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651.O1.6 Myeloma - Biology and Pathophysiology, excluding Therapy I

Program: Oral and Poster Abstracts
Type: Oral
Sunday, December 5, 2010: 4:30 PM-6:00 PM
414 AB (Orange County Convention Center)
Moderators:
Noopur Raje, MD, Massachusetts General Hospital and Shmuel Yaccoby, PhD, University of Arkansas for Medical Sciences
4:30 PM
Myeloma Cell Self-Renewal Depends on JAG2 Expression and Is Mediated by IGF1 or SCF Loop

David Chiron, PhD, in, training1*, Sophie Maiga1*, Géraldine Descamps1*, Severine Marionneau1*, Thilbaud Ouiller1*, Jerome Moreaux, PhD2*, Bernard Klein, PhD, MD3*, Philippe Moreau4*, Jean-Luc Harousseau5, Regis Bataille, MD, PhD6*, Martine Amiot1* and Catherine Pellat-Deceunynck, PhD7

1Nantes Angers Cancer Center, Inserm UMR_S892, Nantes, France
2Inserm U847, Inserm U847, Montpellier, France
3INSERM U847, CHU Montpellier, University of Montpellier1, Montpellier, France
4Hematology Department, CHU de Nantes, Nantes, France
5Haematology, Centre anticancereux Rene Gauducheau, Saint Herblain, France
6Cancer Center, Angers, France
7CRCNA, INSERM UMR_S892, Nantes, France

4:45 PM
The ZZ Domain of Sequestosome-1/p62 Plays An Important Role In Stromal Cell Support of Myeloma Cell Growth and Osteoclast Formation

Jumpei Teramachi, DDS, PhD1*, Jolene J. Windle, PhD2*, David Roodman, MD, PhD3 and Noriyoshi Kurihara, DDS, PhD1

1Medicine/Hematology-Oncology, University of Pittsburgh and The Center for Bone Biology at UPMC, Pittsburgh, PA
2Human Genetics, Virginia Commonwealth University, Richmond, VA
3Medicine/Hematology-Oncology, University of Pittsburgh, The Center for Bone Biology at UPMC, and VA Pittsburgh Healthcare System, Pittsburgh, PA

5:00 PM
  Involvement of Ets Factor Spi-B and Id2 In Waldenström’s Macroglobulinemia

Yangsheng Zhou, MD1*, Xia Liu, MD1*, Lian Xu1*, Zachary Hunter2*, Jenny Sun, MD1*, Guang Yang, MD1*, Bryan Ciccarelli3*, Christopher Patterson1* and Steven P Treon, MD, PhD3

1Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA
2Bing Center for Waldenstroms macroglobulinemia, Dana-Farber Cancer Institute, Boston MA, Boston, MA
3Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

5:15 PM
Annexin II Interactions with the Annexin II Receptor Enhance Multiple Myeloma Cell Adhesion and Growth In the Bone Marrow Microenvironment

Sonia D'Souza, PhD1*, Noriyoshi Kurihara, DDS, PhD2, Yusuke Shiozawa, MD, PhD3, Russell Taichman, MD3, Deborah Galson, PhD1* and David Roodman1

1Medicine/Hematology-Oncology, University of Pittsburgh, Bone Biology Center of UPMC, and VA Pittsburgh Healthcare System, Pittsburgh, PA
2Medicine/Hematology-Oncology, University of Pittsburgh and The Center for Bone Biology at UPMC, Pittsburgh, PA
3Periodontics & Oral Medicine, University of Michigan, Ann Arbor, MI

5:30 PM
In Vitro and In Vivo Evidences of Osteocyte Involvement In Myeloma-Induced Osteolysis

Nicola Giuliani, MD, PhD1, Paola Storti, PhD1*, Manuela Abeltino2*, Marina Bolzoni1*, Marzia Ferretti3*, Mirca Lazzaretti, PhD4*, Benedetta Dalla Palma1*, Katia Todoerti5*, Eugenia Martella, MD6*, Luca Agnelli7*, Antonino Neri, MD8*, Vittorio Rizzoli, MD, PhD1 and Carla Palumbo3*

1Internal Medicine, Hematology and BMT, University of Parma, Parma, Italy
2Clinical Sciences, University of Parma, Parma, Italy
3Anatomy, University of Modena, Modena, Italy
4Genetica, Biologia dei Microrganismi, Antropologia, Evoluzione, University of Parma, Italy
5Dept Medical Sciences, Hematology 1 CTMO, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
6Pathology, University of Parma, Parma, Italy
7Department of Medical Sciences, Fondazione IRCCS Policlinico, Milano, Italy
8Dipartimento Scienze Mediche, Ematologia 1 CTMO, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Universitŕ di Milano, Milano, Italy

5:45 PM
Targeting the CD28-B7 Pro-Survival Pathway In Multiple Myeloma

Jayakumar R Nair, Ph.D.1*, Louise Carlson1*, Cheryl H Rozanski, BS1*, Chandana Koorella1*, Megan Murray1*, John D Shaughnessy Jr., PhD2, P.Leif Bergsagel, MD3, Lawrence H. Boise, PhD4, Asher A. Chanan-Khan5* and Kelvin P Lee, MD1

1Immunology, Roswell Park Cancer Institute, Buffalo, NY
2Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR
3Hem/Onc, Mayo Clinic Arizona, Scottsdale, AZ
4Hematology & Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
5Roswell Park Cancer Institute, Buffalo, NY

*signifies non-member of ASH