57th ASH Annual Meeting and Exposition (December 5-8, 2015): 602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation II

Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation Oral and Poster Abstracts
Oral

W307, Level 3 (Orange County Convention Center)

Moderators:

Pieter van Vliebergher, and Francine E. Garrett-Bakelman, MD, PhD, Weill Cornell Medical College

Disclosures:

No relevant conflicts of interest to declare.

7:00 AM

433

Specific Patterns of DNA Remethylation in the Bone Marrow Cells of Dnmt3a Deficient Mice after Induced Expression of Wild Type Human DNMT3A

Shamika Ketkar-Kulkarni¹, Angela Maria Verdoni, PhD²^*, Nichole Helton³^*, Christopher B Cole⁴, Celia Venezia²^*, Mieke Hoock⁵^*, Catrina Fronick⁶^*, Michelle O'Laughlin⁷^*, Robert S. Fulton, PhD⁷^*, David Spencer, MD/PhD⁸ and Timothy J. Ley, MD⁸

¹Department of Internal Medicne, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, St Louis, MO
²Department of Internal Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, St. Louis, MO
³Division of Oncology, Washington University in St. Louis School of Medicine, Saint Louis, MO
⁴Department of Medicine, Washington University School of Medicine, Siteman Cancer Center, Saint Louis, MO
⁵Department of Internal Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, St Louis, MO
⁶Washington University School of Medicine, Saint Louis, MO
⁷McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO
⁸Division of Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO

7:15 AM

434

A Chromatin Reader That Acts As a Key to Lock in and Coordinate Recruitment of Transcription Factors and a Novel Polycomb Complex to Bivalent Chromatin Thus Driving Formation of Germinal Centers and B-Cell Lymphomas

Wendy Béguelin¹^*, Matt Teater¹^*, Connie Corcoran²^*, Michelle Hamline²^*, Randy D. Gascoyne³, Ross L. Levine, MD⁴, Omar Abdel-Wahab⁴, Rita Shaknovich¹, Olivier Elemento⁵^*, Vivian J. Bardwell²^* and Ari Melnick, MD¹

¹Weill Cornell Medical College, New York, NY
²University of Minnesota, Minneapolis, MN
³British Columbia Cancer Agency, Vancouver, BC, Canada
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY

7:30 AM

435

Dose-Dependent Role of the Cohesin Complex in Normal and Malignant Hematopoiesis

Aaron D. Viny, MD, MS^1,2, Christopher J. Ott, PhD³, Barbara Spitzer, MD^2,4, Martin A Rivas, PhD⁵^*, Cem Meydan⁵^*, Efthymia Papalexi²^*, Dana Yelin, MD^2,6^*, Kaitlyn Shank, BS²^*, Jaime Reyes⁷^*, April Chiu, MD⁸^*, Swapna Thota, MD^9,10^*, Jaroslaw P Maciejewski, MD, PhD, FACP^9,11, Ari Melnick, MD⁵, James E. Bradner, MD^3,12 and Ross L. Levine, MD^1,13

¹Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Medicine/Hematology-Oncology and Department of Pharmacology, Weill Cornell Medical College, New York, NY
⁶Department of Medicine, Rabin Medical Center, Beilinson Campus, Petah-Tikva, Israel
⁷Dana-Farber Cancer Institute, Boston, MA
⁸Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁹Department of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
¹⁰Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
¹¹Translational Hematology and Oncology Research, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
¹²Harvard Medical School, Boston, MA
¹³Memorial Sloan Kettering Cancer Center, New York, NY

7:45 AM

436

Enhancer Landscapes Reveal Transcription Factor Network Dependencies in Chronic Lymphocytic Leukemia

Christopher J. Ott, PhD¹, Alexander J. Federation, PhD¹^*, Siddha Kasar, PhD¹^*, Josephine L. Klitgaard, MSc, PhD¹^*, Stacey M. Fernandes¹^*, Jennifer R. Brown, MD, PhD² and James E. Bradner, MD¹

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA

8:00 AM

437

Allele-Specific Crispr Targeting Reveals Epigenetic and Phenotypic Effects of a MMSET Gain of Function Mutation Found in Relapsed Acute Lymphoblastic Leukemia

Jon Oyer, PhD¹^*, Christine Will, M.S.¹^*, Xiaoxiao Huang²^*, Teresa Ezponda, PhD¹^*, Relja Popovic, PhD³^*, Yupeng Zheng, Ph.D.²^*, Neil L Kelleher, PhD²^* and Jonathan D. Licht, MD⁴

¹Feinberg School of Medicine Division of Hematology/Oncology, Northwestern University, Chicago, IL
²Proteomics Center of Excellence, Northwestern University, Evanston, IL
³Abbvie, North Chicago, IL
⁴Feinberg School of Medicine, Division of Hematology/Oncology, Northwestern University, Chicago, IL

8:15 AM

438

Epigenetic Changes Accompany Disordered Hemoglobin Regulation in Juvenile Myelomonocytic Leukemia

Silvia Fluhr^1,2^*, Christopher Felix Krombholz¹^*, Angelina Meier¹^*, Christoph Plass^3,4^*, Charlotte Niemeyer^1,4 and Christian Flotho^1,4^*

¹Division of Pediatric Hematology/Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
²Hermann Staudinger Graduate School, University of Freiburg, Freiburg, Germany
³Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
⁴German Cancer Consortium, Heidelberg, Germany

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^*signifies non-member of ASH

602.O2.6 602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation II