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Late Breaking Abstracts

Tuesday, December 9, 2008: 7:30 AM-9:00 AM
Halls B and C (Moscone Center)
Moderators:
Leonard I. Zon, MD and J. Evan Sadler, MD, PhD
Rituximab, Fludarabine, and Cyclophosphamide (R-FC) Prolongs Progression Free Survival in Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) Compared with FC Alone: Final Results from the International Randomized Phase III REACH Trial

Tadeusz Robak, MD, PhD1, Sergey I Moiseev, MD2*, Anna Dmoszynska, MD3*, Philippe Solal-Céligny, MD4*, Krzysztof Warzocha, MD, PhD5*, Javier Loscertales, MD6*, John Catalano, MD7, Boris V Afanasiev, MD8*, Loree Larratt, MD9, Christian Geisler, MD, DMSc10, Marco Montillo, MD11, Peter Ganly, BMBCh, PhD12*, Caroline Dartigeas, MD13*, András Rosta, MD, PhD14*, Ann Janssens, MD15*, Myriam Mendila, MD16*, Jörg Maurer16* and Michael K. Wenger, MD16*

1Dept of Haematology, Medical University, Lodz, Poland
2Hematology Department, Saint Petersburg Pavlov State Medical University, Saint Petersburg, Russia
3Klinika Hematoonkologii i Transplantacji, Szpiku Akademii Medycznej w Lublinie, Lublin, Poland
4Department of Hematolgy, Clinique Victor Hugo, Le Mans, France
5Instytut Hematologii I Transfuzjologii, Klinika Chorob Wewnetrznychi Hematologii, Warsaw, Poland
6Dept. Hematology, Hopital de la Princesa, Madrid, Spain
7Dorevitch Pathology Laboratory, Frankston Hospital, Frankston, Australia
8BMT Centre of Saint Petersburg, Pavlov State Medical University, Saint Petersburg, Russia
9Dept of Hematology, 2E3.33 Walter C. Mackenzie Health Sciences Centre, Edmonton, Canada
10Haematology Departement, Rigshospitalet, Copenhagen, Denmark
11Divisione Ematologia, Ospedale Niguarda, Milano, Italy
12Department of Haematology, Christchurch Hospital, Christchurch, New Zealand
13Service d'Hématologie et Thérapie Cellulaire, CHU de Tours, Tours, France
14"A" Department of Medicine, National Institute of Oncology, Budapest, Hungary
15UZ Gasthuisberg, Leuven, Belgium
16Pharmaceuticals Division, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Human Adenylate Kinase 2 Deficiency Causes a Profound Haematopoietic Defect Associated with Sensorineural Deafness

Marina Cavazzana-Calvo, MD, PhD1, Chantal Lagresle-Peyrou2*, Emmanuelle M Six2*, Capucine Picard, MD2*, Frederic Rieux-Laucat2*, Vincent Michel3*, Andrea Ditadi2*, Corinne Demerens-de-Chappedelaine2*, Estelle Morillon2*, Françoise Valensi2*, Karen L Simon-Stoos4*, James C Mullikin5*, Lenora M Noroski6*, Céline Besse7*, Nicolas Wulffraat8*, Alina Ferster, MD, PhD9, Manuel M Abecasis, MD10*, Fabien Calvo, MD, PhD11*, Christine Petit, PhD3*, Fabio Candotti, MD5, Laurent Abel, PhD12* and Alain Fischer, MD, PhD13*

1Inserm Research Unit U-768, INSERM, Université Paris Descartes, IFR94, AP-HP Hopital Necker Enfants-Malades, Paris, France
2Inserm Research Unit U-768, INSERM, Université Paris Descartes, IFR94, Paris, France
3Unité de Génétique et Physiologie de l'Audition, UMRS587, INSERM, Université Paris VI, Institut Pasteur, Paris, France
4Genetics & Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD
5Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD
6Division of Allergy and Immunology, Department of Pediatrics, Baylor College of Medicine, Houston, TX
7Centre National de Génotypage, Evry, France
8Department of Immunology/BMT, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands
9Hémato-oncologie pédiatrique, Children's University Hospital Reine Fabiola, Brussels, Belgium
10Bone Marrow Transplantation Unit, Instituto Português de Oncologia, Lisboa, Portugal
11Clinical Investigation Center, INSERM U716, INSERM, APHP Hopital Saint-Louis, Paris, France
12Laboratory of Human Genetics of Infectious Diseases, INSERM U-550, INSERM, Université Paris Descartes, 75015, France
13Service d'Immunologie et Hematologie Pediatrique, INSERM, Université Paris Descartes, IFR94, AP-HP Hopital Necker Enfants-Malades, Paris, France

TET2 Is a Novel Tumor Suppressor Gene Inactivated in Myeloproliferative Neoplasms: Identification of a Pre-JAK2 V617F Event

