Jeffrey E Rubnitz, MD, PhD¹, Ronda Kaufman, PhD^2*, Raul C. Ribeiro, MD³, Boris Klebanov, MA, MS^4*, Joel Ellis, PhD^4*, Yosef Landesman, PhD^4*, Hagop Youssoufian, MD^2*, Tami Rashal, MD^2* and Sharon Shacham^2*

¹Oncology, St. Jude Children's Research Hospital, Memphis, TN
²Karyopharm Therapeutics, Inc, Newton, MA
³St. Jude Children's Research Hospital, Memphis, TN
⁴Karyopharm Therapeutics Inc., Newton, MA

Haifa Kathrin Al-Ali, MD^1*, Nadja Jaekel, MD^2*, Karolin Hubert^1*, Rainer Krahl, Ph.D^3*, Mathias Haenel, MD^4*, Georg Maschmeyer, MD⁵, Regina Herbst, MD^4*, Christian Jakob, MD^6*, Susann Schultze, MD^7*, Song-Yau Wang, MD^7*, Oana Brosteanu, PhD^8* and Dietger Niederwieser, MD⁷

¹University of Leipzig, Leipzig, Germany
²Hematology and Oncology, University of Leipzig, Leipzig, Germany
³Department of Hematology and Oncology, University Hospital of Leipzig, Leipzig, Germany
⁴Klinikum Chemnitz, Chemnitz, Germany
⁵Department of Hematology, Oncology and Palliative Care, Klinikum Ernst von Bergmann, Potsdam, Germany
⁶Klinikum Ernst von Bergmann, Potsdam, Germany
⁷University Hospital of Leipzig, Leipzig, Germany
⁸Zentrum fuer Klinische Studien, University of Leipzig, Leipzig, Germany

Raoul Tibes, MD, PhD¹, Heidi E. Kosiorek, MS^2*, Amylou C. Dueck, PhD², Lisa Sproat, MD, MSW³, Jeanne Palmer, MD^4*, James L. Slack, MD⁵, Devinder Singh, MD^6*, Eileen Gebhart, MSN, RN, ANP-BC^7*, Emily Knight, RN^8*, Shahrukh K. Hashmi, MD⁹, Ryan A Wilcox, MD, PhD¹⁰, James M Bogenberger, PhD¹¹, Ruben A. Mesa² and Aref Al-Kali, MD¹²

¹Division of Hematology and Medical Oncology, Mayo Clinic Arizona, Phoenix, AZ
²Mayo Clinic, Scottsdale, AZ
³Division of Hematology and Medical Oncology, Mayo Clinic Arizona, Scottsdale, AZ
⁴Hematology/Oncology, Mayo Clinic Arizona, Scottsdale, AZ
⁵Department of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ
⁶Hematology/Medical Oncology, Arizona Center for Cancer Care, Glendale, AZ
⁷Arizona Center for Cancer care, Glendale, AZ
⁸Mayo Clinic Arizona, Scottsdale, AZ
⁹Division of Hematology, Mayo Clinic, Rochester, MN
¹⁰Hematology, Mayo Clinic, Rochester, MN
¹¹Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ
¹²Mayo Clinic, Rochester, MN

Rodrigo Omar Jacamo, PhD^1*, Hong Mu, MD, PhD^2*, Qi Zhang^1*, Dhruv Chachad, MS^1*, Wang Zhiqiang^3*, Wencai Ma, PhD^4*, Min Zhang, MD, PhD^3*, Po Yee Mak, MPhil^1*, Duncan Mak, BSc, MPhil^1*, Peter Ruvolo, PhD¹, Teresa McQueen^1*, Scott Lowe^5*, Johannes Zuber, MD, PhD^6*, Dirk Eulberg, MBA^7*, Anna Kruschinski^7*, Marina Konopleva, MD, PhD¹, R Eric Davis, MD^4* and Michael Andreeff, MD, PhD⁸

