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504.O1.6 504. Hematopoiesis - Cytokines, Signal Transduction, Apoptosis and Cell Cycle Regulation: Growth and Survival Signaling in Normal and Leukemic Hematopoietic Cells

Program: Oral and Poster Abstracts
Type: Oral
Monday, December 12, 2011: 10:30 AM-12:00 PM
Room 24 (San Diego Convention Center)
Moderators:
Seth J. Corey, MD, Children's Memorial Hospital and Reuben Kapur, PhD, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research

Disclosures:
No relevant conflicts of interest to declare.
10:30 AM
Mtor Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

Demetrios Kalaitzidis, PhD1*, Stephen M. Sykes2, Natalie Punt3*, Yuefeng Tang, PhD4*, Steven W. Lane5*, Clary Clish, PhD6*, D. Gary Gilliland, MD, PhD7, David T. Scadden, MD8, David Guertin, PhD9* and Scott A. Armstrong, MD, PhD10

1Children's Hospital of Boston, Boston
2Massachusetts General Hospital Center for Regenerative Medicine, Department of Stem Cell and Regenerative Biology at Harvard University and The Harvard Stem Cell Institute, Boston, MA
3Division of Hematology/Oncology, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA
4University of Massachusetts Medical School, Worcester, MA
5Queensland Institute of Medical Research, Brisbane, Australia
6The Broad Institute of MIT and Harvard, Boston, MA
7Merck Research Laboratories, Boston, MA
8Massachusetts General Hospital Center for Regenerative Medicine and Cancer Center, Department of Stem Cell and Regenerative Biology at Harvard University and The Harvard Stem Cell Institute, Boston, MA
9University of Massachusetts Medical School, Worcester
10Pediatric Hematology Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Boston, MA

10:45 AM
Non-Lineage/Stage Restricted Effects of a Gain-of-Function Mutation in Tyrosine Phosphatase Ptpn11 (Shp2) on Malignant Transformation of Hematopoietic Cells

Dan Xu1*, Xia Liu1*, Wen-Mei Yu1*, Howard J. Meyerson2*, Stanton L. Gerson, MD1 and Cheng-Kui Qu1

1Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH
2Pathology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH

11:00 AM
TNF-α/Fas-RIP-1-Induced Cell Death Signaling Separates Hematopoietic Stem Cells/Progenitors Into Two Distinct Populations

Yechen Xiao1*, Andrew Volk2*, Shubin Zhang1*, Wei Wei1*, Peter Breslin3* and Jiwang Zhang4*

1Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL
2Cancer center, Oncology institute, Maywood, IL
3Oncology institute, Cardinal Bernardin Cancer Center and Department of Biology, Loyola University, Maywood, IL
4Oncology Institute, Cardinal Bernardin Cancer Center and Pathology Department, Loyola University Medical Center, Maywood, IL

11:15 AM
Impaired Reconstitution Potential of TGFβ-Hypersensitive Human Hematopoietic Stem Cells

Emma Rörby1*, Matilda Nifelt Hägerström1*, Ulrika Blank1*, Göran Karlsson, Ph.D.2* and Stefan Karlsson, M.D., Ph.D., Prof.1

1Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden
2UCL Cancer Institute, Stem Cell Laboratory, London, United Kingdom

11:30 AM
Icsbp/Irf8 Cooperates with Tel to Regulate Fas Induced Apoptosis in Myeloid Leukemia. 

Weiqi Huang, PhD1* and Elizabeth A. Eklund, MD2

1Medicine, Feinberg School, Northwestern University, Chicago, IL
2Northwestern University Feinberg School of Medicine and Jesse Brown VA Medical Center, Chicago, IL

11:45 AM
The PP2A Subunit B55α Suppresses Survival Signaling in Acute Myeloid Leukemia Cells

Peter P. Ruvolo, PhD1, Vivian Ruvolo2*, Zhihong Zeng3*, YiHua Qui, MD4*, Liran Zhou, PhD5*, Kelly E Gallagher6*, Marina Konopleva, M.D., Ph.D.7, Steven M. Kornblau, MD8 and Michael Andreeff, M.D., Ph.D.9

1Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Section of Molecular Hematology and Therapy, Department of Leukemia, MD Anderson Cancer Center, Houston, TX
3Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX
4Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
5Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
6Leukemia, MD Anderson Cancer Center
7mdacc, Houston, TX
8Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
9Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

*signifies non-member of ASH