology Division, Department of Molecular Biothecnologies and Health Sciences, Torino, Italy
³Unit of Cancer Epidemiology, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Torino, Italy
⁴Pathology Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Torino, Italy
⁵Department of Pathology, Boston Children's Hospital, Boston, MA

Jie He, PhD^1*, Shan Zhong, PhD^1*, Michelle Nahas, PhD^1*, Mark Bailey^1*, Jon Chung, PhD^1*, Geoff Otto, PhD^1*, Doron Lipson, PhD^1*, Phil Stephens, PhD^1*, Vincent A. Miller, MD^1*, Jeff Ross, MD^1,2*, Tariq I Mughal, MD^1,3 and Jo-Anne Vergilio, MD^1*

¹Foundation Medicine, Inc., Cambridge, MA
²Albany Medical College, Albany, NY
³Tufts Medical Center, Cambridge, MA

Raji Shameem, MD^1*, Muhammad Saad Hamid, MD^2*, Nasheed Mohammad Hossain, MD³, Jeffrey Mufson, MD⁴ and Patricia L. Kropf, MD⁵

¹Department of Hematology/Oncology, Fox Chase Cancer Center/Temple University Hospital, Philadelphia, PA
²Internal Medicine Department, Wayne State University/Detroit Medical Center, Detroit, MI
³Hematology/Medical Oncology, Fox Chase Cancer Center/Temple University Hospital, Philadelphia, PA
⁴Department of Medicine, Temple University Hospital, Philadelphia, PA
⁵Fox Chase Cancer Center, Philadelphia, PA

Gregory S. Calip, PharmD, MPH, PhD^1,2,3*, Wan-Ju Lee, MS^1,2*, Todd A. Lee, PharmD, PhD^1,2*, Glen T. Schumock, PharmD, MBA, PhD^1,2* and Brian C.-H. Chiu, PhD⁴

¹Center for Pharmacoepidemiology and Pharmacoeconomic Research, University of Illinois at Chicago, Chicago, IL
²Department of Pharmacy Systems, Outcomes and Policy, University of Illinois at Chicago, Chicago, IL
³Population Health, Behavior and Outcomes Program, University of Illinois Cancer Center, Chicago, IL
⁴Department of Public Health Sciences, The University of Chicago, Chicago, IL

Leyre Bento, MD^1*, Antonia María Bautista-Gili, MD^1*, Francesc García^2*, Jordi Martínez-Serra, PhD^1*, Lucía García-Mañó, MD^1*, Marta García-Recio, MD^1*, Carmen Ballester, MD^1*, Jordi Ginés, MD^1*, Paloma López, MD^1*, Jaime Daumal^1*, Rafael Ramos, MD^1*, Antonio Salar, MD, PhD^2*, Antonia Sampol, MD, PhD^1*, Juan Besalduch, MD, PhD¹ and Antonio Gutiérrez, MD, PhD^1*

¹Hospital Son Espases, Palma de Mallorca, Spain
²Hospital del Mar, Barcelona, Spain

Elizabeth A. Morgan, MD¹, M. Patrick Sweeney^2*, Tamiwe Tomoka, M.D.^3*, Nadja Kopp, M.S.^4*, Robert A Redd, MS^5*, Christopher Daniel Carey, M.D.,^6*, Leo Masamba, M.D.^7*, Steve Kamiza, M.D.^3*, Geraldine S Pinkus, MD^8*, Donna S. Neuberg, Sc.D.⁹, Scott J. Rodig, M.D., Ph.D.⁸, Danny A. Milner Jr., M.D., M.Sc.^8* and David M. Weinstock, M.D.¹⁰

¹Department of Pathology, Brigham and Women's Hospital, Boston, MA
²Tulane University School of Medicine, New Orleans, LA
³Department of Histopathology, University of Malawi College of Medicine, Blantyre, Malawi
⁴Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁵Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
⁶Department of Pathology, Brigham & Women's Hospital, Boston, MA
⁷Department of Medicine, University of Malawi College of Medicine, Blantyre, Malawi
⁸Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
⁹Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
¹⁰Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

