Abhishek Maiti, MBBS¹, Sergej Konoplev, MD, PhD^2*, Courtney D. DiNardo, MD, MSc³, Tapan M. Kadia, MD⁴, Farhad Ravandi, MBBS⁵, Naval Daver, MD⁶, Naveen Pemmaraju, MD¹, Gautam Borthakur, MD¹, Prithviraj Bose, MD⁷, Ghayas C. Issa, MD¹, Nicholas J. Short, MD¹, Musa Yilmaz, MD⁷, Yesid Alvarado, MD⁷, Alessandra Ferrajoli, MD⁸, Elias Jabbour, MD¹, Nitin Jain, MD⁹, Maro Ohanian, DO^1*, Koichi Takahashi, MD, PhD¹⁰, Philip A. Thompson, MB, MS¹¹, Caitlin R. Rausch, PharmD^12*, Kathryn Montalbano^13*, Sherry A. Pierce, BSN, BA^1*, Keyur P. Patel, MBBS, PhD², Guillermo Garcia-Manero, MD¹, Hagop M. Kantarjian, MD¹⁴ and Marina Konopleva, MD, PhD¹⁵

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, The University of Texas, M.D. Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁸Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁹Associate Professor of Medicine Department of Leukemia The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁰Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
¹¹The University of Texas MD Anderson Cancer Center, Houston, TX
¹²Pharmacy, MD Anderson Cancer Center, Houston, TX
¹³University of Texas M.D. Anderson Cancer Center, Houston, TX
¹⁴University of Texas MD Anderson Cancer Center, Houston, TX
¹⁵Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX

Bruno Paiva, PhD^1*, María Belén Vidriales^2*, Maria Desamparados Sampere Talens^3*, Fabian Tarin^4*, Enrique Colado^5*, Celina Benavente^6*, María Teresa Cedena, MD^7*, Joaquin Sanchez, MD^8*, Teresa Caballero-Velázquez, MD, PhD^9*, Lourdes Cordon^10*, David Martínez-Cuadron, MD^11*, Teresa Bernal del Castillo, MD, PhD^12*, Carmen Botella^13*, Sofia Grille, MD, PhD¹⁴, Josefina Serrano, MD^15*, Carlos Rodriguez^16*, Jesús Lorenzo Algarra^17*, Juan Manuel Alonso Dominguez, MD, PhD, MSc^18*, Maria Luz Amigo, MD^19*, Manuel BARRIOS García, MD, PhD^20*, Raimundo García-Boyero, MD^21*, Mercedes Colorado, MD^22*, Jaime Perez De Oteyza, MD, PhD²³, Manuel Perez Encinas, MD^24*, Lissette Del Pilar Costilla, MD^25*, Maria Jose Sayas^26*, Olga Pérez-López^27*, Marcos González^28*, Jose A. Perez-Simon, MD, PhD²⁹, Joaquin Martinez-Lopez, MD, PhD^30*, Claudia Lucia Sossa^31*, Alberto Orfao, MD, PhD³², Jesús F. San-Miguel³³, Miguel Sanz, MD, PhD^34* and Pau Montesinos, MD, PhD^35*

¹Clinica Universidad De Navarra, Pamplona, Navarra, Spain
²Instituto de Investigación Biomédica de Salamanca, Hospital Universitario de Salamanca, Salamanca, Spain
³Hospital Universitario y Politécnico La Fe, Valencia, ESP
⁴Hospital General Universitario De Alicante, Alicante, ESP
⁵Hospital Universitario Central de Asturias, Oviedo, Spain
⁶Hospital Clinico San Carlos. Madrid, Madrid, Spain
⁷Hematology Department, Hospital Universitario 12 de Octubre,, Madrid, Spain
⁸Hospital Universitario Reina Sofia, Cordoba, Spain
⁹Department of Hematology, Hospital Universitario Virgen del Rocio; Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla,Spain, Sevilla, Spain
¹⁰Hospital Universitario La Fe, Valencia, Spain
¹¹Hospital Universitari i Politècnic La Fe, Valencia, Spain
¹²Central de Asturias Universitary Hospital, Oviedo, Spain
¹³Hematology department, Hospital General Universitario de Alicante, Alicante, Spain
¹⁴Hospital de Clínicas. Montevideo, Montevideo, Uruguay
¹⁵University Hospital Reina Sofia, Cordoba, Spain
¹⁶Hospital Gran Canaria Dr Negrín, Las Palmas, ESP
¹⁷Hospital General de Albacete, Albacete, ESP
¹⁸Hospital Universitario Fundacion Jimenez Diaz - IISFJD-UAM, Madrid, Madrid, Spain
¹⁹Hematology and Medical Oncology Department, Hospital Morales Meseguer, IMIB, Murcia, Spain, Murcia, ESP
²⁰Hospital Regional Universitario de Málaga, Málaga, ESP
²¹Hematology and hemotherapy department, Hospital Universitario General de Castellón, Castellón de la Plana, Spain
²²Hematology Department, University Hospital "Marqués de Valdecilla", Santander, Spain
²³Hospital Universitario Madrid Sanchinarro, Madrid, Spain
²⁴Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain
²⁵Hematology, Hospital Miguel Servet. Zaragoza, Zaragoza, Spain
²⁶Hospital Universitario Doctor Peset, Valencia, Spain
²⁷Hospital Universitario Virgen del Rocío, Dos Hermanas, Spain
²⁸Departamento de Hematología, Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC), CIBERONC, Salamanca, Spain
²⁹Hospitales Univ. Virgen Del Rocío, Virgen De La Macarena, Seville, Spain
³⁰Hematology Department Hospital 12 de Octubre, Complutense University, H12O-CNIO Clinical research unit, CIBERONC, Madrid, Spain
³¹Hematology and Hematopoietic Stem Cell Transplantation Unit, Clinica FOSCAL, Floridablanca, Santander, Colombia
³²University of Salamanca, Salamanca, Salamanca, Spain
³³University of Navarra, Pamplona, Spain
³⁴Hematology Department, Hospital Universitario La Fe de Valencia,, Valencia, Spain
³⁵Hematology Department, Hospital Universitario La Fe de Valencia,, Valencia, Spain, Spain

