-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

New Approaches in Chronic Lymphocytic Leukemia and Prolymphocytic Leukemia

PhD Trainee
Program: Education Program
Sunday, December 6, 2015: 9:30 AM-11:00 AM
Tangerine 2 (WF2), Level 2 (Orange County Convention Center)
Monday, December 7, 2015: 2:45 PM-4:15 PM
Chapin Theater (W320), Level 3 (Orange County Convention Center)

Description:

There have been major improvements in the management of CLL as well as in our understanding of the molecular pathogenesis of disease. The overall theme of this session is to understand the molecular mechanisms that underlie poor prognosis CLL and how an increased understanding of these processes will lead to improvement in disease management. The emergence of B cell receptor antagonists has been a major advance to improve outcome in patients with relapsed and poor prognosis CLL.

Now that increased numbers of patients have received these agents, resistance is emerging and Dr. Jennifer Woyach will discuss what is known about the molecular basis of the mechanisms of resistance to B cell receptor antagonists.

Dr. Claire Dearden will discuss poor prognosis variants including prolymphocytic leukemia and how we can improve outcome for these patients.

Dr. Stephan Stilgenbauer will discuss emerging prognostic markers in CLL and will in particular focus on ways that these markers that will help stratify treatment decisions in CLL.

Chair:
John Gribben, MD, DSc, Barts Cancer Center, The London School of Medicine

Disclosures:
Gribben: Janssen: Honoraria ; Pharmacyclics: Honoraria ; Celgene: Consultancy , Honoraria ; Gilead: Honoraria ; Roche/Genentech: Honoraria .

Jennifer A. Woyach, MD

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH

Claire E Dearden, MD, FRCP, FRCPath

The Royal Marsden Hospital Biomedical Research Centre, London and Surrey, United Kingdom

Stephan Stilgenbauer

Department of Internal Medicine III, Ulm University, Ulm, Germany

See more of: Education Program