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Last updated December 3, 2009. Please note that this site represents the latest program changes
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Coagulation Biochemistry

Special Interest Sessions
Tuesday, December 8, 2009: 12:00 PM-1:30 PM
265-268 (Ernest N. Morial Convention Center)
Moderators:
Philip Fay, PhD and Henri M. H. Spronk, PhD
12:00 PM
Increasing Hydrophobicity and Disulfide Bridging Between A1 and C2 Subunits Improves Factor VIII Stability

Hironao Wakabayashi, MD, PhD1, Amy E Griffiths, MS2* and Philip Fay, PhD3

1Biochemistry & Biophysics -712, University of Rochester, Rochester, NY
2Biochemistry & Biophysics , PO Box 712, University of Rochester, Rochester, NY
3Biochemistry and Biophysics, University of Rochester, Rochester, NY

12:15 PM
Conservation of Hemostatic System Component Function Between Zebrafish and Mammals

Yosef Kalish, MD1*, Arunima Ghosh, MBBS, PhD2*, Jordan A. Shavit, MD, PhD3 and David Ginsburg, MD4

1LSI, University of Michigan, Ann Arbor, MI
2LSI, University of Michigan, Howard Hughes Medical Institute, Ann Arbor, MI
3Department of Pediatrics, University of Michigan School of Medicine, University of Michigan, Ann Arbor, MI
4Departments of Pediatrics,Internal Medicine and Human Genetics, University of Michigan School of Medicine, University of Michigan, Howard Hughes Medical Institute, Ann Arbor, MI

12:30 PM
Membrane Phosphatidylserine and Plasma Calcium Levels Switch Factor Xa From An Inactive Dimer to An Active Monomer

Tilen Koklic1*, Rinku Majumder, PhD2 and Barry Lentz1

1Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC
2Chapel Hill, Univ. of North Carolina at, Chapel Hill, NC

12:45 PM
Feedback Activation of Factor XI by Thrombin Is Essential for Hemostasis In Vivo

Henri M. H. Spronk, PhD1*, Sabine Wilhelm2*, Rene Van Oerle3*, Menno L. Knetsch4*, David Gailani5, Rafal Pawlinski6*, Nigel Mackman7, Hugo ten Cate8 and Thomas Renné9*

1Department of Internal Medicine, Cardiovascular Research Institute, Laboratory for Clinical Thrombosis and Haemostasis, Maastricht, Netherlands
2Institute for Clinical Biochemistry and Pathobiochemistry, Universityhospital of Würzburg, Würzburg, Germany
3Department of Internal Medicine, Cardiovascular Research Institute Maastricht, The Netherlands, Laboratory for Clinical Thrombosis and Haemostasis
4Center for Biomaterials Research, Department of Medicine, Maastricht University, Maastricht, Netherlands
5Department of Pathology and Medicine, Vanderbilt University School of Medicine, Nashville, TN
6Division of Hematology and Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United St
7University of North Carolina at Chapel Hill, Chapel Hill, NC
8Department of Internal Medicine, Cardiovascular Research Institute Maastricht, The Netherlands, Laboratory for Clinical Thrombosis and Haemostasis, Maastricht, Netherlands
9Karolinska Institute, Stockholm, Sweden

1:00 PM
Enhanced Cell-Associated Fibrinolytic Pathway but Not Coagulation Pathway Activity Contributes to Motility in Metastatic Breast Cancer Cells

Jennifer C Carter, PhD*, Robert A Campbell, PhD*, Jennifer A Gibbons, PhD*, Alisa S. Wolberg, PhD and Frank C. Church, PhD

Pathology and Laboratory Medicine, UNC - Chapel Hill School of Medicine, Chapel Hill, NC