Claudia Nunez-Torron, MD^1*, Fernando Martin Moro^2*, Juan Marquet Palomanes^2*, Miguel Piris-Villaespesa, MD^3*, Ernesto Roldan^2*, Alejandro Luna, MD^3*, Adolfo Saez^2*, Valentín Garcia-Gutiérrez, MD, PhD³, Lucía Rubio^2*, Maria Eulalia Rodriguez^2*, Anabelle Chinea, MD^4*, Ana Lario^5*, Gemma Moreno Jiménez, MD^4*, Javier Lopez Jimenez, MD, PhD^6* and Pilar Herrera Puente^7*

¹Hematology, Hospital Ramon y Cajal, 28034, Spain
²Hospital Universitario Ramón y Cajal, Madrid, Spain
³Hematology, Hospital Universitario Ramón y Cajal, Madrid, Spain
⁴Hematology and Hemotherapy Department, Hospital Universitario Ramón y Cajal, Madrid, Spain
⁵Hospital Ramón y Cajal, Madrid, Madrid, ESP
⁶University Hospital Ramon y Cajal, Madrid, Spain
⁷Hematology department, Hospital Ramón y Cajal, Madrid, Spain

James Yu, MD¹, Jingxin Sun, MD, PhD^2*, Yuan Du^3* and Chung-Che Chang, MD, PhD⁴

¹Internal Medicine Department, Adventhealth Orlando Hospital, Orlando, FL
²Department of Hematology and Medical Oncology, Baylor College of Medicine, Huston, TX
³Research Institute, Adventhealth Orlando Hospital, Orlando, FL
⁴Hematology and Molecular Pathology Labs, Adventhealth Orlando Hospital, Orlando, FL

Anna Maierhofer, PhD^*, Constance Baer, PhD, Christian Pohlkamp, MD^*, Manja Meggendorfer, PhD, Wolfgang Kern, MD, Claudia Haferlach, MD and Torsten Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany

Hassan Awada, MD^1*, Carmelo Gurnari, MD^2*, Arda Durmaz^3*, Simona Pagliuca, MD⁴, Misam Zawit, MBBS^4*, Cassandra M Kerr, MS^4* and Valeria Visconte, PhD⁴

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland
³Department of Systems biology and Bioinformatics, CWRU, cleveland
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH

Min Yang, MD, PhD^1*, Yi Zhang, Medical Master^2*, Jinghan Wang, MD, PhD^3*, Lixia Liu^4*, Chengcheng Wang^5*, Feng Lou^6*, Shanbo Cao^7* and Jie Jin, MD, PhD⁸

¹The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²The First Affiliated Hospital Zhejiang Univ. School of Med, Hangzhou, China
³Key Laboratory of Hematopoietic Malignancies, Zhejiang Province, Hangzhou, China
⁴Acornmed Biotechnology Co., Ltd., Beijing, China
⁵AcornMed Biotechnology Co., Ltd., Beijing, China
⁶AcornMed Biotechnology Co., Ltd.7 Floor, Building 8, Vpark, No.18 Kechuang 13th Street, Beijing, China, Beijing, China
⁷Acornmed Biotechnology Co.,Ltd., Beijing, China
⁸Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China

Amy Song^1*, Omar Altabbakh, BS^2*, David A. Sallman, MD³, Eric Padron, MD⁴, Chetasi Talati, MD³ and Mohammad O Hussaini, MD^5,6*

