Giuseppe Cataldo, PhD^1*, Mary M. Lunzer, MA^2*, Donald A. Simone, PhD^1*, Eyup Akgün, PhD^2*, John D. Belcher, PhD³, Gregory M Vercellotti⁴ and Philip S. Portoghese, PhD^2*

¹School of Dentistry, Department of Diagnostic and Biological Sciences, Division of Basic Sciences, University of Minnesota, Minneapolis, MN
²College of Pharmacy, Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN
³Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
⁴Vascular Biology Center, Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN

Jianxun Lei, PhD^*, Ying Wang, MD, PhD^*, Jinny Paul, PhD^*, Susan Thompson, B.S.^*, Ritu Jha, M.Sc^* and Kalpna Gupta, PhD

Vascular Biology Center, Division of Hematology, Oncology & Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN

Dachuan Zhang, MS¹, Grace Chen, PhD^1*, Deepa Manwani, MD², Arthur Mortha, PhD^3*, Chunliang Xu, PhD^1*, Jeremiah J. Faith, PhD^4*, Robert D. Burk, MD^5*, Yuya Kunisaki, MD, PhD^1*, Jung-Eun Jang, PhD^1*, Christoph Scheiermann, PhD¹, Miriam Merad, MD, PhD⁶ and Paul S. Frenette, MD¹

¹Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY
²Department of Pediatrics, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY
³The Immunology Institute, Mount Sinai School of Medicine, New York, NY
⁴The Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY
⁵Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY
⁶Gene and Cell Medicine, Mount Sinai Medical Center, New York, NY

Adam M Bush, MS^1,2*, Roberta Miyeko Kato, MD^3*, Thomas D. Coates, MD² and John C Wood, MD, PhD^4*

¹Biomedical Engineering, University of Southern California, Los Angeles, CA
²Hematology Oncology, Children's Hospital Los Angeles, Los Angeles, CA
³Pulmonology, Children's Hospital Los Angeles, Los Angeles, CA
⁴Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA

Kathryn L. Hassell, MD¹, James R. Eckman, MD², Elizabeth S Klings, MD³, Robert J. Adams, MD, MS^4*, Julie A. Panepinto, MD, MSPH⁵, Tracey Grant, MS^6*, Wayne Huggins, PhD^6*, Deborah R. Maiese, MPA^6*, Ellen M. Werner, PhD⁷, Erin M. Ramos, PhD, MPH^8* and Carol M. Hamilton, PhD^6*

¹University of Colorado Denver Health Sciences Center, Aurora, CO
²Hematology&Oncology, Emory University, Atlanta, GA
³The Pulmonary Center, R-304, Boston University Sch. of Med., Boston, MA
⁴Medical University of South Carolina, Charleston, SC
⁵The Medical College of Wisconsin/Children's Research Institute of the Children's Hospital of Wisconsin, Milwaukee, WI
⁶RTI International, Research Triangle Park, NC
⁷Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
⁸National Human Genome Research Institute, National Institutes of Health, Bethesda, MD

Yankai Zhang, PhD^1*, Jacy R Crosby, MS^2*, Eric Boerwinkle, PhD^3*, Betty Pace, MD⁴ and Vivien A. Sheehan, MD, PhD⁵

¹Department of Pediatrics, Hematology Center, Baylor College of Medicine, Houston, TX
²School of Public Health, Univeristy of Houston Heath Sciences Center, Houston, TX
³Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX
⁴Sickle Cell Center, Georgia Regents University, Augusta, GA
⁵Hematology Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX