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101.P1.53 Red Cells and Erythropoiesis, Structure and Function, Metabolism and Survival, Excluding Iron: Poster I

Program: Oral and Poster Abstracts
Type: Poster
Saturday, December 4, 2010: 5:30 PM-7:30 PM
Hall A3/A4 (Orange County Convention Center)
Release of Alkaline Phosphatase Caused by PIGV Mutations In Patients with Hyperphosphatasia-Mental Retardation Syndrome (HPMR), a Recently Found Second Inherited GPI Anchor Deficiency

Yoshiko Murakami, MD, PhD1*, Peter M Krawitz, MD, PhD2*, Peter N Robinson, MD, PhD2*, Stefan Mundlos, MD, PhD2*, Yusuke Maeda, MD, PhD1* and Taroh Kinoshita, PhD1

1Rsrch. Inst. for Microbial Diseases, Osaka University, Suita, Japan
2Institut für Medizinische Genetik, Charité - Universitätsmedizin Berlin, Berlin, Germany

Poster Board Number: I-1011
Impairment of Erythropoiesis In Inbred Cellular Prion Protein Deficient Mice

Hana Glierova, MS1*, Martin Panigaj, MS1*, Jana Semberova, MD2*, Olga Janouskova, PhD1*, Eva Dvorakova, MS1*, Jan Zivny, PhD3* and Karel Holada, PhD1

1Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
2Div. of Hematology, CBER FDA, Rockville, MD
3Institute of Pathological Physiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

Poster Board Number: I-1012
Characterization of the Hematologic Phenotype of rpS6 Heterozygous Null Mice as a Model of the Erythroid Failure In Diamond-Blackfan Anemia

Sioban B. Keel, MD1 and Janis L. Abkowitz, MD2

1Medicine, University of Washington, Seattle, WA
2University of Washington, Seattle, WA

Poster Board Number: I-1013
Two Mouse Models Illustrate Different Mechanisms of Anemia of Cancer

Airie Kim, M.D.1*, Victoria Gabayan1*, Oliver Dorigo, M.D., Ph.D.2*, Tomas Ganz, M.D., Ph.D.1 and Seth Rivera, M.D., Ph.D.1

1Medicine/ Pulmonary & Critical Care Medicine, UCLA, Los Angeles, CA
2Obstetrics & Gynecology, UCLA, Los Angeles, CA

Poster Board Number: I-1014
Metabolomic Evaluation of Normal, In Vivo, Red Cell Aging

Katrin Soldau*, Katharina von Loehneysen, PhD*, Xiuling Xu, PhD* and Jeff S. Friedman, MD, PhD

Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA

Poster Board Number: I-1015
A Novel Approach for In Vivo Measurement of Red Cell Redox Status

Xiuling Xu, PhD*, Katharina von Loehneysen, PhD*, Deborah Noack*, Andrew Vu* and Jeff S. Friedman, MD, PhD

Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA

Poster Board Number: I-1016
Comparison of Erythropoietin, GDF-15, IL-6 and Hepcidin Levels In a Large Cohort of Elderly Individuals with Anemia of Known and Unknown Etiology

Katharina von Loehneysen, PhD*, Xiuling Xu, PhD*, Pauline Lee, PhD*, Jill Waalen, MD* and Jeff S. Friedman, MD, PhD

Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA

Poster Board Number: I-1017
Sec23b deficiency In Mice Results In Pancreatic Destruction and Defective long Term Hematopoietic Stem Cell Function

Matthew Vasievich, BS1*, Bin Zhang, PhD2*, Jesse Rinehart, PhD3*, Morgan Jones, BS/MS4*, Ivan Maillard, MD, PhD5 and David Ginsburg, MD6

1Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI
2Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, OH
3Department of Cellular and Molecular Physiology and Systems Biology Institute, Yale University School of Medicine, New Haven, CT
4Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI
5Life Sciences Institute and Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan, Ann Arbor, MI
6University of Michigan Medical School and Howard Hughes Medical Institute, Ann Arbor, MI

Poster Board Number: I-1018
Vascular Endothelial Growth Factor (VEGF) Increases KCC4 Expression In Erythroid Cells Via Signaling Pathways Involving HIF-1α

Caryn S Gonsalves1* and Clinton H. Joiner, MD, PhD2

1Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
2Children's Hosp. Med. Ctr., Cincinnati, OH

Poster Board Number: I-1019
Hereditary Stomatocytosis Associated with a Loss of Function Mutation In Rh-Associated Glycoprotein (RhAG)

