Magnus Tobiasson, MD^1*, Donal McLornan, MD PhD^2*, Mohsen Karimi^3*, Marios Dimitriou, PhD^3*, Monika Jansson^3*, Asmaa Ben Azenkoud^4*, Martin Jädersten^1*, Greger Lindberg^5*, Hani Abdulkadir^6*, Austin G. Kulasekararaj, MBBS, MD, MRCP, FRCPath^7*, Johanna Ungerstedt, Associate Professor^6*, Andreas Lennartsson^8*, Karl Ekwall^8*, Ghulam J Mufti⁹ and Eva Hellström-Lindberg, MD, PhD^10*

¹Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Sweden, Stockholm, Sweden
²Department of Haematological Medicine, King’s College Hospital NHS Foundation Trust, London, United Kingdom
³Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet,, Stockholm, Sweden
⁴asmaa.ben.azenkoud@ki.se, Stockholm, Sweden
⁵Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Sweden, Stockholm, Sweden
⁶Department of Medicine Huddinge, Karolinska Institutet, and Hematology Center, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden
⁷Department of Haematological Medicine, Kings College Hospital NHS Foundation Trust, London, United Kingdom
⁸Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden
⁹Department of Haematological Medicine, King’s College Hospital NHS Foundation Trust, London, United Kingdom, London, United Kingdom
¹⁰Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden

Francoise Solly, MD^1*, Catherine Koering, PhD^2*, Aminetou mint Mohamed, PhD^3*, Delphine Maucort-Boulch, MD^4*, Guillaume Robert, PhD^5*, Patrick Auberger, PhD^5*, Pascale Flandrin-Gresta, MD PhD^1*, Lionel Adès, MD, PhD^6*, Pierre Fenaux, MD, PhD⁷, Olivier Kosmider, MD, PhD^8*, Emmanuelle Tavernier-Tardy, MD PhD^1*, Jérôme Cornillon, MD^9*, Denis Guyotat, MD PhD^1*, Lydia Campos, MD, PhD¹⁰, Franck Mortreux, PhD^11* and Eric Wattel, MD PhD¹¹

¹Saint-Etienne University Hospital, Saint-Etienne, France
²Lyon I University, Pierre-Bénite, France
³Lyon I University, France, France
⁴Lyon I University, Lyon, China
⁵Inserm U1065, Nice, France, Nice, France
⁶Hospital St Louis, Paris 7 University, Paris, France
⁷Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
⁸APHP Laboratoire d'Hématologie, Hôpital Cochin, Paris, France
⁹Department of Hematology, Saint-Etienne University Hospital, Saint-Etienne, France
¹⁰Laboratoire Hematologie, Hopital Nord, Saint-Etienne, France
¹¹Lyon I University, Lyon, France

Yosaku Watatani, MD^1*, Yasunobu Nagata, MD, Ph.D.^2*, Vera Grossmann, MSc³, Yusuke Okuno, MD, Ph.D.^4*, Tetsuichi Yoshizato, MD^2*, Yusuke Shiozawa, MD^2*, Genta Nagae, MD, PhD^5*, Kenichi Yoshida, MD, Ph.D.^2*, Keisuke Kataoka, MD, PhD^2*, Susanne Schnittger, PhD³, Masashi Sanada, MD, Ph.D.^6*, Ayana Kon, MD, Ph.D.^2*, Yuichi Shiraishi, MD, Ph.D.^7*, Kenichi Chiba, BA^7*, Hiroko Tanaka, BA^7*, Tsuyoshi Nakamaki, MD⁸, Shuichi Miyawaki, MD⁹, Shigeru Chiba, M.D., Ph.D.¹⁰, Tamara Alpermann^3*, Niroshan Nadarajah, M.Sc.^3*, Phillip Koeffler, MD¹¹, Hans-Ulrich Klein^12*, Martin Dugas^13*, Hiroyuki Aburatani, MD, PhD^5*, Claudia Haferlach, MD³, Wolfgang Kern, MD³, Satoru Miyano, MD, Ph.D.^7*, Lee-Yung Shih, MD¹⁴, Seishi Ogawa, MD, Ph.D.², Torsten Haferlach³ and Hideki Makishima, MD, Ph.D.²

¹Department of Pathology and Tumor biology,, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³MLL Munich Leukemia Laboratory, Munich, Germany
⁴Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁵Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
⁶Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
⁷Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁸Division of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
⁹Japan Adult Leukemia Study Group, Hamamatsu, Japan
¹⁰Department of Clinical and Experimental Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
¹¹Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA
¹²Institute of Medical Informatics, University of Münster, Münster, Germany
¹³Institute of Medical Informatics, University of Munster, Munster, Germany
¹⁴Department of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, College of Medicine Chang Gung University, Taipei, Taiwan

