57th ASH Annual Meeting and Exposition (December 5-8, 2015): 201. Granulocytes, Monocytes and Macrophages II

Granulocytes, Monocytes and Macrophages Oral and Poster Abstracts
Oral

W312, Level 3 (Orange County Convention Center)

Moderators:

Hongbo R. Luo, PhD, Harvard Med. School and and Harry L Malech, MD, National Institutes of Health

Disclosures:

No relevant conflicts of interest to declare.

6:15 PM

Contribution of Lipocalin-2 from Both Myeloid Cells and Epithelium/Liver Is Required for Optimal Resistance to K. Pneumonia Infection

Elisabeth Præstekjær Cramer¹^*, Sara Louise Dahl¹^*, Björn Rozell²^*, Kasper Jermiin Knudsen³^*, Kim Thomsen⁴^*, Claus Moser⁴^*, Niels Borregaard¹ and Jack B. Cowland¹

¹The Granulocyte Research Laboratory, Department of Hematology, Copenhagen University Hospital, Copenhagen, Denmark
²Department of Experimental Medicine, Faculty of Health and Medical Sciences,, University of Copenhagen, Copenhagen, Denmark
³The Finsen Laboratory, Copenhagen University Hospital and Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
⁴Department of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark

6:30 PM

884

Long-Term Hematologic Response to Eliglustat in Patients with Gaucher Disease Type 1: Results from a Phase 2 and Two Phase 3 Trials

Neal J. Weinreb, MD, FACP¹, Timothy M Cox, MD²^*, Elena Lukina, MD³^*, Pramod Mistry, MD, PhD, FRCP⁴^*, Jennifer Angell⁵^*, Sebastiaan Gaemers, MD⁵^* and M. Judith Peterschmitt, MD⁵^*

¹University Research Foundation for Lysosomal Storage Diseases, Coral Springs, FL
²University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
³National Research Center for Hematology, Moscow, Russia
⁴Yale University, New Haven, CT
⁵Genzyme, a Sanofi company, Cambridge, MA

6:45 PM

885

Time Course of Acquisition of a CSF3R Mutation and Subsequent Development of AML in a Patient with Cyclic Neutropenia

Maksim Klimiankou, PhD¹^*, Olga Klimenkova, PhD¹^*, Lothar Kanz, Prof. Dr. med.², Cornelia Zeidler, MD³^*, Karl Welte, Prof. Dr. med.⁴ and Julia Skokowa, Prof. Dr.¹^*

¹Division of Translational Oncology, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany
²Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany
³Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
⁴Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, University Hospital Tuebingen, Tuebingen, Germany

7:00 PM

886

Identification of the Origin of Eosinophils

Andre Olsson, Ph.D.¹^*, Nathan Salomonis, PhD²^*, Harinder Singh¹^* and H. Leighton Grimes, PhD¹

¹Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Biomedical Informatics, Cincinnati Children’s Hospital Research Medical Center, Cincinnati, OH

7:15 PM

887

Pikfyve Regulates Lysosomal Biogenesis and Functions in Macrophages

Sang H Min, MD¹, Lehn Weaver, MD, PhD²^*, Aae Suzuki¹^*, Jessica Guzman¹^* and Charles S. Abrams, MD¹

¹School of Medicine, University of Pennsylvania, Philadelphia, PA
²The Children's Hospital of Philadelphia, Philadelphia, PA

7:30 PM

888

Neutrophil DREAM Is a Novel Regulator for Beta2 Integrin Function through NF-Kappab Signaling and Modulates Neutrophil Recruitment during Vascular Inflammation

Andrew Barazia¹^*, Jing Li, Ph.D.¹, Kyungho Kim, PhD¹^*, Chinnaswamy Tiruppathi, Ph.D.¹^* and Jaehyung Cho, Ph.D.^1,2

¹Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL
²Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL

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^*signifies non-member of ASH

201.O2.6 201. Granulocytes, Monocytes and Macrophages II