Program: Oral and Poster Abstracts
Session: 653. Myeloma: Therapy, excluding Transplantation: Poster I
METHODS: This was a retrospective study evaluating 35 patients with NXG and coexisting MG from 1994-2015 who were evaluated in the Hematology Outpatient Clinic at the Mayo Clinic, Rochester. All patients had a biopsy proven diagnosis of NXG with the concurrent presence of a serum monoclonal gammopathy.
RESULTS: The median age at diagnosis was 56 years (range: 26-88). Most patients had a plasma cell dyscrasia (28 MGUS; 5 Smoldering myeloma) while 2 had chronic lymphocytic leukemia. The most common monoclonal (M) protein was IgG kappa (60%). The median M-spike was 1.1 g/dL (range: 0–3). The most common site of NXG was periocular (66%). All patients received treatment, with over half requiring >3 different lines of treatment. The treatments were heterogeneous and included excision, intra-lesional injection, radiotherapy as well as systemic treatment. The types of systemic treatment used and clinical response are reported in Table 1. The median follow up was 46 months (range: 4–234) and the median survival was not reached but at the time of analysis 80% were still alive. At last follow-up, 80% of patients had signs of either clinical improvement or stable skin disease. Eight patients (23%) had disease progression to multiple myeloma at a median of 67 months (Range: 21 – 107).
CONCLUSIONS: We report the clinical findings and treatment outcomes of one of the largest series of patients with NXG associated with MG. The clinical course is generally indolent but malignant transformation is not uncommon. Cutaneous objective responses can be achieved with various systemic agents used in the treatment of lymphoproliferative malignancies.
Table 1. Treatment Types and Clinical Response Rates
Treatment |
No of patientsA |
Clinical Benefit Rate B |
Response rateC |
Chemotherapy - Chlorambucil +/- Steroids - Melphalan/Steroids - Cytoxan/Steroids - Cladribine - Vincristine/doxorubicin/dexamethasone - High dose therapy with stem cell rescue - Fludarabine/cyclophosphamide/rituximab |
5 3 4 3 2 3 1 |
2/5 (40%) 0/3 (0%) 1/4 (25%) 1/3 (33%) 1/2 (50%) 2/3 (67%) 1/1 (100%) |
1/5 (20%) 0/3 (0%) 0/4 (0%) 1/3 (33%) 0/2 (0%) 2/3 (67%) 1/1 (100%) |
Novel agents - Thalidomide +/- Steroids - Lenalidomide +/- Steroids - Bortezomib +/- Steroids - Bortezomib/Lenalidomide/Dexamethasone |
11 14 4 1 |
5/11 (45%) 10/14 (71%) 2/4 (50%) 1/1 (100%) |
4/11 (36%) 7/14 (50%) 1/4 (25%) 1/1 (100%) |
Intravenous immunoglobulin |
4 |
3/4 (75%) |
2/4 (50%) |
Systemic steroids alone |
11 |
4/11 (36%) |
4/11 (36%) |
Rituximab |
6 |
2/6 (33%) |
1/6 (17%) |
AntibioticsD |
3 |
0/3 (0%) |
0/3 (0%) |
ImmunosuppressantsE |
6 |
1/6 (17%) |
0/6 (0%) |
A No of patients who underwent a particular therapy amongst the 35 patients in the study cohort.
B Clinical Benefit: Improvement or stable skin disease
C Response: Improvement in skin disease
DAntibiotics: Fluoroquinolones, Tetracycline
EImmunosuppressants: Cyclosporine, Methotrexate, Plaquenil
Disclosures: Kumar: Celgene, Millennium, Onyx, Novartis, Janssen, Sanofi: Research Funding ; Celgene, Millennium, Onyx, Janssen, Noxxon, Sanofi, BMS, Skyline: Consultancy ; Skyline, Noxxon: Honoraria .
See more of: Myeloma: Therapy, excluding Transplantation
See more of: Oral and Poster Abstracts
*signifies non-member of ASH