¹New Jersey Medical School, Rutgers University, Newark, NJ
²Nova Southeastern University, Clearwater, FL
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁴Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁵Department of Hematopathology and Lab Medicine, 1978, tampa, FL
⁶Moffitt Cancer Center, Tampa, FL

Sydney Fobare^1,2, Jessica Kohlschmidt, PhD^1,3, Hatice Gulcin Ozer, PhD^4*, Krzysztof Mrózek, MD, PhD¹, Deedra Nicolet, MS^1,3*, Alice S. Mims, MD^1,2, Ramiro Garzon, MD^1,2, James S. Blachly, MD^1,2, Shelley Orwick, BS^1*, Andrew J Carroll, PhD⁵, Richard M. Stone, MD⁶, Eunice S. Wang, MD⁷, Jonathan E. Kolitz, MD⁸, Bayard L. Powell, MD⁹, Christopher C. Oakes, PhD^1,10, Ann-Kathrin Eisfeld, MD^2,11, Erin Hertlein, PhD^1,2* and John C. Byrd, MD^1,2

¹The Ohio State University Comprehensive Cancer Center, Columbus, OH
²Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH
³Alliance Statistics and Data Center, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴Department of Biomedical Informatics, The Ohio State University, Columbus, OH
⁵Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
⁶Dana-Farber/Partners CancerCare, Boston, MA
⁷Roswell Park Comprehensive Cancer Center, BUFFALO, NY
⁸Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY
⁹Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC
¹⁰OSU, Columbus, OH
¹¹Division of Hematology, The Ohio State University, Columbus, OH

Sean Koebley, PhD^1*, Andrey Mikheikin, PhD^1*, Kevin Leslie, PhD^1*, Wendy McConnell-Wells^1*, Joshua H Lehman^1*, Daniel Guest^1*, Taha Al Juhaishi, MD^2*, Xiaojie Zhang, MD^2*, Catherine H Roberts, PhD^2*, Loren Picco, PhD^1*, Amir Ahmed Toor, MD^2*, Alden Chesney, MD³ and Jason Reed, PhD^1,4*

¹Department of Physics, Virginia Commonwealth University, Richmond, VA
²Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA
³Department of Pathology, VCU School of Medicine, Richmond, VA
⁴Massey Cancer Center, VCU Medical Center, Richmond, VA

Pavinder Kaur^1*, Anil Pahuja^1*, Kevin Nguyen^1*, Pedro Marques Ramos, PhD^2*, Ling Du, PhD^3*, Jacqueline J Cloos^4*, Maaike E Heidinga^4*, Yvonne J.M Oussoren-Brockhoff^4*, Angele Kelder^4*, Xun Li¹, Sarah Larson, MD⁵, Shabnam Tangri^1*, Ghanashyam Sarikonda^1* and Naveen Dakappagari^1*

¹Navigate BioPharma Services, Inc., a Novartis subsidiary, Carlsbad, CA
²Novartis International AG, Basel, Switzerland
³Novartis Pharmaceuticals, Cambridge, MA
⁴Vrije University Medical Center, Amsterdam, Netherlands
⁵University of California Los Angeles, Los Angeles, CA

Disha Dalela, MD¹, Qiming Shi^2*, Karl Simin, MD^3*, Jonathan Gerber, MD^4* and Shyam A. Patel, MD, PhD^5*

¹Department of Medicine, University of Massachusetts, Shrewsbury, MA
²Department of Population Health & Quantitative Sciences, University of Massachusetts, Worcester, MA
³Department of Molecular, Cell & Cancer Biology, University of Massachusetts, Worcester, MA
⁴Department of Medicine- Hematology/Oncology, University of Massachusetts, Worcester, MA
⁵Department of Medicine- Hematology/Oncology, University of Massachusetts, 55 Lake Avenue North, MA

Anneke D. van Dijk, MD^1,2*, Fieke W Hoff, BSc^1*, Yihua Qiu^3*, Eveline S. de Bont, MD, PhD^1*, Sophia W.M. Bruggeman, PhD^1*, Terzah M Horton, MD, PhD⁴ and Steven M. Kornblau, MD⁵

¹Department of Pediatric Oncology/ Hematology, University Medical Center Groningen, Groningen, Netherlands
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁴Baylor College of Medicine, Houston, TX
⁵Department of Stem Cell Transplantation, M.D. Anderson Cancer Center University of Texas, Houston, TX

Hang Su^1*, Mei-Jun Long, MD, PhD^1,2*, Joel E Michalek, PhD^1*, Michael Weil, PhD^3* and Chul S Ha, MD¹

¹The University of Texas Health Science Center At San Antonio, San Antonio, TX
²The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
³Colorado State University, Fort Collins, CO