Gina Westhofen^1*, Christina Ganster^1*, Fabian Beier, MD^2*, Tienush Rassaf^3*, Haifa Kathrin Al-Ali, MD^4*, Reingard Stuhlmann^5*, Ulrike Bacher^1*, Tim H. Brümmendorf⁶, Ulrich Germing, MD^7*, Norbert Gattermann, MD⁸ and Detlef Haase, MD^1*

¹Department of Hematology and Medical Oncology, Georg-August-University Göttingen, Göttingen, Germany
²Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University, Aachen, Germany
³Department of Cardiology, Pneumology, Angiology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
⁴University of Leipzig, Leipzig, Germany
⁵Asklepios Klinik St. Georg, Hamburg, Germany
⁶Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University Hospital, Aachen, Germany
⁷Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
⁸Dept. of Hematology, Oncology, and clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany

June Takeda, MD^1*, Kenichi Yoshida, MD, Ph.D.^1*, Hideki Makishima, MD, Ph.D.¹, Tetsuichi Yoshizato, MD^1*, Yusuke Shiozawa, MD^1*, Yuichi Shiraishi, MD, Ph.D.^2*, Yusuke Okuno, MD, Ph.D.^3*, Ayana Kon, MD, Ph.D.^1*, Yasunobu Nagata, MD, Ph.D.^1*, Keisuke Kataoka, MD, Ph.D.^1*, Kenichi Chiba, BA^2*, Hiroko Tanaka, BA^2*, Masashi Sanada, MD, Ph.D.^4*, Mamiko Sakata-Yanagimoto, MD, Ph.D.^5*, Naoshi Obara, MD, Ph.D.^5*, Tsuyoshi Nakamaki, MD⁶, Ken Ishiyama, MD, Ph.D.⁷, Akira Haigaishi, MD, Ph.D.^8*, Shigeru Chiba, M.D., Ph.D.⁵, Hiraku Mori, MD, Ph.D.^6*, Norio Asou, MD, Ph.D.⁹, Hitoshi Kiyoi, MD¹⁰, Chikara Hirase, MD, Ph.D.^11*, Kiyotoshi Imai, MD, Ph.D.^12*, Nobuaki Dobashi, MD¹³, Toru Kiguchi, MD, Ph.D.^14*, Yasushi Miyazaki, MD, Ph.D.¹⁵, Tomoki Naoe, MD, Ph.D.¹⁶, Satoru Miyano, MD, Ph.D.^2*, Kensuke Usuki, MD, Ph.D.^8*, Shuichi Miyawaki, MD, Ph.D.¹⁷, Yoichiro Kamatani, MD, Ph.D.^18*, Yukihide Momozawa, MD, Ph.D.^18*, Michiaki Kubo, MD, Ph.D.^18*, Chantana Polprasert, MD^19*, Jaroslaw P. Maciejewski, MD, Ph.D.²⁰ and Seishi Ogawa, MD, Ph.D.¹

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
³Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁴Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
⁵Department of Clinical and Experimental Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
⁶Division of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
⁷Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
⁸Deptartment of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
⁹Department of Hematology, Saitama Medical University International Medical Center, Hidaka, Japan
¹⁰Department of Hematology and Oncology, Nagoya University, Nagoya, Japan
¹¹Department of Hematology and Rheumatology, Kinki University, Osaka-Sayama, Japan
¹²Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
¹³Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
¹⁴Department of Hematology, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, Hiroshima, Japan
¹⁵Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
¹⁶National Hospital Organization Nagoya Medical Center, Nagoya, Japan
¹⁷Tokyo Metropolitan Ohtsuka Hospital, Tokyo, Japan
¹⁸RIKEN, Saitama, Japan
¹⁹Department of Translational Hematology and Oncology Research, Taussing Cancer Institute, Cleveland Clinic, Cleveland, OH
²⁰Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Yang Jo Chung, PhD¹, Suntae Kim, Ph. D^2*, Zhenhua Zhang, MD^2* and Peter D. Aplan, MD³

¹Genetics Branch, NIH/NCI/CCR, Bethesda, MD
²NIH/NCI/CCR, Bethesda, MD
³NCI/CCR/Genetics branch, National Institutes of Health, Bethesda, MD

Akiko Nagamachi, Ph.D.^1*, Yuko Ozaki, Ph.D.^1*, Hirotaka Matsui, MD, PhD², Akinori Kanai, Ph.D.^1* and Toshiya Inaba, MD¹

¹Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
²Department of Molecular Laboratory Medicine, Kumamoto University, Kumamoto, Japan

