57th ASH Annual Meeting and Exposition (December 5-8, 2015): 311. Disorders of Platelet Number or Function: Immune Thrombocytopenia and Platelet Survival

Disorders of Platelet Number or Function Oral and Poster Abstracts
Oral

W315, Level 3 (Orange County Convention Center)

Moderators:

James B. Bussel, MD, Weill Cornell Medical College and Jenny M. Despotovic, DO, MS, Baylor College of Medicine

Disclosures:

Bussel: Amgen: Honoraria , Membership on an entity’s Board of Directors or advisory committees , Research Funding ; Cangene: Membership on an entity’s Board of Directors or advisory committees , Research Funding ; Novartis: Honoraria , Membership on an entity’s Board of Directors or advisory committees , Research Funding ; GSK: Honoraria , Membership on an entity’s Board of Directors or advisory committees , Research Funding ; protalex: Consultancy , Membership on an entity’s Board of Directors or advisory committees , Research Funding ; rigel: Honoraria , Membership on an entity’s Board of Directors or advisory committees , Research Funding .

7:30 AM

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety and Efficacy of Romiplostim in Children with Immune Thrombocytopenia (ITP)

Michael D Tarantino, MD^1,2, James B. Bussel³^*, Victor S. Blanchette⁴^*, Jenny Despotovic⁵^*, Carolyn Bennett⁶^*, Ashok Raj, MD⁷, Bronwyn Williams⁸^*, Donald Beam⁹^*, Jaime Morales¹⁰^*, Melissa J. Rose¹¹^*, Nancy Carpenter¹²^*, Kun Nie¹³^* and Melissa Eisen¹³^*

¹Bleeding & Clotting Disorders Institute, Peoria, IL
²Pediatrics/OSF St. Francis - Children's Hospital of Illinois, University of Illinois College of Medicine - Peoria, Peoria, IL
³Department of Pediatrics, Division of Hematology, Weill Medical College of Cornell University, New York, NY
⁴Hospital for Sick Children, Toronto, ON, Canada
⁵Texas Children’s Cancer and Hematology Centers, Houston, TX
⁶Emory University, Atlanta, GA
⁷Pediatric Blood and Cancer Disorders Clinic, Louisville, KY
⁸The Royal Children’s Hospital, Herston, Australia
⁹Cook Childrens Medical Center, Fort Worth, TX
¹⁰Louisiana State University Health Sciences Center, New Orleans, LA
¹¹Nationwide Children’s Hospital and The Ohio State University College of Medicine, Columbus, OH
¹²Amgen Ltd., Uxbridge, United Kingdom
¹³Amgen Inc., Thousand Oaks, CA

7:45 AM

Splenic and Circulating Human T Follicular Helper Cell Regulation By B Cell Depleting Therapy during Immune Thrombocytopenia

Sylvain Audia, MD, PhD^1,2^*, Marzia Rossato, PhD³^*, Maxime Samson, MD, PhD^1,2^*, Malika Trad, PhD²^*, Kim Santegoets, PhD³^*, Alexandrine Gautheron, PhD²^*, Olivier Facy, MD, PhD⁴^*, Pablo Ortega-Deballon, MD, PhD⁴^*, Laurent Martin, MD, PhD⁵^*, Marion Ciudad²^*, Nona Janikashvili, PhD²^*, Philippe Saas, PhD⁶, Timothy Radstake, MD, PhD³^* and Bernard Bonnotte, MD, PhD^1,2^*

¹Department of Internal Medicine and Clinical Immunology, University Hospital, Dijon, France
²CR INSERM 1098, University of Bourgogne/Franche-Comté, Dijon, France
³University Medical Center, Laboratory of Translational Immunology, Utrecht, Netherlands
⁴Department of Surgery, University Hospital, Dijon, France
⁵Department of Pathology, University Hospital, Dijon, France
⁶EFS BFC, INSERM UMR 1098/Université Bourgogne Franche-Comté/ EFS BFC/LabEx lispSTIC, Besancon, France

8:00 AM

Serious and Non-Serious Infections in Non-Splenectomized Adults Treated for Persistent or Chronic Primary Immune Thrombocytopenia: Effect of Treatments and Protection of Vaccines. Results of the French Nationwide Faith Study

Guillaume Moulis, MD¹^*, Maryse Lapeyre-Mestre, MD, PhD²^*, Aurore Palmaro³^* and Laurent Sailler, MD, PhD⁴^*

¹Internal Medicine Department, Toulouse University Hospital; UMR 1027 Inserm-, Toulouse, France
²Service de Pharmacologie Médicale et Clinique, INSERM U 1027, Toulouse, France
³UMR 1027 INSERM-University of Toulouse, Toulouse, France
⁴Internal Medicine Department, Toulouse University Hospital; UMR 1027 Inserm-University of Toulouse, Toulouse, France

8:15 AM

A Humanized Anti FcÎ³riia Scfv Inhibits Platelet Activation, Aggregation and Thrombus Formation in Heparin-Induced Thrombocytopenia (HIT)

Jose Perdomo, PhD¹, Jaa Yien New, PhD¹^*, Zohra Ahmadi¹^*, Xing-Mai Jiang, PhD¹^* and Beng H Chong, MBBS, PhD²

¹St George and Sutherland Clinical School, University of New South Wales, Kogarah, Australia
²Haematology Department, The St. George Hospital, Kogarah, Australia

8:30 AM

Regulation of Platelet Lifespan in the Presence and Absence of TPO Signaling

Marion Lebois¹^*, Mark R. Dowling^1,2^*, Philip D. Hodgkin^1,2^*, Benjamin T. Kile^1,2^*, Warren S. Alexander^1,2 and Emma C. Josefsson^1,2

¹The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia
²Department of Medical Biology, The University of Melbourne, Parkville, Australia

8:45 AM

Platelet GPIba Is Important for Thrombopoietin Production and Thrombopoietin-Induced Platelet Generation

Miao Xu, MSc, MD^1,2,3^*, Li Ma, PhD^1,4,5^*, Naadiya Carrim, PhD^1,6,7^*, Issaka Yougbare, PhD^1,4,5^*, June Li, MSc^1,6,8^*, Pingguo Chen, MD, PhD⁹, Guangheng Zhu, MD¹⁰^* and Heyu Ni, MD, PhD^11,12

¹Toronto Platelet Immunobiology Group, Toronto, ON, Canada
²Laboratory Medicine, LKSKI-Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada
³Keenan Research Centre for Biomedical Science of St.Michael's Hospital; Department of Laboratory Medicine and Pathobiology, University of Toronto; St. Michael's Hospital; Toronto Platelet Immunobiology Group, Toronto, ON, Canada
⁴Keenan Research Centre for Biomedical Science of St.Michael's Hospital; Li Ka Shing Knowledge Institute; Department of Laboratory Medicine, St. Michael's Hospital; Toronto Platelet Immunobiology Group, Toronto, ON, Canada
⁵Canadian Blood Services, Toronto, ON, Canada
⁶Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada
⁷Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Toronto, ON, Canada
⁸3Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Toronto, ON, Canada
⁹Toronto Platelet Immunobiology Group, Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Canadian Blood Services, Toronto St. Michael's Hospital, University of Toronto, Toronto, ON, Canada
¹⁰Toronto Platelet Immunobiology Group, Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada
¹¹Canadian Blood Services, Canada, St. Michael's Hospital, Toronto, ON, Canada
¹²Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

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311.O3.6 311. Disorders of Platelet Number or Function: Immune Thrombocytopenia and Platelet Survival