-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

636.O1.6 636. Myelodysplastic Syndromes – Basic and Translational Studies: Translation of Genetic and Epigenetic Studies

Myelodysplastic Syndromes – Basic and Translational Studies Program: Oral and Poster Abstracts
Type: Oral
Monday, December 7, 2015: 2:45 PM-4:15 PM
Valencia D (W415D), Level 4 (Orange County Convention Center)
Moderators:
Stephanie Halene, M.D., Ph.D., Yale University School of Medicine and Omar Abdel-Wahab, Memorial Sloan Kettering Cancer Center

Disclosures:
No relevant conflicts of interest to declare.
2:45 PM

Hideki Makishima, MD, Ph.D.1,2, Kenichi Yoshida, MD, Ph.D.2*, Thomas LaFramboise, PhD3*, Tetsuichi Yoshizato, MD2*, Matthew Ruffalo3*, Mikkael A. Sekeres, MD, MS4, Bartlomiej Przychodzen, MSc5*, Hiromichi Suzuki, MD, PhD2*, Masashi Sanada, MD, Ph.D.6*, Yasunobu Nagata, MD, Ph.D.2*, Yusuke Okuno, MD, Ph.D.7*, Yusuke Sato, MD, PhD2*, Aiko Sato-Otsubo, PhD2*, Michael J. Clemente1*, Naoko Hosono, MD., PhD.8*, Yuichi Shiraishi, MD, Ph.D.9*, Kenichi Chiba, BA9*, Hiroko Tanaka, BA9*, Yusuke Shiozawa, MD2*, Ines Gomez-Segui, MD, PhD1*, Holleh Husseinzadeh, MD10*, Swapna Thota, MD5*, Kathryn Guinta1*, Brittney Dienes1*, Tsuyoshi Nakamaki, MD11, Shuichi Miyawaki, MD12, Yogen Saunthararajah, M.D.1, Shigeru Chiba, M.D., Ph.D.13, Satoru Miyano, MD, Ph.D.9*, Lee-Yung Shih, MD14, Seishi Ogawa, MD, Ph.D.2 and Jaroslaw P. Maciejewski, MD, Ph.D.5

1Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
2Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
3Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH
4Leukemia Program, Cleveland Clinic, Cleveland, OH
5Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
6Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
7Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
8Department of Hematology and Oncology, Fukui prefectural Hospital, Fukui, Japan
9Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
10Dept of Heme-Onc, U.PENN, philadelphia
11Division of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
12Division of Hematology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo, Japan
13Department of Clinical and Experimental Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
14Department of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, College of Medicine Chang Gung University, Taipei, Taiwan

3:00 PM

Ashwin Unnikrishnan, PhD1,2*, Elli Papaemmanuil, PhD3*, Dominik Beck, PhD1*, Arjun Verma, B.Sc.1*, Ashu Kumari, PhD4*, Laura A. Richards5*, Kathy Knezevic1*, Vashe Chandrakanthan, Ph.D.1*, Julie A.I. Thoms, Ph.D.1*, Melinda L. Tursky, Ph.D.1*, Yizhou Huang1*, Sally Galbraith, Ph.D.6*, Austin G. Kulasekararaj, MBBS, MD, MRCP, FRCPath7*, Magnus Tobiasson, MD8*, Petter S. Woll, Ph.D.9*, Andrea Pellagatti, PhD10*, Susan R. Wilson, Ph.D.6*, Robert Lindeman, MD11, Jacqueline Boultwood, PhD12, Kevin Lynch, MBBS13*, Sten Eirik Jacobsen, MD PhD14*, Ghulam J Mufti, FRCP, FRCPath15, Eva Hellstrom-Lindberg, MD, PhD16, Karen Lee Mackenzie, PhD17*, Jason W.H. Wong, Ph.D.1*, Peter J Campbell, MD, PhD18* and John E. Pimanda, MD Ph.D.1,2,11

1Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia
2Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
3Memorial Sloan Kettering Cancer Center, New York
4Children's Cancer Institute Australia, Sydney, Australia
5Children’s Cancer Institute Australia, Sydney, Australia
6School of Mathematics and Statistics, University of New South Wales, Sydney, Australia
7Department of Haematological Medicine, Kings College Hospital NHS Foundation Trust, London, United Kingdom
8Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Sweden, Stockholm, Sweden
9Haemopoietic Stem Cell Laboratory, Weatherall Institute for Molecular Medicine, University of Oxford, Oxford, United Kingdom
10Nuffield Department of Clinical Laboratory Sciences, Leukaemia Research Fund Molecular Haematology Unit, Headington, Oxford, United Kingdom
11Haematology Department, Prince of Wales Hospital, Sydney, Australia
12LRF Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, United Kingdom
13Celgene Pty Ltd, Sydney, Australia
14MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
15Department of Haematological Medicine, King’s College London, London, United Kingdom
16Dept. of Med., Div. of Hem., Karolinska Institutet, Stockholm, Sweden
17Childrens Cancer Institute Australia, Sydney, Australia
18Cancer genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