Vitória Ceni Ceni, MD^1*, Katia B Pagnano, MD, PhD², Gislaine B O Duarte, MD^2*, Marina DB Pellegrini^2*, Bruno Kosa Duarte, MD, PhD^2*, Konradin Metze, MD, PhD^3* and Irene Lorand-Metze, MD, PhD^4*

¹Hematology and Hemotherapy Center, University of Campinas, Campinas, AC, Brazil
²Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
³Department of Pathology, Faculty of Medicine, University of Campinas, Campinas, Brazil
⁴Department of Internal Medicine, Faculty of Medicine, University of Campinas, CAMPINAS, Brazil

Romy E. Van Weelderen^1,2*, Kim Klein, MD^3,4*, Bianca F. Goemans, MD, PhD⁵, Christian M. Zwaan, MD, PhD^5,6, Hester A. De Groot-Kruseman, PhD^5,7*, Jonas Abrahamsson, MD, PhD^8*, Nira Arad-Cohen, MD, PhD^9*, Emmanuelle Bart-Delabesse, PharmD, PhD^10*, Barbara Buldini, MD, PhD^11*, Barbara De Moerloose, MD, PhD^12*, Michael Dworzak, MD, PhD^13*, Sarah Elitzur, MD^14*, José M. Fernández Navarro, MD^15*, Robert B. Gerbing, MA^16*, Erin Guest, MD¹⁷, Shau-Yin Ha, MD, PhD^18*, Christine J. Harrison, PhD, FRCPath¹⁹, Henrik Hasle, MD²⁰, Kathy Jackson, MD, PhD^21*, Charikleia Kelaidi, MD^22*, Hélène Lapillonne, MD, PhD^23*, Guy Leverger, MD, PhD^24*, Franco Locatelli, MD, PhD²⁵, Takako Miyamura, MD, PhD²⁶, Sophia Polychronopoulou, MD, PhD^22*, Mareike Rasche, MD^27*, Jeffrey E. Rubnitz, MD²⁸, Jan Stary, MD, PhD^29*, Daisuke Tomizawa, MD, PhD³⁰, Femke Verwer^2,7* and Gertjan J.L. Kaspers, Prof. MD, PhD^3,5

¹Department of Pediatric Hematology and Oncology, Emma Children’s Hospital, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
²Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
³Department of Pediatric Hematology and Oncology, Emma Children's Hospital, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
⁴Wilhelmina Children’s Hospital/University Medical Center Utrecht, Utrecht, Netherlands
⁵Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁶Department of Pediatric Oncology/Hematology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, Netherlands
⁷Dutch Childhood Oncology Group, Utrecht, Netherlands
⁸Department of Pediatrics, Queen Silvia Children's Hospital, Gothenburg, Sweden
⁹Pediatric Hematology Oncology Department, Ruth Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa, Israel
¹⁰Laboratoire d'Hématologie secteur Génétique des Hémopathies, IUC Toulouse-Oncopole, Toulouse, France
¹¹Pediatric Hematology-Oncology, Department of Women's and Children's Health, University of Padova, Padova, Italy
¹²Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
¹³St. Anna Children's Hospital and Cancer Research Institute, Medical University of Vienna, Vienna, Austria
¹⁴Pediatric Hematology and Oncology, Schneider Children's Medical Center and Tel Aviv University, Tel Aviv, Israel
¹⁵Pediatric Oncohematology Unit, Hospital Universitari i Politècnic la Fe, Valencia, Spain
¹⁶Children's Oncology Group, Monrovia, CA
¹⁷Division of Hematology/Oncology/Bone Marrow Transplantation, Children's Mercy, Kansas City, MO
¹⁸Department of Pediatrics, Queen Mary Hospital, Hong Kong, Hong Kong
¹⁹Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, ENG, United Kingdom
²⁰Pediatrics, Aarhus University Hospital, Aarhus, Denmark
²¹St. Jude Children’s Research Hospital, Memphis, TN
²²Department of Pediatric Hematology and Oncology, Aghia Sophia Children’s Hospital, Athens, Greece
²³Pediatric Hematology and Oncology Department, Hôpital Armand Trousseau, Paris, France
²⁴Pediatric Hematology and Oncology Department, Hôpital Armand-Trousseau, Paris, France
²⁵Department of Pediatric Hematology/Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
²⁶Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan
²⁷Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany
²⁸Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
²⁹Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic
³⁰Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan

Lars Bullinger, MD¹, Javier Martinez Elicegui^2*, Eric Sträng, PhD^3*, Castellani Gastone^4*, Caroline A Heckman, PhD⁵, Ana Heredia Casanoves^6*, Jurjen Versluis^7*, Moritz Gerstung, PhD^8*, María Abáigar, PhD^9*, Alberto Hernandez-Sanchez^2*, Laura Jamilis^6*, Raúl Azibeiro Melchor^2*, Peter JM Valk, PhD¹⁰, Klaus H. Metzeler, MD¹¹, Rosa Ayala, MD, PhD^12*, Joaquin Martinez Lopez^13*, Hervé Dombret, MD¹⁴, Pau Montesinos, MD, PhD^15*, Jorge Sierra, MD¹⁶, Claude Preudomme^17*, Frederik Damm, MD^18*, Ken I Mills, PhD, FRCPath, BSc¹⁹, Jiri Mayer^20*, Christian Thiede, MD²¹, Maria Teresa Voso, MD²², Sergio Amadori²³, Guillermo F Sanz, MD, PhD²⁴, Frederico Calado^25*, Konstanze Dohner, MD²⁶, Verena I Gaidzik, MD²⁷, Michael Heuser²⁸, Torsten Haferlach, MD²⁹, Marta Sobas, MD PhD^30*, Amin T. Turki, MD, PhD³¹, Dirk Reinhardt, MD³², Rubén Villoria Medina^6*, Michel van Speybroeck, MSc^33*, Renate Schulze-Rath, MD, MSc^34*, Jesús M Hernández Rivas, MD, PhD⁹, Brian J. P. Huntly, PhD, MRCP, MB, FRCPath³⁵, Hartmut Döhner²⁷ and Gert J. Ossenkoppele, MD, PhD³⁶

¹Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine, Berlin, Germany
²Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
³Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, Berlin, Germany
⁴University of Bologna (UNIBO), Bologna, Italy
⁵Institute for Molecular Medicine Finland,, University of Helsinki, Helsinki, Finland
⁶GMV Innovating Solutions, Valencia, Spain
⁷Erasmus University Medical Center Cancer Institute, Rotterdam, Rotterdam, Netherlands
⁸European Bioinformatics Institute, Hinxton, United Kingdom
⁹Universidad de Salamanca, IBSAL, Centro de Investigación del Cáncer, IBMCC-CSIC, Salamanca, Spain
¹⁰Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands
¹¹Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
¹²Hematology Department, Hospital Universitario 12 de Octubre,, Madrid, Spain
¹³Hospital Universitario 12 de Octubre, Madrid, Spain
¹⁴Division of Hematology, EA3518 Saint-Louis Institute for Research, Hôpital Saint-Louis, APHP, University of Paris, Paris, France, Paris, France
¹⁵Hematology Department, Hospital Universitario La Fe de Valencia,, Valencia, Spain, Spain
¹⁶Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
¹⁷University Hospital, Lille, France
¹⁸Hematology, Oncology, and Tumorimmunology, Charité - Universitätsmedizin Berlin, Berlin, Germany
¹⁹Patrick G Johnston Centre for Cancer Research, Queens University Belfast, Belfast, United Kingdom
²⁰University Hospital Brno, Czech Republic, Brno, CZE
²¹Dept. of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
²²Dipartimento di Biopatologia e Diagnostica per Immagini, University of Rome Tor Vergata, Rome, Italy
²³Department of Biomedicine and Prevention, University of Rome Tor Vergata, Roma, RM, Italy
²⁴Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain
²⁵Novartis, Oncology Region Europe, Basel, Switzerland
²⁶Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²⁷Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
²⁸Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²⁹MLL Munchner Leukamie Labor Gmbh, Munchen, Germany
³⁰Department of Hematology, Wroclaw Medical University, Wroclaw, Poland
³¹Department of Bone Marrow Transplantation, University Hospital Essen, West German Cancer Center, Essen, Germany
³²Department of Pediatric Hematology and Oncology, Essen University Hospital, Essen, Germany
³³Data Sciences, Janssen Pharmaceutica N.V., Beerse, Belgium
³⁴Bayer Pharma AG, Berlin, Berlin, Germany
³⁵Department of Haematology, University of Cambridge, Cambridge, United Kingdom
³⁶Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands

Lara Duchstein^1*, Hillary S Sloane, PhD^2*, Johannes Fredebohm, PhD^1* and Matthew Ryder^2*

¹Sysmex Inostics GmbH, Hamburg, Germany
²Sysmex Inostics, Inc., Baltimore, MD

Yasmin Alwash, MD^1,2, Rashmi Kanagal-Shamanna, MD³, Veronica A Guerra, MD¹, Naval Daver, MD¹, Marina Konopleva, MD, PhD¹, Farhad Ravandi, MBBS¹, Tapan M. Kadia, MD¹, Courtney D. DiNardo, MD, MSc¹, Ghayas C. Issa, MD⁴, Gautam Borthakur, MD¹, Sanam Loghavi, MD³, Koichi Takahashi, MD, PhD¹, Musa Yilmaz, MD⁴, Abhishek Maiti, MBBS⁴, Hagop M. Kantarjian, MD⁵, Steven M. Kornblau, MD¹ and Nicholas J. Short, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, Professor and Chairman, Department of Leukemia, Samsung Distinguished University Chair in Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Metis Hasipek, PhD^1*, Yihong Guan, PhD^1*, Dale Grabowski, BS^1*, Xiaorong Gu, PhD^1*, Yogenthiran Saunthararajah, MD¹, Robert Silverman, PhD^2*, George R Stark, PhD^2*, Jaroslaw Maciejewski, PhD^1* and Babal K. Jha, PhD^1*

