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401.P1.44 Basic Science and Clinical Practice in Blood Transfusion: Poster I

Program: Oral and Poster Abstracts
Type: Poster
Saturday, December 4, 2010: 5:30 PM-7:30 PM
Hall A3/A4 (Orange County Convention Center)
Peripheral Blood Stem Cell (PBSC) Donors Experience Higher Levels of Pain and Toxicities Early On, While Bone Marrow (BM) Donors Experience Slower Recovery and More Late Pain: A Prospective Study of the National Marrow Donor Program (NMDP)Clinically Relevant Abstract

Michael A. Pulsipher, MD1, Pintip Chitphakdithai, PhD2*, Brent R. Logan, PhD3*, Steven C. Goldstein, MD4, John E. Levine, M.D., M.S.5, Michael Lankiewicz, MD6, David Stroncek, MD7 and Dennis L. Confer, MD8*

1University of Utah, Salt Lake City, UT
2Center for International Blood and Marrow Transplant Research, Minneapolis, MN
3Medical College of Wisconsin, Milwaukee, WI
4University of Pennsylvania, Philadelphia, PA
5University of Michigan, Ann Arbor, MI
6BloodCenter of WI, Milwaukee, WI
7Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD
8National Marrow Donor Program, Minneapolis, MN

Poster Board Number: I-87
Transfusion Requirements and Outcomes In the Cohort of Patients Undergoing Isolated CABG Treated with Prasugrel or Clopidogrel: TRITON-TIMI 38 Data AnalysisClinically Relevant Abstract

Lawrence T Goodnough1, George Despotis2*, Peter K Smith3*, Jerrold H Levy, MD4, Robert Poston5*, Mary Short6*, Govinda Weerakkody6* and LeRoy Lenarz6*

1Pathology and Medicine, Stanford University Medical Center, Stanford, CA
2Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO
3Duke University Medical Center, Durham, NC
4Emory University Hospital, Atlanta, GA
5Boston University, Boston, MA
6Lilly USA, LLC, Indianapolis, IN

Poster Board Number: I-88
HLA Alloantibody Persistence and De Novo Production of HLA Alloantibodies of Donor Origin Following Reduced Intensity Allogeneic Hematopoietic Stem Cell TransplantationClinically Relevant Abstract

Ross M Fasano, MD1*, Sharon Adams2*, Aleah Smith3*, Theresa Donohue, MS, PA-C3*, Charles D. Bolan Jr., MD4, Kyoko Sugimoto, MD, PhD3*, Willy A. Flegel, MD2 and Richard Childs, MD3

1Hematology/Oncology, Children's National Medical Center, Washington DC, DC
2Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD
3National Heart, Lung, and Blood Institute, Hematology Branch, National Institutes of Health, Bethesda, MD
4Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

Poster Board Number: I-89
Iron Deficiency without Anemia In Premenopausal Blood Donors Is Associated with Future Deferral From Whole Blood DonationClinically Relevant Abstract

Sant-Rayn S Pasricha, MBBS, MPH1*, Zoe McQuilten, MBBS, FRACP, FRCPA1*, Mark Westerman, PhD2*, Anthony Keller3*, Elizabeta Nemeth, PhD4, Tomas Ganz, MD, PhD5 and Erica M Wood, MBBS6

1Transfusion Medicine Services, Australian Red Cross Blood Service, Melbourne, Australia
2Intrinsic LifeSciences, LLC, La Jolla, CA
3Australian Red Cross Blood Service, Osborne Park, Australia
4Medicine, UCLA, Los Angeles, CA
5School of Medicine, University of California Los Angeles, Los Angeles, CA
6Australian Red Cross Blood Service, Melbourne, VIC, Australia

Poster Board Number: I-90
Novel Kelnull Allele Detected In a Brazilian Woman with the Kell Null Phenotype

Edmir Boturão-Neto, MD, PhD1*, Mihoko Yamamoto, MD, PhD1, Akemi Kuroda Chiba, MSc1*, Elisa Yuriko Sugano Kimura1*, Maria do Carmo V. C. Oliveira, MSc2* and José Orlando Bordin, MD, PhD3

1Hematology and Hemotherapy, Universidade Federal de São Paulo, São Paulo, Brazil
2Hematology and Hemotherapy, Fundação de Hematologia e Hemoterapia de Pernambuco, Recife, Brazil
3Hematology and Hemotherapy, Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil

Poster Board Number: I-91
Dissimilar Respiratory and Hemodynamic Responses In TRALI Induced by Stored Red Cells and Whole Blood Platelets

John-Paul Tung1*, John F Fraser2*, Maria Nataatmadja3*, Adrian G Barnett4*, Kathryn I Colebourne5*, Kristen M Glenister6*, Anna Y Zhou6*, Peter Wood7*, Christopher C Silliman, MD/PhD8 and Yoke Lin Fung9*

