Lijun Yao^1,2*, Reyka G Jayasinghe, PhD^1,2*, Beena E Thomas^3*, Swati S Bhasin, PhD^4*, Nicolas Fernandez, PhD^5*, Taxiarchis Kourelis, MD^6,7,8, Deon Doxie^9*, David E. Avigan, MD^10,11,12, Madhav V. Dhodapkar, MD¹³, Shaji K. Kumar, MD^7,8,14,15, Ravi Vij, MBBS^1,16,17, Shaadi Mehr, PhD^18,19*, Mark Hamilton, PhD^18*, Hearn Jay Cho, MD, PhD²⁰, Daniel Auclair²¹, Sacha Gnjatic, PhD^22*, Manoj Bhasin, PhD^3,23* and Li Ding, PhD^1,2,24,25*

¹Department of Medicine, Washington University School of Medicine, Saint Louis, MO
²McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO
³Emory School of Medicine, Aflac Cancer and Blood Disorders Center, Atlanta, GA
⁴Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Atlanta, GA
⁵Human Immune Monitoring Center, Icahn School of Medicine at Mt. Sinai, New York, NY
⁶Mayo Clinic, Rochester, MN
⁷Division of Hematology, Mayo Clinic, Rochester, MN
⁸Mayo Clinic Rochester, Division of Hematology, Rochester, MN
⁹Emory University, Atlanta, GA
¹⁰Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
¹¹Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
¹²Beth Israel Deaconess Medical Center, Boston, MA
¹³Emory University School of Medicine, Atlanta, GA
¹⁴Department of Hematology, Mayo Clinic Rochester, Rochester, MN
¹⁵Hematology, Mayo Clinic, Rochester, MN
¹⁶Washington University School of Medicine, Ballwin, MO
¹⁷Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO
¹⁸Multiple Myeloma Research Foundation, Norwalk, CT
¹⁹MMRF, New York, NY
²⁰MMRF; Icahn School of Medicine at Mount Sinai, Norwalk, CT
²¹Multiple Myeloma Research Foundation (MMRF), Norwalk, CT
²²Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York
²³Genomics, Proteomics, Bioinfomatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA
²⁴Genetics, Washington University School of Medicine, Saint Louis, MO
²⁵Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO

Arghya Ray, PhD¹, Ting DU, PhD^1*, Krishan Chauhan^2*, Yan Song, PhD^3*, Dharminder Chauhan, PhD¹ and Kenneth Anderson, MD⁴

¹Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Department of Biomedical Engineering, Wentworth Institute of Technology, Boston, MA
³Dana-Farber Cancer Institute, Harvard Medical School, Brookline, MA
⁴The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Aparna Raval^1*, Habib Hamidi^1*, Olivia Hwang^1*, Cherie Green^1*, Catarina Maia^2*, Marta Lasa^2*, Maika Onishi¹, Paula Rodriguez-Otero^2*, Jesús F. San-Miguel², Jorge D. Gallo^3*, Bruno Paiva, PhD^2* and Fredrik Schjesvold, MD, PhD⁴

¹Genentech, Inc., South San Francisco, CA
²University of Navarra, Pamplona, Spain
³F. Hoffmann-La Roche Ltd, Basel, Switzerland
⁴Oslo Myeloma Center, Oslo University Hospital and KG Jebsen Center for B Cell Malignancies, University of Oslo, Oslo, Norway

Benjamin G Barwick, PhD¹, Vikas A. Gupta, MD, PhD ², Shannon M Matulis, PhD^2*, Jonathan C Patton, B.S.^3*, Doris R Powell, MA^4*, Yanyan Gu, MD, PhD^5*, David L. Jaye, MD⁶, Karen N Conneely, Ph.D.^7*, Yin C Lin, Ph.D.^8*, Craig C Hofmeister, MD, MPH⁹, Ajay Nooka, MD, MPH¹⁰, Jonathan J Keats, PhD¹¹, Sagar Lonial, MD¹², Paula M Vertino, PhD^13* and Larry H. Boise, PhD¹⁴

