Claudia Haferlach, MD, Annette Fasan, PhD^*, Manja Meggendorfer, PhD^*, Melanie Zenger^*, Susanne Schnittger, PhD, Wolfgang Kern, MD and Torsten Haferlach

MLL Munich Leukemia Laboratory, Munich, Germany

Eve Poret^1*, Fanny Angelot Delettre^1*, Sabeha Biichle^2*, Anne Roogy^1*, Louis Benazet^3*, Maider Pagadoy^3*, Chrystelle Vidal^3*, Franck Leroux^3*, Véronique Harrivel^4*, Christophe Ferrand, PhD⁵, Veronique Salaun^6*, Zehaira Benseddik^7*, Julien Guy^8*, Marie Christine Jacob^9*, Christophe Roumier^10*, Jean Feuillard^11*, Liliana Vila^12*, Lucile Baseggio^13*, Adriana Plesa^14*, Christine Arnoulet^15*, B Benet^16*, Bernard Drenou, MD^17*, Veronique Latger Cannard^18*, Marie-Christine Bene, MD^19*, Michel Ticchioni^20*, Daniel Lusina^21*, Valerie Bardet^22*, Magalie LE Garff Tavernier^23*, Elizabeth Macintyre, MD, PhD²⁴, Vahid Asnafi, MD PhD^25*, Maria Elena Noguera^23*, Sabrina Bouyer^26*, Carine Lecoq Lafon^27*, Mikael Roussel, MD, PhD^28*, Fabrice Jardin^29*, Francoise Solly, MD^30*, Lydia Campos, MD, PhD³¹, Anne Galoisy^32*, Anne Arnaud^33*, Sylvie Daliphard^34*, Franck Genevieve, MD, PhD^35*, Romaric Lacroix^36*, Françoise Schillinger^37*, Estelle Seilles^1*, Delphine Binda^3*, Eric Deconinck³⁸, Philippe Saas, PhD³⁹ and Francine Garnache Ottou, PhD^5*

¹EFS BFC, INSERM UMR1098, Besançon cedex, France
²INSERM UMR 1098/Université Bourgogne Franche-Comté/EFS BFC, Besancon, France
³Inserm CIC1431, CHRU de Besançon, Besançon cedex, France
⁴CHU Amiens, AMIENS, France
⁵EFS BFC, Inserm UMR1098, University hospital Besancon, University Franche Comte, Besancon, France
⁶CHU CAEN, CAEN, France
⁷CH CHARTRES, CHARTRES, France
⁸CHU DIJON, DIJON, France
⁹CHU GRENOBLE, GRENOBLE, France
¹⁰CHRU LILLE, LILLE, France
¹¹Laboratoire d'hématologie, CHU, Limoges, France
¹²HOSPITAL LYON EDOUARD HERRIOT, LYON, France
¹³HOSPITAL LYON SUD, LYON Pierre Benite, France
¹⁴HOSPITAL LYON SUD, LYON, France
¹⁵IPC, MARSEILLE, France
¹⁶CHR METZ, METZ, France
¹⁷CH MULHOUSE, MULHOUSE, France
¹⁸CHU NANCY, NANCY, France
¹⁹Hopital Hotel Dieu, Laboratoire d'Hematologie, Nantes, France
²⁰CHU NICE, NICE, France
²¹Hematology Laboratory, CHU Avicenne, Paris, France
²²Department of Hematology, Imagine Institute, Hôpital Universitaire Necker -Enfants Malades Paris, Paris, France
²³APHP, PARIS, France
²⁴Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France
²⁵Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, Paris, France
²⁶CHU POITIERS, POITIERS, France
²⁷CHU REIMS, REIMS, France
²⁸INSERM U917 - CHU de Rennes, Rennes, France
²⁹Centre Henri Becquerel, Rouen, France
³⁰Saint-Etienne University Hospital, Saint-Etienne, France
³¹Laboratoire Hematologie, Hopital Nord, Saint-Etienne, France
³²CHU STRASBOURG, STRASBOURG, France
³³CHU NIMES, NIMES, France
³⁴CHU ROUENS, ROUENS, France
³⁵CHU ANGERS, ANGERS, France
³⁶APHM, MARSEILLE, France
³⁷EFSBFC, Besançon cedex, France
³⁸Hematology, INSERM UMR1098 - CHU Jean Minjoz, Besancon, France
³⁹EFS BFC, INSERM UMR 1098/Université Bourgogne Franche-Comté/ EFS BFC/LabEx lispSTIC, Besancon, France

Steven M. Kornblau, MD¹, Peter Ruvolo, PhD², Rui-Yu Wang, MD, PhD¹, Vivian Ruvolo, MS^3*, Yihua Qiu, MD^1*, Venkata Lokesh Battula, PhD⁴, Zhihong Zeng, MD³, Teresa McQueen^2*, Suk-Young Yoo^5*, Marina Konopleva, MD, PhD⁶ and Michael Andreeff, M.D., Ph.D.⁶

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
²Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Section of Molecular Hematology and Therapy, Leukemia Department, UT MD Anderson Cancer Center, Houston, TX
⁵Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁶Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston

Hidemasa Matsuo, MS^1*, Naomi Nakamura, MS^1*, Daisuke Tomizawa, MD, PhD², Akiko M. Saito^3*, Nobutaka Kiyokawa, MD, PhD^4*, Keizo Horibe, MD, PhD³, Yoko Nishinaka-Arai, PhD^5*, Mayu Tokumasu, MD^6*, Hiroshi Itoh, MS^1*, Yasuhiko Kamikubo, MD, PhD^1*, Hideki Nakayama, MD, PhD^7*, Akitoshi Kinoshita, MD, PhD⁸, Takashi Taga, MD, PhD^9*, Akio Tawa, MD, PhD^10*, Tomohiko Taki, MD, PhD¹¹, Shiro Tanaka, PhD^12* and Souichi Adachi, MD, PhD¹

