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Description:
Advances in modern genomic technologies have led not only to a better description of the spectrum of molecular lesions in myeloid neoplasms, but also to a definition of clonal architecture, including its complex hierarchy, dynamics and subclonal diversity. Clonal processes within stem and progenitor cell compartments, while characteristic of leukemic outgrowth, can be also detected in bone marrow failure and during aging.
Dr. Busque’s presentation will focus on clonal events occurring during normal aging and premalignant hematopoiesis and clues to their potential implications for the understanding of molecular pathogenesis of leukemia and molecular diagnostics.
Dr. Majeti will present recent concepts and methods for investigations of clonal evolution of leukemic and pre-leukemic progenitor and stem cells in myeloid neoplasms.
Dr. Niemeyer’s talk will address aspects of clonality, clonal diversity and germ line lesions serving as ancestral events in the context of pediatric myeloid neoplasia and preleukemia.