57th ASH Annual Meeting and Exposition (December 5-8, 2015): 703. Adoptive Immunotherapy: Clinical Studies

Adoptive Immunotherapy Oral and Poster Abstracts
Oral

W314, Level 3 (Orange County Convention Center)

Moderators:

Jacalyn Rosenblatt, MD, Beth Israel Deaconess Medical Center, Harvard Medical School and Jae H Park, MD, Memorial Sloan Kettering Cancer Center

Disclosures:

Park: Juno Therapeutics: Other: Advisory Board , Research Funding ; Genentech: Research Funding ; Amgen: Consultancy .

12:00 PM

Adoptive Transfer of WT1-Specific TCR Gene-Transduced Lymphocytes in Patients with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Isao Tawara, MD, PhD¹^*, Masahiro Masuya, MD, PhD², Shinichi Kageyama, MD, PhD³^*, Tetsuya Nishida, MD, PhD⁴^*, Seitaro Terakura, MD, PhD⁴^*, Makoto Murata, MD, PhD⁴, Hiroshi Fujiwara, MD, PhD⁵, Yoshiki Akatsuka, MD, PhD⁶, Hiroaki Ikeda, MD, PhD³^*, Yoshihiro Miyahara, MD, PhD³^*, Daisuke Tomura, PhD⁷^*, Ikuei Nukaya, PhD⁷^*, Kazutoh Takesako, PhD⁷^*, Nobuhiko Emi, MD, PhD⁸, Masaki Yasukawa, MD, PhD⁵, Naoyuki Katayama, MD, PhD² and Hiroshi Shiku, MD, PhD³^*

¹Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Japan
²Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
³Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Japan
⁴Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁵Department of Hematology, Clinical Immunology and Infectious disease, Ehime University Graduate School of Medicine, Toon, Japan
⁶Division of Hematology, Fujita Health University, Toyoaka, Japan
⁷Takara Bio Inc., Otsu, Japan
⁸Division of Hematology, Fujita Health University, Toyoake, Japan

12:15 PM

Wilms´Tumor 1 Protein Is Highly Expressed on Malignant Plasma Cells and Provides a Novel Target for Immunotherapeutic Approaches

Guenther Koehne, MD PhD¹, Satyajit Kosuri, MD¹, Ekaterina Doubrovina, MD, PhD²^*, Tao Dao, PhD³^*, Andrew Scott³^*, Achim A Jungbluth, MD⁴^* and Richard J O'Reilly, MD²^*

¹Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
³Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, New York, NY
⁴Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY

12:30 PM

Allogeneic T-Cells Expressing an Anti-CD19 Chimeric Antigen Receptor Cause Remissions of B-Cell Malignancies after Allogeneic Hematopoietic Stem Cell Transplantation without Causing Graft-Versus-Host Disease

Jennifer N Brudno, MD¹, Robert Somerville²^*, Victoria Shi³^*, Jeremy J. Rose, BA⁴^*, David C. Halverson, MD⁴^*, Daniel H. Fowler, MD⁴^*, Dennis D. Hickstein, MD³, Juan C. Gea-Banacloche, MD⁴^*, Steven Z. Pavletic, MD, MS³, Andre Goy, MD⁵, Tangying L Lu²^*, Steven Feldman²^*, Alex Iwamoto²^*, Roger Kurlander⁶, Irina Maric⁷, Brenna Hansen³^*, Jennifer S. Wilder, RN⁸^*, Bazetta Blacklock-Shuver³^*, Frances T. Hakim³^*, Steven A. Rosenberg, MD, PhD⁹^*, Ronald E. Gress, MD⁴ and James N. Kochenderfer, MD¹⁰

¹Center for Cancer Research, National Cancer Institute, Bethesda, MD
²Surgery Branch, NIH, NCI, Bethesda, MD
³ETIB, NIH, NCI, Bethesda, MD
⁴Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
⁵John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ
⁶Dept. of Laboratory Medicine, NIH, Clinical Center, Bethesda, MD
⁷Department of Laboratory Medicine, NIH Clinical Center, Bethesda, MD
⁸Frederick National Laboratory for Cancer Research, Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick, MD
⁹Surgery Branch, NCI, NIH, Bethesda, MD
¹⁰Experimental Transplantation and Immunology Branch, National Cancer Institute/National Institutes of Health, Bethesda, MD

12:45 PM

100

CD4 CAR T Cells Mediate CD8-like Cytotoxic Anti-Leukemic Effects Resulting in Leukemic Clearance and Are Less Susceptible to Attenuation By Endogenous TCR Activation Than CD8 CAR T Cells

Yinmeng Yang, BS^1,2^*, Tasha Lin, MD¹^*, Elad Jacoby, MD¹, Haiying Qin, MS¹^*, Elizabeth Grier Gardner, MD¹^*, Christopher Daniel Chien, PhD¹, Daniel W. Lee III, MD¹ and Terry J. Fry, M.D.¹

¹Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
²Tumor Biology Department, Georgetown University, Washington, DC

1:00 PM

101

Human Cytokine-Induced Memory-like NK Cells Exhibit in Vivo Anti-Leukemia Activity in Xenografted NSG Mice and in Patients with Acute Myeloid Leukemia (AML)

Rizwan Romee, MD¹, Rosario Maximillian, MD, PhD²^*, Melissa M Berrien-Elliott, PhD³^*, Julia A Wagner²^*, Brea A Jewell²^*, Timothy Schappe²^*, Jeffrey W Leong², Stephanie E Schneider²^*, Sarah Willey²^* and Todd A Fehniger, MD, PhD²

¹BMT and Leukemia Program, Washington University School of Medicine, Saint Louis, MO
²Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO
³Washington University School of Medicine, Saint Louis, MO

1:15 PM

102

Phase I Trial of IL-21 Ex Vivo Expanded NK Cells Administration to Prevent Disease Relapse after Haploidentical Stem-Cell Transplantation for Myeloid Leukemias

Stefan O. Ciurea, MD¹, Dean A. Lee, MD, PhD², Kai Cao, MS, MD³^*, Gabriela Rondon, MD¹, Julianne Chen¹^*, Dana B. Willis³^*, Sairah Ahmed, MD¹, Eric Yvon, PhD¹^*, Katayoun Rezvani, MD PhD¹, Elizabeth J. Shpall, MD¹ and Richard E. Champlin, MD¹

¹Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
²Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
³Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

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^*signifies non-member of ASH

703.O1.6 703. Adoptive Immunotherapy: Clinical Studies