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203.O4.6 Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and Other Infections: T cell Signaling and Therapeutic Targeting

Program: Oral and Poster Abstracts
Type: Oral
Tuesday, December 7, 2010: 7:30 AM-9:00 AM
330 DEFG + Corridor (Orange County Convention Center)
Moderators:
Vassiliki A Boussiotis, MD, PhD, Beth Israel Deaconess Medical Center, Harvard Medical School and Eduardo M. Sotomayor, H. Lee Moffitt Cancer Center & Research Institute
7:30 AM
The Function of Thymic Innate TCRαß+ CD8+ T Cells Is Regulated by Constitutive Expression of B7-H1

Moutih Rafei, PhD1*, Marie-Pierre Hardy, MSc.2* and Claude Perreault, MD3

1Medicine, IRIC, University of Montreal, Montreal, QC, Canada
2Medicine, The Institute for Research in Immunology and Cancer (University of Montreal), Montreal, QC, Canada
3IRIC, Montreal, QC, Canada

7:45 AM
Rap1-GTP Augments Activation of Smad and p38 Mediated Signaling Downstream of TGF-β Receptor In T Lymphocytes

Nikolaos Patsoukis, PhD*, Lequn Li, MD, PhD and Vassiliki A Boussiotis, MD, PhD

Hematology-Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

8:00 AM
Reinforcement of Cancer Immunotherapy by Adoptive Transfer of Cblb-Deficient Cytotoxic T Lymphocytes Combined with a Dendritic Cell Vaccine

Christina Lutz-Nicoladoni1*, Patrizia Stoizner2*, Magdalena Pircher1*, Stephanie Wallner1*, Anna Maria Wolf3*, Guenther Gastl4*, Josef Penninger5*, Gottfried Baier6* and Dominik Wolf, MD7*

1Tyrolean Cancer Research Institute, Medical University Innsbruck, Innsbruck, Austria
2Department of Dermatology and Venereology, Medical University Innsbruck, Austria
3Hematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
4Department of Internal Medicine V (Hematology and Oncology), Innsbruck Medical University, Innsbruck, Austria
5Institute of Molecular Biotechnology, Austrian Academy of Science, Vienna, Austria
6Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University Innsbruck, Innsbruck, Austria
7Department of Hematology and Oncology, Innsbruck Medical University, Innsbruck, Austria

8:15 AM
A Novel Method to Expand Viral Reactive CTL From a Selectively Accessed Portion of a Cryopreserved Cord Unit to Prevent Viral Infections After Transplantation

Rebecca Lopez, PhD1*, Christa Zerbe, MD1*, Sumithira Vasu, MD2, Herb Cullis, President, Afc3* and Richard Childs, MD4

1Heart, Lung, and Blood Institute; Hematology Branch, National Institutes of Health, Bethesda, MD
2Hematology Branch, National Heart Lung and Blood Institute, Bethesda, MD
3American Fluoroseal Corporation, Gaithersburg, MD
4National Heart, Lung, and Blood Institute, Hematology Branch, National Institutes of Health, Bethesda, MD

8:30 AM
Surface Expression of PR1 Peptide on Thymic Dendritic Cells Does Not Eliminate PR1-Specific CD8+ Cells In Umbilical Cord Blood

Lisa S St. John, PhD1*, Karen Clise-Dwyer, PhD1*, Rebecca Patenia1*, Anna Sergeeva, PhD1*, Elizabeth J. Shpall, MD1, Qing Ma, PhD2* and Jeffrey J. Molldrem, MD1

1Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX
2Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX

8:45 AM
IL-15 Administration to In-Vivo Expand Adoptively Transferred NK Cells In Rhesus Macaques

Rebecca Lopez, PhD1*, Stephanie Sellers2*, Cynthia E. Dunbar, MD3 and Richard Childs, MD4

1Heart, Lung, and Blood Institute; Hematology Branch, National Institutes of Health, Bethesda, MD
2NHLBI, NIH, Bethesda, MD
3Editor-in-Chief, Blood, Washington, DC
4National Heart, Lung, and Blood Institute, Hematology Branch, National Institutes of Health, Bethesda, MD

*signifies non-member of ASH