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-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant

201. Granulocytes, Monocytes and Macrophages: Poster II

Program: Oral and Poster Abstracts
Type: Poster
Sunday, December 11, 2011: 6:00 PM-8:00 PM
Hall GH (San Diego Convention Center)
TLR-Signaling Induces Granulocytic MDSCs Generation by Directing Myeloid Lineage Commitment During Polymicrobial Sepsis

Yaxian Kong*, Weimei Zhang*, Wei Liu*, Peng Miao* and Hui Zeng*

Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

Surface HLA-DR Expression in Monocyte Subpopulations During Adverse Events After Hematopoietic Stem Cell Transplantation

Michaela Döring, MD1*, Susanne Haufe, MS1*, Annika Erbacher, MD1*, Ingo Müller, MD, PhD2*, Rupert Handgretinger, MD, PhD1, Michael Hofbeck, MD, PhD3* and Gunter Kerst, MD, PhD3*

1Department of General Pediatrics, Hematology and Oncology, University Children`s Hospital, Tübingen, Germany
2Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
3Pediatric Cardiology, University Children's Hospital, Tübingen, Germany

Contribution of Decreased Migration of Monocytes to Impaired Inflammation in Gaucher Disease 

Tamar Katz, Ph.D1*, Noam Bettman, MSc.2*, Hanna Rosenbaum, MD1 and Irit Avivi, MD1*

1Hematology and Bone Marrow Transplantation, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
2Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

Processing of α-Defensin in Subcellular Fractionations of Promyelocytic Cell Line PLB-985

Andreas Glenthøj*, Jack B Cowland and Niels Borregaard

The Granulocyte Research Laboratory, Department of Hematology, State University Hospital, Rigshospitalet, Copenhagen, Denmark

Leukocyte Integrin Activation and Alterations in Parathyroid Hormone Levels Following G-CSF Administration

Robert E. Donahue1, Laura Tuschong2*, Thomas R. Bauer2, Dennis D. Hickstein2*, Yu Ying Yau3* and Susan F. Leitman3

1Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Rockville, MD
2Experimental Transplantation and Immunology Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD
3Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, MD

mRNA and Protein Expression Levels of Secretory Leukocyte Protease Inhibitor (SLPI) Are Severely Reduced in Patients with Severe Congenital Neutropenia (CN)

Wienke Ellerbeck1*, Olga Klimenkova2*, Julia Skokowa, MD, PhD2* and Karl Welte, MD2

1Molecular Hematopoiesis, Hannover Medical School, Hannover
2Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany

Gaucher  Disease  and  Multiple  Myeloma: A Diagnostic  and  Treatment  Challenge

Hanna Rosenbaum, MD1, Irit Avivi, MD1*, Eliezer A. Rachmilewitz2 and Paulina Petchenko, MD2*

1Hematology and Bone Marrow Transplantation, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
2Department of Hematology, The Edith Wolfson Medical Center, Holon, Israel

Lipopolysaccharide(LPS)-Induction of the HTLV-1 LTR in Monocytes

Junichi Tsukada1, Takehiro Higashi1*, Atsushi Iwashige1*, Takefumi Katsuragi1*, Naho Nomura1*, Takahiro Yamaguchi1*, Tsukasa Nakanishi1*, Noriaki Kitamura1*, Ai Kawahara1*, Yasuhiro Yoshida2* and Hiroaki Morimoto1*

1Cancer Chemotherapy Center and Hematology, University of Occupational and Environmental Health, Kitakyushu, Japan
2Immunology and Parasitology, University of Occupational and Environmental Health

A Serologic and Molecular Study of the HNA-3 System-Associated Neonatal NeutropeniaClinically Relevant Abstract

Larissa Barbosa Lopes1*, Samira Ali Abbas2*, Wilson Baleotti Jr.3*, Rodrigo Buzinaro Suzuki3*, Akemi Kuroda Chiba, MSc4*, Dante Mario Langhi Jr.5*, Carlos Chiattone6* and Jose Orlando Bordin, MD7

1Universidade Federal de São Paulo, Marília, Brazil
2Universidade Federal de São Paulo, São Paulo, Brazil
3Hemocentro da Faculdade de Medicina de Marília, Marília, Brazil
4Hematology and Hemotherapy, Universidade Federal de São Paulo, São Paulo, Brazil
5Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil
63Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil
7Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo, Sao Paulo, Brazil

Cellular and Biochemical Properties of Cell-Free DNA: A Prognostic Marker In Severe Sepsis Patients

Travis J Gould1*, Dhruva Dwivedi2*, Laura Pepler2*, Laura Swystun, BSc3*, Zakhar Lysov, BSc3* and Patricia Liaw, PhD4

1Department of Medical Science, McMaster University, Hamilton, ON, Canada
2McMaster University, Hamilton, ON, Canada
3Medical Sciences, McMaster University & David Braley Cardiac Vascular and Stroke Research Institute, Hamilton, ON, Canada
4Medicine, McMaster University & David Braley Cardiac, Vascular, and Stroke Research Institute, Hamilton, ON, Canada

G6PC3 Deficiency Associated with Congenital Neutropenia and Enterocolitis

Jana Diestelhorst1,2*, Daniel Kotlarz1,2*, Giridharan Appaswamy, PhD1*, Rita Beier, MD1*, Peter M Krawitz, MD, PhD3,4,5*, Peter N Robinson, MD, PhD3,4,5*, Jochen Hecht, PhD3,5*, Jacek Puchalka, PhD2*, Alejandro A. Schäffer, PhD6*, Dietmar Pfeifer, PhD7*, Ulrich Baumann, MD8*, Eva-Doreen Pfister, MD8*, Gudrun Brandes, PhD9*, Gabriella Palla, MD10*, Roland Jacobs, PhD11*, Hans H. Kreipe, MD12*, Stefan Mundlos, MD3,4,5* and Christoph Klein, MD, PhD1,2

1Department of Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany
2Department of Pediatrics, Dr. von Hauner Kinderspital, Ludwig Maximilian University, Munich, Germany
3Max Planck Institute for Molecular Genetics, Berlin, Germany
4Institut für Medizinische Genetik und Humangenetik, Charité Universitätsmedizin Berlin, Berlin, Germany
5Berlin-Brandenburg Center for Regenerative Therapies, Charité Universitätsmedizin Berlin, Berlin, Germany
6National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD
7Department of Hematology and Oncology, Genomics Core Lab, University of Freiburg Medical Center, Freiburg, Germany
8Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
9Institute for Cellular Biology in the Centre for Anatomy, Hannover Medical School, Hannover, Germany
10Department of Gastroenterology and Hepatology, University of Pisa, Pisa, Italy
11Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
12Institute of Pathology, Hannover Medical School, Hannover, Germany

Monocytic CCR2+ Myeloid Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T Cell Infiltration Into the Tumor Microenvironment

Alexander Lesokhin, MD1, Tobias Hohl, MD, PhD2*, Taha Merghoub, PhD3*, Daniel Hirschhorn-cymerman, PhD3*, Eric G. Pamer, MD1*, Alan N Houghton, MD3* and Jedd D Wolchok, MD, PhD1*

1Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA
3Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY

*signifies non-member of ASH