Maria Feola, MS^1,2*, Tenzin Choesang, MS^1*, Weili Bao, MS^1*, Li Huihui, MS^1,3*, Huiyong Chen, PhD^1*, Shuming Sun, PhD^1*, Petra Pham, MS^4*, Guiyuan Li, MD^3*, Amit Verma, MD⁵, Antonia Follenzi, MD PhD^2* and Yelena Ginzburg, MD¹

¹New York Blood Center, New York, NY
²University of Piemonte Orientale, Amedeo Avogadro, Novara, Italy
³Cancer Research Institute, Central South University, Changsha, China
⁴Platelet Biology Laboratory, New York Blood Center, New York, NY
⁵Department of Medicine-Oncology, Albert Einstein College of Medicine, Bronx, NY

Fernanda Marconi Roversi, PhD^1*, Nathalia Moreno Cury, MSc^2*, Matheus Rodrigues Lopes, MSc^1*, Fernando Vieira Pericole, M.D.^1*, Marisa Claudia Alvarez Prax, PhD^1*, Karla Priscila Ferro, PhD^1*, Patricia Favaro, PhD^1*, José Andres Yunes, PhD^2* and Sara T Saad, M.D., PhD¹

¹Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, São Paulo, Brazil
²Centro Infantil Boldrini, Campinas, São Paulo, Brazil

Bhumika J. Patel^1*, Bartlomiej Przychodzen, MSc^2*, Michael J. Clemente^3*, Cassandra M. Hirsch^2*, Tomas Radivoyevitch, PhD^4*, Swapna Thota, MD^1*, Thomas LaFramboise, PhD^5*, Hirotoshi Sakaguchi, MD, PhD^6*, Seiji Kojima, MD, PhD^7*, Hetty E. Carraway, MD, MBA⁸, Mikkael A. Sekeres, MD, MS⁸, Seishi Ogawa, MD, Ph.D.⁹, Hideki Makishima, MD, Ph.D.⁹ and Jaroslaw P. Maciejewski, MD, Ph.D.¹

¹Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
³Taussig Cancer Institute, Cleveland Clinic, Translational Hematology Oncology Research, Cleveland, OH
⁴Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH
⁵Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH
⁶Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
⁷Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁸Leukemia Program, Cleveland Clinic, Cleveland, OH
⁹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Niroshan Nadarajah, M.Sc.^*, Manja Meggendorfer, PhD^*, Wolfgang Kern, MD, Claudia Haferlach, MD and Torsten Haferlach

MLL Munich Leukemia Laboratory, Munich, Germany

Samuel Ojo Abegunde, MD, BSc, MBBS^* and Michael J. Rauh, MD, PhD

Department of Pathology & Molecular Medicine, Queen's University, Kingston, ON, Canada

Pier Paolo Leoncini, PhD^1*, Alice Bertaina, MD, PhD², Dimitrios Papaioannou, MD^3*, Christian Flotho^4*, Riccardo Masetti, MD^5*, Silvia Bresolin, PhD^6*, Giuseppe Menna, MD^7*, Nicola Santoro^8*, Marco Zecca, MD^9*, Giuseppe Basso, Prof, MD⁶, Giovanni Nigita, PhD^10*, Sara Pagotto, PhD^11*, Katia D'Ovidio, PhD^12*, Rossella Rota^13*, Carlo M. Croce, MD¹⁴, Charlotte Marie Niemeyer, Prof, MD¹⁵, Franco Locatelli, MD, PhD² and Ramiro Garzon, MD¹⁶

¹Deèartment of Pediatric Hematology, Ospedale Pediatrico Bambino Gesù, Rome, Italy
²Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
³Division of Hematology, Comprehensive Cancer center, The Ohio State university, Columbus
⁴Pediatrics, University of Freiburg, Freiburg, Germany
⁵Pediatric Oncology and Hematology, University of Bologna, Bologna, Italy
⁶Woman and Child Health Department, University of Padova, Padova, Italy
⁷Pediatric Hematology, Ospedale Pausillipon, Naples, Italy
⁸Policlinico di Bari, Bari, Italy
⁹Pediatric Hematology/Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹⁰Ohio State University, Columbus, OH
¹¹Unit of General Pathology, Aging Research Center (Ce.S.I.), G. d'Annunzio University Foundation, Chieti, Italy
¹²Ospedale Pediatrico Bambino Gesù, Rome, Italy
¹³Pediatric Hematology, Ospedale Pediatrico Bambino Gesù, Rome, Italy
¹⁴The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹⁵Children's Hospital, University Medical Center, Freiburg, Germany
¹⁶Comprehensive Cancer Center, The Ohio State University, Columbus, OH

