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3782 Leukapheresis Reduces 4-Week Mortality in Leukemia Patient with Hyperleukocytosis-a Retrospective Study from a Tertiary Center

Acute Myeloid Leukemia: Commercially available Therapy, excluding Transplantation
Program: Oral and Poster Abstracts
Session: 615. Acute Myeloid Leukemia: Commercially available Therapy, excluding Transplantation: Poster III
Monday, December 7, 2015, 6:00 PM-8:00 PM
Hall A, Level 2 (Orange County Convention Center)

Nan Xinyu1*, Srivastava Pallavi1*, Mamta Puppala, MSc2*, Sai Ravi Pingali, MD,1*, Ibrahim Ibrahim1*, Lawrence Rice, MD3, Alexandria T. Phan, MD4 and Swaminathan Padmanabhan Iyer, MD5

1Houston Methodist Cancer Center, Weill Cornell Medical College, Houston
2Houston Methodist Research Institute, Weill Cornell Medical College, Houston
3Department of Medicine, Houston Methodist Hospital, Weill Cornell Medical College, Houston, TX
4Houston Methodist Cancer Center, Houston, TX
5Hematology, Early Drug Development, Houston Methodist Cancer Center/Weill Cornell Medical College, Houston, TX

Background: Hyperleukocytosis is complication of leukemia and is defined as peripheral white blood cell (WBC) count greater than 100, 000/mm^3. The high WBC count can increase blood viscosity and lead to leukostatsis, which is a medical emergency most commonly seen in acute leukemias. The use of Leukapheresis, is controversial and there are few guidelines. We performed a retrospective review of outcomes in patients with hyperleukocytosis who received leukapheresis in Houston Methodist Hospital between 2006 and 2015.

Methods: The patient data was queried from METEOR (Methodist Environment for Translational Enhancement and Outcomes Research), a clinical data warehouse and analytics environment that integrates existing business data warehouse with internal and external research databases and national registries to support clinical research and outcome studies for improving patient care cost-effectively. METEOR data warehouse contains records dating back to January 1, 2006 with over 1 million unique patients and over 4 million unique patient encounters. We queried for the diagnosis of leukemia and those that received at least one course of leukapheresis and also obtained baseline demographics, and overall outcomes.

Results: We reviewed 5585 of whom 42 patients who meet the criteria-patients, 29 of them have diagnosis of AML, 6 with CLL, 4 with ALL, and 3 with CML. The baseline demographics included 29 males and 13 females, whose median age was 52.5; 19 were Caucasians while 10 were African Americans, 5 Hispanic, 5 Asian and 3 reportedly as others.

As shown in Table 1, the population is divided into 3 groups according to WBC before leukapheresis. Group 1 has 7 patients with WBC <100,000, median of 80.460.  Group 2 has 17 patients with WBC range from 100,000 to 200,000, median of 150,740.  Group 3 has 18 patients with WBC above 200,000, median of 252,200.  

In group 1, the average leukostatsis symptom grade is 1.43, average % decrease of WBC is 34.54%, ( blast-84%). In group 2, the average leukostatsis symptom grade is 1.88, average % decrease of WBC is 48.25%, ( blast- 69%). In group 3, the average leukostatsis symptom grade is 1.06, average % decrease of WBC is 42.81%, (blast-59.5%).

In terms of complications, in group 1, 42.86% presented with acute kidney injury (AKI), 28.57% with tumor lysis syndrome, 28.57% with disseminated intravascular coagulation (DIC), 28.57% with sepsis, 14.29% with pneumonia, 42.86% with respiratory failure, 14.29% and with acute coronary syndrome (ACS). In group 2, 17.65% presented with AKI, 47.06% with TLS, 47.06 % with DIC, 23.53% with sepsis, 11.76% with pneumonia, 41.18% with respiratory failure, and 5.88% with acute coronary syndrome. In group 3 11.10 % presented with acute kidney injury, 44.44% with TLS, 38.89 % with DIC, 22.22% with sepsis, 11.11% with pneumonia, 27.78 % with respiratory failure, and 5.56 % with ACS. The 4 weeks mortality rate are 42.86% for group 1, 29.41% for group 2, and 22.22% for group 3.

Conclusions: We have validated the Hyperleukocytosis grading schema and usefulness of leukapheresis. Our data indicates comparable mortality in pts with WBC between 100 -200,000 and > 200,000. Further statistical review of this data set will be presented at the ASH Meeting, Orlando 2015

 

Table 1

 

Group 1

Group 2

Group 3

WBC range

<100,000

100,000 to 200,000

>200,000

Number of patients

7

17

18

Average leukostasis symptom grade

1.43

1.88

1.06

% Lymphoid leukemia

14.29%

17.65%

33.33%

Median WBC before leukapheresis

80,460

150,740

252,200

Average % decrease of WBC

34.54%

48.25%

42.81%

Median % of blast before leukapheresis

84%

69%

59.5%

Average % change in %blast

5.35%

11.23%

-6.55%

Average Creatinine after Leukapheresis

2.39

1.47

1.38

Average uric acid after leukapheresis

8.77

6.52

6.75

Average Fibrinogen after leukapheresis

424.25

336.78

300.56

% Acute kidney injury

42.86%

17.65%

11.10%

% Tumor lysis syndrome

28.57%

47.06%

44.44%

% DIC

28.57%

47.06%

38.89%

% Sepsis

28.57%

23.53%

22.22%

% Pneumonia

14.29%

11.76%

11.11%

% Respiratory failure

42.86%

41.18%

27.78%

% Acute Coronary Syndrome

14.29%

5.88%

5.56%

% 4 weeks Mortality

42.86%

29.41%

22.22%

References:

1. Novotny JR, Müller-Beissenhirtz H, Herget-Rosenthal S, Kribben A, Dührsen U. Grading of symptoms in hyperleukocytic leukaemia: a clinical model for the role of different blast types and promyelocytes in the development of leukostatsis syndrome. Eur J Haematol 2005:74:501-510

Disclosures: No relevant conflicts of interest to declare.

*signifies non-member of ASH