¹Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Section of Molecular Hematology and Therapy, Leukemia Department, UT MD Anderson Cancer Center, Houston, TX
³Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Memorial Sloan Kettering Cancer Center, New York, NY
⁶Research Institute of Molecular Pathology (IMP), Vienna, Austria
⁷NOXXON Pharma AG, Berlin, Germany
⁸Section of Molecular Hematology & Therapy, Department of Leukemia; Department of Stem Cell Transplantation & Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Tadakazu Akiyama, PhD^1*, Shin-ichiro Takayanagi, PhD^2*, Yoshimi Maekawa^1*, Kohta Miyawaki, MD^3*, Fumiaki Jinnouchi, MD^3*, Takashi Jiromaru, MD^3*, Takeshi Sugio, MD^3*, Shinya Daitoku, MD^3*, Hirotake Kusumoto, MD^3*, Munetake Shimabe, PhD^2*, Satoshi Nishikawa^2*, Kengo Yamawaki^2*, Kousuke Iijima^1*, Masanori Hiura^1*, Takeshi Takahashi, PhD^1*, Yoshikane Kikushige, MD, PhD^3*, Hiromi Iwasaki, MD, PhD⁴, Koichi Akashi, MD, PhD⁵ and Tomonori Tawara, PhD^1*

¹R&D Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan
²R&D Division, Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan
³Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
⁴Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
⁵Kyushu University Hospital, Fukuoka, Japan

Steffan T. Nawrocki, Ph.D.¹, Yingchun Han, MD^2*, Ronan LE Moigne, PhD^3*, Valeria Visconte, PhD^2*, Bartlomiej Przychodzen, MSc^2*, Mark Rolfe, PhD³, Stevan Djakovic, PhD^4*, Daniel Anderson^3*, David Wustrow, PhD^3*, Han-Jie Zhou^3*, Steve Wong, PhD^3*, Anjali Advani, MD⁵, Hetty E. Carraway, MD, MBA⁶, Jaroslaw P. Maciejewski, MD, Ph.D.², Mikkael A. Sekeres, MD, MS⁶, Kevin R. Kelly, MD, PhD⁷ and Jennifer S. Carew, Ph.D.²

¹CTRC Institute for Drug Development, University of Texas Health Science Center at San Antonio, San Antonio, TX
²Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
³Cleave Biosciences, Burlingame, CA
⁴Cleave Biosciences, Burlingame
⁵Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH
⁶Leukemia Program, Cleveland Clinic, Cleveland, OH
⁷University of Southern California Keck School of Medicine, Los Angeles, CA

Raśl Montiel-Esparza, MD^1*, Hanna A. Knaus, MD^2*, Joshua F. Zeidner, MD³, Ante Vulic, MD^2*, Gabrielle T. Prince, MD², B. Douglas Smith, MD², Mark J. Levis, MD, PhD², Howard Streicher, MD^4*, Judith E. Karp, MD², Leo Luznik, MD^2* and Ivana Gojo, MD²

¹Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
²Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
³Department of Medicine, Division of Hematology/Oncology, University of North Carolina-Lineberger Comprehensive Cancer Center, Chapel Hill, NC
⁴NCI NIH-CTEP, Rockville, MD

Diana Azzam, PhD^1*, Claude-Henry Volmar, PhD^1*, Al-Ali Hassan, PhD^2*, Aymee Perez, PhD^3*, Justin M. Watts, MD^3*, Fernando Vargas, MD^3*, Roy Elias^3*, Francisco Vega, MD, PhD⁴, Arthur Zelent, PhD³, Christopher R. Cogle, MD⁵, Claes Wahlestedt, PhD^1* and Ronan T. Swords, MD, PhD, FRCPI, FRCPath⁶

¹Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami, Miami
²Miami Project to Cure Paralysis, University of Miami, Miami
³Sylvester Comprehensive Cancer Center, University of Miami, Miami
⁴Department of Pathology and Laboratory Medicine, Division of Hematopathology, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, and Jackson Memorial Hospital, Miami, FL
⁵Division of Hematology/Oncology, University of Florida, Gainesville, FL
⁶Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami Hospitals, Miami, FL

Toshiyuki Nakatani, PhD^1*, Ken Uda^1*, Takeshi Yamaura^1*, Masaru Takasaki^1*, Akimi Akashi^2*, Fangli Chen, MD^2*, Yuichi Ishikawa, MD, PhD², Fumihiko Hayakawa, MD, PhD^2*, Shinji Hagiwara, PhD^1*, Hitoshi Kiyoi, MD, PhD² and Tomoki Naoe, MD, Ph.D.³

¹Pharmaceutical and Healthcare Research Laboratories, FUJIFILM Corporation, Kaisei, Japan
²Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
³National Hospital Organization Nagoya Medical Center, Nagoya, Japan

