57th ASH Annual Meeting and Exposition (December 5-8, 2015): 701. Experimental Transplantation: Basic Biology, Engraftment and Disease Activity: Poster I

Experimental Transplantation: Basic Biology, Engraftment and Disease Activity Oral and Poster Abstracts
Poster

Hall A, Level 2 (Orange County Convention Center)

Intestinal Epithelial HIF-2 Is Protective in Gut Graft-Versus-Host-Disease

Rena Feinman, PhD¹, Iriana Colorado, MSc¹^*, Keyi Wang, BSc²^*, Eugenia Dziopa, MSc¹^*, Leah Dziopa, MSc¹^*, Zheng Yang, MSc¹^* and Robert Korngold, PhD¹

¹Department of Research, Hackensack University Medical Center, Hackensack, NJ
²Department of Chemistry, Chemical Biology and Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ

1866

Allogeneic Transplanst for ACUTE Myeloid Leukemia: Cut Off Levels of WT1 Expression in 207 Patients and Pre-Emptive Therapy of Relapse

Carmen Di Grazia, MD¹^*, Simona Geroldi²^*, Raffaella Grasso, PhD³^*, Maurizio Miglino, PhD³^*, Nicoletta Colombo, PhD³^*, Elisabetta Tedone²^*, Silvia Luchetti²^*, Teresa Lamparelli²^*, Francesca Gualandi, MD⁴^*, Adalberto Ibatici, MD⁵^*, Stefania Bregante²^*, Maria Teresa van Lint²^*, Anna Maria Raiola²^*, Alida Dominietto, MD⁶^*, Riccardo Varaldo²^*, Federica Galaverna²^*, Anna Ghiso²^* and Andrea Bacigalupo, MD^7,8

¹Second Division of Hematology and Bone Marrow Transplantation, IRCCS AOU San Martino-IST, Genoa, Italy
²Divisione Ematologia e Trapianto di Midollo, IRCCS San Martino-IST, Genoa, Italy
³Chair of Hematology, Department of Internal Medicine (DiMI), IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy
⁴Second division of Hematology and Bone Marrow Transplantation,IRCCS AOU San Martino-IST, IRCCS San Martino-IST, Genoa, Italy
⁵First Division of Hematology and Bone Marrow Transplantation, IRCCS AOU San Martino-IST, Genoa, Italy
⁶Second division of Hematology and Bone Marrow Transplantation, IRCCS AOU San Martino-IST, Genoa, Italy
⁷Second Division of Hematology and Bone Marrow Transplantation,IRCCS AOU San Martino-IST, IRCCS San Martino-IST, Genoa, Italy
⁸Policlinico Gemelli, Catholic University, Rome, Italy

1867

Protection of Transplanted Hematopoietic Stem Cells from Inflammatory Recipient Marrow Environment through Specific TNF-α Signal Blockade

Takashi Ishida, M.D.^1,2^*, Sachie Suzuki, M.D.³^*, Chen-Yi Lai, Ph.D.¹^*, Masaaki Higashihara, M.D., Ph.D.⁴, Hiromitsu Nakauchi, MD, PhD⁵ and Makoto Otsu, M.D., Ph.D.¹

¹Division of Stem Cell Processing / Stem Cell Bank, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
²Department of Hematology, Kitasato University, Graduate School of Medical Science, Sagamihara, Japan
³Department of Hematology, Tsukuba University, Ibaraki, Japan
⁴Department of Hematology, Kitasato Univ. School of Med., Sagamihara, Japan
⁵Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

1868

A Preclinical Non-Human Primate Model to Test Reversible Myeloablation Following IV Busulfan Therapy without Stem Cell Rescue

Nadim Mahmud, MD, PhD^1,2, Amit Khanal, MD³^*, Simona Taioli, MS³^*, Emre Koca, MD³^*, Sujata Gaitonde, MD, FACP⁴^*, Benjamin Petro, BS³^*, Karen Sweiss, PharmD⁵^* and Damiano Rondelli, MD^1,3

¹University of Illinois Cancer Center, Chicago
²Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
³Section of Hematology/Oncology, Dept. of Medicine, University of Illinois at Chicago, Chicago
⁴Department of Pathology, University of Illinois at Chicago, Chicago
⁵Department of Pharmacy Practice, University of Illinois at Chicago, Chicago

1869

Defining Engraftment Patterns and Interactions Between Hematopoietic Stem Cells and Stromal Cells after in Utero Transplantation

Saloomeh Mokhtari¹, Christopher D Porada, PhD², Evan Joseph Colletti, PhD³^* and Graca Almeida-Porada, MD, PhD¹

¹Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC
²Wake Forest Institute for Regenerative Medicine, Winston Salem, NC
³Charles River Laboratories, Reno, NV

1870

Impact of Erythropoietin Modulation Using Hyperbaric Oxygen on Umbilical Cord Blood CD34+ Cell Homing

Omar S. Aljitawi, MD¹, Tara L. Lin, MD², George Vielhauer³^*, Aaron Cheung³^*, Maegan L. Capitano, Ph.D.⁴, Dandan Li, MS²^*, Amanda Wise³^*, Brea C. Lipe, MD¹, Soumen Paul, PhD²^*, Mary Laughlin⁵^* and Hal E. Broxmeyer, Ph.D.⁴

¹Division of Hematology/Oncology, University of Kansas Medical Center, Kansas City, KS
²University of Kansas Medical Center, Kansas City, KS
³University of Kansas Medical Center, Kansas City
⁴Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN
⁵Cleveland Cord Blood Center, Cleveland

1871

The Intravenous Route Optimizes Engraftment and Survival in the Murine Model of in Utero Hematopoietic Cell Transplantation (IUHCT)

Matthew M Boelig, MD¹^*, Aimee G Kim, MD¹^*, Haiying Li¹^*, Alan W Flake, MD² and William H Peranteau, MD²

¹Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Pediatric General, Thoracic and Fetal Surgery and The Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA

1872

Antithymocyte Globulin Treatment at the Time of Transplantation Impairs Donor Hematopoietic Stem Cell Engraftment

Zheng Hu, PhD¹^*, Feng Jin¹^*, Jin He²^*, Chunhui Jin³^*, Wei Fan¹^*, Yanhong Shan¹^*, Zefeng Zhang¹^*, Liguang Sun¹^* and Yong-Guang Yang, MD, PhD⁴

¹The First Hospital and Institute of Immunology, Jilin University, Changchun, China
²The First Hospital, Jilin University, Changchun, China
³Columbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons,, New York
⁴Center for Translational Immunology, Columbia University, New York

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^*signifies non-member of ASH

701.P1.24 701. Experimental Transplantation: Basic Biology, Engraftment and Disease Activity: Poster I