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602.O3.8 Disordered Gene Expression in Hematologic Malignancy, Including Epigenetic Regulation (III)

Oral and Poster Abstracts
Oral Session
Tuesday, December 9, 2008: 7:00 AM-9:00 AM
3002-3004 - West (Moscone Center)
Moderators:
Steven D. Gore, MD and Peter Valk
7:00 AM
Autoregulation of MEIS1 through a Distal Enhancer in Acute Leukemia

Qianfei Wang, PhD1, Jingfang Dong, PhD1*, Ryan Mattison, MD1*, Shyam Prabhakar, PhD2*, Fabio Eiji Arimura3*, Joseph Kaberlein1*, Chong-zhi Wang, PhD4*, Qianben Wang, PhD5*, Marcelo Nobrega, PhD3* and Michael Thirman, MD1

1Medicine, University of Chicago, Chicago, IL
2Genome Institute of Singapore, Genome, Singapore
3Human Genetics, University of Chicago, Chicago, IL
4Anesthesia & Critical Care, University of Chicago, Chicago, IL
5Dana-Farber Cancer Institute and Harvard Medical School, Boston

7:15 AM
A MEIS1 Dependent Genetic Program in Leukemia Associated with Cell Cycle Entry and ‘Stemness’

Ashish Kumar, MBBS, PhD1, Baolin Wu2* and John H. Kersey, MD3

1Pediatric Heme/Onc/BMT, University of Minnesota, Minneapolis, MN
2Biostatistics Division, School of Public Health, University of Minnesota, Minneapolis, MN
3Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN

7:30 AM
Cbfb-MYH11 Can Block Hematopoiesis and Alter Gene Expression through Mechanisms Independent of Cbfb and Runx1 Repression

R. Katherine Hyde, PhD1*, Yasuhiko Kamikubo, MD, PhD1*, Lemlem Alemu1*, Ling Zhao, MD, PhD1*, Chenwei Wang2* and Pu Paul Liu, MD, PhD1

1Gmbb/Ods, NIH/NHGRI, Bethesda, MD
2Gtb, NHGRI/NIH, Bethesda, MD

7:45 AM
NKX3.1 Is a Direct TAL1 Target Gene That Mediates the TAL1 Dependent Proliferation of Human T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Sophie Kusy1*, Nicolas Goardon, PhD2*, Florence Armstrong3*, Francoise Pflumio3* and paul-Henri Romeo1*

1Laboratoire de recherche sur la Réparation et la Transcription dans les cellules Souches (LRTS), Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), CEA, Fontenay-aux-Roses cedex, France
2Weatherall Institute of Molecular Medicine, University of Oxford, MRC Molecular Haematology Unit, Oxford, United Kingdom
3Laboratoire de recherche sur les cellules Souches Hématopoïétiques et Leucémiques (LSHL), Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), CEA, Fontenay-aux-Roses cedex, France

8:00 AM
ZKSCAN3, a Novel Zinc Finger Transcription Factor, Regulates Cyclin D2 Expression in Multiple Myeloma (MM) Cells

Lin Yang1* and Robert Z. Orlowski, MD, PhD2

1Lymphoma and Myeloma, MD Anderson Cancer Center, Houston, TX
2University of Texas M. D. Anderson Cancer Center, Houston, TX

8:15 AM
hTERT Transcriptional Repression in Acute Myeloid Leukemias

Valérie Capraro1*, Linda Zane1*, Lauriane Kuhn2*, Jérôme Garin3*, Perrine Galia4*, Claude Preudhomme5*, Eric Gilson6*, Xavier Thomas7, Mohamed Elhamri8*, Youcef Chelgoun8*, Nathalie Bonnefoy-Berard9*, Franck Mortreux1* and Eric Wattel1*

1Oncovirologie et Biotherapies, CENTRE LEON BERARD, FRE CNRS 3011, Université Lyon 1, LYON Cedex 08, France
2Laboratoire d'Etude de la Dynamique des Protéomes, CEA / Inserm 0880 / UJF, Grenoble CEDEX 09, France
3Laboratoire d'Etude de la Dynamique des Protéomes, CEA / Inserm 0880 / UJF, Grenoble Cedex 09, France
4LCMT, Lyon, France
5MILE Study Group, on Behalf of European LeukemiaNet (ELN, WP13), Munich, Germany
6Lbmc, Cnrs UMR5239, Ifr 128, FACULTE DE MEDECINE DE LYON SUD, UNIVERSITE LYON 1, Villeurbanne
7GRAALL Group, Lyon, France
8Hematology Department, Hospices Civils de Lyon, Lyon, France
9IFR Biosciences Lyon-Gerland, Laboratoire d'homéostasie lymphocytaire, INSERM U503, Lyon, France

8:30 AM
Gene Expression Profiling in AML with Normal Karyotype: A Multicenter Study Investigating Molecular Markers in 252 Cases

Alexander Kohlmann, PhD1, Lars Bullinger, MD2, Christian Thiede, MD3*, Markus Schaich, MD3, Susanne Schnittger, PhD1, Konstanze Dohner, MD2*, Martin Dugas, MD4*, Hartmut Dohner, MD2*, Gerhard Ehninger, MD3 and Torsten Haferlach, MD1

1MLL Munich Leukemia Laboratory, Munich, Germany
2Internal Medicine III, University of Ulm, Ulm, Germany
3Medical Clinic I, University Hospital, Dresden, Germany
4Department of Medical Informatics and Biomathematics, University of Münster, Münster, Germany

8:45 AM
Constitutive Activation of SHP2 Protein Tyrosine Phosphatase Cooperates with HoxA10 Overexpression for Progression to Acute Myeloid Leukemia in a Murine Model

Hao Wang, MD1*, Stephan Lindsey, PhD1*, Iwona Konieczna1*, Elizabeth Horvath, MS2*, Ling Bei, MD3, Weiqi Huang, MD, PhD3* and Elizabeth A. Eklund, MD2

1Medicine, Northwestern University, Chicag, IL
2Northwestern University Feinberg School of Medicine and Jesse Brown VA Medical Center, Chicago, IL
3Hematology/Oncology, Robert H. Lurie Comp. Cancer Ctr., Chicago, IL

*signifies non-member of ASH