57th ASH Annual Meeting and Exposition (December 5-8, 2015): 711. Cell Collection and Processing I

Cell Collection and Processing Oral and Poster Abstracts
Oral

Tangerine 2 (WF2), Level 2 (Orange County Convention Center)

Moderators:

Lawrence S. Lamb Jr., PhD, University of Alabama at Birmingham and Carolyn A. Keever-Taylor, PhD, Medical College of Wisconsin

Disclosures:

No relevant conflicts of interest to declare.

4:30 PM

379

Distinct Patterns of Early Hematopoietic Reconstitution in Patients Receiving Notch Expanded Non HLA-Matched Off-the-Shelf Cord Blood Derived Hematopoietic Stem and Progenitor Cells

Jianqiang Li, PhD, MSc^*, Allen Jiang^*, Filippo Milano, MD, PhD, Suzan Imren, MD^*, David Charles Keahi Oliver, BS^*, Joseph Blake^* and Colleen Delaney, MD, MSc

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA

4:45 PM

380

Selective Depletion of Alloreactive Donor T Cells with Adenosine: An Efficient, Scaleable, GMP-Compliant, Low-Cost Method to Prevent Gvhd While Preserving Antiviral and Antileukemic Activity in Haploidentical Stem Cell Transplant

Greg Whitehill, BS¹^*, Shoba Amarnath, BSc, MSc, PhD²^*, Keyvan Keyvanfar, BS¹^*, Pawel Muranski, MD¹, Minoo Battiwalla, MD, MS¹, Austin John Barrett, MD, FRCP, FRCPath¹ and Dhana Chinnasamy, PhD¹^*

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²National Cancer Institute, National Institutes of Health, Bethesda, MD

5:00 PM

381

Inhibition of Both Activated p38 MAPK and mTOR C1 Potentiates the Effect of SR1 on Promotion of Hematopoietic Stem Cell Expansion Ex Vivo

Xiaoyi Li, PhD & MD¹^*, Xiao Ma, MS²^*, Yi Luo, MD, PhD³, Peng Danyue, PhD & MD²^*, Daohong Zhou, MD⁴ and Lingbo Liu, PhD, MD²^*

¹Institute of Hematology, Union Hospital & Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Institute of Hematology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
³Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR
⁴Division of Radiation Health, Department of Pharmaceutical Sciences and Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock

5:15 PM

382

Safety and Functional Studies of Ex Vivo Generated Megakaryocytic Progenitors/Platelets in a Myeloablative Non-Human Primate Model

Xin Guan, B.S.¹^*, Meng Qin, PhD¹^*, Yu Zhang, B.S.¹^*, Zhihua Ren, MD, PhD^1,2^*, Wenhong Jiang, BS²^*, Yupo Ma, MD, PhD³, Wei Dai, PhD⁴^* and Yongping Jiang, PhD¹

¹Biopharmaceutical R&D Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
²Biopharmagen corp, Suzhou, China
³Department of Pathology, Stony Brook University, Stony Brook, NY
⁴Environmental Medicine, NYU Langone Medical Center, Tuxedo, NY

5:30 PM

383

Myeloid Cells in Peripheral Blood Mononuclear Cell (PMBC) Concentrates Inhibit the Expansion of Chimeric Antigen Receptor (CAR) T Cells

David F. Stroncek, MD¹, Daniel W. Lee III, MD², Jiaqiang Ren, MD, PhD¹^*, Marianna Sabatino, MD¹^*, Hanh Khuu, MD¹^*, Melinda S. Merchant, MD³^* and Crystal L. Mackall, MD⁴

¹Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD
²Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
³Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD
⁴Pediatric Oncology Branch, National Cancer Institute/National Institutes of Health, Bethesda, MD

5:45 PM

384

Proteomic Analysis of Reprograming of Mesenchymal Stem/Stromal Cells (MSC) Following Interferon Gamma Identifies Pathways That Are Upregulated in Suppression

Qingdong Guan, MD, PhD^1,2, Tanner Shpiruk, MSc²^*, Peyman Ezzati, PhD²^*, Oleg Krokhin, PhD²^*, Scott Gilpin²^*, James Doerksen²^*, Victor Spicer²^*, Swaroop Bhagwat, MSc²^*, John Wilkins, PhD²^* and Donna A. Wall, MD^1,2

¹Cellular Therapy Laboratory, CancerCare Manitoba, Winnipeg, MB, Canada
²College of Medicine, University of Manitoba, Winnipeg, MB, Canada

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^*signifies non-member of ASH

711.O2.6 711. Cell Collection and Processing I