¹Winship Cancer Institute / Hematology and Medical Oncology, Emory University, Atlanta, GA
²Winship Cancer Institute/ Hematology and Medical Oncology, Emory University, Atlanta, GA
³Emory Integrated Genomics Core, Emory University, Atlanta, GA
⁴Hematology and Medical Oncology / Winship Cancer Institute, Emory University, Atlanta, GA
⁵Emory University Winship Cancer Institute, Atlanta, GA
⁶Department of Pathology, Emory University, Atlanta, GA
⁷615 Michael Street, Emory University, Atlanta, GA
⁸Baylor Scott & White Research Institute, Baylor Institute for Immunology Research, Dallas
⁹Winship Cancer Institute / Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA
¹⁰Winship Cancer Institute, Emory University, Atlanta, GA
¹¹Translational Genomics Research Institute, Phoenix, AZ
¹²Department of Hematology and Medical Oncology, Emory University - Winship Cancer Institute, Atlanta, GA
¹³Department of Biomedical Genetics, University of Rochester Medical Center, Atlanta, GA
¹⁴Emory University, Atlanta, GA

Raphael Lutz, MD^1*, Abdelrahman Mahmoud^2*, Mohamed H.S. Awwad^1*, Charles D. Imbusch, PhD^2*, Tobias Boch, MD^3*, Brian G.M. Durie, MD⁴, Niels Weinhold, PhD^1*, Marc S. Raab, MD^1*, Carsten Müller-Tidow, MD^1*, Simon Haas, PhD^3,5*, Benedikt Brors, PhD^2*, Hartmut Goldschmidt, MD^1,6 and Michael Hundemer, MD^1*

¹Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
²Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
³Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁴Cedars Sinai Cancer Center, Los Angeles, CA
⁵Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), Heidelberg, Germany
⁶National Center for Tumor Diseases (NCT), Heidelberg, Germany

Daniel Auclair¹, Mark Bustoros, MD², Carrie Cibulskis, BSc^3*, Teni Dowdell, BSc^4*, Svetlana Gavrilov, MD, PhD^1*, Cody J Boehner, BS^2*, Jennifer Yesil, MSc^5*, Steven E. Labkoff, MD^1*, Shaadi Mehr, PhD^1*, Romanos Sklavenitis-Pistofidis, MD^2*, Salomon Manier, MD, PhD⁶, Elizabeth D. Lightbody, PhD^2*, Annette S. Kim, MD, PhD⁷, Justin Rhoades^8*, Keith L Ligon, MD, PhD^9*, Niall Lennon, PhD^3*, Viktor Adalsteinsson, PhD^4*, Jane Wilkinson, PhD^4*, Hearn Jay Cho, MD, PhD¹ and Irene M. Ghobrial, MD¹⁰

¹Multiple Myeloma Research Foundation, Norwalk, CT
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Genomics Platform, Broad Institute, Cambridge, MA
⁴Broad Institute | Genomics Platform, Cambridge, MA
⁵Multiple Myeloma Research Foundation (MMRF), Norwalk, CT
⁶Service des Maladies du Sang, CHU Lille, Lille, France
⁷Department of Pathology, Brigham and Women's Hospital, Boston, MA
⁸Broad Institute of MIT and Harvard, Cambridge, MA
⁹Pathology Dept, Dana-Farber Cancer Institute, Boston, MA
¹⁰Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Miguel Gonzalez-Velez, MD^1*, Mariano Arribas^2*, Heidi E. Kosiorek, MS^3*, Richard Butterfield III^3*, Carlo Guerrero, MD^4*, Luke Mountjoy, DO⁵, Jeremy Larsen⁶, Craig B. Reeder, MD⁷, P. Leif Bergsagel, MD⁸, A. Keith Stewart, MB, ChB² and Rafael Fonseca, MD⁹

¹Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ
²Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
³Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ
⁴Houston Methodist Cancer Center, Houston, TX
⁵Hematology Department, Colorado Blood Cancer Institute, Denver, CO
⁶Mayo Clinic, Phoenix, AZ
⁷Mayo Clinic Hospital, Phoenix, AZ
⁸Division of Hematology, Mayo Clinic, Scottsdale, AZ
⁹Division of Hematology and Oncology, Mayo Clinic, Phoenix, AZ