Yixuan Ren, B.S.^*, Victoria Brown, M.S.^*, Shanhu Hu, Ph.D.^*, Jeremy Lopez, B.S.^*, Sofija Miljovska, Ph.D.^*, Darby Schmidt, Ph.D.^*, Michael Bradley, Ph.D.^*, Kevin Sprott, Ph.D.^*, Eric Olson, Ph.D.^*, Christian C. Fritz, PhD^* and Yoon Jong Choi, Ph.D.^*

Syros Pharmaceuticals, Watertown, MA

Jong Bok Lee^1,2*, Weihsu Claire Chen, PhD^3*, Elena Streck^1,4*, Sohyeong Kang^2*, Mark D. Minden, MD, PhD³, John E. Dick, PhD^3,5,6 and Li Zhang, PhD MD^1,2,6*

¹Toronto General Research Institute, University Health Network, Toronto, ON, Canada
²Department of Immunology, University of Toronto, Toronto, ON, Canada
³Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁴Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany
⁵Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
⁶Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

Giulia Daniele^1*, Clelia Tiziana Storlazzi^1*, Cristina Papayannidis, MD, PhD², Ilaria Iacobucci, PhD^3*, Angelo Lonoce^1*, Margherita Perricone^4*, Mariana Lomiento^5*, Fabiana Mammoli^5*, Elena Marasco^6*, Vilma Mantovani^6*, Hilmar Quentmeier, PhD^7*, Giorgia Simonetti, PhD^8*, Antonella Padella^8*, Vincenzo Franza^9*, Hans G. Drexler, MD, PhD⁷, Jie Ding, PhD^7*, Orazio Palumbo^10*, Massimo Carella^10*, Niroshan Nadarajah, M.Sc.^11*, Renč Massimiliano Marsano^1*, Antonio Palazzo^1*, Emanuela Ottaviani^8*, Carmen Baldazzi, PhD^8*, Nicoletta Testoni^8*, Sergio Ferrari, MD, PhD^5* and Giovanni Martinelli, MD, PhD²

¹Department of Biology, University of Bari, Bari, Italy
²Bologna University School of Medicine, Bologna, Italy
³"Serągnoli" Institute of Hematology, University of Bologna, Bologna, Italy
⁴Institute of Hematology, Bologna, Italy
⁵Department of Life Science, University of Modena and Reggio Emilia, Modena, Italy
⁶Center for Applied Biomedical Research (CRBA), Bologna, Italy
⁷DSMZ, Braunschweig, Germany
⁸University of Bologna, Bologna, Italy
⁹Institute of Hematology "Seragnoli", University of Bologna, Bologna, Italy
¹⁰Medical Genetics Unit, IRCCS, San Giovanni Rotondo, Italy
¹¹MLL Munich Leukemia Laboratory, Munich, Germany

Harry Dolstra, PhD^1*, Mieke W.H. Roeven, MD^2*, Jan Spanholtz, PhD^3*, Basav Hangalapura, PhD^1*, Marleen Tordoir^3*, Frans Maas^1*, Marij Leenders^1*, Fenna Bohme^3*, Nina Kok^3*, Carel Trilsbeek^1*, Jos Paardekooper^1*, Anniek B. Van der Waart, PhD^1*, Peter Westerweel, MD, PhD^4*, Tjeerd J.F. Snijders, MD⁵, Gerard M.J. Bos, MD, PhD⁶, Jan J. Cornelissen, MD, PhD⁷, Hans Pruijt, MD, PhD⁸, Gerwin Huls, MD, PhD^2*, Aniek de Graaf, PhD^1*, Bert A. van der Reijden, PhD¹, Nicole M.A. Blijlevens, MD, PhD², Joop H. Jansen, PhD¹, Arnold van der Meer, PhD^1*, Jeannette Cany, PhD^1*, Frank Preijers, PhD^1* and Nicolaas P.M. Schaap, MD, PhD²

¹Department of Laboratory Medicine, Radboud university medical center, Nijmegen, Netherlands
²Department of Hematology, Radboud university medical center, Nijmegen, Netherlands
³Glycostem Therapeutics, Oss, Netherlands
⁴Albert Schweitzer Hospital, Dordrecht, Netherlands
⁵MST, Enschede, Netherlands
⁶Dept. of Internal Medicine, University Hospital Maastricht, Maastricht, Netherlands
⁷Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
⁸Jeroen Bosch Hospital, S-Hertogenbosch, Netherlands