¹Department of Human Health Sciences, Kyoto University, Kyoto, Japan
²Division of Leukemia and Lymphoma, Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan
³Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
⁴Department of Pediatric Hematology and Oncology Research, National Research Institute For Child Health and Development, Tokyo, Japan
⁵Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan
⁶Department of Pediatrics, Kyoto University, Kyoto, Japan
⁷Department of Pediatrics, National Hospital Organization, Fukuoka-Higashi Medical Center, Koga, Japan
⁸Department of Pediatrics, St Marianna University School of Medicine, Kawasaki, Japan
⁹Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan
¹⁰Department of Pediatrics, National Hospital Organization, Osaka National Hospital, Osaka, Japan
¹¹Department of Molecular Diagnostics and Therapeutics, Kyoto Prefectural University of Medicine, Kyoto, Japan
¹²Department of Pharmacoepidemiology, Kyoto University, Kyoto, Japan

Klaus H. Metzeler, MD^1,2,3, Tobias Herold, MD^1*, Maja Rothenberg-Thurley, PhD^1*, Susanne Amler^4*, Cristina Sauerland^4*, Stephanie Schneider, PhD^1*, Nikola P Konstandin, PhD^5*, Annika Maria Dufour, PhD^1*, Kathrin Bräundl^5*, Bianka Ksienzyk^5*, Evelyn Zellmeier^5*, Luise Hartmann, MSc^2,3,5*, Philipp A. Greif, MD^2,3, Michael Fiegl, MD^1*, Marion S. Subklewe, MD^1,2,3, Stefan K. Bohlander, MD^6*, Utz Krug, MD⁷, Wolfgang E Berdel, MD⁸, Bernhard J Wörmann, MD^9*, Thomas Büchner, MD^8*, Andreas Faldum, PhD^4*, Wolfgang Hiddemann, MD^1,3,10, Jan Braess, MD^11* and Karsten Spiekermann, MD^1,2,3

¹Laboratory for Leukemia Diagnostics, Dept. of Internal Medicine III, University Hospital Großhadern, Ludwig-Maximilians-Universität, Munich, Germany
²German Cancer Consortium (DKTK), Munich, Germany
³German Cancer Research Center (DKFZ), Heidelberg, Germany
⁴Institute for Biometry and Clinical Research, University of Münster, Münster, Germany
⁵Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany
⁶Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
⁷Klinikum Leverkusen, Leverkusen, Germany
⁸Department of Medicine A, University of Münster, Münster, Germany
⁹Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine, Campus Virchow, Berlin, Germany
¹⁰German Cancer Consortium (DKTK), Heidelberg, Germany
¹¹Oncology and Hematology, St. John-of-God Hospital, Regensburg, Germany

Aleksandra Golos, MD, PhD^1*, Dorota Jesionek-Kupnicka, Md, PhD^2*, Tadeusz Robak, MD, PhD³, Ewa Wawrzyniak, PhD^3*, Lidia Anna Gil, MD, PhD⁴, Mieczyslaw Komarnicki, MD, PhD⁴, Anna Wache, MD^4* and Agnieszka Wierzbowska, MD, PhD^1*

¹Medical University of Lodz, Department of Hematology, Lodz, Poland
²Medical University of Lodz, Department of Pathology, Lodz, Poland
³Department of Hematology, Medical University of Lodz, Lodz, Poland
⁴University of Medical Sciences, Department of Hematology, Poznan, Poland

Ekaterina Bulycheva, MD^1*, Jiri Mayer², William Hermann Krüger, MD, PhD^3*, Peter Dreger, MD⁴, Anna Mies^1,5*, Zuzana Sustkova, MD^6*, Zdenek Racil, MD^6*, Jirina Prochazkova, MD^6*, Eva Walter, MD^7*, Carsten Hirt^3*, Mark Ringhoffer, MD^8*, Wolfgang E Berdel, MD⁹, Hubert Serve, MD^10*, Christoph Rollig^11*, Katja Sockel, MD^12*, Martin Bornhäuser, MD^13*, Gerhard Ehninger, MD¹⁴, Christian Thiede, MD, PhD^1,5 and Uwe Platzbecker, MD^5,15

¹Medical Department I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
²Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
³Department of Internal Medicine C, Hematology and Oncology, Marrow Transplantation, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
⁴Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
⁵German Cancer Consortium, German Cancer Research Center Heidelberg, Heidelberg, Germany
⁶Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic
⁷Department of Internal Medicine V, University Hospital of Heidelberg, Heidelberg, Germany
⁸Department of Internal Medicine III, Municipal Hospital of Karlsruhe, Karlsruhe, Germany
⁹Department of Medicine A, University Hospital Münster, Muenster, Germany
¹⁰Dept. of Internal Medicine, University Hospital of Frankfurt, Frankfurt, Germany
¹¹University Hospital Carl Gustav Carus Dresden, Dresden, Germany
¹²Medizinische Klinik I, Universitaetsklinikum C.G.Carus, Dresden, Germany
¹³Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
¹⁴Medical Dept. 1, University Hospital TU Dresden, Dresden, Germany
¹⁵Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Dresden, Germany

Nikolaus Jahn, MD^1*, Mridul Agrawal, MD^1*, Lars Bullinger, MD¹, Daniela Weber^1*, Andrea Corbacioglu, PhD^1*, Verena I. Gaidzik, MD^1*, Felicitas Thol, MD², Michael Heuser, MD², Juergen Krauter, MD^3*, Gudrun Göhring⁴, Andrea Kuendgen, MD^5*, Walter Fiedler, MD⁶, Mohammad Amen Wattad, MD⁷, Gerhard Held, MD^8*, Doris Kraemer, MD^9*, Heinz A. Horst, MD, PhD¹⁰, Michael Lübbert, MD, PhD¹¹, Arnold Ganser, M.D.², Richard F. Schlenk, MD¹², Hartmut Dohner, MD¹, Konstanze Dohner, M.D.¹² and Peter Paschka, MD¹

¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
³Department of Hematology and Oncology, Braunschweig Hospital, Braunschweig, Germany
⁴Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
⁵Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
⁶Department of Hematology and Oncology, University Hospital Eppendorf, Hamburg, Germany
⁷Department of Hematology, Oncology and Stem Cell Transplantation, Kliniken Essen Sued, Essen, Germany
⁸Department of Internal Medicine I, University Hospital of Saarland, Homburg, Germany
⁹Department of Oncology and Hematology, Klinikum Oldenburg, Oldenburg, Germany
¹⁰Department of Internal Medicine II, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
¹¹Department of Haematology and Oncology, University of Freiburg, Freiburg, Germany
¹²University Hospital of Ulm, Ulm, Germany

B. Douglas Smith, MD¹, Andrew W. Roberts, MBBS, PhD², Gail J. Roboz, MD³, Mark DeWitte, VMD⁴, Anna Ferguson, BSN, RN^1*, Linda Garrett, RN^2*, Tania Curcio^5*, Kaysey F. Orlowski^6*, Sue Dasen, MS^4*, Debra M. Bensen-Kennedy, MD⁴ and Roland B. Walter, MD, PhD, MS⁶

¹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
²Div. of Cancer and Haem., The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia
³Division of Hematology / Oncology, Weill Cornell Medical College, New York, NY
⁴CSL Behring, King of Prussia, PA
⁵Division of Hematology and Medical Oncology, Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY
⁶Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA

Rose McGlauflin^1*, Anna Whitaker^1*, Amanda J Favreau¹, Christine Duarte^1* and Pradeep Sathyanarayana²

¹Maine Medical Center Research Institute, Scarborough, ME
²Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME

Manja Meggendorfer, PhD^1*, Wolfgang Kern, MD¹, Karolína Perglerová^2*, Susanne Schnittger, PhD¹, Claudia Haferlach, MD¹ and Torsten Haferlach¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²MLL2 s.r.o., Praha, Czech Republic

Feng-Ming Tien, MD^1*, Wen-Chien Chou, MD, PhD², Hsin-An Hou, MD, PhD^1*, Yu-Chiao Chiu^3*, Eric Y. Chuang, Sc.D.^3*, Chien-Yuan Chen, MD, PhD^1*, Jih-Luh Tang, MD, PhD¹, Ming Yao, MD^1*, Shang-Yi Huang^1*, Bor-Sheng Ko^4*, Szu-Chun Hsu, MD^2*, Shang-Ju Wu, MD, PhD^1*, Woei Tsay, MD, PhD^1* and Hwei-Fang Tien, MD, PhD¹

¹Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
²Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
³Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan
⁴National Taiwan University Hospital, Taipei, Taiwan

Jared Wallace^1*, Dominique Kagele^1*, Ruozhen Hu^1*, Marah Runtsch^1*, Margaret Alexander^1*, Thomas Huffaker^1*, Timothy Mosbruger^2*, Timothy Dahlem^3*, W. Zac Stephens^1*, Dinesh S. Rao, MD, PhD⁴, Rodney R. Miles, MD, PhD⁵, June Round, PhD^1* and Ryan M. O'Connell, PhD^1*

¹Pathology, University of Utah, Salt Lake City, UT
²Hunstman Cancer Institute, University of Utah, Salt Lake City, UT
³Mutation Generation and Detection Core, University of Utah, Salt Lake City, UT
⁴UCLA, Los Angeles, CA
⁵Department of Pathology, University of Utah, Salt Lake City, UT

David K Edwards V, B.A., B.S.¹, Angela Rofelty, BS^2*, Anupriya Agarwal, PhD², Stephen E Kurtz, PhD^3*, Elie Traer, MD, PhD², Patrice Lee, PhD^4*, David Chantry, PhD^4*, Marc Loriaux, MD, PhD^2*, Brian J. Druker, MD⁵, Shannon K. McWeeney, PhD^6* and Jeffrey W. Tyner, PhD¹

¹Knight Cancer Institute, Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR
²Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR
³Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁴Array Biopharma, Boulder, CO
⁵Howard Hughes Medical Institute, Oregon Health & Science University, Knight Cancer Institute, Portland, OR
⁶Department of Bioinformatics and Computational Biology, Oregon Health & Science University, Portland, OR

Anjali S. Advani, MD¹, Paul Elson, PhD^2*, Valeria Visconte, PhD^3*, Jennifer S. Carew, PhD³, Jaime Fensterl^4*, Bartlomiej Przychodzen, MSc^3*, Mikkael A. Sekeres, MD, MS¹, Cassandra M Hirsch^5*, Alek Nielsen^6*, John Desamito^4*, Hetty E. Carraway, MD, MBA¹, Aaron T. Gerds, MD, MS¹, Betty K. Hamilton, MD^7,8, Sudipto Mukherjee, MD, PhD¹, Ronald M. Sobecks, MD⁷, Matt Kalaycio, MD⁷, Yogen Saunthararajah, M.D.⁹ and Jaroslaw P. Maciejewski, MD, PhD¹⁰