Mattia D'Agostino, MD^1*, Juan-José Lahuerta, MD, PhD^2*, Ruth Wester, MD^3*, Anders Waage, MD, PhD⁴, Uta Bertsch^5*, Elena Zamagni, MD^1*, Maria-Victoria Mateos, MD, PhD², Alessandra Larocca¹, Daniele Dall'Olio^1*, Niels W.C.J. Van De Donk⁶, David Cairns, MSc, PhD^7*, Serena Rocchi^1*, Hans Salwender, MD^5*, Joan Blade Creixenti², Bronno van der Holt, PhD^3*, Castellani Gastone^1*, Giovannino Ciccone^1*, Andrea Capra^1*, Jan Dürig, MD^5*, Sara Bringhen, MD¹, Sonja Zweegman, MD, PhD³, Michele Cavo^1*, Hartmut Goldschmidt, MD⁵, Gordon Cook, MB ChB, PhD^7*, Jesus Maria Hernández-Rivas, MD, PhD², Jesus F. San-Miguel, MD, PhD², Mario Boccadoro¹ and Pieter Sonneveld, MD, PhD³

¹HARMONY, European Network, Italy
²HARMONY, European Network, Spain
³HARMONY, European Network, Netherlands
⁴HARMONY, European Network, Norway
⁵HARMONY, European Network, Germany
⁶Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam, Netherlands
⁷HARMONY, European Network, United Kingdom

Samuel Cutler, MSc^1*, Dan Gaston, PhD^2*, Philipp Knopf^3*, Andrea Thoni, MD^4*, Nicholas Allen Forward, MD, MSc, FRCPC^5,6, Darrell J White, MD⁷, Julie Wagner, PhD^4*, Marissa Goudie^4* and Manal Elnenaei, MBChB, PhD, FRCPath^2*

¹Pathology, Dalhousie University, Wellington, NS, Canada
²Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Halifax, NS, Canada
³Pathology, Dalhousie, Halifax, NS, Canada
⁴Pathology, NSHA, Halifax, NS, Canada
⁵Capital District Health Authority/Dalhousie University, Halifax, NS, CAN
⁶Hematology, Nova Scotia Health Authority/ Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada
⁷Dalhousie University and QEII Health Sciences Centre, Halifax, NS, Canada

Mattia D'Agostino, MD^1*, Marina Ruggeri^1*, Sara Aquino^1*, Nicola Giuliani¹, Maddalena Arigoni^2*, Massimo Gentile^1*, Martina Olivero^3*, Iolanda Donatella Vincelli^1*, Andrea Capra^1*, Chiara Mussatto^1*, Antonio Ledda^1*, Paola Tacchetti^1*, Caterina Musolino^1*, Claudia Cellini^1*, Francesca Patriarca^1*, Stelvio Ballanti^1*, Raffaele Calogero^2*, Pellegrino Musto¹, Mario Boccadoro¹ and Francesca Gay, MD¹

¹GIMEMA, European Myeloma Network, Italy
²Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università degli Studi di Torino, Torino, Italy
³Dipartimento di Oncologia, Università degli Studi di Torino, Torino, Italy

Oliver C Cohen, MBBS, BSc, FRCPath^1*, Andreia Ismael^1*, Richa Manwani, MBBS, FRCPath, BSc^2*, Sriram Ravichandran, MBBS, MRCP, FRCPath^1*, Steven Law, MBBS, BSc^1*, Darren Foard^2*, Ana Martinez-Naharro^1*, Shameem Mahmood^2*, Sajitha Sachchithananthan^1*, Philip N Hawkins^1*, Helen J Lachmann^1*, Julian D Gillmore^1*, Marianna Fontana^3*, Rodney H Falk, MD^4*, Carol Whelan^1* and Ashutosh D. Wechalekar, MBBS, FRCP, FRCPath, DM^5,6

¹National Amyloidosis Centre, Royal Free Hospital, London, United Kingdom
²National Amyloidosis Centre, National Amyloidosis Centre, Royal Free Hospital, London, United Kingdom
³National Amyloidosis Centre, National Amyloidosis Centre, Royal Free Hospital, London, GBR
⁴Harvard Medical School/ Brigham and Women's Hospital, Boston, MA
⁵National Amyloidosis Centre, University College London, London, United Kingdom
⁶University College London Hospitals NHS Foundation Trust, London, United Kingdom

Shebli Atrash, MD¹, Evelyn M. Flahavan^2*, Tao Xu^3*, Esprit Ma^4*, Sudeep Karve^5*, Wan-Jen Hong, MD^4*, Gilbert Jirau-Lucca^4*, Michael Nixon^4* and Sikander Ailawadhi, MD⁶

¹Levine Cancer Institute-Morehead (Hematology), Charlotte, NC
²Roche Products Ltd, Welwyn Garden City, United Kingdom
³F. Hoffmann-La Roche Ltd, Basel, Switzerland
⁴Genentech, Inc., South San Francisco, CA
⁵AbbVie, Inc., North Chicago, IL
⁶Mayo Clinic, Jacksonville, FL

