57th ASH Annual Meeting and Exposition (December 5-8, 2015): 201. Granulocytes, Monocytes and Macrophages I

Granulocytes, Monocytes and Macrophages Oral and Poster Abstracts
Oral

W340, Level 3 (Orange County Convention Center)

Moderators:

Niels Borregaaard, University of Copenhagen and Peter Gaines, Ph.D., University of Massachusetts Lowell

Disclosures:

No relevant conflicts of interest to declare.

2:45 PM

MUC-1 Regulates MiR34a Expression in Acute Myeloid Leukemia Cells Resulting in an Accumulation of Granulocytic Myeloid-Derived Suppressor Cells

Athalia Rachel Pyzer, MD¹^*, Dina Stroopinsky, PhD¹^*, Hasan Rajabi, PhD²^*, Jacalyn Rosenblatt, MD¹, Maxwell Douglas Coll¹^*, Salvia Jain, MD³, Kristen Anna Palmer¹^*, Ashujit Tagde, PhD, BPharm²^*, Katarina Luptakova, MD¹, Malgorzata McMasters, MD¹^*, James D. Levine, MD¹, Robin Joyce, MD⁴, Jon E. Arnason, MD¹, Myrna Rita Nahas, MD¹^*, Rebecca Karp Leaf, MD¹, Abigail Washington¹^*, Michal Bar-Natan, M.D¹^*, Poorvi Somaiya Dutt¹^*, Donald Küfe, MD²^* and David E. Avigan, MD¹

¹Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
²Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³Malignant Hematology and Bone Marrow Transplantation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁴Division of Hematology and Oncology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA

3:00 PM

644

The Mechanism of Type I Interferon-Mediated Polarization of Tumor-Associated Neutrophils in Mice and Human

Lisa Andzinski, PhD¹^*, Mozhgan Dehghan Harati²^*, Edyta Zyla²^*, Nadine Kasnitz¹^*, Stephanie Stahnke¹^*, Ching-Fang Wu, MD, PhD³^*, Marcus Gereke, PhD⁴^*, Maren von Köckritz-Blickwede, PhD⁵^*, Bastian Schilling, MD⁶^*, Sven Brandau, PhD⁷^*, Lothar Kanz, MD⁸, Karl Welte, MD⁹^*, Siegfried Weiss, PhD¹^*, Julia Skokowa, Prof. Dr.¹⁰^* and Jadwiga Jablonska, PhD¹¹^*

¹Molecular Immunology, Helmholtz Centre for Infection Research, HZI, Braunschweig, Germany
²Division of Translational Oncology, Department of Hematology, Oncology, Immunology, Rheumatology and Pulmonology University Hospital Tuebingen, Tuebingen, Germany
³Division of Nephrology, Department of Internal Medicine, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan
⁴Immune Regulation, Helmholtz Centre for Infection Research, HZI, Braunschweig, Germany
⁵Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany
⁶Department of Dermatology, University Hospital, West German Cancer Center, University Duisburg-Essen, Essen, Germany
⁷Department of Otorhinolaryngology, University Hospital, University of Duisburg-Essen, Essen, Germany
⁸Dept. of Medicine II, University of Tübingen, Tübingen, Germany
⁹University Children’s Hospital Tuebingen, Tuebingen, Germany
¹⁰Division of Translational Oncology, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany
¹¹Division of Translational Oncology, Department of Hematology, Oncology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany

3:15 PM

645

A Common Progenitor for Macrophages, Osteoclasts and Dendritic Cells Newly Discovered in Human Bone Marrow and Cord Blood Yields Dendritic Cells with T-Cell Priming Ability

Yanling Xiao, MD, PhD¹^*, Joanna Aleksandra Grabowska, MSc¹^*, Riccardo Mezzadra, PhD student¹^*, Maarten J. van Tol, PhD²^*, Arjan C Lankester, MD, PhD² and Jannie Borst, PhD¹^*

¹Division of Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands
²Dept. of Pediatrics, Leiden University Medical Center, Leiden, Netherlands

3:30 PM

646

Tet2 Is a Novel Regulator of Murine Macrophage Differentiation and Polarization

Alyssa Cull, MSc¹^*, Brooke Snetsinger, MSc¹^* and Michael J. Rauh, MD, PhD²

¹Dept. Pathology & Molecular Medicine, Queen's University, Kingston, ON, Canada
²Department of Pathology & Molecular Medicine, Queen's University, Kingston, ON, Canada

3:45 PM

647

Genome-Wide Binding Studies of Acetyl-STAT3 Demonstrates a Novel Regulatory Pathway in Dendritic Cells

Yaping Sun, MD, PhD¹, Matthew Iyer, MD, PhD^2,3^*, Meng Zhao, PhD⁴^*, Richard McEachin, PhD²^*, Yi-Mi Wu, PhD³^*, Xuhong Cao, MS³^*, Katherine Oravecz-Wilson, MS¹^*, Cynthia Zajac, BS¹^*, Nathan Mathewson, PhD^1,5, Julia Wu, BS^1,5^*, Corinne Rossi, MD¹^*, Tomomi Toubai, M.D., Ph.D.¹, Zhaohui Qin, PhD⁴^*, Arul Chinnaiyan^3,6^* and Pavan Reddy, MD¹

¹Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
²Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI
³Ctr for Translational Pathology, Howard Hughes Medical Institute, Ann Arbor, MI
⁴Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA
⁵Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI
⁶Department of Pathology, University of Michigan, Ann Arbor, MI

4:00 PM

648

Homozygous Mutations in PHRF1 and PPARG in a Patient with Congenital Neutropenia and Profound Monocytosis: Understanding the Pathway Beyond Monocyte Versus Granulocyte Cell-Fate Choice

Houra Loghmani-khouzani, PhD¹^*, Maksim Klimiankou, PhD¹^*, Siarhei Kandabarau, BS²^*, Cornelia Zeidler, MD, MPH³^*, Karl Welte, Prof. Dr. med.⁴ and Julia Skokowa, Prof. Dr.¹^*

¹Division of Translational Oncology, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany
²Department of Molecular hematopoiesis, Hannover Medical School, Hannover, Germany
³Severe Chronic Neutropenia International Registry, Department of Molecular Hematopoiesis, Medical School Hannover, Hannover, Germany
⁴Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, University Hospital Tuebingen, Tuebingen, Germany

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^*signifies non-member of ASH

201.O1.6 201. Granulocytes, Monocytes and Macrophages I