3:15 PM

Tetsuichi Yoshizato, MD1*, Yusuke Shiozawa, MD1*, Kenichi Yoshida, MD, Ph.D.1*, Yoshiko Atsuta, MD, Ph.D2,3*, Chika Ito3*, Keisuke Kataoka, MD, PhD1*, Makoto Onizuka, MD, PhD4, Hiromichi Suzuki, MD, PhD1*, Kenichi Chiba, BA5*, Hiroko Tanaka, BA5*, Yuichi Shiraishi, MD, Ph.D.5*, Yasunobu Nagata, MD, Ph.D.1*, Masashi Sanada, MD, Ph.D.6*, Hidehiro Itonaga, MD, PhD7*, Yoshinobu Kanda, MD, PhD8, Yasushi Miyazaki, MD9, Hideki Makishima, MD, Ph.D.1, Satoru Miyano, MD, Ph.D.5* and Seishi Ogawa, MD, PhD1*

1Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
2Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
3Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
4Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
5Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
6Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
7Department of Hematology, Sasebo City General Hospital, Sasebo, Japan
8Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
9Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan

3:30 PM

Nagisa Hasegawa, MD1,2,3*, Goro Sashida, MD, PhD1,4, Motohiko Oshima, PhD1, Hirotaka Matsui, MD, PhD5, Atsunori Saraya1*, Changshan Wang, PhD1*, Tomoya Muto, MD, PhD2,3*, Chiaki Nakaseko, MD, PhD2,3, Koutaro Yokote, MD, PhD6* and Atsushi Iwama, MD, PhD1

1Department of Cellular and Molecular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
2Department of Hematology, Chiba University Hospital, Chiba, Japan
3Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
4International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
5Department of Molecular Laboratory Medicine, Kumamoto University, Kumamoto, Japan
6Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chhiba, Japan

3:45 PM

Lindsay M LaFave, PhD1*, Wendy Béguelin, PhD2*, Richard Koche, PhD3*, Matt Teater2*, Efthymia Papalexi4*, Barbara Spitzer, MD5, Sarah Knutson, PhD6*, John Campbell, PhD6*, Heike Keilhack, PhD7*, Paul M Thomas, PhD8*, Neil L Kelleher, PhD8*, Omar Abdel-Wahab9, Ari M. Melnick, MD10, Scott A. Armstrong, MD, PhD11 and Ross L. Levine, MD9,12

1Human Oncology and Pathogenesis Department, Memorial Sloan Kettering Cancer Center, New York, NY
2Weill Cornell Medical College, New York, NY
3Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY
4Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
5Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
6Epizyme, Cambridge, MA
7Epizyme, Inc, Cambridge, MA
8Proteomics Center of Excellence, Northwestern University, Evanston, IL
9Memorial Sloan Kettering Cancer Center, New York, NY
10Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY
11Memorial Sloan-Kettering Cancer Center, New York, NY
12Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

4:00 PM

Tzu-Chieh Ho, PhD1, James Taggart, BS1*, Elianna Amin, PhD1*, Haiming Xu, PhD2*, Trevor Barlowe, BA1*, Alexander R Perez, BS3*, Patrick Tivnan, BS1*, Rachel Okabe, BS1*, Christopher Lengner, PhD4*, Amit Verma, MD5, Gail J Roboz, MD6, Monica L. Guzman, PhD7, Christina S Leslie, PhD3*, Stephen D. Nimer, MD8 and Michael G. Kharas, PhD1

1Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY
2Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York
3Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY
4Department of Animal Biology, Department of Cell and Developmental Biology and Institute for Regenerative Medicine, Schools of Veterinary Medicine and Medicine, University of Pennsylvania, Philadelphia, PA
5Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
6Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY
7Division of Hematology and Medical Oncology, Department of Medicine and Department of Pharmacology, Weill Cornell Medical College, New York, NY
8Sylvester Comprehensive Cancer Center, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL

*signifies non-member of ASH