Hideki Makishima, MD, Ph.D.^1,2, Kenichi Yoshida, MD, Ph.D.^2*, Thomas LaFramboise, PhD^3*, Tetsuichi Yoshizato, MD^2*, Matthew Ruffalo^3*, Mikkael A. Sekeres, MD, MS⁴, Bartlomiej Przychodzen, MSc^5*, Hiromichi Suzuki, MD, PhD^2*, Masashi Sanada, MD, Ph.D.^6*, Yasunobu Nagata, MD, Ph.D.^2*, Yusuke Okuno, MD, Ph.D.^7*, Yusuke Sato, MD, PhD^2*, Aiko Sato-Otsubo, PhD^2*, Michael J. Clemente^1*, Naoko Hosono, MD., PhD.^8*, Yuichi Shiraishi, MD, Ph.D.^9*, Kenichi Chiba, BA^9*, Hiroko Tanaka, BA^9*, Yusuke Shiozawa, MD^2*, Ines Gomez-Segui, MD, PhD^1*, Holleh Husseinzadeh, MD^10*, Swapna Thota, MD^5*, Kathryn Guinta^1*, Brittney Dienes^1*, Tsuyoshi Nakamaki, MD¹¹, Shuichi Miyawaki, MD¹², Yogen Saunthararajah, M.D.¹, Shigeru Chiba, M.D., Ph.D.¹³, Satoru Miyano, MD, Ph.D.^9*, Lee-Yung Shih, MD¹⁴, Seishi Ogawa, MD, Ph.D.² and Jaroslaw P. Maciejewski, MD, Ph.D.⁵

¹Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
²Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH
⁴Leukemia Program, Cleveland Clinic, Cleveland, OH
⁵Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁶Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
⁷Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁸Department of Hematology and Oncology, Fukui prefectural Hospital, Fukui, Japan
⁹Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
¹⁰Dept of Heme-Onc, U.PENN, philadelphia
¹¹Division of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
¹²Division of Hematology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo, Japan
¹³Department of Clinical and Experimental Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
¹⁴Department of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, College of Medicine Chang Gung University, Taipei, Taiwan

Ashwin Unnikrishnan, PhD^1,2*, Elli Papaemmanuil, PhD^3*, Dominik Beck, PhD^1*, Arjun Verma, B.Sc.^1*, Ashu Kumari, PhD^4*, Laura A. Richards^5*, Kathy Knezevic^1*, Vashe Chandrakanthan, Ph.D.^1*, Julie A.I. Thoms, Ph.D.^1*, Melinda L. Tursky, Ph.D.^1*, Yizhou Huang^1*, Sally Galbraith, Ph.D.^6*, Austin G. Kulasekararaj, MBBS, MD, MRCP, FRCPath^7*, Magnus Tobiasson, MD^8*, Petter S. Woll, Ph.D.^9*, Andrea Pellagatti, PhD^10*, Susan R. Wilson, Ph.D.^6*, Robert Lindeman, MD¹¹, Jacqueline Boultwood, PhD¹², Kevin Lynch, MBBS^13*, Sten Eirik Jacobsen, MD PhD^14*, Ghulam J Mufti, FRCP, FRCPath¹⁵, Eva Hellstrom-Lindberg, MD, PhD¹⁶, Karen Lee Mackenzie, PhD^17*, Jason W.H. Wong, Ph.D.^1*, Peter J Campbell, MD, PhD^18* and John E. Pimanda, MD Ph.D.^1,2,11

¹Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia
²Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
³Memorial Sloan Kettering Cancer Center, New York
⁴Children's Cancer Institute Australia, Sydney, Australia
⁵Children’s Cancer Institute Australia, Sydney, Australia
⁶School of Mathematics and Statistics, University of New South Wales, Sydney, Australia
⁷Department of Haematological Medicine, Kings College Hospital NHS Foundation Trust, London, United Kingdom
⁸Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Sweden, Stockholm, Sweden
⁹Haemopoietic Stem Cell Laboratory, Weatherall Institute for Molecular Medicine, University of Oxford, Oxford, United Kingdom
¹⁰Nuffield Department of Clinical Laboratory Sciences, Leukaemia Research Fund Molecular Haematology Unit, Headington, Oxford, United Kingdom
¹¹Haematology Department, Prince of Wales Hospital, Sydney, Australia
¹²LRF Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, United Kingdom
¹³Celgene Pty Ltd, Sydney, Australia
¹⁴MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
¹⁵Department of Haematological Medicine, King’s College London, London, United Kingdom
¹⁶Dept. of Med., Div. of Hem., Karolinska Institutet, Stockholm, Sweden
¹⁷Childrens Cancer Institute Australia, Sydney, Australia
¹⁸Cancer genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