David Simon Kliman, MBBS^1*, Louise Imlay-Gillespie, BMed^1*, Kirsten McIlroy, MBBS, FRCPA^2*, Anthony Gill, MBBS, MD, FRCPA^2*, Christopher Arthur, MBBS, FRACP, FRCPA¹, Luke Coyle, MBBS, FRACP, FRCPA¹, Keith Fay, MBChB, FRACP, FRCPA¹, Ian H. Kerridge, MBBS, MPhil, FRACP, FRCPA^1*, Naomi Mackinlay, MBBS, FRACP, FRCPA^3*, Stephen Mulligan, MBBS, PhD, FRACP, FRCPA³, William S Stevenson, MBBS, PhD, FRACP, FRCPA¹, Christopher M Ward, MBChB, PhD, FRACP, FRCPA^1,4 and Matthew Greenwood, MBBS, FRACP, FRCPA^1*

¹Department of Haematology, Royal North Shore Hospital, Sydney, Australia
²Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, Australia
³Department of Haematology, Royal North Shore Hospital, St Leonards, Australia
⁴Kolling Institute of Medical Research, University of Sydney, Sydney, Australia

Lobna Alkebsi, PhD^1*, Hiroshi Handa, MD PhD^2*, Kenichi Tahara, MD^3*, Hiroaki Shimizu, PhD^3*, Takuma Ishizaki, PhD^3*, Kunio Yanagisawa, PhD^3*, Saitoh Takayuki, MD PhD^4*, Tetsuhiro Kasamatsu, PhD^1*, Makiko Takizawa, MD PhD^3* and Hirokazu Murakami, MD PhD¹

¹Graduate School of Health Sciences, Gunma University, Maebashi, Japan
²Blood Transfusion Service, Gunma University Hospital, Maebashi, Japan
³Department of Medicine and Clinical Sciences, Graduate School of Medicine, Maebashi, Japan
⁴Oncology Center, Gunma University Hospital, Maebashi, Japan

Branimir Spassov, MD, PhD^1*, Donka Vassileva, MD, PhD^2*, Georgi Michaylov, MD, PhD^3*, Gueorgui Balatzenko, MD, PhD^4* and Margarita Guenova, MD, PhD^5*

¹Department of Clinical Hematology, National Hospital for Active Therapy of Hematological Diseases, SOFIA, Bulgaria
²Laboratory of Nuclear Medicine, National Specialized Hospital for Active Treatment of Hematological Diseases, SOFIA, Bulgaria
³Department of Clinical Hematology, National Specialized Hospital for Active Treatment of Hematological Diseases, SOFIA, Bulgaria
⁴Laboratory of Cytogenetics & Molecular Biology, National Hospital for Active Therapy of Hematological Diseases, SOFIA, Bulgaria
⁵Laboratory of Hematopathology & Immunology, National Specialized Hospital for Active Treatment of Hematological Diseases, SOFIA, Bulgaria

Thai Hong Tran, PhD^1*, Krupa Scott, MS^1*, Shyun-Shyun Lee^1*, Reshma Singh, PhD^2*, Shawn Cogan^2*, Jennifer Bordeaux, PhD^1*, Hummel Jennifer, MD^1*, Jelveh Lameh, PhD^1*, Catherine Tribouley^2*, Sadik Kassim^3*, Shabnam Tangri, PhD^1* and Naveen Dakappagari, PhD^1*

¹Genoptix Inc., a Novartis company, Carlsbad, CA
²Novartis Pharmaceuticals, East Hanover, NJ
³Novartis Institute of Biomedical Research, Cambridge, MA

Xuejun Tian, M.D./Ph.D.^1*, Ali Shahsafaei^2* and David M. Dorfman, MD, PhD³

¹Pathology, Brigham and Women's Hospital / Harvard Medical School, Boston, MA
²Brigham and Women's Hospital, Boston, MA
³Department of Pathology, Brigham and Women's Hospital, Boston, MA

Zhi-Zhang Yang, M.D¹, Tammy Price-troska^1*, Anne J Novak, PhD² and Stephen M Ansell, M.D., Ph.D.³

¹Mayo Clinic, Rochester, MN
²College of Medicine, Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN

Laurent Miguet, PhD^1,2,3*, Luc Fornecker, MD^4*, Marie Wyrwas^5*, Sarah Cianferani^6*, Raoul Herbrecht, MD⁴, Jean-Francois Leseve^5*, Veronique Latger-Cannard^5*, Caroline Mayeur-Rousse, MD^1* and Laurent Mauvieux, MD, PhD^1,2,3

¹Hopital Hautepierre, Laboratoire d'hematologie, Strasbourg, France
²Université de Strasbourg, EA3430, Strasbourg, France
³FMTS, Strasbourg, France
⁴Oncology and Hematology, Hopital de Hautepierre, Strasbourg, France
⁵Nancy University Hospital, Nancy, France
⁶Laboratoire de spectrometrie de masse bioorganique (LSMBO) CNRS UMR 7178 institut pluridisciplinaire Hubert Curien Strasbourg, strasbourg, France

Matthew A Care, PhD^1,2*, Stephen M Thirdborough, PhD^3,4*, Andrew J Davies, MRCP PhD^5*, Peter W.M. Johnson, FRCP^4*, Andrew Jack, PhD, MB⁶, Sharon Barrans, PhD^7*, David R Westhead, PhD^8*, Mark S Cragg, PhD^3,4*, Reuben M Tooze, PhD, FRCP^1,2 and Stephen A Beers, PhD^3,4*

¹Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
²Cancer Research UK Centre, Leeds, United Kingdom
³Cancer Sciences Unit, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, United Kingdom
⁴Cancer Research UK Centre, Southampton, United Kingdom
⁵Cancer Research UK Centre, University of Southampton, Southampton, United Kingdom
⁶HMDS, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
⁷St James Institute of Oncology, HMDS, Leeds, United Kingdom
⁸Bioinformatics Group, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom

Ting Lu, MD.^1*, Peng Li, MD., Ph.D^1*, Chengfeng Bi, MD., Ph.D.^2*, Shuang Yu, MD.^1*, Daoxin Ma, MD., Ph.D^1*, Kai Fu, MD, PhD² and Chunyan Ji, MD, PhD^1*

¹Department of Hematology, Qilu Hospital, Shandong University, Jinan, China
²Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE

Zachary Hunter, PhD^1*, Yang Cao, MD^2*, Guang Yang, PhD¹, Xia Liu, MD^1*, Jie Chen, PhD^1*, Lian Xu^1*, Nicholas Tsakmaklis^1*, Jiaji Chen^1*, Christopher J Patterson, MFA^1*, Jorge J Castillo, MD³ and Steven P Treon, MD, PhD¹

¹Bing Center for WM, Dana Farber Cancer Institute, Boston, MA
²Dept of Physiology & Biophysics, University of California, Irvine, Irvine, CA
³Division of Hematologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

David Foureau, Ph.D.^1*, Lawrence J Druhan, PhD², Nury M Steuerwald, PhD^3*, Sarah A Baxter, PhD^2*, Omotayo O. Fasan, MBBS, MRCP^4*, Belinda R Avalos, MD² and Nilanjan Ghosh, MD, PhD⁵

¹Immnune Monitoring Core Laboratory Cannon Research Center/Carolinas Healthcare System, Charlotte, NC
²Department of Hematologic Oncology and Blood Disorders, The Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC
³Molecular Biology Core Facility, Carolinas HealthCare System, Charlotte, NC
⁴1240 Lost Oak Rd, Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, CHARLOTTE, NC
⁵Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC

Greg Hapgood, MD¹, Anja Mottok, MD², Graham W Slack, MD^3*, Randy D. Gascoyne³, Christian Steidl, MD², Kerry J. Savage, MD MSc^1,2 and Andrew P. Weng, MD, PhD³

¹British Columbia Cancer Agency, Centre for Lymphoid Cancer and Department of Medical Oncology, Vancouver, BC, Canada
²Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada
³British Columbia Cancer Agency, Centre for Lymphoid Cancer, Department of Pathology and Laboratory Medicine, Vancouver, BC, Canada

Connie Batlevi, MD, PhD¹, Franck Rapaport, PhD^2*, Andrew M. Intlekofer, MD, PhD¹, Anne Reiner, MPH^3*, Craig H Moskowitz, MD⁴, Steven M Horwitz, MD¹, Andrew D Zelenetz, MD, PhD¹, Lia Palomba, MD⁵, Alison J Moskowitz, MD¹, John F. Gerecitano, MD⁶, Paul A Hamlin Jr., MD¹, Amanda R. Copeland, RN, MSN, CNS^1*, Matthew J Matasar, MD, MS^1*, Craig S. Sauter, MD⁷, Anita Kumar, MD¹, Ariela Noy, MD¹, David J. Straus, MD¹, Carol S. Portlock, MD¹, Frederick Criscuolo, Phd^8*, Jie He, PhD^9*, Daniel Royston, MD^10*, Sohail Balasubramanian, MS^9*, Yekaterina Reznikovskaya, BA^1*, Janine D. Pichardo, BS^11*, Phil Stephens, PhD^9*, Vincent Miller, MD^12*, Ross L. Levine, MD⁶, Venkatraman Seshan, PhD^13*, Ahmet Dogan, MD, PhD¹¹ and Anas Younes, MD¹

¹Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Bioinformatics, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Medicine, Lymphoma and Adult BMT Services, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Memorial Sloan Kettering Cancer Center, New York, NY
⁷Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Bioinformatics, Memorial Sloan Kettering Cancer Center, New York, NY
⁹Foundation Medicine, Inc., Cambridge, MA
¹⁰Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
¹¹Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
¹²Foundation Medicine, Cambridge, MA
¹³Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY

Ruth Mary de Tute, PhD, FRCPath^1*, Sharon Barrans, PhD^2*, Andy C. Rawstron, PhD², Christopher T Manbridge^3*, Josh Caddy^4*, Keith Pugh, PhD^5*, Peter W.M. Johnson, FRCP⁶, Andrew J Davies, MRCP^7* and Andrew Jack, PhD, MB⁸

¹St. James's Institute of Oncology, HMDS, Leeds, United Kingdom
²St James Institute of Oncology, HMDS, Leeds, United Kingdom
³University of Southampton, Cancer Research UK Clinical Centre, Southampton, United Kingdom
⁴University of Southampton, SCTU, Southampton, United Kingdom
⁵Southampton Clinical Trials Unit, University of Southampton, Southampton, United Kingdom
⁶Cancer Research UK Centre, University of Southampton, Southampton, United Kingdom
⁷Southampton University, SCTU, Southampton, United Kingdom
⁸HMDS, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

Tami Katz, Ph.D^1,2*, Shoham Shivtiel-Arad, Ph.D^1*, Hitam Saadi^2*, Noam Bettman, PhD^1*, Lina Bisharat, MSc^1*, Irit Avivi, MD^3* and Netanel A Horowitz, MD^1,2*

¹Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel
²Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
³Department of Hematology and Bone Marrow Transplantation, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Renato Zambello^1,2*, Barbara Mariotti, PhD^3*, Antonella Teramo, PhD^1*, Marzia Rossato, PhD^3*, Gregorio Barilà, MD^4*, Giulia Calabretto, BS^5*, Chiara Ercolin, BS^1*, Tamara Berno, MD^1*, Livio Trentin, MD¹, Monica Facco, MS^2*, Gianpietro Semenzato^6* and Flavia Bazzoni, PhD^3*

¹Department of Medicine, Hematology and Clinical Immunology Section, Padua University School of Medicine, Padua, Italy
²Venetian Institute of Molecular Medicine (VIMM), Padua, Italy
³Department of Pathology and Diagnostic, section of General Pathology, Verona University School of Medicine, Verona, Italy
⁴Department of Medicine Hematology and Clinical Immunology, Padova University School of Medicine, Padova, Italy
⁵Venetian Institute of Molecular Medicine (VIMM), Padova University School of Medicine, Padova, Italy
⁶Department of Medicine, Hematology and Clinical Immunology, Padua School of Medicine, Padova, Italy