Stephen E. Kurtz, PhD^1*, Daniel Bottomly, MS^2*, Beth Wilmot, PhD^2*, Shannon K. McWeeney, PhD^2*, William Rice, PhD^3*, Stephen B Howell, MD^4*, Avanish Vellanki^3*, Brian J. Druker, MD⁵ and Jeffrey W. Tyner, PhD⁶

¹Division of Hematology and Medical Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, OR
²Department of Bioinformatics and Computational Biology, Oregon Health & Science University, Portland, OR
³Aptose Biosciences, Inc., Mississauga, ON, Canada
⁴Aptose Biosciences Inc., San Diego, CA
⁵Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR
⁶Knight Cancer Institute, Oregon Health & Science University, Portland, OR

Silvia Arcangeli^1*, Marco Bardelli^2*, Sarah Tettamanti^1*, Maria Caterina Rotiroti^1*, Luca Simonelli^2*, Chiara F Magnani^1*, Luca Varani^2*, Andrea Biondi, Prof, MD¹ and Ettore Biagi, MD^1*

¹Centro Ricerca Tettamanti, Clinica Pediatrica, Universitą Milano Bicocca, Osp. San Gerardo/Fondazione MBBM, Monza (MB), Italy
²Istituto di Ricerca in Biomedicina, Universitą degli Studi della Svizzera Italiana, Bellinzona, Switzerland

Masumi Ueda, MD¹, Paolo F. Caimi, MD¹, Tammy Stefan^2*, Hillard M. Lazarus, MD¹, Brenda Cooper, MD¹, Marcos de Lima, MD^1*, Stanton L. Gerson, MD¹ and David N. Wald, MD PhD^3*

¹Adult Hematologic Malignancies & Stem Cell Transplant Section, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH
²Department of Pathology, Case Western Reserve University, Cleveland, OH
³Department of Pathology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH

Ivana Gojo, MD¹, Jan H. Beumer, PharmD, PhD^2,3*, Keith Pratz, MD¹, Jiuping Ji^4*, Lihua Wang, PhD^5*, Michelle A. Rudek, PharmD, PhD^1*, Michael A. McDevitt, MD, PhD¹, Maria R. Baer, MD⁶, Amanda Blackford, ScM^1*, B. Douglas Smith, MD¹, Steven D. Gore, MD⁷, Hetty E. Carraway, MD, MBA⁸, Margaret M. Showel, MD^1*, Mark J. Levis, MD, PhD¹, Amy E. DeZern, MD, MHS¹, Douglas Gladstone, MD¹, Tania Jain, MD¹, Jackie Greer, RN^1*, Marie Pouquet, PharmD^2*, Ali-walbi Ismail, PharmD, MS^2*, James Herman, MD^1*, Weijie Poh, PhD¹, Larry Karnitz, PhD^9*, Scott H. Kaufmann, MD, PhD⁹, Alice Chen, MD^10* and Judith E Karp, MD¹

¹Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
²Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA
³Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA
⁴National Cancer Institute, National Clinic Target Validation Laboratory, Bethesda, MD
⁵National Cancer Institute, Frederick, MD
⁶Greenebaum Cancer Center, University of Maryland Baltimore, Baltimore, MD
⁷Yale Cancer Center, New Haven, CT
⁸Leukemia Program, Cleveland Clinic, Cleveland, OH
⁹Mayo Clinic, Rochester, MN
¹⁰Cancer Therapy Evaluation Program, National Cancer Institute, Rockville, MD

Yanyan Zhang, PhD^1*, Erika Saavedra, MD^2*, Ruoping Tang^3*, Shu-Hui Liu^4*, Tod Smeal^5*, Valeria Fantin, PhD^5*, Stephane De Botton, MD, PhD^6*, Ollivier Legrand, MD, PhD⁷, William Vainchenker, MD, PhD^8,9,10, Flavia Pernasetti^5* and Fawzia Louache, PhD^1,11*

¹Gustave Roussy, Inserm U1009, Villejuif, France
²Gustave Roussy, Inserm 1170, Villejuif, France
³Service d'Hematologie et de Therapie cellulaire, Hopital St Antoine, Paris, France
⁴Oncology-Rinat R&D, Pfizer Worldwide Research and Development, La Jolla, CA
⁵Oncology Research Unit, Pfizer Worldwide Research and Development, San Diego, CA
⁶Gustave Roussy, Service d'hématologie, Villejuif, France
⁷Hopital Saint Antoine, APHP, Hematology Dpt, Paris, France
⁸LABEX GR-Ex, Paris, France
⁹Université Paris 11, Orsay, France
¹⁰INSERM U1170, Institut Gustave Roussy, Villejuif, France
¹¹Université Paris 11, Villejuif, France

Ronan T. Swords, MD, PhD, FRCPI, FRCPath¹, Tino Schenk, PhD^2*, Sven Stengel, PhD^2*, Veronica Sylvina Gil, PhD^2*, Kevin R. Petrie, PhD², Aymee Perez, PhD^3*, Rodriguez Ana^3*, Justin M. Watts, MD^3*, Fernando Vargas, MD^3*, Roy Elias^3* and Arthur Zelent, PhD³

¹Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami Hospitals, Miami, FL
²Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom
³Sylvester Comprehensive Cancer Center, University of Miami, Miami

Zezhou Wang, PhD^1,2*, Peter Dove^2*, Aisha Shamas-Din, PhD^1*, Rose Hurren^1*, Xiaoming Wang^1*, Neil MacLean^1*, Marcela Gronda^1*, Feng Bo^1*, Janessa Li^1*, Clarissa Skorupski^1*, Wissam Hadri^2*, David O'Neill, PhD^2,3*, Ahmed Aman, PhD^4*, Rima Al-awar, PhD^4*, Mark D. Minden, MD, PhD⁵, Malik Slassi, PhD^2* and Aaron D. Schimmer, MD, PhD⁵

¹Princess Margaret Cancer Centre, Toronto, ON, Canada
²Fluorinov Pharma Inc., Toronto, ON, Canada
³Fight Against Cancer Innovation Trust, Toronto, ON, Canada
⁴Ontario Institute for Cancer Research, Toronto, ON, Canada
⁵Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada

Ka Leung Li, BSc (Hons)^1,2*, Sarah C Bray, PhD^1,2*, Diana Iarossi, BSc (Hons)^1,2*, Julian Adams, PhD^1,2*, Longjin Zhong^1,2*, Ben Noll, BSc (Hons)^1,2*, Muhammed H Rahaman, BSc (Hons)^1,2*, Jennifer Richmond, BSc(Hons)^3*, Luen Bik To, MBBS, PhD^4,5, Ian D Lewis, MBBS, PhD, FRACP, FRCPA^1,4,6, Richard B Lock, PhD³, Shudong Wang, PhD^1,2* and Richard J D'Andrea, PhD^1,2

¹Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, Australia
²School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, Australia
³Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia
⁴School of Medicine, University of Adelaide, Adelaide, Australia
⁵Department of Haematology, SA Pathology and Royal Adelaide Hospital, Adelaide, Australia
⁶Haematology, SA Pathology, Adelaide, Australia

Watkins M Krystal, MS^*, Russell Walker, MS^*, Nathan Fishkin, PhD^*, Charlene Audette^*, Yelena Kovtun, PhD^* and Angela Romanelli, PhD

ImmunoGen, Inc., Waltham, MA

David S Millan, PhD^*, Monica A Alvarez Morales, MS^*, Kenneth J Barr, PhD^*, Daniel Cardillo, MS^*, Alan Collis, PhD^*, Christopher J Dinsmore, PhD^*, Jaime A Escobedo, PhD^*, Kevin P Foley, PhD^*, Torsten Herbertz, PhD^*, Stephen Hubbs, BS^*, Goss S Kauffman, BS^*, Katherine J Kayser-Bricker, PhD^*, Mark T Kershaw, MSc^*, George P Luke, PhD^*, Matthew W Martin, PhD^*, Crystal McKinnon, BS^*, Rachel L Mendes, MS^*, Kristina R Muskiewicz, MA^*, Shawn ER Schiller, MS^*, Patricia Soulard, MS^*, Adam C Talbot, PhD^*, Duncan Walker, PhD, Lili Yao, MS^* and Grace L Williams, PhD^*

FORMA Therapeutics, Watertown, MA