Susan Bal, MD, MBBS¹, Smith Giri, MBBS², Kelly N. Godby, MD^3* and Luciano J. Costa, MD, PhD⁴

¹O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
²Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, New Haven, CT
³University of Alabama at Birmingham, Birmingham, AL
⁴O’ Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Vestavia, AL

Kristin Larsen^1*, Meera Mohan, MD^1*, Clyde Bailey^1*, Kerri Hill^1*, Horace Spencer^2*, Mathew Kottarathara, MD^1*, Richa Parikh, MD^1*, Shadiqul Hoque, MD^1*, Amani Erra, MD^1*, Angel Mitma, MD^1*, Pankaj Mathur, MD^1*, Guido Tricot, MD, PhD^1*, Sharmilan Thanendrarajan, MD¹, Maurizio Zangari, MD, FACP¹, Frits van Rhee, MD¹ and Carolina D. Schinke, MD¹

¹Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR
²Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR

Patrick Mellors¹, Surendra Dasari, PhD^2*, Mindy Kohlhagen^3*, Bonnie Kaye Arendt^3*, Morie Gertz⁴, Shaji K. Kumar, MD⁵, Francis K. Buadi, MB, CHB^5*, Maria Alice V. Willrich, PhD^3*, John A. Lust, MD, PhD⁵, Prashant Kapoor, MD⁴, Martha Q. Lacy, MD⁴, David Dingli, MD, PhD⁴, Yi L. Hwa, NP⁵, Amie Fonder, PA-C, MS^5*, Miriam A. Hobbs, APRN, CNP, DNP^5*, Suzanne R. Hayman, MD⁵, Taxiarchis Kourelis, MD⁴, Rahma M Warsame, MD⁶, Eli Muchtar, MD^4*, Nelson Leung, MD⁵, Ronald S. Go, MD^5,7, Yi Lin, MD, PhD⁵, Wilson I Gonsalves, MD⁴, Mustaqeem A. Siddiqui, MD, MBA⁵, Robert A. Kyle, MD⁴, S. Vincent Rajkumar, MD⁴, David L. Murray, MD, PhD^3* and Angela Dispenzieri, MD⁵

¹Department of Internal Medicine, Mayo Clinic, Rochester, MN
²Department of Health Sciences Research, Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁴Mayo Clinic Rochester, Division of Hematology, Rochester, MN
⁵Division of Hematology, Mayo Clinic, Rochester, MN
⁶Mayo Clinic, Rochester, MN
⁷Mayo Clinic Rochester, Division of Hematology, Onalaska, WI

Calogerina Catalano, PhD^1,2*, Joanna Blocka, MD^3*, Stefanie Huhn, PhD^3*, Nagarajan Paramasivam, Ph.D.^4*, Matthias Schlesner, PhD^5*, Niels Weinhold, PhD^1,6*, Rolf Sijmons, MD^7*, Christian Langer, MD^8*, Klaus Preuss, Ph.D.^9*, Brian G.M. Durie, MD¹⁰, Björn Nilsson, MD, PhD^11*, Hartmut Goldschmidt, MD^3,12, Obul Reddy Bandapalli, PhD^2,13,14*, Kari Hemminki, MD, PhD^15,16* and Asta Försti, Ph.D.^2,13,14*

¹Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
²Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
³Department of Hematology, Oncology, and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany
⁴Computational Oncology, Molecular Diagnostics Program, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany
⁵Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁶Clinical Cooperation Unit (CCU) Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁷University Medical Center Groningen, University of Groningen, Groningen, Netherlands
⁸Kempten Clinic, Kempten, Germany, Kempten, Germany
⁹José Carreras Center for Immuno and Gene Therapy, Universität Des Saarlandes, Homburg/Saar, Germany
¹⁰Cedars Sinai Cancer Center, Los Angeles, CA
¹¹Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden
¹²National Center for Tumor Diseases Heidelberg, Heidelberg, Germany
¹³Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany, Heidelberg, Germany
¹⁴Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany
¹⁵Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, DEU
¹⁶Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Pilsen, Czech Republic, Pilsen, Czech Republic

Anaïs Schavgoulidze^1*, Valerie Lauwers-Cances^2*, Aurore Perrot, MD, PhD^3*, Herve Avet-Loiseau⁴ and Jill Corre, PharmD, PhD^5*

