-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
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601.P1.13 601. Chromosomal Rearrangements and DNA Repair: Poster I

Chromosomal Rearrangements and DNA Repair Program: Oral and Poster Abstracts
Type: Poster
Saturday, December 5, 2015: 5:30 PM-7:30 PM
Hall A, Level 2 (Orange County Convention Center)
1218
XRCC5 Plays an Important Role in Homologous Recombination, Genome Stability and Survival of Myeloma Cells

Edward Laane, MD, PhD1,2,3*, Purushothama Nanjappa2*, Subodh Kumar, PhD2,3*, Florence Magrangeas4*, Stephane Minvielle4*, Hele Everaus, MD, PhD5, Kenneth C Anderson, MD2, Herve Avet-Loiseau6,7*, Masood A Shammas, PhD2,3 and Nikhil C. Munshi, MD3,8

1North Estonia Medical Centre Foundation, Tallinn, Estonia
2The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
3VA Boston Healthcare System, West Roxbury, MA
4Centre de Recherche en Cancérologie Nantes-Angers UMR Inserm 892—CNRS 6299 and Institut de Recherche Thérapeutique de l’Université de Nantes (IRT-UN), Nantes, France
5Hematology-Oncology, Tartu University Hosptial, Tartu, Estonia
6IUCT-Oncopole, Toulouse, France
7Unité de Génomique du Myélome, CHU Rangueil, Toulouse, France
8Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Boston, MA
1219
Zinc Finger Nuclease (ZFN) Targeted Homologous Recombination Assay Detects Elevated Inter Homologous Recombination Activity and Copy Neutral Loss of Heterozygosity (CN-LOH)  in Internal Tandem Duplication Mutated FLT3 (FLT3-ITD) Acute Myeloid Leukaemia (AML)

Terry J Gaymes* and Ghulam J Mufti

Department of Haematological Medicine, Kings College London, London, United Kingdom
1220
Identification of Novel Fusion Genes and Differentially Expressed Genes in Acute Leukemia through Transcriptome Analysis

Dong-Hyun Lee, MD1*, Young-Uk Cho, MD, PhD1, Seongsoo Jang, MD, PhD1, Chan-Jeoung Park, MD, PhD1, Mi Hyun Bae, MD, PhD1*, Dae-Young Kim, MD, PhD2*, Jung-Hee Lee, MD, PhD2*, Je-Hwan Lee, MD, PhD2, Kyoo-Hyung Lee, MD, PhD2, Jong Jin Seo, MD, PhD3* and Eul-Ju Seo, MD, PhD1*

1Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea
2Department of Hematology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea
3Department of Pediatrics, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea
1221
Mutations in Cohesin Complex As Potential Targets for Therapeutic Intervention By PARP (Poly ADP Ribose Polymerase) Inhibitors in Myelodysplastic SyndromeClinically Relevant Abstract

Nazia Matto1*, Terry J Gaymes2*, Austin G. Kulasekararaj, MBBS, MD, MRCP, FRCPath3*, Syed A Mian, BSc, M.Phil4* and Ghulam J Mufti, FRCP, FRCPath5

1Department of Haematology Medicine, Kings College London, London, United Kingdom
2Department of Haematological Medicine, Kings College London, London, United Kingdom
3Department of Haematological Medicine, Kings College Hospital NHS Foundation Trust, London, United Kingdom
4Department of Haematological Medicine, King's College London, London, United Kingdom
5Department of Haematological Medicine, King’s College London, London, United Kingdom
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*signifies non-member of ASH