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Description:
Phospholipids are asymmetrically distributed between the outer and inner leaflets of the plasma membrane. The disruption of such asymmetrical distribution in various processes is epitomized by the exposure of phosphatidylserine (PS), the predominant anionic lipid, on the surface of activated platelets for facilitating coagulation or the surface of apoptotic cells for inducing phagocytosis. This session will describe recent exciting advances in the identification and characterization of novel families of phospholipid scramblases and flippases that mediate PS exposure.
Dr. Shigekazu Nagata will describe the identification of two families of membrane proteins (TMEM16 and XKR families) that promote phospholipid scrambling, and discuss the role of ATP11C, a member of the P4-type ATPases, as a major flippase in the plasma membrane.
Dr. Gary Gilbert will describe a strain-dependent lethality in TMEM16F-deficient mice, as well as the graded deficiency in PS exposure in the surviving mice.
Dr. Johan Heemskerk will discuss how platelets regulate and support thrombin generation, fibrin formation and clot contraction. He will also discuss the complex platelet phenotype presented in Scott syndrome patients and mice deficient in TMEM16 proteins.