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321.O1.6 321. Blood Coagulation and Fibrinolytic Factors: Biochemistry and Engineering of Coagulation Proteins

Blood Coagulation and Fibrinolytic Factors Program: Oral and Poster Abstracts
Type: Oral
Saturday, December 5, 2015: 4:00 PM-5:30 PM
W315, Level 3 (Orange County Convention Center)
Moderators:
Jeremy P. Wood, PhD, Blood Center of Wisconsin and Gary E. Gilbert, MD, VA Boston Healthcare System, Harvard Medical School

Disclosures:
No relevant conflicts of interest to declare.
4:00 PM
121
The X-Ray Structure of a Variant of Human Factor V Provides Structural Insights into the Procofactor Activation Paradox

Shekhar Kumar, PhD1*, Steven Stayrook, PhD2*, Rodney M. Camire, PhD1 and Sriram Krishnaswamy, PhD1

1Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
2Biochemistry & Biophysics, University of Pennsylvania, Philadelphia, PA
4:15 PM
122
Long-Range Allosteric Linkage Between Exosites Reciprocally Regulates the Zymogenicity of Prothrombin Derivatives

Joseph A. Micucci, PhD1*, Parvathi Kamath, PhD1*, Anuja Khan, PhD1*, Paul E. Bock, PhD2* and Sriram Krishnaswamy, PhD3

1Children's Hospital of Philadelphia, Philadelphia, PA
2Vanderbilt University, Nashville, TN
3Research Insitute, Children's Hospital of Philadelphia, Philadelphia, PA
4:30 PM
123
Bioengineering Coagulation Factor VIII through Ancestral Protein Reconstruction

Philip Zakas, BS1*, Kristopher Knight2*, Ernest T Parker, BA2*, H. Trent Spencer, PhD3, Eric Gaucher, PhD4* and Christopher B Doering, PhD2

1Graduate Program in Molecular and Systems Pharmacology, Laney Graduate School, Emory University, Atlanta, GA
2Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
3Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA
4School of Biology, Georgia Institute of Technology, Atlanta, GA
4:45 PM
124
Prothrombin Membrane Binding and Gla-Dependent Function Are Not Required for Effective Hemostasis In Vivo

Lindsey A. Greene, MD1,2, Nabil K. Thalji, BS3, Harlan Bradford, BA4*, Sriram Krishnaswamy, PhD. MD3 and Rodney M. Camire, PhD5

1Department of Pediatrics, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA
2Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
3The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
4Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
5Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
5:00 PM
125
Tissue Factor Decryption By Oxidative Stress-Induced Lipid Peroxidation: Potential Mechanisms

Shabbir Ansari*, Usha R Pendurthi, PhD and L. Vijaya Mohan Rao, Ph.D.

Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX
5:15 PM
126
Engineered Factor Xa Variants Retain Procoagulant Activity Independent of Direct Factor Xa-Inhibitors

Daniël Verhoef*, Mark Schreuder*, Ka Lei Cheung*, Pieter H. Reitsma and Mettine H.A. Bos, Ph.D.

Division of Thrombosis and Hemostasis, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands
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*signifies non-member of ASH