Afshin Beheshti, PhD^1*, Donna S Neuberg, ScD², J. Tyson McDonald, PhD^3* and Andrew M. Evens, DO, MSc⁴

¹Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA
²Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
³Cancer Research Center, Hampton University, Hampton, VA
⁴Tufts Medical Center Cancer Center, Boston, MA

Tibor Bedekovics, PhD^1*, Sajjad Hussain, PhD^1*, Andrew L Feldman, MD² and Paul J. Galardy, MD¹

¹Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN
²Mayo Clinic, Rochester, MN

Alexander JA Deutsch, PhD^1*, Beate Rinner, PhD^2*, Kerstin Wenzl, MSc^1*, Katharina Troppan, MD^1*, Beata Pursche^1*, Hildegard T. Greinix, MD¹, Christine Beham-Schmid, MD^3* and Peter Neumeister, MD^4*

¹Internal Medicine / Hematology, Medical University Graz, Graz, Austria
²Hematology, Medical University Graz, Graz, Austria
³Institute of Pathology / Hematopathology, Medical University Graz, Graz, Austria
⁴Internal Medicine / Hematology, Medical Universitiy of Graz, Graz, Austria

Clémentine Sarkozy, MD¹, Sarah Huet, PharmD, PhD^2*, Victoria Carlton^3*, Alain Delmer, MD, PhD⁴, Fabrice Jardin^5*, Marie-Helene Delfau-Larue, MD, PhD^6*, Malek Faham^7* and Gilles Salles, MD, PhD⁸

¹Hematology, Hospices Civils de Lyon, Pierre Bénite, France
²Laboratoire d’hématologie, Hospices Civils De Lyon, Pierre Bénite, France
³Adaptive Biotechnologies Corp., South San Francisco, CA
⁴Hematology, CHU de reims, Reims, France
⁵Centre Henri Becquerel, Rouen, France
⁶Department of Biological Hematology and immunology, APHP, Groupe Hospitalier Mondor, CRETEIL, France
⁷Adaptive Biotech, san francisco, CA
⁸Hematology, Centre Hospitalier Lyon-Sud, Pierre-Benite, France

Lalita Norasetthada, MD¹, Weerasak Nawarawong, MD², Arnuparp Lekhakula, MD, MS^3*, Jakrawadee Julamanee, MD^3*, Chittima Sirijerachai, MD^4*, Kanchana Chansung, MD^4*, Kitsada Wudhikarn, MD^5*, Udomsak Bunworasate⁶, Noppadol Siritanaratanakul, MD⁷, Archrob Khuhapinant, MD, PhD⁷, Tontanai Numbenjapon, MD^8*, Kannadit Prayongratana, MD^9*, Tawatchai Suwanban, MD^10*, Suporn Chuncharunee, MD¹¹, Pimjai Niparuck, MD^11*, Somchai Wongkhantee, MD^12*, Peerapon Wong, MD^13*, Nisa Makruasi, MD^14*, Nonglak Kanitsap, MD^15* and Tanin Intragumtornchai, MD, MSc⁵

¹Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand
²Department of Medicine, Chiang Mai University, Chiang Mai, Thailand
³Department of Internal Medicine, Prince of Songkla University, Songkla, Thailand
⁴Department of Medicine, Khon Kaen University, Khon Kaen, Thailand
⁵Department of Internal Medicine, Chulalongkorn University, Bangkok, Thailand
⁶King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand
⁷Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
⁸Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand
⁹Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand
¹⁰Department of Medicine, Rajavithi Hospital, Bangkok, Thailand
¹¹Department of Internal Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
¹²Department of Medicine, Khonkaen Regional Hospital, Khon Kaen, Thailand
¹³Department of Medicine, Naresuan University, Phitsanulok, Thailand
¹⁴Department of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand
¹⁵Department of Medicine, Thammasat University, Bangkok, Thailand

Madeleine Duvic, MD¹, Steven M Horwitz, MD², Youn H Kim, MD³, Pier Luigi Zinzani⁴, Gajanan Bhat, PhD^5*, Pankaj Sharma^6* and Sue Yancik^7*