1Research and Business Development, Australian Red Cross Blood Service, Brisbane, Australia
2Intensive Care Unit and Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia
3Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia
4Institute of Health and Biomedical Innovation and School of Public Health, Queensland University of Technology, Brisbane, Australia
5Medical and Quality Services, Australian Red Cross Blood Service, Brisbane, Australia
6Research and Business Development, Australian Red Cross Blood Service, Melbourne, Australia
7Hematology Department, Princess Alexandra Hospital, Brisbane, Australia
8Research Department, Bonfils Blood Center, Denver, DC
9Critical Care Research Group and Cardiac Surgery Research Group, The Prince Charles Hospital, Brisbane, Australia

Poster Board Number: I-92
SAFETY of PROTHROMBIN COMPLEX CONCENTRATES IN PATIENTS REQUIRING RAPID REVERSAL of ANTICOAGULANT TREATMENT with the VITAMIN K ANTAGONISTS :a Systematic Review and a Meta-Analysis of the LiteratureClinically Relevant Abstract

Francesco Dentali, MD1, Chiara Marchesi2*, Matteo Giorgi Pierfranceschi3*, Mark A. Crowther, MD, FRCPC4, David Garcia, MD5, Elaine M. Hylek, MD, MPH6*, Dan Witt7*, Nathan Clark7*, Alessandro Squizzato2*, Davide Imberti8* and Walter Ageno, MD2*

1Clinical Medicine, University of Insubria, Varese, Italy, Gornate Olona, Italy
2Clinical Medicine, University of Insubria, Varese, Italy
3Hospital of Piacenza, Piacenza
4St. Joseph's Hospital, Hamilton, ON, Canada
5University of New Mexico, Albuquerque, NM
6Boston Medical Center, Boston University, Boston, MA
7Kaiser permanente, Denver
8Hospital of Ferrara, Ferrara, Italy

Poster Board Number: I-93
Transfusion Requirements In Cariovascular Surgery (TRICI)Clinically Relevant Abstract

Nadine Shehata, MD, MSc1, Laura Alexandra Burns2*, Howard Nathan, MD3*, Paul Hebert, MD, MHSc4*, Gregory T Hare, MD, PhD5*, Dean Fergusson, PhD6* and C. David Mazer, MD7*

1Division of Hematology, St. Michael's Hospital, Toronto, ON, Canada
2Anesthesia, St. Michael's Hospital, Toronto, ON
3Anesthesia, University of Ottawa, Ottawa, ON, Canada
4Medicine, Surgery, Anesthesiology and Epidemiology, University of Ottawa, Ottawa, Canada
5Anesthesia, University of Toronto, Toronto, Canada
6Centre for Transfusion Research, University of Ottawa, Ottawa, Canada
7University of Toronto, Toronto, Canada

Poster Board Number: I-94
Prothrombin Complex Concentrate (Octaplex®) In Patients Requiring Immediate Reversal of Vitamin K Antagonist AnticoagulationClinically Relevant Abstract

Madeline Song*, Connor Warne, BSc* and Mark A. Crowther, MD, FRCPC

Medicine, McMaster University & St Joseph's Hospital, Hamilton, ON, Canada

Poster Board Number: I-95
Rapid One-Tube Long PCR-Sequencing for ABO Genotyping From Exons 2 to 7

Geon Park, MD, PhD1*, Sook Jin Jang1*, Dae Soo Moon1*, Young Jin Park1* and Ji Young Huh, MD, PhD2*

1Department of Laboratory Medicine, Chosun University College of Medicine, Gwangju, South Korea
2Department of Laboratory Medicine, CHA University, Seongnam, South Korea

Poster Board Number: I-96
Molecular Basis of the Rare Gene Complex, D(C)-, Which Encodes Four Low Prevalence Antigens In the Rh Blood Group System

Christine Halter Hipsky1*, Christine Lomas-Francis, M.Sc., FIBMS2*, Kim Hue-Roye1*, Cheng-Han Huang, MD, PhD3 and Marion Reid, Ph.D., FIBMS1*

1Laboratory of Immunochemistry, New York Blood Center, New York, NY
2Laboratory of Immunohematology, New York Blood Center, Long Island City, NY
3The Lindsley F. Kimball Rsch. Inst. Biochem. Molecular Genetics, New York Blood Center, New York, NY

Poster Board Number: I-97
Influence of Prophylactic Platelet Transfusions on the Recovery of Bone Marrow Function After Intensive Chemotherapy for Acute Myeloid LeukemiaClinically Relevant Abstract

Roland MH Kivit1*, Peter Joosten2*, Mels Hoogendoorn2* and Joost TM De Wolf3

1Sanquin Blood Bank North East, Groningen, Netherlands
2Internal Medicine/Hematology, Medical Center Leeuwarden (MCL), Leeuwarden, Netherlands
3Hematology, University Medical Center Groningen (UMCG), Groningen, Netherlands

Poster Board Number: I-98
Thrombin Activation of Protease-Activated Receptor-2 on Neutrophils Primes the Respiratory Burst

Ashley Bock, BS1*, Marguerite Kelher, MS1*, Samina Khan, BS1*, Kirk Hansen, PhD2*, Monika Dzieciatkowska2* and Christopher C Silliman, MD/PhD1