¹Leukemia Program, Cleveland Clinic, Cleveland, OH
²Cleveland Clinic, Quantitative Health Sciences, Cleveland, OH
³Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁴Leukemia Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁵Department of Translational Hematology and Oncology Research, Taussing Cancer Institute, Cleveland Clinic, Cleveland, OH
⁶Cleveland Clinic, Cleveland
⁷Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁸Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁹Experimental Hematology and Hematopoiesis Section, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH
¹⁰Experimental Hematology and Hematopoiesis Section, Taussig Cancer Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Han-Seung Park, MD^1*, Je-Hwan Lee, MD, PhD¹, Jung-Hee Lee, MD, PhD^1*, Dae-Young Kim, MD, PhD^2*, Eun-Ji Choi, MD^1*, Eun-Hye Hur^1*, Chan-Jeoung Park, MD, PhD³, Soseul Kim^4*, Sangsoon Yoon^4*, Kyeongcheon Jung^4* and Kyoo-Hyung Lee, MD, PhD¹

¹Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
²Department of Hematology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea
³Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
⁴Dinona Institute, Dinona Inc., Seoul, South Korea

Grigory Tsaur, MD, PhD^1*, Olga Plekhanova^2*, Elena Fleischman, MD, PhD^3*, Elena Volochnik^4*, Olga Sokova, PhD^3*, Anatoly Kustanovich, PhD^4*, Irina Kalinina, MD, PhD^5*, Alexander Popov, MD, PhD^1*, Leonid Saveliev, MD, PhD^6*, Egor Shorikov, MD, PhD^1* and Larisa Fechina, MD, PhD¹

¹Pediatric Oncology and Hematology, Regional Children's Hospital #1, Research Institute of Medical Cell technolgies, Yekaterinburg, Russia
²Pediatric Oncology and Hematology, Regional Children's Hospital #1, Yekaterinburg, Russia
³N.N. Blokhin Russian Cancer Research Center Russian Academy of Medical Science, Moscow, Russia
⁴Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus
⁵D. Rogachev Federal Research Institute of Pediatric Hematology, Oncology and Immunology, Moscow, Russia
⁶Chair of Laboratory Medicine, Ural State Medical Academy, Research Institute of Medical Cell Technologies, Yekaterinburg, Russia

David Sanford, MD¹, Jorge E. Cortes, MD², Farhad Ravandi, MD¹, Wei Qiao^3*, Keyur P. Patel, MD, PhD^4*, Thuyvan Hoang¹, Tapan Kadia, MD¹, Hagop M. Kantarjian, MD¹ and Gautam Borthakur, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Maria Knyrim^*, Madlen Jentzsch, MD^*, Marius Bill, MD PhD^*, Juliane Grimm^*, Karoline Schubert^*, Michael Cross, PhD^*, Georg-Nikolaus Franke, MD^*, Wolfram Poenisch, MD^*, Vladan Vucinic, MD^*, Gerhard Behre, MD^*, Dietger Niederwieser, MD and Sebastian Schwind, MD

Hematology and Oncology, University of Leipzig, Leipzig, Germany

Christina Orsmark-Pietras^1,2*, Henrik Lilljebjörn^1*, Marianne Rissler^1*, Vladimir Lazarevic^3*, Alexandros Arvanitakis^1,3*, Mats Ehinger^4*, Gunnar Juliusson, M.D, Ph.D.³ and Thoas Fioretos^1,2

¹Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden
²Department of Clinical Genetics, University and Regional Laboratories Region Skåne, Lund, Sweden
³Department of Hematology, Skåne University Hospital, Lund, Sweden
⁴Department of Pathology, Skåne University Hospital, Lund, Sweden

Hendrik Folkerts, MSc^1*, Bart-Jan A.T.J. Wierenga, PhD^2*, Paul J. Coffer, PhD³, Jan Jacob Schuringa, PhD² and Edo Vellenga, MD, PhD²

¹Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
²Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University Groningen, Groningen, Netherlands
³Department of Cell Biology, University Utrecht, Utrecht, Netherlands

Jae-Sook Ahn, MD, PhD^1*, Hyeoung-Joon Kim, MD, PhD^1,2, Yeo-Kyeoung Kim, M.D., Ph.D.¹, Seung-Shin Lee, MD^1*, Sung-Hoon Jung, MD, PhD^3*, Deok-Hwan Yang, MD, PhD¹, Je-Jung Lee³, Park Hee Jeong^2*, Seung Hyun Choi, PhD^2*, Chul Won Jung, MD, PhD⁴, Jun-Ho Jang, MD, PhD^4*, Heeje Kim, MD, PhD⁵, Joon Ho Moon, M.D., Ph.D.⁶, Sang Kyun Sohn, MD, PhD⁶, Sung-Hyun Kim⁷ and Dennis Dong Hwan Kim, MD, PhD⁸

¹Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, South Korea
²Genomic Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, South Korea
³Department of Hematology-Oncology,Chonnam National University Hwasun Hospital, Hwasun, South Korea
⁴Divison of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
⁵Dept. of Hem./Onc., Catholic HSCT Center, Seoul, South Korea
⁶Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, South Korea
⁷Dong-A University Medical Center, Busan, South Korea
⁸Department of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada

Christophe Willekens, MD^1*, Angelo Paci^2*, Serge Koscielny^3*, Alice Marceau^4*, Jean-Baptiste Micol, MD^5*, Sophie Broutin^2*, Cyril Quivoron^6*, Véronique Saada^2*, Vianney Poinsignon^2*, Franck Griscelli^2*, Vincent Ribrag, MD⁷, Cristina Castilla-Llorente^5*, Claude Preudhomme⁴, Virginie Lacronique-Penard^6* and Stéphane De Botton^5*