Irene Gañán-Gómez, PhD^1*, Yamini Ogoti^1*, Matteo Marchesini, PhD^1*, Yue Wei, PhD¹, Hui Yang, MD, PhD¹, Shan Jiang^2*, Naran Bao^1*, Carlos E. Bueso-Ramos, MD³, Guillermo Garcia-Manero, MD⁴ and Simona Colla, PhD^1*

¹Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
²Department of Genomic Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Eiju Negoro, MD, PhD^1*, Chantana Polprasert, MD^2*, Tomas Radivoyevitch, PhD^3*, Vera Adema^4*, Naoko Hosono, MD, PhD.^5*, Hideki Makishima, MD, Ph.D.⁶, Bartlomiej Przychodzen, MSc^1*, Mikkael A. Sekeres, MD, MS⁷, Valeria Santini, MD⁸, Kathy McGaw^9*, Alan F. List, MD⁹, Francesc Sole, PhD⁴ and Jaroslaw P. Maciejewski, MD, Ph.D.¹⁰

¹Department of Translational Hematology and Oncology Research, Taussing Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand
³Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH
⁴Josep Carreras Leukaemia Research Institute, Barcelona, Spain
⁵Department of Hematology and Oncology, University of Fukui, Fukui, Japan
⁶Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁷Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH
⁸AOU Careggi, University of Florence, Florence, Italy
⁹Department of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, Tampa, FL
¹⁰Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Yuesheng Meng, MD PhD, Fanli Hua, MD PhD^*, Ying Li, MD^* and Song Gao, MD^*

Dept of Hematology, Fudan University Jinshan Hospital, Shanghai, China

Lisa J. McReynolds, MD, PhD¹, Peter D. Aplan, MD², Donald Small, MD, PhD³, Li Ding, MD^4*, Kirby D. Johnson^5*, Emery H Bresnick, Ph.D.⁵ and Steven M. Holland, MD^1*

¹Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
²NCI/CCR/Genetics branch, National Institutes of Health, Bethesda, MD
³Department of Oncology and Pediatrics, Johns Hopkins University, Baltimore, MD
⁴Laboratory of Clinical Infectious Diseases, National Institue of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
⁵Department of Cell and Regenerative Biology, Carbone Cancer Center, UW-Madison Blood Research Program, University of Wisconsin School of Medicine and Public Health, Madison, WI

Wolfgang Kern, MD¹, Manja Meggendorfer, PhD^1*, Seishi Ogawa, MD, Ph.D.², Claudia Haferlach, MD¹, Susanne Schnittger, PhD¹ and Torsten Haferlach¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Chunkang Chang, MD, PhD^*, Chengming Fei, MD^*, Juan Guo, MD^*, Youshan Zhao, MD^*, Shucheng Gu, MD^* and Xiao Li, MD, PhD

Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

Anne-Sophie Bouillon^1*, Monica S. Ferreira, PhD^1*, Benjamin Werner, PhD^2,3*, Sebastian Hummel^1*, Jens P. Panse, MD¹, Petra Reinecke, MD^4*, Jennifer Schemenau^5*, Rainer Haas, MD^6*, Arne Traulsen, PhD^3*, Tim H. Bruemmendorf, MD¹, Ulrich Germing, MD^6* and Fabian Beier, MD^1*

¹Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University, Aachen, Germany
²Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom
³Department of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Plön, Germany
⁴Institute of Pathology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany
⁵Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany
⁶Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

Maximilian Mossner^1*, Alexandra Stoehr^1*, Johann-Christoph Jann^1*, Florian Nolte, MD^2*, Verena Nowak^1*, Julia Oblaender^1*, Jovita Pressler^1*, Christina Xanthopoulos^1*, Iris Palme^1*, Claudia D Baldus, MD³, Torsten Schulze, MD^4*, Tobias Boch, MD^1*, Georgia Metzgeroth, MD^1*, Martin Neumann, MD^3*, Wolf-Karsten Hofmann, MD¹ and Daniel Nowak, MD^1*

¹Department of Hematology and Oncology, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
²St. Hedwig-Krankenhaus, Berlin, Germany
³Department of Hematology and Oncology, Charité University Hospital, Berlin, Germany
⁴Department of Transfusion Medicine, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany

Fernanda Marconi Roversi, PhD^1*, Fernando Vieira Pericole, M.D.^1*, Adriana da Silva Santos Duarte, Ph.D.^1*, Karla Priscila Ferro, PhD^1*, Flávia Adolfo Corrocher, MSc^1*, Bruna Palodetto, MSc^1*, Ana Leda Longhini, PhD^1*, Maurizio Botta, PhD^2* and Sara T Saad, M.D., PhD¹

¹Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, São Paulo, Brazil
²Department of biotechnology, chemistry and pharmacy, University of Siena, Siena, Italy