Connie M Westhoff, PhD1* and Seth Alper, MD, PhD2*

1Immunohematology and Genomics, New York Blood Center, New York, NY
2Renal Division and Molecular and Vascular Medicine Unit, Harvard Medical School, Boston, MA

Poster Board Number: I-1020
Usefulness of microparticles’s Release to Improve Diagnosis of Hereditary Spherocytosis: Results of a Multicentre Study

François Mullier1*, Elodie Lainey2*, Odile Fenneteau2*, Lydie M. Da Costa, MD, PhD3, Françoise Schillinger, MD4*, Nicolas Bailly5*, Yvan Cornet5*, Christian Chatelain6, Jean-Michel Dogné7* and Bernard Chatelain5

1Hematology laboratory, UCL Mont-Godinne, Namur Research Institute for LIfe Sciences (NARILIS), Yvoir, Belgium
2Service d'Hématologie Biologique, Hôpital Robert Debré, AP-HP, Paris, France
3Service of Hématologie Biologique, Hôpital R. Debré, Paris, France
4Hematology Laboratory, EFS Bourgogne Franche-Comté, Besancon, France
5Hematology Laboratory, UCL Mont-Godinne, Namur Research Institute for LIfe Sciences (NARILIS), Yvoir, Belgium
6Hematology, UCL Mont-Godinne,Namur Research Institute for LIfe Sciences (NARILIS), Mont Godinne, Belgium
7Department of Pharmacy, University of Namur, Namur Research Institute for LIfe Sciences (NARILIS), Namur, Belgium

Poster Board Number: I-1021
The Telomere Length In Peripheral Blood Lymphocytes Is a Useful Predictor of the Response to Immunosuppressive Therapy In Patients with Acquired Aplastic Anemia

Yoshiyuki Takahashi, MD, PhD1*, Sayoko Doisaki, MD1*, Nobuhiro Nishio, MD, PhD1*, Hideki Muramatsu, MD, PhD1*, Akira Shimada, MD, PhD1*, Asahito Hama, MD, PhD1* and Seiji Kojima2*

1Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
2Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Japan

Poster Board Number: I-1022
Role of BMP Signaling In the Anemia of Chronic Disease 

Andrea U. Steinbicker, MD, MPH1*, Ashley J. Vonner2*, Chetana Sachidanandan, PhD3*, Lisa K. Lohmeyer1*, David T. Scadden, MD4, Randall T. Peterson, PhD2*, Kenneth D. Bloch, MD5* and Paul B. Yu, MD, PhD2*

1The Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA
2The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA
3Institute of Genomics & Integrative Biology, Delhi, India
4Massachusetts General Hospital and the Harvard Stem Cell Institute, Boston, MA
5Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA

Poster Board Number: I-1023
A Novel, Three Dimensional (3D) Culture System for the Efficient, Single-Step Erythropoietic Differentiation of Mouse Embryonic Stem Cells (mESCs)

Iliana Fauzi1*, Nicki Panoskaltsis, MD, PhD, FRCP2 and Athanasios Mantalaris, PhD1*

1Department of Chemical Engineering, Imperial College London, London, United Kingdom
2Department of Hematology, Imperial College London, London, United Kingdom

Poster Board Number: I-1024
Negative Autoregulation by Fas Stabilizes the Erythroid Progenitor Pool and Accelerates the Erythropoietic Stress Response

Miro Koulnis*, Ying Liu* and Merav Socolovsky

Department of Pediatrics & Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA

Poster Board Number: I-1025
Dynamic Erythropoietin Receptor Trafficking within Cell Surface, and Intracellular Pools

Seema Singh1*, Karen Leu2*, Bruce Mortensen2*, Christine Emerson1*, Anamika Pradeep1*, Peter R. Young2*, Peter J Schatz2*, Jennifer M Green2* and Don M. Wojchowski1

1COBRE Center of Excellence in Stem Cell Biology and Regenerative Medicine, Maine Medical Center Research Institute, Scarborough, ME
2Affymax, Inc., Palo Alto, CA

Poster Board Number: I-1026
Characterization of Hematopoietic Stem Cell Frequency and Function In Unexplained Anemia of the Elderly

Wendy W Pang, Ph.D.1*, Elizabeth Price, MD, MPH2, Irving L. Weissman3 and Stanley L. Schrier, MD4

1Institute for Stem Cell and Regenerative Medicine, Stanford University, Stanford, CA
2Hematology, Stanford University, Stanford, CA
3Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA
4Division of Hematology, Stanford University School of Medicine, Stanford, CA

Poster Board Number: I-1027

*signifies non-member of ASH