1Research Department Bonfils Blood Center, School of Medicine University of Colorado Denver, Denver, CO
2Pediatrics, School of Medicine University of Colorado Denver, Aurora, CO

Poster Board Number: I-99
BeadChip -Human Erythrocyte Antigen Determination for Leukoreduced Blood

Xin Lin*, Ermelina Enriquez*, Dipika B. Patel*, Jigar Patel*, Yuhua Song*, Yi Zhang* and Ghazala Hashmi*

Bioarray Solution, An Immucor Company, Warren, NJ

Poster Board Number: I-100
Is Transfusion of Rh Positive Red Blood Cells to ccDee Patients From a Cosmopolitan Population Safe?Clinically Relevant Abstract

Marie-Helene Vandeput, PharmD.*, Dominique Latinne, MD., PhD.*, Thibaut Gervais* and Stephane L Eeckhoudt, Pharm, D., PhD.*

Haematology Div., Cliniques universitaires Saint Luc, Brussels, Belgium

Poster Board Number: I-101
Comparison of RH Genotypes In Rh Alloimmunized and Non-Alloimmunized Patients with Sickle Cell Disease

Stella T Chou, MD1, David Friedman, MD1*, Tannoa Jackson2*, Kim Smith-Whitley, MD1 and Connie M Westhoff3

1Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA
2Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA
3New York Blood Center, New York City, NY

Poster Board Number: I-102
Expression of P-Selectin and Platelet-Neutrophil (PMN) Interactions In Untreated and Mirasol® PRT Treated Platelet Concentrates During Routine Storage

Daniel R Ambruso, MD1, Raymond P. Goodrich, PhD2* and Susanne Marschner, PhD2*

1Bonfils Blood Center, Denver, CO
2CaridianBCT Biotechnologies, Lakewood, CO

Poster Board Number: I-103
Combinatorial Antimicrobicidal Peptides Exhibit Enhanced Activity Against Bacterial Contaminants In Stored Platelet Concentrates (PCs)

Krishna Mohan V. Ketha, PhD1, Shilpakala Sainath Rao, PhD2 and Chintamani D Atreya, PhD1*

1Lab of Cellular Hematology, CBER (Food and Drug Administration), Bethesda, MD
2Division of Hematology, CBER/FDA, Bethesda, MD

Poster Board Number: I-104
A Multi-Center, Open Label Study Evaluating the Efficacy of Iron Chelation Therapy with Deferasirox In Transfusional Iron Overload Patients with Myelodysplastic Syndromes or Aplastic Anemia Using Quantitative R2 mriClinically Relevant Abstract

Yoo-Hong Min1, Hyeoung Joon Kim2, Kyoo-Hyung Lee3*, Jae Hoon Lee, MD4, Hee-Sook Park5*, Jin Seok Kim6*, Hyeok Shim, MD7*, Chu-Myung Seung8*, Chul Soo Kim9*, Jooseop Chung, MD, PhD10, Myung Soo Hyun11*, Deog-Yeon Jo, MD, PhD12, Chul Won Jung13*, Sang Kyun Sohn14, Hwi-Joong Yoon, MD, PhD15, Byung Soo Kim16*, Young-Don Joo17* and Chi-Young Park18*

1Div. of Hem., Yonsei Univ. College of Med., Seoul, South Korea
2Genome Research Center for Hematopoietic Diseases, Chonnam National Univ. Hwasun Hospital, Hwasun, South Korea
3Department of hematology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, South Korea
4Department of Internal Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science, Incheon, South Korea
5Soonchunhyang university, Seoul, South Korea
6Department of Internal Medicine, Yonsei University Severance Hospital, Seoul, South Korea
7Internal Medicine, Wonkwang University School of Medicine, Iksan, South Korea
8Department of Internal Medicine, Ehwa University, Seoul, South Korea
9Hematology/Oncology, Inha University Hospital, Incheon, South Korea
10Hem.-Onc. Section Dept. of Internal Medicine, Pusan National Univ. Hosp., Pusan, South Korea
11Department of Internal Medicine, Yeungnam University Medical Center, Daegu
12Department of Hematology/Oncology, Chungnam National University Hospital, Daejeon, South Korea
13Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, South Korea
14Department of Internal Medicine, Kyungpook National University Hospital, Daegu, South Korea
15University Hospital, Kyung Hee, Seoul, South Korea
16Hematology, Korea University Anam Hospital, Seoul, South Korea
17Dept. of Internal Med./Hem., Inje Univ. Busan Baik-Hospital, Busan, South Korea
18Chosun university, South Korea

Poster Board Number: I-105
Effective Reduction of Blood Product Use In a Community Teaching Hospital: a Possible Interventional ModelClinically Relevant Abstract

Alex Politsmakher, MD1*, Dipanita Barua, MD1* and Harvey Dosik, MD2

1Medicine, New York Methodist Hospital, Brooklyn, NY
2New York Methodist Hospital, Brooklyn, NY

Poster Board Number: I-106

*signifies non-member of ASH