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH

Giulia Maggioni, MD^1*, Cristina Astrid Tentori, MD^1*, Maria Teresa Voso, MD², Sonja Heibl, MD^3*, Klaus H. Metzeler, MD⁴, Jan Moritz Middeke, MD^5*, Joana Desterro^6*, Maria Carmo-Fonseca^7*, Erica Travaglino^1*, Paola Fazi, MD^8*, Alfonso Piciocchi, MS^8*, Annika Maria Dufour, PhD^4*, Jordi Esteve^9*, Marta Pratcorona, MD^10*, Valentina Mancini, MD^11*, Federico Lussana, MD^12*, Karsten Spiekermann^13*, Christian Thiede, MD¹⁴, Friedrich Stolzel, MD^15*, Aida Botelho de Sousa^16*, Mar Tormo^17*, Pamela Acha^18*, Montserrat Arnan^19*, Nicola Fracchiolla, MD^20*, Marcus Hentrich^21*, Christoph Sippel^22*, Bernhard Heilmeier^23*, Marcos Lemos^24*, Albertina Nunes^25*, Sonia Matos^26*, Marina Diaz^9*, Ana Garrido, MD^10*, David Gallardo, MD^27*, Susana Vives, MD^28*, Olga Salamero^29*, Elisabetta Todisco, MD PhD^30*, Claudia Basilico, MD^31*, Francesco Passamonti^32*, Sigrid Machherndl-Spandl, MD^33*, Lisa Pleyer^34*, Jorge Sierra^35*, Francesc Solé, PhD³⁶ and Matteo Giovanni Della Porta, MD^1*

¹Cancer Center, IRCCS Humanitas Research Hospital & Humanitas University, Rozzano (Milan), Italy
²University of Rome Tor Vergata, Rome, Italy
³Dept. of Internal Medicine IV, Klinikum Wels-Grieskirchen GmbH, Wels, Austria
⁴Laboratory for Leukemia Diagnostics, Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany
⁵Dept. of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
⁶Instituto Portugues de Oncologia de Lisboa, Servico de Hematologia, Lisboa, Portugal
⁷Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Portugal, Lisboa, Portugal
⁸GIMEMA Foundation, Rome, Italy
⁹Hematology Dpt. Hospital Clínic, Barcelona, Barcelona, Spain
¹⁰Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
¹¹Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
¹²Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Please Choose A State, Italy
¹³Dept. of Hematology and Oncology, Laboratory for Leukemia Diagnostics, University Hospital, LMU Munich, Munich, Germany
¹⁴Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden, Germany
¹⁵Department of Hematology and Oncology, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
¹⁶Hospital dos Capucho, Lisboa, Portugal
¹⁷Hematology Dpt., Hospital Clínico Universitario, Valencia, Spain
¹⁸Hematology Dpt, Hospital Germans Trias y Pujol, Catalan Institute of Oncology, Badalona and Jose Carreras Leukemia Research Institute, Badalona, Spain
¹⁹Hematology Dpt., Hospital Duran Reynals, Catalan Institute of Oncology, Hospitalet, Barcelona, Spain
²⁰UOC Oncoematologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Di, Milan, ITA
²¹Dept. of Hematology and Oncology,, Red Cross Hospital, Munich, Germany
²²Hematology Dpt., Hospital Clínic, Barcelona, Barcelona, Spain
²³Department of Oncology and Hematology, Hospital Barmherzige Brueder, Regensburg, Germany
²⁴Hospital dos Capuchos, Centro Hospitalar Lisboa Central, Lisboa, Portugal
²⁵Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
²⁶GenoMed - Diagnósticos de Medicina Molecular SA, Lisboa, Portugal
²⁷Hematology Department, ICO - Hospital Doctor Josep Trueta, Girona, Spain
²⁸Hematology Department, ICO - Hospital Germans Trias i Pujol, Badalona, Spain
²⁹Hematology Dpt. Hospital Vall d'Hebron, Barcelona, Spain
³⁰European Institute of Oncology, Milano, Italy
³¹ASST dei Sette Laghi, Presidio di Varese Osp Circolo Fondazione Macchi, Varese, Italy
³²Division of Hematology, Department of Medicine and Surgery, University of Insubria, Varese, Italy
³³1st. Internal Department – Hematology with stem cell transplants, hemostaseology and medical oncology, Elisabethinen Hospital, Linz, Austria
³⁴3rd Medical Department with Hematology and Medical Oncology, Hemostaseology, Rheumatology and Infectious Diseases, Paracelsus Medical University, Salzburg, Austria, Salzburg, Austria
³⁵Hematology Dpt. Hospital Santa Creu i Sant Pau, Barcelona, Spain
³⁶MDS Research Group, Institut de Recerca Contra la Leucèmia Josep Carreras, Institut Català d’Oncologia-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Badalona, Spain