¹Institut Universitaire du Cancer de Toulouse-Oncopole, Laboratoire d'onco-hématologie, Fonsorbes, France
²USMR, service d'Epidemiologie, CHU Toulouse, Toulouse, France
³Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France
⁴Unite de Genomique du Myelome, IUC-T Oncopole, Toulouse, France
⁵Unite de Génomique du Myélome, IUC-T Oncopole, Toulouse, France

Xue-Han Mao, MD^1*, Yan Xu, MD^2,3*, Yuting Yan^4,5*, Jiahui Liu^4*, Huishou Fan^4*, Weiwei Sui^4*, Shuhui Deng, MD^4*, Chenxing Du, MD^6*, Dehui Zou, MD^6*, Lugui Qiu, MD⁴ and Gang An^7*

¹Institute of Hematology & Blood Diseases Hospital, TIANJIN, China
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Institute of Hematology & Blood Diseases Hospital, Chinese Academic Medical Science & Peking Union Medical College, Tianjin, China
⁴National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁵Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA
⁶State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, TIANJIN, China
⁷lymphoma and myeloma center, National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Karen Sweiss, PharmD¹, Benjamin G Barwick, PhD², Gregory Sampang Calip, PharmD, MPH, PhD^3*, Damiano Rondelli, MD⁴, Craig C Hofmeister, MD, MPH⁵ and Pritesh Patel, MB, ChB⁴

¹Department of Pharmacy Practice, University of Illinois, Hinsdale, IL
²Winship Cancer Institute / Hematology and Medical Oncology, Emory University, Atlanta, GA
³Department of Pharmacy Systems, Outcomes and Policy, University of Illinois at Chicago, Chicago, IL
⁴Division of Hematology/Oncology, University of Illinois, Chicago, IL
⁵Winship Cancer Institute, Emory University, Atlanta, GA

Ariosto Siqueira Silva, PhD^1*, Rafael Renatino-Canevarolo, PhD^1*, Mark B. Meads, PhD^1*, Maria D Coelho Siqueira Silva, MSc^1*, Praneeth Reddy Sudalagunta, PhD^1*, Christopher Cubitt^1*, Gabriel De Avila, BS^2*, Raghunandan Reddy Alugubelli^3*, Amit Kulkarni, PhD^4*, Melissa Mitchell^4*, Hongyue Dai^4*, Qi Zhang, PhD^4*, Oliver Hampton^4*, Xin Lu^5*, Dimple A. Modi, PhD^6*, Monica Motwani, PhD^5*, Jason Harb, PhD^5*, Jeremy A. Ross^5* and Kenneth H. Shain, MD, PhD ¹

¹Moffitt Cancer Center, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL
³Department of Malignant Hematology, H Lee Moffitt Cancer Center, Tampa, FL
⁴M2GEN, Tampa, FL
⁵AbbVie, Inc., North Chicago, IL
⁶AbbVie Inc., North Chicago, IL

Benjamin Diamond, MD¹, Kylee H Maclachlan, FRACP, FRCPA^2*, Andriy Derkach, PhD^3*, Venkata Yellapantula, PhD^1*, Even H Rustad, MD, PhD^1*, Malin Hultcrantz, MD, PhD¹, Urvi A Shah, MD¹, Jessica Hong^2*, Heather J Landau, MD^4,5, Christine Iacobuzio-Donahue, MD, PhD^6*, Elli Papaemmanuil, PhD⁷, Shani I Irby^2*, Laura Crowley^8*, Michael Crane^8*, Mayris Webber^9*, David Goldfarb, M.P.H^10,11*, Rachel Zeig-Owens, M.P.H^11,12*, Orsi Giricz, PhD¹³, Amit Verma, MBBS¹⁴, David Prezant, MD^10,11*, Ahmet Dogan, MD, PhD⁶, Sohrab P Shah^15*, Yanming Zhang, MD¹⁶, Ola Landgren, MD, PhD¹ and Francesco Maura, MD¹

¹Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²MSKCC, New York, NY
³Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, Scarsdale, NY
⁵Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁷5Computational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
⁸MSSM, New York, NY
⁹Montefiore, New York, NY
¹⁰Bureau of Health Services, Fire Department of the City of New York, Brooklyn, NY
¹¹Department of Medicine, Pulmonary Division, Montefiore Medical Center, Bronx, NY
¹²Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY
¹³Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY
¹⁴Hematology/Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
¹⁵Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁶Department of Pathology, Memorial Sloan Kettering Cancer Center, Chicago, IL