Tetsuichi Yoshizato, MD^1*, Yusuke Shiozawa, MD^1*, Kenichi Yoshida, MD, Ph.D.^1*, Yoshiko Atsuta, MD, Ph.D^2,3*, Chika Ito^3*, Keisuke Kataoka, MD, PhD^1*, Makoto Onizuka, MD, PhD⁴, Hiromichi Suzuki, MD, PhD^1*, Kenichi Chiba, BA^5*, Hiroko Tanaka, BA^5*, Yuichi Shiraishi, MD, Ph.D.^5*, Yasunobu Nagata, MD, Ph.D.^1*, Masashi Sanada, MD, Ph.D.^6*, Hidehiro Itonaga, MD, PhD^7*, Yoshinobu Kanda, MD, PhD⁸, Yasushi Miyazaki, MD⁹, Hideki Makishima, MD, Ph.D.¹, Satoru Miyano, MD, Ph.D.^5* and Seishi Ogawa, MD, PhD^1*

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
³Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
⁴Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
⁵Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁶Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
⁷Department of Hematology, Sasebo City General Hospital, Sasebo, Japan
⁸Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
⁹Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan

Nagisa Hasegawa, MD^1,2,3*, Goro Sashida, MD, PhD^1,4, Motohiko Oshima, PhD¹, Hirotaka Matsui, MD, PhD⁵, Atsunori Saraya^1*, Changshan Wang, PhD^1*, Tomoya Muto, MD, PhD^2,3*, Chiaki Nakaseko, MD, PhD^2,3, Koutaro Yokote, MD, PhD^6* and Atsushi Iwama, MD, PhD¹

¹Department of Cellular and Molecular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
²Department of Hematology, Chiba University Hospital, Chiba, Japan
³Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
⁴International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
⁵Department of Molecular Laboratory Medicine, Kumamoto University, Kumamoto, Japan
⁶Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chhiba, Japan

Lindsay M LaFave, PhD^1*, Wendy Béguelin, PhD^2*, Richard Koche, PhD^3*, Matt Teater^2*, Efthymia Papalexi^4*, Barbara Spitzer, MD⁵, Sarah Knutson, PhD^6*, John Campbell, PhD^6*, Heike Keilhack, PhD^7*, Paul M Thomas, PhD^8*, Neil L Kelleher, PhD^8*, Omar Abdel-Wahab⁹, Ari M. Melnick, MD¹⁰, Scott A. Armstrong, MD, PhD¹¹ and Ross L. Levine, MD^9,12

¹Human Oncology and Pathogenesis Department, Memorial Sloan Kettering Cancer Center, New York, NY
²Weill Cornell Medical College, New York, NY
³Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Epizyme, Cambridge, MA
⁷Epizyme, Inc, Cambridge, MA
⁸Proteomics Center of Excellence, Northwestern University, Evanston, IL
⁹Memorial Sloan Kettering Cancer Center, New York, NY
¹⁰Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY
¹¹Memorial Sloan-Kettering Cancer Center, New York, NY
¹²Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

Tzu-Chieh Ho, PhD¹, James Taggart, BS^1*, Elianna Amin, PhD^1*, Haiming Xu, PhD^2*, Trevor Barlowe, BA^1*, Alexander R Perez, BS^3*, Patrick Tivnan, BS^1*, Rachel Okabe, BS^1*, Christopher Lengner, PhD^4*, Amit Verma, MD⁵, Gail J Roboz, MD⁶, Monica L. Guzman, PhD⁷, Christina S Leslie, PhD^3*, Stephen D. Nimer, MD⁸ and Michael G. Kharas, PhD¹

¹Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY
²Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York
³Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Animal Biology, Department of Cell and Developmental Biology and Institute for Regenerative Medicine, Schools of Veterinary Medicine and Medicine, University of Pennsylvania, Philadelphia, PA
⁵Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
⁶Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY
⁷Division of Hematology and Medical Oncology, Department of Medicine and Department of Pharmacology, Weill Cornell Medical College, New York, NY
⁸Sylvester Comprehensive Cancer Center, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL