57th ASH Annual Meeting and Exposition (December 5-8, 2015): 311. Disorders of Platelet Number or Function: Thrombotic Microangiopathies

Disorders of Platelet Number or Function Oral and Poster Abstracts
Oral

W315, Level 3 (Orange County Convention Center)

Moderators:

Spero R Cataland, MD, The Ohio State University and Keith R. McCrae, MD, Cleveland Clinic

Disclosures:

Cataland: Ablynx: Consultancy .

2:00 PM

103

Modified Ham Test Distinguishes aHUS from TTP and Predicts Response to Eculizumab

Eleni Gavriilaki, MD¹, Xuan Yuan, MD, MSc¹, Zhaohui Ye, PhD², Michael B. Streiff, MD¹, Thomas S Kickler, M.D.³, Alison R Moliterno, MD¹, John Sperati, MD⁴^* and Robert A. Brodsky, MD¹

¹Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
²Division of Hematology and Stem Cell Program in the Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD
³Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
⁴Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

2:15 PM

104

Anti-Idiotypic-Designed-Ankyrin-Repeat-Molecules (DARPins) Universally Neutralize Plasma-Derived Autoantibodies in Acquired TTP Patients

Monica M Schaller, Asst Prof, PhD^1,2^*, Monique Vogel, PhD³^*, Magdalena Skowronska, PhD student^1,2^*, Irmela Sulzer¹^* and Johanna A. Kremer Hovinga Strebel, Prof, MD^1,2

¹University Clinic of Hematology and Central Hematology Laboratory, Bern University Hospital, Inselspital, Bern, Switzerland
²Department of Clinical Research, University of Bern, Bern, Switzerland
³Institute of Immunology, Inselspital, Bern and the University of Bern, Bern, Switzerland

2:30 PM

105

Human Neutrophil Peptides (HNPs) Enhance Thrombus Formation Under Flow By Inhibiting Proteolytic Activity of Plasma ADAMTS13 Metalloprotease

Vikram G. Pillai, Ph.D.¹^*, Jialing Bao, Ph.D.², Jenny McDaniel, M.D.³^*, Catherine B. Zander1, Ph.D.¹^*, Wenjing Cao, M.D., Ph.D.¹^*, Khalil Bdeir, Ph.D.⁴^*, Douglas B. Cines, MD⁴ and X. Long Zheng, MD, PhD¹

¹Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL
²Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA
³Division of Hematology and Oncology, University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL
⁴Department of Pathology and Laboratory Medicine, The University of Pennsylvania, Philadelphia, PA

2:45 PM

106

Identification of T Cell Epitope of ADAMTS13 in Thrombotic Thrombocytopenic Purpura Patients

Laurent Gilardin, MD, Master^1,2,3^*, Sandrine Delignat, Master^1,3,4^*, Bernard Maillere, PhD⁵^*, Bagirath Gangadharan, PhD^1,3,4^*, Ivan Peyron, PhD^1,3,4^*, Mathieu Ing, Master^1,3,4^*, Nimesh Gupta, PhD^1,3,4^*, Yu Chun Lone, PhD⁶^*, Agnes Veyradier, MD, PhD^2,7^*, Jean-Baptiste Latouche, MD, PhD⁸^*, Srini Kaveri, PhD, DVM^1,3,4^*, Paul Coppo, MD, PhD^2,9^* and Sébastien Lacroix-desmazes, PhD^1,3,4^*

¹INSERM, UMR S 1138, Centre de Recherche des Cordeliers, Paris, France
²Saint-Antoine Hospital, Centre National de Référence sur les Microangiopathies Thrombotiques, Paris, France
³Université Pierre et Marie Curie - Paris 6, Paris, France
⁴Université Paris Descartes - Paris 5, Paris, France
⁵CEA-Saclay Institute of Biology and Technologies, SIMOPRO, Labex LERMIT, Labex VRI, Gif sur Yvette, France
⁶INSERM, U1014, Hôpital Paul Brousse, Villejuif, France
⁷Lariboisière Hospital, Service d'hématologie biologique, Paris, France
⁸CHU CH.NICOLLE, Laboratoire de Génétique Moléculaire, Rouen, France
⁹Hematology, Saint-Antoine Hospital, Paris, France

3:00 PM

107

ADAMTS13 Reactive CD4+ T Cells Targeting CUB-2 Domain Derived Peptides in Autoimmune Thrombotic Thrombocytopenic Purpura

Fabian Verbij, MSc¹^*, Femke de Heij¹^*, Annelies Turksma, PhD²^*, Paul Kaijen¹^*, Rob Fijnheer, MD, PhD³^*, Nicoletta Sorvillo, PhD¹^*, Anja ten Brinke, PhD²^* and Jan Voorberg, PhD¹

¹Department of Plasma Proteins, Sanquin Research, Amsterdam, Netherlands
²Department of Immunopathology, Sanquin Research, Amsterdam, Netherlands
³University Medical Center Utrecht, Utrecht, Netherlands

3:15 PM

108

Profiling the Autoantibody Repertoire of Acquired Thrombotic Thrombocytopenic Purpura (aTTP) Patients By Single Cell Sorting and Deep Sequencing of Splenic B-Cells

Magdalena Skowronska, PhD student^1,2^*, Monica M Schaller, Asst Prof, PhD^1,2^* and Johanna A. Kremer Hovinga Strebel, Prof, MD^1,2

¹Department of Clinical Research, University of Bern, Bern, Switzerland
²University Clinic of Hematology and Central Hematology Laboratory, Bern University Hospital, Inselspital, Bern, Switzerland

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^*signifies non-member of ASH

311.O2.6 311. Disorders of Platelet Number or Function: Thrombotic Microangiopathies