denotes an abstract that is clinically relevant.
denotes that this is a recommended PHD Trainee Session.
denotes that this is a ticketed session.
Program: Special Scientific Symposia
Session: Overcoming the Barrier of TP53 Dysfunction to Cure Blood Cancers
Session: Overcoming the Barrier of TP53 Dysfunction to Cure Blood Cancers
Sunday, December 6, 2015, 7:30 AM-9:00 AM
Hall E1, Level 2
(Orange County Convention Center)
Biology of Tp53 loss and mutations
Guillermina Lozano, Ph.D.
The University of Texas MD Anderson Cancer Center
The p53 tumor suppressor is a potent transcription factor that activates numerous genes that determine a cell's response (be it apoptosis, cell cycle arrest or senescence) to stress or DNA damage. As such it is the most oft altered tumor suppressor in human cancers with missense mutations accounting for approximately 70% of alterations. Mutant p53 proteins have gain-of-function activates that contribute to more aggressive tumors with increased metastatic properties. Mechanisms by which mutant p53 exerts its gain of function will be discussed.
Disclosures: No relevant conflicts of interest to declare.
See more of: Overcoming the Barrier of TP53 Dysfunction to Cure Blood Cancers
See more of: Special Scientific Symposia
See more of: Special Scientific Symposia