Cinnie Yentia Soekojo, MD^1,2, Tae-Hoon Chung^2*, Muhammad Shaheryar Furqan^2* and Wee-Joo Chng, MBBS, PhD, FRCPath, FRCP^1,2

¹Department of Hematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore
²Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

Kylee H Maclachlan, MBChB, PhD^1*, Binbin Zheng-Lin, MD MSc^2*, Venkata Yellapantula, PhD^1*, Andriy Derkach, PhD^3*, Even H Rustad, MD, PhD^1*, Benjamin Diamond, MD¹, Malin Hultcrantz, MD, PhD¹, Ahmet Dogan, MD, PhD⁴, Yanming Zhang, MD⁵, Gareth Morgan, MD, PhD⁶, Ola Landgren, MD, PhD^1,7 and Francesco Maura, MD^1,7

¹Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Cytogenetics Laboratory, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Perlmutter Cancer Center, New York University Langone Health, New York, NY
⁷Weill Cornell Medical College, New York, NY

Zhaoyun Liu^1*, Fu Mi^2*, Mei Han^3*, Mengyue Tian, PhD^1*, Hui Liu^2*, Rong Fu, PhD^1* and Zonghong Shao, PhD²

¹Tianjin Medical University General Hospital, Tianjin, China
²Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China
³Tianjin Medical University General Hospital, tianjin, China

Lanting Liu^1*, Zhen Yu, MD^2*, Hui Cheng^2*, Weiwei Sui^3*, Shuhui Deng, MD^3*, Xiaojing Wei^2*, Chenxing Du, MD^4*, Wenyang Huang^3*, Gang An^5*, Wen Zhou, PhD⁶, Tao Cheng⁷, Lugui Qiu, MD² and Mu Hao^4*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tiajin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, TIANJIN, China
⁵lymphoma and myeloma center, National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁶Cancer Research Institute, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education; Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Central South University, Changsha, Hunan, China
⁷State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China

James Rowland, MBBS, BPharm^1* and Peter Mollee, FRACP, MBBS, MSc, FRCPA²

¹Princess Alexandra Hospital, Brisbane, QLD, Australia
²Department of Haematology, Princess Alexandra Hospital, Brisbane, QLD, Australia

Aisha Jibril, BSc^1*, Jayna J Mistry, BSc^1*, Jamie A Moore, BSc, MSc^1*, Charlotte Hellmich, MBBChir^2,3*, Victoria Willimott, MB BS^4*, Kristian M Bowles, MBBS, PhD^1,3 and Stuart A Rushworth, PhD¹

¹Norwich Medical School, University of East Anglia, Norwich, United Kingdom
²Norwich Medical School, University of East Anglia, Norwich, ENG, United Kingdom
³Department of Haematology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom
⁴Department of Haematology, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, United Kingdom

Fang Liu, MD^1*, Jeries Kort, MD², Shashirekha Shetty, PhD^2*, Ravikumar Kyasaram^3*, John Shanahan^4* and Timothy E. O'Brien, MD⁵

¹university hospitals, Cleveland, OH
²University Hospitals Cleveland Medical Center, Cleveland, OH
³University hospitals cleveland medical center, cleveland, OH
⁴University Hospital Cleveland Medical Center, Cleveland, OH
⁵Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, OH

Xuelian Tan^1,2*, Timothy Cody Ashby, PhD^3*, Yuqi Zhu^1*, Can Li, MD^3*, Xuxing Shen, MBBS^1*, Qierra Brockman, BA^1*, Dongzheng Gai, MD^3*, Sarah K Johnson, PhD³, Donghoon Yong^3*, Carolina D. Schinke, MD³, Maurizio Zangari, MD, FACP³, Frits van Rhee, MD³, John Shaughnessy Jr., PhD^3*, Dingming Huang, PhD^2*, Ivana Frech, DSc, PhD, MBA^1*, Guido J. Tricot, MD, PhD³ and Fenghuang Zhan, MD, PhD^1,3

¹Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Internal Medicine, University of Iowa, Iowa City, IA
²State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chengdu, China
³Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR

Neeraj Sharma, PhD^1*, James B Smadbeck, PhD^2*, Nadine Abdallah, MD^3*, Kathryn E. Pearce, MS^4*, Yan Asmann, PhD⁵, Jess Peterson, MD⁴, Rhett P. Ketterling, MD^6*, Patricia Greipp, DO⁴, P. Leif Bergsagel, MD⁷, S. Vincent Rajkumar, MD⁸, Shaji K. Kumar, MD⁸ and Linda B Baughn, PhD⁹

¹Mayo Clinic, Rochester, MN
²Center for Individualized Medicine, Biomarker Discovery, Mayo Clinic, Rochester, MN
³Department of Internal Medicine, Division of Hematology and Oncology, Mayo Clinic, Rochester, MN
⁴Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁵Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL
⁶Division of Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁷Division of Hematology, Mayo Clinic, Scottsdale, AZ
⁸Mayo Clinic Rochester, Division of Hematology, Rochester, MN
⁹Division of Laboratory Genetics, Mayo Clinic, Rochester, MN

Allan de souza Santos, BS^1*, Herbert Henrique de Melo Santos, MD^2*, Marco Aurelio Salvino, MD, PhD^3,4, Sarah Queiroz Silva, MD^5*, Larissa Ferreira Lucas, MD^6*, Alessandro de M. Almeida, MD^7,8, Mariane Melo Santos, BS, MsC^9*, Juliana Andrade Santos, MD^10*, Vania T. M. Hungria, MD, PhD¹¹, Maria da Gloria B. Arruda, MD, PhD^12,13*, Alex Torres, PhD^14* and Edvan De Queiroz Crusoe, MD, PhD^15,16

¹Immunology, mollecular and cytometry Laboratory- ICS, Federal University of Bahia, Salvador, Brazil
²Immunology, molecullar and Cytometry Laboratory- ICS, Federal University of Bahia, Salvador, Brazil
³Hematology and Bone Marrow Transplantation UNIT, Rede D'or Oncologia, Salvador, Brazil
⁴Universidade Federal De Bahia, Salvador, Brazil
⁵Hematology, Rede D'or Oncologia- Salvador, Salvador, Brazil
⁶Hematology, CLinica CEHON Rede D'or Oncologia, salvador, Brazil
⁷Stem Cell Transplant Unit, Federal University of Bahia, Salvador, Brazil
⁸Hematology and Bone Marrow Unit, Rede D´or Oncologia, salvador, Brazil
⁹Immunology, mollecullar and cytometry Laboratory- ICS, Federal University of Bahia, salvador, Brazil
¹⁰Hematology, Clinica CEHON Rede D'or oncologia, Salvador, Brazil
¹¹Department of Hematology, Clinica São Germano and Santa Casa Medical School, São Paulo, Brazil
¹²Federal University of Bahia, Salvador, Brazil
¹³Hematology, Clinica CEHON Rede D'or Oncologia, salvador, Brazil
¹⁴Immunology, Federal University of Bahia, salvador, Brazil
¹⁵Rua Dra Doutro Vianna S/n, Universidade Federal da Bahia- Hospital Universitario, Salvador, Brazil
¹⁶Hematology department- D'or Oncologia, Clinica CEHON Rede D'or Oncologia, Salvador, Brazil

Tomoaki Mori^1*, Cristina Panaroni, PhD¹, Chukwuamaka Onyewadume^2* and Noopur S. Raje, MD¹

¹Cancer Center, Massachusetts General Hospital, Boston, MA
²Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center, Boston, MA

Lijun Yao^1,2*, Reyka G Jayasinghe, PhD^1,2*, Tianjiao Wang, BA^2,3*, Julie O'Neal, PhD^4,5*, Ruiyang Liu, BS^1,2*, Michael P. Rettig, PhD^6,7, Chia-Feng Tsai, PhD^8*, Steven M. Foltz, BS, MS^1,2, Danny Kohnen, MBA^9*, Smrithi Mani, BS^10*, Fernanda Martins Rodrigues, MSc^2,3,11, Michael C. Wendl, D SC, MS, PHS^12,13*, Matthew A. Wyczalkowski, PhD^12,14*, Scott R. Goldsmith, MD^15,16, Ying Zhu, PhD^8*, Mark A Fiala, MSW^17*, Liu Tao, BS, PhD^8*, Ravi Vij, MD, MBA^6,18,19, Li Ding, PhD^1,2,20,21* and John F. DiPersio, MD^4,17

¹Department of Medicine, Washington University School of Medicine, Saint Louis, MO
²McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO
³Medicine, Washington University School of Medicine, Saint Louis, MO
⁴Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
⁵Department of Medicine, Division of Oncology, Washington University School of Medicine, Webster Groves, MO
⁶Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO
⁷Department of Internal Medicine, Division of Oncology, Washington Univ. School of Med., Saint Louis, MO
⁸Pacific Northwest National Laboratory, Richland, WA
⁹Washington University in St. Louis, St. Louis, MO
¹⁰Washington University in St. Louis, Saint Louis, MO
¹¹Division of Biological and Biomedical Sciences, Washington University in St. Louis, Saint Louis, MO
¹²Department of Medicine, Washington University in St. Louis, St. Louis, MO
¹³McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO
¹⁴McDonnell Genome Institute, Washington University in St. Louis, St. Louis, St. Louis, MO
¹⁵Division of Oncology, Washington University, Rock Hill, MO
¹⁶Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO
¹⁷Washington University School of Medicine, Saint Louis, MO
¹⁸Washington University School of Medicine, Siteman Cancer Center, Saint Louis, MO
¹⁹Washington University School of Medicine, Ballwin, MO
²⁰Genetics, Washington University School of Medicine, Saint Louis, MO
²¹Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO

Ehsan Malek, MD^1,2, E. Ricky Chan, PhD^2,3*, Daniel Qu^4*, Jane Reese^2,5*, Robert Fox^5*, Byung-Gyu Kim, PhD, DVM^2,6*, Paolo F Caimi, MD^2,5, Marcos de Lima, MD^2,5 and James J. Driscoll, MD, PhD^2,5

¹Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Shaker Hts, OH
²Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH
³Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH
⁴Case Western Reserve University School of Medicine, Cleveland, OH
⁵Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, OH
⁶Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH

Jessica Caro, MD¹, David Cairns, MSc, PhD^2*, Tom Menzies^3*, Charlotte Pawlyn, BA, PhD, MBBChir, MRCP, FRCPath⁴, Eileen M Boyle, MD, MSc^1*, Gareth Morgan, MD, PhD¹, Gordon Cook, MB ChB, PhD^2*, Martin F. Kaiser, MD, FRCP, FRCPath⁵, Roger G Owen, MD^6*, Walter M Gregory, PhD^2*, Graham H Jackson, MD, MA, MB BS, FRCP, FRCPath⁷, Brian Walker, PhD^8*, Jennifer LJ Heaney, PhD^9*, Mark T Drayson, MB ChB, PhD, FRCPath^9* and Faith E. Davies¹

¹Perlmutter Cancer Center, New York University Langone Health, New York, NY
²Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom
³Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom
⁴Institute of Cancer Research, Sutton, United Kingdom
⁵The Institute of Cancer Research, London, United Kingdom
⁶St. James’s University Hospital, Leeds, United Kingdom
⁷Department of Haematology, Newcastle University, Newcastle upon Tyne, United Kingdom
⁸Indiana University School of Medicine, Bloomington, IN
⁹Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom

Manoj Bhasin, PhD^1*, Beena E Thomas^1*, Reyka G Jayasinghe, PhD^2*, Nicolas Fernandez, PhD^3*, Swati S Bhasin, PhD^4*, Taxiarchis Kourelis, MD⁵, Madhav V. Dhodapkar, MD^6,7, Ravi Vij^8*, Shaji K. Kumar, MD⁵, Shaadi Mehr, PhD^9*, Mark Hamilton, PhD^9*, Hearn Jay Cho, MD, PhD¹⁰, Daniel Auclair¹¹, Sacha Gnjatic^12*, Li Ding, PhD^2* and David E. Avigan, MD¹³

¹Emory School of Medicine, Aflac Cancer and Blood Disorders Center, Atlanta, GA
²Department of Medicine, Washington University School of Medicine, Saint Louis, MO
³Human Immune Monitoring Center, Icahn School of Medicine at Mt. Sinai, New York, NY
⁴School of Medicine, Emory University, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Atlanta, GA
⁵Mayo Clinic Rochester, Division of Hematology, Rochester, MN
⁶Emory University School of Medicine, Atlanta, GA
⁷Winship Cancer Institute, Emory University, Atlanta, GA
⁸Washington University School of Medicine, St Louis, MO
⁹Multiple Myeloma Research Foundation, Norwalk, CT
¹⁰MMRF; Icahn School of Medicine at Mount Sinai, Norwalk, CT
¹¹Multiple Myeloma Research Foundation (MMRF), Norwalk, CT
¹²Mount Sinai School of Medicine, New York, NY
¹³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA