57th ASH Annual Meeting and Exposition (December 5-8, 2015): 601. Chromosomal Rearrangements and DNA Repair: Genomic Instability and Clonal Evolution In Hematopoietic Malignancy

Chromosomal Rearrangements and DNA Repair Oral and Poster Abstracts
Oral

W312, Level 3 (Orange County Convention Center)

Moderators:

and Markus Muschen, MD, PhD, University of California San Francisco

Disclosures:

No relevant conflicts of interest to declare.

7:30 AM

163

Differential Regulation of c-Myc/Lin28 Discriminates Subclasses of Rearranged MLL Leukemia

Lili Chen, PhD¹, Yuqing Sun¹^*, Jingya Wang, PhD¹^*, Hui Jiang, PhD²^* and Andrew G. Muntean, PhD¹

¹Department of Pathology, University of Michigan, Ann Arbor, MI
²Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI

7:45 AM

164

PI3Kdelta Inhibitors Increase Genomic Instability By Upregulating Aid Expression

Mara Compagno¹^*, Wang Qi¹^*, Chiara Pighi¹^*, Feilong Meng²^*, Taek-Chin Cheong¹^*, Teresa Poggio³^*, Fernanda Langellotto¹^*, Claudia Voena³^*, Monica Gostissa²^*, Frederick Alt²^* and Roberto Chiarle^1,3

¹Department of Pathology, Boston Children's Hospital, Boston, MA
²Department of Genetics, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA
³Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy

8:00 AM

165

Crispr-Cas9 Induced MLL-Rearrangements Cause Clonal Outgrowth in CD34+ Hematopoietic Stem Cells

Jana Reimer¹^*, Sabine Knoess¹^*, Maurice Labuhn¹^*, Emmanuelle Marie Charpentier, PhD^2,3^*, Jan-Henning Klusmann, MD¹ and Dirk Heckl, PhD¹^*

¹Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
²Regulation in Infection Biology (REGI), Helmholtz Centre for Infection Research / Hannover Medical School,, Hannover, Germany
³The Laboratory for Molecular Infection Medicine Sweden, Umea, Sweden

8:15 AM

166

Exposure to Inflammatory Immune Responses As Driver of Clonal Evolution in Childhood Acute Lymphoblastic Leukemia

Lars Klemm, BSc, MSc¹^*, Srividya Swaminathan, DPhil²^*, Elli Papaemmanuil, PhD³^*, Anthony M Ford⁴, Mel Greaves⁵, Rafael Casellas⁶^*, David Schatz⁷^*, Michael R. Lieber, MD-PhD⁸^* and Markus Muschen, MD, PhD⁹

¹University of California San Francisco, San Francisco, CA
²University of California, San Francisco, San Francisco, CA
³Memorial Sloan Kettering Cancer Center, New York
⁴Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom
⁵Haematology-Oncology, Institute of Cancer Research, Sutton, United Kingdom
⁶NIAMS, National Institutes of Health, Bethesda, MD
⁷Yale University School of Medicine, New Haven, CT
⁸University of Southern California, Los Angeles, CA
⁹Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA

8:30 AM

167

Kinetics of CLL Subclonal Architecture: Spontaneous Disease Progression or Treatment-Induced Selection?

Ceri Oldreive¹^*, Nick Davies, PhD¹^*, Anna Skowronska, PhD^1,2^*, Marwan Kwok, MB ChB, MRCP¹^*, Guy Pratt, MD PhD¹, Paul Moss¹, Michael John Griffiths, BSc²^*, Samuel Clokie²^*, A. Malcolm R Taylor¹^* and Tatjana Stankovic¹

¹School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom
²West Midlands Regional Genetics Laboratory, Birmingham, United Kingdom

8:45 AM

168

Models of Pluripotent and Somatic Stem Cells to Study Tissue-Specific Sensitivities in Fanconi Anemia

Timothy Michael Chlon, PhD¹, Susanne I Wells, PhD¹^*, Sonya Ruiz-Torres¹^*, Matthew Kuhar²^* and James M Wells, PhD¹^*

¹Cancer and Blood Diseases Institute, Cincinnati Children's Hospital, Cincinnati, OH
²Developmental Biology, Cincinnati Children's Hospital, Cincinnati, OH

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^*signifies non-member of ASH

601.O1.6 601. Chromosomal Rearrangements and DNA Repair: Genomic Instability and Clonal Evolution In Hematopoietic Malignancy