¹Service d’Hématologie, Gustave Roussy Cancer Center, Villejuif, France
²Département de biologie-pathologie, Institut Gustave Roussy, Villejuif, France
³Service de biostatistiques et épidémiologie, Institut Gustave Roussy, Villejuif, France
⁴Hematology Laboratory, CHRU Lille, Lille, France
⁵Gustave Roussy Cancer Center, Villejuif, France
⁶Inserm U985, Institut Gustave Roussy, Villejuif, France
⁷Service d'Hématologie, Institut Gustave Roussy, Villejuif, France

Christoph Niemöller^1*, Sabine Bleul^1*, Nadja Blagitko-Dorfs, PhD^1*, Christine Greil, MD^1*, Kenichi Yoshida, MD, Ph.D.^2*, Rainer Claus, MD^1*, Dietmar Pfeifer, PhD^1*, Seishi Ogawa, MD, PhD^2*, Michael Lübbert, MD^1* and Heiko Becker, MD¹

¹Department of Internal Medicine I, University Freiburg - Medical Center, Freiburg, Germany
²Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Christophe Willekens, MD^1*, Jean-Baptiste Micol, MD^2*, Vianney Poinsignon^3*, Cyril Quivoron^4*, Véronique Saada^3*, Sophie Broutin^3*, Marie Terroir-Cassou-Mounat^5*, David Ghez^2*, Jean-Henri Bourhis, MD, PhD², Jacques Bosq, MD^3*, Vincent Ribrag, MD⁶, Angelo Paci^3*, Virginie Lacronique-Penard^4* and Stéphane De Botton^2*

¹Service d’Hématologie, Gustave Roussy Cancer Center, Villejuif, France
²Gustave Roussy Cancer Center, Villejuif, France
³Département de biologie-pathologie, Institut Gustave Roussy, Villejuif, France
⁴Inserm U985, Institut Gustave Roussy, Villejuif, France
⁵Département de medecine nucléaire, Institut Gustave Roussy, Villejuif, France
⁶Service d'Hématologie, Institut Gustave Roussy, Villejuif, France

Sally Agersborg, MD, PhD^1*, Maya Thangavelu, PhD¹, Wanlong Ma, BS^1*, Steven Brodie, Ph.D^2*, Christopher Mixon, MD^3*, Wayne Chen, MD^1* and Maher Albitar¹

¹NeoGenomics Laboratories, Irvine, CA
²NeoGenomics Laboratories, Ft. Myers, FL
³NeoGenomics Laboratories, Nashville, TN

Giorgia Simonetti, PhD^1*, Antonella Padella^1*, Ítalo Faria do Valle^2*, Gabriele Fontanarosa^2*, Elisa Zago, PhD^3*, Marianna Garonzi^4*, Cristina Papayannidis, MD, PhD⁵, Maria Chiara Abbenante, MD^1*, Giovanni Marconi, MD^1*, Viviana Guadagnuolo, PhD^1*, Maria Chiara Fontana^6*, Samantha Bruno^7*, Anna Ferrari, PhD^1*, Elisa Zuffa, PhD^1*, Eugenia Franchini^1*, Annalisa Astolfi, PhD^8*, Elisa Dan^7*, Barbara Sinigaglia^7*, Ilaria Iacobucci, PhD^7*, Simona Soverini⁹, Michele Cavo, MD^7*, Emanuela Ottaviani^7*, Alberto Ferrarini, PhD^4*, Massimo Delledonne, PhD^3*, Daniel Remondini, PhD^2* and Giovanni Martinelli, MD, PhD⁵

¹University of Bologna, Bologna, Italy
²Department of Physics and Astronomy, University of Bologna, Bologna, Italy
³Personal Genomics, Verona, Italy
⁴Department of Biotechnology, University of Verona, Verona, Italy
⁵Bologna University School of Medicine, Bologna, Italy
⁶"Seràgnoli" Institute of Hematology, Bologna University School of Medicine, Bologna, Italy
⁷"Seràgnoli" Institute of Hematology, University of Bologna, Bologna, Italy
⁸Centro Interdipartimentale per la Ricerca sul Cancro “G. Prodi”, University of Bologna, Bologna, Italy
⁹Institute of Hematology, S.Orsola-Malpighi University Hospital, Bologna, Italy

Anthony Palmer^1*, Brian Parkin², Hidde Posthuma^3*, Shin Mineishi, MD⁴, John M. Magenau⁵ and Sami N. Malek²

¹Pediatrics, University of Michigan, Ann Arbor, MI
²Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
³University of Michigan, Ann Arbor, MI
⁴Blood and Marrow Transplantation and Cell Therapy Program, University of Alabama at Birmingham, Birmingham, AL
⁵Adult Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, MI

Emilia Carolina Malafaia, MD^1,2*, A. Mario Marcondes, MD, PhD^3,4, Ekapun Karoopongse, MD^3*, Daniele Serehi, BS^2*, Maria de Lourdes L. F. Chauffaille, MD, PhD^1,2, H. Joachim Deeg, MD^3,4 and Daniella M. Bahia Kerbauy, MD, PhD^1,2*

¹Fleury Medicine and Health, São Paulo, Brazil
²Federal University of Sao Paulo - UNIFESP, São Paulo, Brazil
³Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁴Department of Medicine, University of Washington, Seattle, WA

Giorgia Simonetti, PhD^1*, Antonella Padella^1*, Ítalo Faria do Valle^2*, Marco Manfrini, PhD^3*, Cristina Papayannidis, MD, PhD³, Carmen Baldazzi, PhD^1*, Maria Chiara Fontana^4*, Viviana Guadagnuolo, PhD^1*, Anna Ferrari, PhD^1*, Elisa Zago, PhD^5*, Marianna Garonzi^6*, Simona Bernardi^7*, Emanuela Ottaviani^1*, Annalisa Astolfi, PhD^8*, Maria Chiara Abbenante, MD^1*, Giovanni Marconi, MD^1*, Simona Soverini⁹, Michele Cavo, MD^10*, Nicoletta Testoni^1*, Alberto Ferrarini, PhD^6*, Massimo Delledonne, PhD^5*, Torsten Haferlach¹¹, Daniel Remondini, PhD^2*, Ilaria Iacobucci, PhD^10* and Giovanni Martinelli¹⁰

¹University of Bologna, Bologna, Italy
²Department of Physics and Astronomy, University of Bologna, Bologna, Italy
³Bologna University School of Medicine, Bologna, Italy
⁴"Seràgnoli" Institute of Hematology, Bologna University School of Medicine, Bologna, Italy
⁵Personal Genomics, Verona, Italy
⁶Department of Biotechnology, University of Verona, Verona, Italy
⁷Unit of Blood Diseases and Stem Cells Transplantation, University of Brescia, Brescia, Italy
⁸Centro Interdipartimentale per la Ricerca sul Cancro “G. Prodi”, University of Bologna, Bologna, Italy
⁹Institute of Hematology, S.Orsola-Malpighi University Hospital, Bologna, Italy
¹⁰"Seràgnoli" Institute of Hematology, University of Bologna, Bologna, Italy
¹¹MLL Munich Leukemia Laboratory, Munich, Germany

Erik Malmberg, MD^1*, Sara Ståhlman^2*, Anna Rehammar^3*, Tore Samuelsson, Professor^1*, Sofie J Alm^1*, Erik Kristiansson, PhD^3*, Jonas Abrahamsson^4*, Hege Garelius, MD^5*, Lars Palmqvist, MD, PhD^1,2 and Linda Fogelstrand, MD, PhD^1,2

¹Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
²Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
³Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden
⁴Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
⁵Department of Medicine, Sect. of Hematology and Coagulation, Sahlgrenska University Hospital, Göteborg, Sweden

Jae-Ho Yoon, M.D.^1*, Hee-Je Kim, M.D.¹, Byung Sik Cho^1*, Seung-Ah Yahng^2*, Seung-Hwan Shin^3*, Sung-Eun Lee, M.D.^1*, Ki-Seong Eom^1*, Yoo-Jin Kim, M.D.¹, Seok Lee, M.D.¹, Chang-Ki Min, M.D.^1*, Seok-Goo Cho, M.D.¹, Dong-Wook Kim⁴, Jong-Wook Lee, M.D.¹ and Woo-Sung Min, M.D.^1*

¹Department of Hematology, Catholic Blood and Marrow Transplantation Center, Cancer Research Institute, Seoul St. Mary’s hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
²Department of Hematology, Catholic BMT Center, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
³Department of Hematology, Catholic Blood and Marrow Transplantation Center, Cancer Research Institute, Yeoeuido St. Mary’s hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Seoul, South Korea
⁴Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea

Martin Neumann, MD^1,2*, Sebastian Vosberg, MSc^3,4,5*, Eva Kristin Von Der Heide, BSc^1*, Cornelia Schlee^1*, Jutta Ortiz Tanchez^1*, Konstandina Isaakidis^1*, Liliana H. Mochmann, BS, MSc^1*, Lars R. Fransecky^1*, Alexander Graf, PhD^6*, Stefan Krebs, PhD^6*, Helmut Blum, PhD^6*, Philipp A. Greif, MD^3,4,7 and Claudia D Baldus, MD^1,2

¹Department of Hematology and Oncology, Charité University Hospital, Berlin, Germany
²German Cancer Consortium (DKTK), Berlin, Germany
³Department of Internal Medicine III, Ludwig-Maximilians-University, Munich, Germany
⁴German Cancer Research Center (DKFZ), Heidelberg, Germany
⁵German Cancer Consortium (DKTK), Heidelberg, Germany
⁶Laboratory for Functional Genome Analysis, Gene-Center, Ludwig-Maximilians-University, Munich, Germany
⁷German Cancer Consortium (DKTK), Munich, Germany

Anna Dolnik, PhD^1*, Sundaram R. Chakkarappan, PhD^1*, Tamara J. Blätte^1*, Sibylle Cocciardi^1*, Jan Krönke, MD^1*, Corbacioglu Andrea, PhD^1*, Karlheinz Holzmann, PhD^2*, Peter Paschka, MD¹, Frank G. Rücker, MD^1*, Silke Kapp-Schwoerer, MD^1*, Verena I. Gaidzik, MD^1*, Richard F. Schlenk, MD¹, Hartmut Döhner, Prof. Dr.¹, Konstanze Döhner, MD¹ and Lars Bullinger, MD¹

¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²University of Ulm, Genomics Core Facility, Ulm, Germany

Elena Manara, PhD^1*, Valeria Bisio, BS^2*, Marco Frison, MD^2*, Katia Polato^2*, Claudia Tregnago, PhD^2*, Barbara Buldini, MD^2*, Riccardo Masetti, MD^3*, Roberto Rondelli, MD^4*, Gianni Cazzaniga, PhD⁵, Andrea Biondi, Prof, MD⁶, Franco Locatelli, Prof, MD, PhD^7*, Martina Pigazzi, PhD^2* and Giuseppe Basso, Prof, MD²

¹Hematology-Oncology Laboratory, IRP-Istituto di Ricerca Pediatrica-University of Padova, Padova, Italy
²Woman and Child Health Department, University of Padova, Padova, Italy
³Pediatric Oncology and Hematology, University of Bologna, Bologna, Italy
⁴Sant'Orsola Hospital, University of Bologna, Bologna, Italy
⁵Department of Pediatrics, Tettamanti Research Center, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
⁶Centro Ricerca Tettamanti, Clinica Pediatrica, Università Milano Bicocca, Osp. San Gerardo/Fondazione MBBM, Monza (MB), Italy
⁷Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy

Simone Weber^1*, Manja Meggendorfer, PhD^1*, Niroshan Nadarajah, M.Sc.^1*, Karolína Perglerová^2*, Susanne Schnittger, PhD¹, Claudia Haferlach, MD¹, Wolfgang Kern, MD¹ and Torsten Haferlach¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²MLL2 s.r.o., Praha, Czech Republic

Pedro Martin-Cabrera, MD^1*, Sabine Jeromin, PhD^1*, Tamara Alpermann^1*, Karolína Perglerová^2*, Claudia Haferlach, MD¹, Wolfgang Kern, MD¹ and Torsten Haferlach¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²MLL2 s.r.o., Praha, Czech Republic

Suzanne Kamel-Reid, PhD, DABMG, FACMG¹, Mariam Thomas, PhD^2*, Mahadeo A. Sukhai, BSc, MSc, PhD^2*, Dwayne L. Barber, PhD³, Swati Garg, PhD^2*, Maksym Misyura, PhD^2*, Roozbeh Dolatshahi^2*, Djamel Harbi^2*, Tong Zhang^2*, Anna Porwit, MD, PhD^4*, Jan M.A. Delabie, MD, PhD^4*, Narmin Ibrahimova^3*, Mohamed Shanavas, MD, FRACP, FRCPA³, Karen W.L. Yee, MD³, Trevor J. Pugh, PhD^5*, Philippe Bedard, MD^3*, Aaron D. Schimmer, MD, PhD³, Tracy L. Stockley, PhD^2*, Vikas Gupta, MD, FRCP, FRCPath³, Mark D. Minden, MD, PhD³ and Andre C Schuh, MD, FRCPC³

¹University Health Network, Molecular Diagnostics, Department of Pathobiology and Laboratory Medicine, Toronto, ON, Canada
²Advanced Molecular Diagnostics Laboratory, University Health Network, Toronto, ON, Canada
³Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁴Department of Pathobiology and Laboratory Medicine, University Health Network, Toronto, ON, Canada
⁵The Ontario Cancer Institute, University Health Network, Toronto, ON, Canada

Hanna A. Knaus, MD^1*, Raúl Montiel-Esparza, MD^1*, Joshua F. Zeidner, MD², Amanda Blackford, ScM^1*, Christopher G. Kanakry, MD¹, Ante Vulic, MD^1*, Mark J. Levis, MD, PhD¹, Judith E. Karp, MD¹, Leo Luznik, MD^1* and Ivana Gojo, MD¹

¹Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
²Department of Medicine, Division of Hematology/Oncology, University of North Carolina- Lineberger Comprehensive Cancer Center, Chapel Hill, NC

Gevorg Tamamyan, MD, MSc^1,2*, Gautam Borthakur, MD², Jorge E. Cortes, MD³, Farhad Ravandi, MD², Elias Jabbour², Naval Daver, MD², Naveen Pemmaraju, MD², Maro Ohanian, DO^2*, Albert Kolomansky, MD^2*, Gabriele Todisco, MD^2*, Ce Shi, MD, PhD^2,4*, Sherry Pierce, BSN, BA^2*, S. Andrew Peng, MS^5*, Marina Konopleva, MD, PhD², Hagop M. Kantarjian, MD² and Tapan Kadia, MD³

¹Department of Oncology, Yerevan State Medical University, Yerevan, Armenia
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, First Affiliated Hospital, Harbin Medical University, Harbin, China
⁵Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX

Pamela S. Becker, MD, PhD^1,2, Michael W. Schmitt, MD, PhD^3*, Zhiyi Xie, PhD^4*, Andrew Carson, PhD^5*, Bradley Patay, MD^5*, Seyed Sina Khankhajeh^6*, Qi Wei^7*, Ling-Hong Hung^7*, Timothy Martins, PhD^8*, Elihu H. Estey, MD^1*, C. Anthony Blau, MD^9,10*, Vivian G. Oehler, MD¹⁰ and Ka Yee Yeung, PhD^7*

¹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
²Division of Hematology and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA
³Hematology and Medical Oncology, University of Washington, Seattle, WA
⁴Invivoscribe, San Diego, CA
⁵Genection, San Diego, CA
⁶Institute of Technology, University of Washington, Tacoma, Tacoma, WA
⁷Institute of Technology, University of Washington, Tacoma, Tacoma, WA
⁸Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA
⁹Center for Cancer Innovation, University of Washington, Seattle, WA
¹⁰Division of Hematology, University of Washington, Seattle, WA

Maxim Norkin, MD, PhD¹, Myron Chang, PhD^2*, An Qi, PhD^3*, Helen Leather, BPharm¹, Lakshmikanth Katragadda, MD¹, Ying Li, MD, PhD^4*, Jan S Moreb, MD¹, W. Stratford May, MD, PhD¹, Randy A. Brown, MD¹, Jack W. Hsu, MD¹, John W Hiemenz, MD^1*, John R Wingard, MD^1* and Christopher R. Cogle, MD¹

¹University of Florida, Gainesville, FL
²Department of Biostatistics, College of Medicine, University of Florida, Gainesville, FL
³University of Florida, College of Medicine, Department of Biostatistics, Gainesville, FL
⁴Pathology, Immunoolgy and Laboratory Medicine, University of Florida, Gainesville, FL

Yuan Li, M.D.^1*, Ming Yue, Ph.D.^1*, John Anastasi, MD², Jeffery Q Shen, Ph.D.^3*, Yali Dou, Ph.D.^4*, Richard A. Larson, MD⁵, James W. Vardiman, MD² and Jason X. Cheng, MD, PhD²

¹University of Chicago, Chicago
²Department of Pathology, University of Chicago, Chicago, IL
³Bioinformatics Core, University of Nevada, Las Vegas, Las Vegas
⁴University of Michigan, Ann Arbor, MI
⁵Medicine, University of Chicago, Chicago, IL

Amy E Knight Johnson, MS^1*, Lucia Guidugli, PhD^1*, Kelly Arndt, BA^1*, Gorka Alkorta-Aranburu, PhD^1*, Viswateja Nelakuditi, MS^1*, Jane E. Churpek, MD², Lucy A Godley, MD, PhD³, Daniela del Gaudio, PhD^1*, Soma Das, PhD^1* and Zejuan Li, MD, PhD¹

¹Human Genetics, University of Chicago, Chicago, IL
²Department of Medicine, Section of Hematology/Oncology, The University of Chicago Medicine, Chicago, IL
³Department of Medicine, Section of Hematology-Oncology, University of Chicago Medical Center, Chicago, IL

Arhamatoulaye Maiga, Ph.D.^1*, Sébastien Lemieux, Ph.D.^1,2*, Caroline Pabst, M.D.^1*, Vincent-Philippe Lavallée, M.D.^1,3*, Michel Bouvier, Ph.D.^1,4*, Guy Sauvageau, M.D., Ph.D.^1,3,5,6 and Josée Hébert, M.D.^1,3,5,6

¹The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada
²Department of Computer Science and Operations Research, Université de Montréal, Montréal, QC, Canada
³Hematology-Oncology Division, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada
⁴Department of Biochemistry, Université de Montréal, Montréal, QC, Canada
⁵Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada
⁶Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada

Shinya Sato, MD, PhD^1*, Yasushi Miyazaki, MD, Ph.D.², Hidehiro Itonaga, MD, PhD^3*, Masataka Taguchi, MD^3*, Yasushi Sawayama, MD, PhD^1*, Daisuke Imanishi, MD, PhD^4*, Tomoko Hata, MD, PhD^1*, Yukiyoshi Moriuchi, MD^3*, Hiroyuki Mishima^5* and Kohichiro Yoshiura^5*

¹Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
²Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
³Department of Hematology, Sasebo City General Hospital, Sasebo, Japan
⁴Department of Hematology, Goto Central Hospital, Goto, Japan
⁵Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Bijender Kumar, PhD^1*, Lei Zhang, PhD.^2,3*, Yunan Miao^2,3*, Gerald Wuenschell^2,3*, Allen Lin^4*, Vinod Pullarkat, MD¹, Guido Marcucci, MD^1*, Robert Hickey, PhD.^2,3* and Ching-Cheng Chen, PhD¹

¹Division of Hematopoietic Stem Cell and Leukemia Research of Beckman Research Institute, Gehr Family Center for Leukemia Research, City of Hope National Medical Center, Duarte, CA
²Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA
³Translational Biomarker Discovery Core, Beckman Research Institute of City of Hope, Duarte, CA
⁴Division of Hematopoietic Stem Cell and Leukemia Research of Beckman Research Institute, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA

Frédéric Barabé, MD^1,2, Malika Laouedj^3* and Philippe Tessier^4*

¹Centre de Recherche du CHU de Québec, Centre de Recherche en Infectiologie, Québec, Canada
²Department of Medicine, Université Laval, Québec, Canada
³Centre de recherche en infectiologie, Centre de recherche du CHU de Quebec, Université laval, Faculté de Medecine, Québec, Canada
⁴Centre de recherche en infectiologie, Centre de recherche du CHU de Québec, Université laval, Faculté de Medecine, Québec, Canada

Sebastian Vosberg, MSc^1,2,3*, Luise Hartmann, MSc^1,2,3*, Stephanie Schneider, PhD^4*, Klaus H. Metzeler, MD^1,2,3, Bianka Ksienzyk^2*, Kathrin Bräundl^1,2,3*, Martin Neumann, MD^3,5*, Claudia D Baldus, MD^3,5, Alexander Graf, PhD^6*, Stefan Krebs, PhD^6*, Helmut Blum, PhD^6*, Karsten Spiekermann, MD^1,2,3, Stefan K. Bohlander, MD^7*, Ulrich Mansmann, PhD^3,8* and Philipp A. Greif, MD^1,2,3

¹German Cancer Research Center (DKFZ), Heidelberg, Germany
²Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany
³German Cancer Consortium (DKTK), Heidelberg, Germany
⁴Laboratory for Leukemia Diagnostics, Dept. of Internal Medicine III, University Hospital Großhadern, Ludwig-Maximilians-Universität, Munich, Germany
⁵Department of Hematology and Oncology, Charité University Hospital, Berlin, Germany
⁶Laboratory for Functional Genome Analysis, Gene-Center, Ludwig-Maximilians-University, Munich, Germany
⁷Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
⁸Institute for Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University (LMU), Munich, Munich, Germany

Mi-Hyun Bae, MD, PhD^1*, Young-Uk Cho, MD, PhD¹, Bohyun Kim^1*, Dong Hyun Lee^1*, Seongsoo Jang, MD, PhD¹, Eul-Ju Seo, MD, PhD^1*, Chan-Jeoung Park, MD, PhD¹, Dae-Young Kim, MD, PhD², Jung-Hee Lee, MD, PhD^3*, Je-Hwan Lee, MD, PhD², Kyoo-Hyung Lee, MD, PhD², Yoon Hwan Chang^4* and In-Suk Kim^5*

¹Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea
²Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
³Department of Hematology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea
⁴Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea
⁵Department of Laboratory Medicine, Pusan National University Yangsan Hospital, Pusan, South Korea