¹Dept. of Dermatology, M.D. Anderson Cancer Center, Houston, TX
²Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY
³Stanford University, Palo Alto, CA
⁴Institute of Hematology and Oncology, University of Bologna, Bologna, Italy
⁵SPECTRUM PHARMACEUTICALS, INC., Irvine, CA
⁶spectrum pharmaceuticals, Irvine, CA
⁷spectrum pharmaceuticals, irvine

Xiaoyu Qu, PhD^1*, Hongli Li, PhD^2*, Oliver W Press, MD, PhD³, Lisa M. Rimsza, M.D.⁴, Rita M. Braziel, MD⁵, Michael Leblanc, PhD^2*, Eric D. Hsi, MD⁶, Sonali M. Smith, MD⁷, Jonathan W. Friedberg, MD, MMSc⁸ and Min Fang, MD, PhD^1*

¹Fred Hutchinson Cancer Research Center, Seattle, WA
²SWOG Statistical Center, Seattle, WA
³Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁴University of Arizona, Tucson, AZ
⁵Oregon Health & Science University, Portland, OR
⁶Cleveland Clinic, Cleveland, OH
⁷University of Chicago, Chicago, IL
⁸University of Rochester, Rochester, NY

Grzegorz Rymkiewicz, MD, PhD^1*, Magdalena Chechlinska^2*, Beata Grygalewicz^3*, Barbara Pienkowska-Grela^3*, Katarzyna Blachnio^1*, Zbigniew Bystydzienski^1*, Joanna Romejko-Jarosinska, MD, PhD^4*, Beata Sledz-Gawronska^1*, Michalina Zajdel^2*, Katarzyna Domanska-Czyz^5*, Renata Woroniecka^3*, Kinga Sikorska-Mali^1*, Jan Konrad Siwicki^2*, Monika Prochorec-Sobieszek, MD, PhD^6,7* and Jan Walewski, MD, PhD Prof⁵

¹Flow Cytometry Laboratory, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, Warsaw, Poland
²Department of Immunology, The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, Warsaw, Poland
³Cytogenetic Laboratory, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, Warsaw, Poland
⁴Department of Lymphoid Malignancy, The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, Warsaw, Poland
⁵Department of Lymphoid Malignancies, The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, Warsaw, Poland
⁶Histopathology Laboratory, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, Warsaw, Poland
⁷Dept. of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland

Katsuhiro Miura, MD^1*, Jun Konishi^2*, Takaaki Miyake^3*, Makita Masanori^4*, Atsuko Hojo^5*, Yasufumi Masaki⁶, Masatoshi Uno^7*, Jun Ozaki^8*, Chikamasa Yoshida^9*, Daigo Niiya^10*, Koichi Kitazume^11*, Yoshinobu Maeda, MD, PhD¹², Jun Takizawa, MD^13*, Rika Sakai¹⁴, Yuichiro Nawa^15*, Tomofumi Yano^10*, Kazuhiko Yamamoto^4*, Kazutaka Sunami², Yasushi Hiramatsu^16*, Kazutoshi Aoyama^17*, Hideki Tsujimura¹⁸, Yoshihiro Hatta¹ and Masatoshi Kanno^19*

¹Department of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
²Department of Hematology, National Hospital Organization Okayama Medical Center, Okayama, Japan
³Department of Oncology/Hematology, Shimane University Hospital, Izumo, Japan
⁴Department of Hematology, Okayama City Hospital, Okayama, Japan
⁵Division of hematology and Oncology, Kasukabe Municipal Hospital, Saitama, Japan
⁶Department of Hematology and Immunology, Kanazawa Medical University, Uchinada, Japan
⁷Division of Internal Medicine, Kaneda Hospital, Okayama, Japan
⁸Department of Hematology, Toyama Prefectural Central Hospital, Toyama, Japan
⁹Department of Hematology, National Hospital Organization Minami-Okayama Medical Center, Okayama, Japan
¹⁰Department of Hematology, Okayama Rosai Hospital, Okayama, Japan
¹¹Department of Hematology, Showa General Hospital, Tokyo, Japan
¹²Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
¹³Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Niigata, Japan
¹⁴Department of Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan
¹⁵Division of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan
¹⁶Department of Haematology and Oncology, Himeji Red Cross Hospital, Himeji, Japan
¹⁷Department of Hematology, Chugoku Central Hospital, Hiroshima, Japan
¹⁸Department of Hematology-Oncology, Chiba Cancer Center, Chiba, Japan
¹⁹Oncology Center, Nara Medical University Hospital, Kashihara, Japan