Catia Patricia Simoes, MD^1*, Bruno Paiva, PhD^2*, David Martínez-Cuadron, MD^3*, Juan-Miguel Bergua, MD^4*, Susana Vives, MD^5*, Jesús Lorenzo Algarra^6*, Mar Tormo, MD⁷, Pilar Martinez, MD^8*, Josefina Serrano, MD^9*, Pilar Herrera, MD^10*, Fernando Ramos^11*, Olga Salamero, MD^12*, Esperanza Lavilla^13*, Cristina Gil^14*, Jose Luiz Lopez Lorenzo, MD^15*, Maria-Belen Vidriales, MD^16*, Jorge Labrador^17*, José F. Falantes^18*, Maria Jose Sayas^19*, Rosa Ayala, MD, PhD^20*, Joaquin Martinez-Lopez, MD^21*, Sara Villar^22*, María José Calasanz, PhD^23*, Felipe Prosper, MD^24*, Jesús F. San-Miguel²⁵, Miguel A. Sanz²⁶ and Pau Montesinos, MD, PhD^27*

¹Clinica Universidad De Navarra, Centro De Investigacion Medica Aplicada (CIMA),, Pamplona, Spain
²Clinica Universidad De Navarra, Pamplona, Navarra, Spain
³Hospital Universitari i Politècnic La Fe, Valencia, Spain
⁴Clinical Hematology, Hospital San Pedro de Alcántara, Cáceres, Spain
⁵Hematology Department, ICO - Hospital Germans Trias i Pujol, Badalona, Spain
⁶Hematology department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain
⁷Hospital Clínico Universitario de Valencia, Valencia, Spain
⁸Haematology department, 12 Octubre Hospital, Madrid, Spain
⁹University Hospital Reina Sofia, Cordoba, Spain
¹⁰Hematology and Hemotherapy Department, Hospital Universitario Ramón y Cajal, Madrid, Spain
¹¹Department of Hematology, Hospital Universitario De LeóN and Instituto De Biomedicina (IBIOMED), Un, Leon, Spain
¹²Department of Hematology, University Hospital Vall d´Hebron, Barcelona, Spain
¹³Hospital Universitario Lucus Augusti, Lugo, Spain
¹⁴Hematology Department, Hospital General Universitario de Alicante, Alicante, Spain
¹⁵Fundación Jiménez Díaz, Madrid, Madrid, Spain
¹⁶Hematology Department, Hospital Clínico Universitario Salamanca (CAUSA/IBSAL), Salamanca, Spain
¹⁷Hematology Department, Research Unit, Hospital Universitario de Burgos, Burgos, Spain
¹⁸Hospital Universitario Virgen del Rocío, Sevilla, Spain
¹⁹Hospital Dr. Peset. Spain, Valencia, Spain
²⁰Hematology Department, Hospital Universitario 12 de Octubre,, Madrid, Spain
²¹Hematology and hemotherapy department, Hospital Universitario 12 De Octubre, Madrid, Spain
²²Hematology Department, Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, Spain
²³University of Navarra, Pamplona, Na, ESP
²⁴CLINICA UNIVERSIDAD DE NAVARRA - DPTO. HEMATOLOGIA, Pamplona, Navarra, Spain
²⁵University of Navarra, Pamplona, Spain
²⁶Hematology Department, University and Polytechnic Hospital La Fe, Valencia, Spain
²⁷Hematology Department, Hospital Universitario La Fe de Valencia,, Valencia, Spain, Spain

Xue Chen, MD^1,2*, Fang Wang, MD², Panxiang Cao, MS^2*, Xiaoli Ma, MD^2*, Lili Yuan, MD^2*, Yang Zhang, MD², Daijing Nie, MD^2*, Jiaqi Chen, MD^2*, Xiaosu Zhou^2*, Ming Liu, MD^2*, Zhixiu Liu, MD^2*, Mingyue Liu^2* and Hongxing Liu, MD^2,3,4

¹Division of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Beijing, China
²Division of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
³Beijing Lu Daopei Institute of Hematology, Beijing, China
⁴Division of Laboratory Medicine, Beijing Lu Daopei Hospital, Beijing, China