Francois Delhommeau1*, Sabrina Dupont2*, Chloe James, MD, PhD3, Aline Masse2*, Jean Pierre le Couedic2*, Veronique Della Valle3*, Antonio Alberdi4*, Philippe Dessen5*, Michaela Fontenay6*, Nicole Casadevall, MD7, Jean Soulier, MD, PhD4, Olivier Bernard8* and William Vainchenker9

1Hematology, Paris 6 University Pierre et Marie Curie, Saint-Antoine Hospital, Paris, France
2U790, Inserm, Villejuif, France
3Universite Bordeaux 2, INSERM U876, Bordeaux, France
4Hematology Laboratory, Hopital Saint-Louis, Paris, France
5Genomics, Institut Gustave Roussy, Villejuif, France
6Groupe Francophone des Myelodysplasies, France
7Laboratoire d'Hematologie, Hopital St Antoine, Paris, France
8INSERM E0210, Hopital Necker ; Université Paris V, Paris, France
9INSERM U790, Institut Gustave Roussy, Villejuif, France

Successful and Safe Treatment of Canine Hemophilia by Continuous Expression of Canine FVIIa: a Model for FVIII/FIX Gene-Based Bypassing Agents

Paris Margaritis1*, Elise Roy1*, Majed N Aljamali1*, Harre Downey1*, Shangzhen Zhou1*, Elizabeth Merricks2*, Aaron Dillow2*, Timothy C Nichols2* and Katherine A. High, MD3

1Hematology Research, The Children's Hospital of Philadelphia, Philadelphia, PA
2Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
3Howard Hughes Medical Institute, The Children's Hospital of Philadelphia, Philadelphia, PA

Tetrahydrobiopterin (6R-BH4): Novel Therapy for Endothelial Dysfunction in Sickle Cell Disease

Lewis Hsu, MD, PhD1, Kenneth I Ataga, M.D.2*, Victor R. Gordeuk, MD3, Paul S. Swerdlow, MD4, Abdullah Kutlar, MD5*, Wally Smith, MD6*, J. Martin Johnston, MD7*, Ian A Chen, MD, MPH, FACP8*, Anne Greist, MD9, Frances Flug, MD10, Susumu Inoue, MD11, Olise M. Nwose, MBBS, MRCPath12*, Saba Sile, MD12* and Emil Kakkis, MD, PhD12*

1Pediatrics, Drexel University, Philadelphia, PA
2Medicine/ Hematology, UNC, Chapel Hill, NC
3Howard University, Washington, DC
44Medicine/Hematology, Wayne State University, Detroit, MI
5Anesthesiology & Periop. Med., Medical College of Georgia, Augusta, GA
6Virginia Commonwealth University, Richmond, VA
7Memorial Health University Medical Center, Savannah, GA
8Medicine, Eastern Virginia Medical School, Norfolk, VA
9Indiana Hemophilia & Thrombosis Ctr., Indianapolis, IN
10Hackensack Univ. Medical Ctr., Hackensack, NJ
11Hurley Medical Center, Flint, MI
12BioMarin Pharmaceutical, Novato, CA

Recombinant Human Erythropoiesis Stimulating Agents in Cancer Patients: Individual Patient Data Meta-Analysis on Behalf of the EPO IPD Meta-Analysis Collaborative Group

Julia Bohlius, MD, MScPH1*, Corinne Brillant2*, Michael Clarke, PhD3*, Sabine Kluge2*, Maryann Napoli4*, Margaret Piper, PhD, MPH5*, Dirk Rades, MD, PhD6*, Isabelle Ray-Coquard, MD7*, Kurt Schmidlin, MD, MPH1*, Martin Schumacher, PhD8*, Guido Schwarzer, PhD8*, Jerome Seidenfeld, MSc, PhD5, David P. Steensma, MD, FACP9, Sven Trelle, MD1*, Michael Untch, MD10*, Olaf Weingart, MD2*, Marcel Zwahlen, PhD1*, Matthias Egger, MD, MSc1* and Andreas Engert, MD2

1University of Bern, Institute of Social and Preventive Medicine, Bern, Switzerland
2Cochrane Haematological Malignancies Group, Department of Internal Medicine I, University Hospital of Cologne, Cologne, Germany
3National Institute for Health Research, UK Cochrane Centre, Oxford, United Kingdom
4Center for Medical Consumers, Cochrane Consumer Network, New York
5Technology Evaluation Center, Blue Cross and Blue Shield Association, Chicago, IL
6University Hospital Lübeck, Department of Radiation Oncology, Lübeck, Germany
7Centre Leon-Berard, Lyon, France
8University Medical Center Freiburg, Department of Medical Biometry and Statistics, Freiburg, Germany
9Division of Hematology, Mayo Clinic Graduate School of Medicine, Rochester, MN
10Clinic for Gynecology, Helios Hospital Berlin-Buch, Berlin, Germany