Michael T Zimmermann^1*, Surendra Dasari^1*, Rebecca L Boddicker¹, Yu Zeng^1*, Bruce Eckloff^1*, Julie M Cunningham^1*, Yanhong Wu^1*, Julie C Porcher^1*, Brian K Link, MD², Stephen Ansell¹, James R Cerhan, MD PhD¹, Jean-Pierre Kocher^1* and Andrew L Feldman, MD¹

¹Mayo Clinic, Rochester, MN
²Division of Hematology, Oncology and Blood & Marrow Transplantation, University of Iowa Hospitals and Clinics, Iowa City, IA

Cassandra Garner, BS¹, Martha Glenn, MD², Rosalie G Waller, BS³, Venkatesh Rajamanickam, MS^4*, Todd Darlington, PhD^5*, Rob Sargent, MS^4* and Nicola J Camp, PhD^2*

¹Department of Human Genetics, University of Utah, Salt Lake City, UT
²Division of Hematology and Hematologic Malignancies, University of Utah School of Medicine, Salt Lake City, UT
³Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT
⁴Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁵Psychiatry, University of Utah, Salt Lake City

Umar Farooq, MD¹, Matthew J Maurer, MS², Stephen M Ansell, M.D., Ph.D.³, Tasha Lin, MD³, Grzegorz S. Nowakowski, MD³, Luis Porrata, MD³, David J. Inwards, MD³, William Macon, MD^4*, Syrbu Sergei, MD^5*, James Cerhan, MD, PhD², Thomas E. Witzig, MD³, Brian K Link, MD¹, Thomas M. Habermann, MD³ and Carrie A. Thompson, MD³

¹Division of Hematology, Oncology and Blood & Marrow Transplantation, University of Iowa Hospitals and Clinics, Iowa City, IA
²Department of Health Sciences Research, Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁵Department of Laboratory Medicine and Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA

Kelly A. Petrowski, MPH^1*, Harsha Poola, MD^2,3*, Katherine Lee Chuy, MD^2*, Shweta Gupta, MD^2,3 and Paul G. Rubinstein, MD^1,2,3

¹The Ruth M. Rothstein CORE Center, Chicago, IL
²Department of Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL
³Section of Hematology/Oncology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL

Lorenz Thurner, MD^1*, Sylvia Hartmann^2*, Klaus-Dieter Preuss, PhD^3*, Natalie Fadle^1*, Maria Kemele^1*, Evi Regitz^1*, Christiane Pott, MD, PhD^4*, Rainer-Maria Bohle^5*, Martin-Leo Hansmann^2* and Michael Pfreundschuh, MD¹

¹José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Saarland University Medical School, Homburg/Saar, Germany
²Dr. Senckenberg Institute of Pathology, Goethe University Hospital of Frankfurt Main, Frankfurt am Main, Germany
³José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Saarland University Medical School, Homburg, Germany
⁴University Hospital Schleswig-Holstein, Kiel, Germany
⁵Institute of Pathology, Saarland University Medical School, Homburg/Saar, Germany

Stefano Luminari, MD, PhD^1*, Maria Cecilia Goldaniga, MD^2*, Marina Cesaretti^1*, Sara Rattotti^3*, Marco Frigeni^4*, Alessandra Tedeschi^5*, Paola Picardi, MD^5*, Simone Ferrero, MD^6*, Federica Cavallo^6*, Giuseppina Cabras^7*, Michele Merli, MD^8*, Emanuele Cencini^9*, Donato Mannina^10*, Gianluca Gaidano^11*, Angela Ferrari^12*, Giuseppina Ricciuti^13*, Rosanna Ciancia, MD¹⁴, Francesca Re, MD^15*, Marcia Torresan Delamain^16*, Inês B Pereira^17*, Athina Lymboussaki, PhD^1*, Vittoria Tarantino, MD^1*, Massimo Federico, MD, PhD¹ and Luca Arcaini^3*

¹Department of Diagnostic, Clinical, and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy
²UO Ematologia e Centro Trapianti di Midollo, IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milano, Italy
³Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁴Unit of Hematology, Dept. of Molecular Medicine, University of Pavia & Dept. Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁵Division of Hematology, Niguarda Ca' Granda Hospital, Milan, Italy
⁶Division of Hematology, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Torino, Italy
⁷Division of Hematology, Ospedale Businco, Cagliari, Italy
⁸Division of Hematology, Ospedale di Circolo and Fondazione Macchi, Varese, Italy
⁹Hematology Unit, Ospedale Santa Maria alle Scotte and University of Siena, Siena, Italy
¹⁰Division of Hematology, Azienda Ospedaliera Papardo, Messina, Messina, Italy
¹¹Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
¹²Hematology Unit, Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy
¹³Department of Hematology, Lymphoma Unit, Spirito Santo Hospital, Pescara, Italy
¹⁴Division of Medical Oncology, National Cancer Institute, Aviano, Italy
¹⁵Division of Hematology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
¹⁶Center of Hematology and Hemotherapy, Department of Internal Medicine, Faculty of Medicine, State University of Campinas, Campinas-SP, Brazil
¹⁷Portuguese Institute of Oncology, Lisbon, Portugal

Kenichi Yoshida, MD, Ph.D.^1*, Rie Nakamoto-Matsubara, MD, PhD^2*, Kenichi Chiba, BA^3*, Yusuke Okuno, MD, Ph.D.^4*, Nobuyuki Kakiuchi, MD^1*, Yuichi Shiraishi, MD, Ph.D.^3*, Yusuke Sato, MD, PhD^1*, Hiromichi Suzuki, MD, PhD^1*, Tetsuichi Yoshizato, MD^1*, Yusuke Shiozawa, MD^1*, Keisuke Kataoka, MD, Ph.D.^1*, Hiroo Ueno, MD^1*, June Takeda, MD^1*, Yasunobu Nagata, MD, Ph.D.^1*, Hiroko Tanaka, BA^3*, Yasuo Iwadate, MD, PhD^5*, Hiroaki Hondoh, MD, PhD^6*, Junya Fukai, MD, PhD^7*, Koji Kajiwara, MD, PhD^8*, Makoto Ideguchi, MD, PhD^8*, Yoshihiro Komohara, MD, PhD^9*, Yukihiko Fujii, MD, PhD^10*, Syunichi Kohriyama, MD, PhD^11*, Masayuki Nitta, MD, PhD^11*, Yoshiharu Muragaki, MD, PhD^11*, Mamiko Sakata-Yanagimoto, MD, Ph.D.^2*, Shingo Suzuki, PhD^12*, Takashi Shiina, PhD^12*, Satoru Miyano, MD, Ph.D.^3*, Shigeru Chiba, MD, PhD², Yamanaka Ryuya, MD, PhD^13* and Seishi Ogawa, MD, Ph.D.¹

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Department of Clinical and Experimental Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
³Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁴Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁵Department of Neurosurgery, Graduate School of Medical Sciences, Chiba University, Chiba, Japan
⁶Department of Neurosurgery, Toyama Prefectural Central Hospital, Toyama, Japan
⁷Department of Neurological Surgery, Wakayama Medical University School of Medicine, Wakayama, Japan
⁸Department of Neurosurgery, Graduate School of Medical Sciences, Yamaguchi University, Yamaguchi, Japan
⁹Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
¹⁰Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan
¹¹Department of Neurosurgery, Faculty of Advanced Techno-Surgery(FATS), Institute of Advanced Biomedical Engineering & Science, Tokyo Women's Medical University, Tokyo, Japan
¹²Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara, Japan
¹³Laboratory of Molecular Target Therapy for Cancer, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Dominic Rose, PhD^*, Tamara Alpermann^*, Claudia Haferlach, MD, Torsten Haferlach and Wolfgang Kern, MD

MLL Munich Leukemia Laboratory, Munich, Germany