57th ASH Annual Meeting and Exposition (December 5-8, 2015): 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Exploring the Biology of Multiple Myeloma

Myeloma: Biology and Pathophysiology, excluding Therapy Oral and Poster Abstracts
Oral

W224ABEF, Level 2 (Orange County Convention Center)

Moderators:

Anja Seckinger, MD, Heidelberg University Hospital and Hervé Avet-Loiseau, University Cancer Center of Toulouse

Disclosures:

Seckinger: Takeda: Other: Travel grant .

4:30 PM

835

The Fusion Gene Landscape in Multiple Myeloma, with Clinical Impact

Alice Cleynen, PhD¹^*, Raphaël Szalat, MD^2,3,4^*, Mehmet Kemal Samur, PhD¹^*, Giovanni Parmigiani, PhD¹^*, Nikhil C. Munshi, MD^4,5 and Hervé Avet-Loiseau, MD⁶^*

¹Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
²Service d'Immuno-Hematologie, Hopital Saint-Louis, APHP, Paris, France
³Medical Oncology, Harvard Medical School, Boston, MA
⁴Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁵VA Boston Healthcare System, West Roxbury, MA
⁶Centre de Recherche en Cancérologie de Toulouse Institut National de la Santé, Toulouse, France

4:45 PM

836

Identification of FAM46C As a Multiple Myeloma Repressor

Yuan Xiao Zhu, PhD¹^*, Chang-Xin Shi, PhD¹^*, Patrick Jedlowski¹^*, Klaus Martin Kortum¹^*, Laura Ann Bruins²^*, Jonathan Ahmann¹^*, Esteban Braggio, PhD¹, Xuewei Wang³^* and A. Keith Stewart²

¹Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
²Mayo Clinic, Scottsdale, AZ
³Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN

5:00 PM

837

Redefining Mutational Profiling Using RNA-Seq: Insight into the Functional Mutational Landscape of Multiple Myeloma

David Mosen-Ansorena, PhD^1,2^*, Niccolo Bolli, MD^3,4, Mehmet K Samur, Ph.D^1,5^*, Florence Magrangeas⁶^*, Stephane Minvielle⁶^*, Kenneth C Anderson, MD⁵, Peter J Campbell, MD, PhD⁴^*, Hervé Avet-Loiseau, MD⁷^*, Giovanni Parmigiani, PhD¹^* and Nikhil C. Munshi, MD^5,8

¹Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
²Harvard School of Public Health, Boston, MA
³Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Cancer genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
⁵LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁶Centre Hospitalier Universitaire de Nantes, Unité Mixte de Genomique du Cancer, Nantes, France
⁷Centre de Recherche en Cancérologie de Toulouse Institut National de la Santé, Toulouse, France
⁸VA Medical Hospital, Boston, MA

5:15 PM

838

Discovery and Characterization of Promoter and Super-Enhancer-Associated Dependencies through E2F and BET Bromodomains in Multiple Myeloma

Mariateresa Fulciniti¹, Charles Y. Lin²^*, Mehmet K Samur, Ph.D³^*, Matthew Lawlor²^*, Kenneth C Anderson¹, James E. Bradner, MD⁴ and Nikhil C. Munshi, MD^5,6

¹The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Dana-Farber Cancer Institute, Boston
³Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
⁴Harvard Medical School, Boston, MA
⁵VA Medical Hospital, Boston, MA
⁶LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

5:30 PM

839

Drug Resistant Myeloma Cells Cause More Severe Bone Destruction in Myeloma

Mu Hao, MD, PhD^1,2^*, Zhimin Gu, PhD¹^*, Reinaldo Franqui Machin¹^*, Hongwei Xu¹^*, Gregory S. Thomas, PhD.¹^*, Lugui Qiu, MD, PhD², Guido J Tricot, MD, PhD³ and Fenghuang Zhan, MD, PhD¹

¹Department of Internal Medicine, University of Iowa, Iowa city, IA
²State Key Lab of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
³Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA

5:45 PM

840

Towards a Network-Based Molecular Taxonomy of Newly Diagnosed Multiple Myeloma

Alessandro Lagana, PhD¹^*, Ben Readhead¹^*, Deepak Perumal, PhD²^*, Brian Kidd¹^*, Hearn Jay Cho, MD, PhD³, Ajai Chari, MD², Sundar Jagannath, MD⁴, Joel Dudley, PhD⁵^* and Samir Parekh, MD²

¹Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
²Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
³Tisch Cancer Institute / Multiple Myeloma Program, Mount Sinai School of Medicine, New York, NY
⁴Hematology and Medical Oncology, Mount Sinai Hospital, New York, NY
⁵Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, NewYork, NY

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^*signifies non-member of ASH

651.O1.3 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Exploring the Biology of Multiple Myeloma