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651.O4.8 Molecular Pathology of Myeloma

Oral and Poster Abstracts
Oral Session
Tuesday, December 9, 2008: 7:00 AM-9:00 AM
2005-2007-2018-2020 - West (Moscone Center)
Moderators:
Helena Jernberg-Wiklund, PhD and Karin Vanderkerken
7:00 AM
CS1 Promotes Multiple Myeloma Cell Adhesion, Clonogenic Growth, and Tumorigenicity Via C-Maf-Mediated Interactions with Bone Marrow Stromal Cells (BMSCs)

Yu-Tzu Tai, PhD1, Ender Soydan2*, Mariateresa Fulciniti2*, Weihua Song2*, Xian-Feng Li2*, Peter Burger2*, Fangxin Hong2*, Giovanni Tonon2*, Kihyun Kim2*, Mathew J. Rumizen2*, Sabikun Nahar, B.S.2*, Klaus Podar2*, Dharminder Chauhan2*, Teru Hideshima2*, Daniel R. Carrasco2*, Nikhil C Munshi2*, Daniel Afar, PhD3 and Kenneth C. Anderson2*

1Medical Oncology, Dana-Farber Cancer Inst., Boston, MA
2Dana-Farber Cancer Inst., Boston, MA
3Research, PDL BioPharma, Inc., Redwood City, CA

7:15 AM
Heparanase Promotes the Osteolytic Phenotype in Multiple Myeloma

Yang Yang1, Joseph P. Ritchie1*, Larry J. Suva2* and Ralph D. Sanderson1*

1Department of Pathology, Center for Metabolic Bone Disease and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
2Dept of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Liitle Rock, AR

7:30 AM
CD32B Expression Reflects Phenotypic and Functional Heterogeneity in Multiple Myeloma (MM)

Ping Zhou, MD, PhD1, Adam M Boruchov, MD2*, James E. Hoffman, MD3, Qianxing Mo4*, Adam Olshen5*, Evan Glasner2*, Ezio Bonvini6*, Scott Koenig6*, Ellen Drieghe2*, Martin Fleisher, PhD7*, Peter Maslak, MD8, Hani Hassoun, MD9, Adam D Cohen, MD2, Heather Landau, MD10, James W. Young, MD11, Suresh C Jhanwar, PhD10*, Stephen D Nimer, MD2* and Raymond L Comenzo12

1Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, Bronx, NY
2Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY
3Education and Training, Medical Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY
4Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY
5Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New City, NY
6MacroGenics, Inc, Rockville, MD
7Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, New York, NY
8Memorial Sloan-Kettering Cancer Ctr., New York, NY
9Memorial Sloan-Kettering Cancer Center, New York, NY
10Memorial Sloan Kettering Cancer Ctr., New York, NY
11Adult Allogeneic Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Ctr., New York, NY
12Hematology Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY

7:45 AM
The Novel Proteasome Inhibitor CEP-18770 Inhibits Myeloma Tumor Growth In Vitro and In Vivo and Enhances the Anti-MM Effects of Melphalan

Eric Sanchez1*, Richard A Campbell, BS1*, Jeffrey A Steinberg1*, Mingjie Li1*, Haiming Chen, MD, PhD1, Benjamin Bonavida, PhD2 and James R. Berenson, MD3

1Hematology/Oncology, Institute for Myeloma & Bone Cancer Research, West Hollywood, CA
2Microbiology, Immunology & Molecular Genetics, University of CA, Los Angeles, Los Angeles, CA
3Institute for Myeloma & Bone Cancer Research, West Hollywood, CA

8:00 AM
The EphrinB2/EphB4 Axis Is Dysregulated in Osteoprogenitors from Myeloma Patients and Its Activation by EphrinB2-Fc or EhpB4-Fc Affects Myeloma Bone Disease and Tumor Growth in Vivo

Angela Pennisi*, Wen Ling*, Xin Li*, Jianmei Chen*, Sharmin Khan* and Shmuel Yaccoby

Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR

8:15 AM
Immunomodulatory Derivatives of Thalidomide (IMiD)-Induced Neutropenia Is Associated with PU.1 Downregulation and Myeloid Maturation Arrest

Rekha Pal, PhD1*, G. David Roodman, MD, PhD2, Markus Y Mapara3, Lynn Mocsinski, MD4*, Alan F List, MD5 and Suzanne Lentzsch3

1Medicine, Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA
2University of Pittsburgh, VA Pittsburgh Healthcare System (646) and the University of Pittsburgh, Pittsburgh, PA
3Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, PA
4Division of Malignant Hematology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
5Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

8:30 AM
Bortezomib Induces Osteoblast Differentiation Via Wnt-Independent Activation of Beta-catenin/TCF Signaling

Ya-wei Qiang*, Bo Hu*, Yu Chen*, Ying Zhong*, Bart Barlogie and John D. Shaughnessy Jr., PhD

Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR

8:45 AM
Adenosine A2A Receptor Agonism and PDE Inhibition: A Synergistic Multi-Target Mechanism Discovered through Systematic Combination Screening in Multiple Myeloma

Richard J Rickles, Ph.D.1*, Laura Pierce1*, Thomas Giordano1*, Winnie F. Tam, Ph.D.1*, Douglas W. McMillin, BSc, PhD2*, Kenneth C. Anderson, MD2, Constantine Mitsiades, M.D., Ph.D.2 and Margaret S Lee, Ph.D.1*

1CombinatoRx, Incorporated, Cambridge, MA
2Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA

*signifies non-member of ASH