Casey L. McAtee, MD^1*, Joseph Lubega, MBChB, MPH^2*, Michael E. Scheurer, PhD, MPH^3* and Rachel E. Rau, MD⁴

¹Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX
²Texas Children's Cancer and Hematology Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX
³Texas Children's Hospital, Houston, TX
⁴Texas Children’s Cancer and Hematology Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX

Ludovic Gabellier, MD^1,2,3*, Caroline Bret, PhD, PharmD^4,5,6*, Guillaume Bossis, PhD^2*, Guillaume Cartron, MD, PhD^7,8,9* and Jerome Moreaux, PhD^6,10,11,12

¹Department of clinical Hematology, University Hospital of Montpellier, Montpellier, France
²Institut de Génétique Moléculaire de Montpellier (IGMM), CNRS, Montpellier, France
³UFR Medicine, University of Montpellier, Montpellier, France
⁴Department of Biological Hematology, CHU Montpellier, Montpellier, France
⁵University of Montpellier, UFR Medecine, Montpellier, France
⁶Institute of Human Genetics, UMR 9002 CNRS-UM, Montpellier, France
⁷CHU Montpellier, Department of Clinical Hematology, Montpellier, France
⁸Centre Hospitalier Universitaire de Montpellier, Montpellier, France
⁹Department of Clinical Hematology, University Hospital of Montpellier, Montpellier, France
¹⁰UFR Médecine, Université Montpellier, Montpellier, France
¹¹Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, CHU Montpellier, Montpellier, France
¹²Institut Universitaire de France, Paris, France

Fieke W Hoff, BSc^1*, Anneke D. van Dijk, MD^1*, Yihua Qiu^2*, Eveline S. de Bont, MD, PhD^1*, Steven M. Kornblau, MD³ and Terzah M Horton, MD, PhD⁴

¹Department of Pediatric Oncology/ Hematology, University Medical Center Groningen, Groningen, Netherlands
²Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Baylor College of Medicine, Houston, TX

Jenny L. Smith, MSc, MEd^1*, Eline J.M. Bertrums, MD^2*, Rhonda E. Ries, MA^1*, Fabiana Ostronoff, MD³, Amanda R. Leonti, MS^4*, Scott N. Furlan, MD^3,5*, Bianca F. Goemans, MD, PhD² and Soheil Meshinchi, MD, PhD^6,7,8

¹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
²Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
³Fred Hutchinson Cancer Research Center, Seattle, WA
⁴Clinical Research Division, Fred Hutchinson Cancer Research Center, Mountlake Terrace, WA
⁵Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA
⁶Department of Pediatrics, University of Washington, Seattle, WA
⁷Clinical Research Division, Fred Hutchinson Cancer Rsrch. Ctr., Seattle, WA
⁸Children's Oncology Group, Monrovia, CA

Svea Stratmann^1*, Sara A Yones^2*, Jitong Sun, PhD^1*, Aron Skaftason^3*, Markus Mayrhofer, PhD^4*, Nina Norgren, PhD^5*, Morten Krogh Herlin, MD^6*, Anna Eriksson, PhD^7*, Martin Hoglund, MD⁷, Josefine Palle, PhD^8*, Kirsi Jahnukainen, MD, PhD^9*, Katja Pokrovskaja Tamm, PhD^10*, Lucia Cavelier, PhD^1* and Linda Holmfeldt, PhD^1,11*

¹Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
²Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
³Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
⁴National Bioinformatics Infrastructure Sweden, Science For Life Laboratory, Uppsala, Sweden
⁵Department of Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Umeå University, Umeå, Sweden
⁶Aarhus University Hospital, Aarhus, Denmark
⁷Department of Medical Sciences, Uppsala University, Uppsala, Sweden
⁸Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
⁹Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
¹⁰Department of Oncology and Pathology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
¹¹The Beijer Laboratory, Uppsala University, Uppsala, Sweden

Sanam Loghavi, MD¹, Courtney D. DiNardo, MD, MSc², Koichi Takahashi, MD, PhD³, Rashmi Kanagal-Shamanna, MD⁴, Tomoyuki Tanaka, MD, PhD^5*, Ken Furudate, DDM, PhD^3*, Nicholas J. Short, MD³, Tapan M. Kadia, MD³, Marina Konopleva, MD, PhD³, Noushin Farnoud, PhD^6*, Sherry A. Pierce, BSN, BA^3*, Joseph D. Khoury, MD¹, Jeffrey L. Jorgensen, MD, PhD^7*, Keyur P. Patel, MBBS, PhD⁷, L. Jeffrey Medeiros, MD¹, Hagop M. Kantarjian, MD⁸, Farhad Ravandi, MBBS⁹ and Sa A Wang, MD^7*

¹Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Hematopathology, Division of Pathology/Lab Medicine, University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX